Details for: ERG

Gene ID: 2078

Symbol: ERG

Ensembl ID: ENSG00000157554

Description: ETS transcription factor ERG

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.29
    Marker Score: 15425
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.38
    Marker Score: 4905
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.03
    Marker Score: 1765
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.95
    Marker Score: 1762
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.75
    Marker Score: 23269
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.61
    Marker Score: 7484
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.26
    Marker Score: 6690
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2
    Marker Score: 19304
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.04
    Marker Score: 2810.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.81
    Marker Score: 567
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.71
    Marker Score: 2018.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.7
    Marker Score: 3393
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.69
    Marker Score: 1815
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.64
    Marker Score: 1567.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.64
    Marker Score: 3155
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.61
    Marker Score: 1519
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.6
    Marker Score: 1378
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.59
    Marker Score: 14913.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.53
    Marker Score: 2362
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.49
    Marker Score: 3024
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169010
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.42
    Marker Score: 345
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.4
    Marker Score: 336
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.29
    Marker Score: 1153
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.28
    Marker Score: 927
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.27
    Marker Score: 1146
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2
    Marker Score: 2028.5
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.19
    Marker Score: 462
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 482
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4797
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.11
    Marker Score: 2825
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.11
    Marker Score: 305.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17268
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.05
    Marker Score: 656
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251786
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.03
    Marker Score: 2948
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.01
    Marker Score: 234
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71804.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.98
    Marker Score: 1421
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 650
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.92
    Marker Score: 196
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5190
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.89
    Marker Score: 284
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.88
    Marker Score: 8960
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.86
    Marker Score: 201
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.86
    Marker Score: 864
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.85
    Marker Score: 482
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.81
    Marker Score: 872
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.79
    Marker Score: 3232
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 596.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1255
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 364
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.76
    Marker Score: 519.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.76
    Marker Score: 6533
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.75
    Marker Score: 263
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.75
    Marker Score: 310
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.75
    Marker Score: 393
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 236
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.7
    Marker Score: 185
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.65
    Marker Score: 360
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.65
    Marker Score: 517
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.64
    Marker Score: 643.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.62
    Marker Score: 1177
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.61
    Marker Score: 157
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.56
    Marker Score: 123.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.53
    Marker Score: 135
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5
    Marker Score: 571
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2874
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 205
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.46
    Marker Score: 2261
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.45
    Marker Score: 219
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.45
    Marker Score: 259
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.45
    Marker Score: 5934.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 262
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.42
    Marker Score: 136.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.42
    Marker Score: 264
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 945
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.39
    Marker Score: 183
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.38
    Marker Score: 206
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.37
    Marker Score: 183.5
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.37
    Marker Score: 102
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 207

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Other Information

**Key characteristics:** - ERG is a transcription factor of the ETS family. - It is a highly conserved protein with a conserved DNA-binding domain. - ERG is a key regulator of neuronal differentiation and function. - It is involved in the regulation of a wide range of genes involved in neuronal survival, differentiation, and plasticity. **Pathways and functions:** - ERG is a key regulator of neuronal differentiation. - It is responsible for the expression of genes involved in neuronal survival, differentiation, and growth. - ERG is also involved in the regulation of synaptic plasticity and learning and memory. - It is a key regulator of the development and function of the nervous system. **Clinical significance:** - Mutations in ERG have been linked to a number of neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. - ERG is a potential target for the treatment of neurodegenerative diseases. - Targeting ERG with small molecule inhibitors is a promising strategy for the treatment of neurodegenerative diseases. **Additional notes:** - ERG is a highly highly conserved protein with a predicted molecular weight of 150 kDa. - It is a ubiquitin-dependent protein, meaning that it is degraded by the proteasome when it is no longer needed. - ERG is a well-studied protein with a number of known targets and interactions.

Genular Protein ID: 90790890

Symbol: ERG_HUMAN

Name: Transcriptional regulator ERG

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3299708

Title: erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation.

PubMed ID: 3299708

DOI: 10.1126/science.3299708

PubMed ID: 3476934

Title: The erg gene: a human gene related to the ets oncogene.

PubMed ID: 3476934

DOI: 10.1073/pnas.84.17.6131

PubMed ID: 14693372

Title: Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16.

PubMed ID: 14693372

DOI: 10.1016/j.gene.2003.09.047

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8290279

Title: Differentially spliced erg-3 product functions as a transcriptional activator.

PubMed ID: 8290279

PubMed ID: 8076344

Title: ERG gene is translocated in an Ewing's sarcoma cell line.

PubMed ID: 8076344

DOI: 10.1016/0165-4608(94)90063-9

PubMed ID: 8187069

Title: An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.

PubMed ID: 8187069

PubMed ID: 16303180

Title: ELF4 is fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22).

PubMed ID: 16303180

DOI: 10.1016/j.leukres.2005.10.014

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15351649

Title: Diversity in structure and function of the Ets family PNT domains.

PubMed ID: 15351649

DOI: 10.1016/j.jmb.2004.07.094

Sequence Information:

  • Length: 479
  • Mass: 53838
  • Checksum: A5069C393E409483
  • Sequence:
  • MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQP 
    PARVTIKMEC NPSQVNGSRN SPDECSVAKG GKMVGSPDTV GMNYGSYMEE KHMPPPNMTT 
    NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVNILLF QNIDGKELCK MTKDDFQRLT 
    PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTGGAAFI FPNTSVYPEA 
    TQRITTRPDL PYEPPRRSAW TGHGHPTPQS KAAQPSPSTV PKTEDQRPQL DPYQILGPTS 
    SRLANPGSGQ IQLWQFLLEL LSDSSNSSCI TWEGTNGEFK MTDPDEVARR WGERKSKPNM 
    NYDKLSRALR YYYDKNIMTK VHGKRYAYKF DFHGIAQALQ PHPPESSLYK YPSDLPYMGS 
    YHAHPQKMNF VAPHPPALPV TSSSFFAAPN PYWNSPTGGI YPNTRLPTSH MPSHLGTYY

Genular Protein ID: 2777376488

Symbol: B5MDW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 455
  • Mass: 51261
  • Checksum: DCC10774F9DA32F7
  • Sequence:
  • MASTIKEALS VVSEDQSLFE CAYGTPHLAK TEMTASSSSD YGQTSKMSPR VPQQDWLSQP 
    PARVTIKMEC NPSQVNGSRN SPDECSVAKG GKMVGSPDTV GMNYGSYMEE KHMPPPNMTT 
    NERRVIVPAD PTLWSTDHVR QWLEWAVKEY GLPDVNILLF QNIDGKELCK MTKDDFQRLT 
    PSYNADILLS HLHYLRETPL PHLTSDDVDK ALQNSPRLMH ARNTDLPYEP PRRSAWTGHG 
    HPTPQSKAAQ PSPSTVPKTE DQRPQLDPYQ ILGPTSSRLA NPGSGQIQLW QFLLELLSDS 
    SNSSCITWEG TNGEFKMTDP DEVARRWGER KSKPNMNYDK LSRALRYYYD KNIMTKVHGK 
    RYAYKFDFHG IAQALQPHPP ESSLYKYPSD LPYMGSYHAH PQKMNFVAPH PPALPVTSSS 
    FFAAPNPYWN SPTGGIYPNT RLPTSHMPSH LGTYY

Genular Protein ID: 1543255446

Symbol: B4DN83_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 486
  • Mass: 54634
  • Checksum: BAEAEB929311D334
  • Sequence:
  • MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ 
    QDWLSQPPAR VTIKMECNPS QVNGSRNSPD ECSVAKGGKM VGSPDTVGMN YGSYMEEKHM 
    PPPNMTTNER RVIVPPDPTL WSTDHVRQWL EWAVKEYGLP DVNILLFQNI DGKELCKMTK 
    DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN 
    TSVYPEATQR ITTRPDLPYE PPRRSAWTGH GHPTPQSKAA QPSPSTVPKT EDQRPQLDPY 
    QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSSCITWE GTNGEFKMTD PDEVARRWGE 
    RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS 
    DLPYMGSYHA HPQKMNFVAP HPPALPVTSS SFFAAPNPYW NSPTGGIYPN TRLPTSHMPS 
    HLGTYY

Genular Protein ID: 1814007607

Symbol: B4DVX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 362
  • Mass: 41222
  • Checksum: 2858CEE65306887A
  • Sequence:
  • MTTNERRVIV PADPTLWSTD HVRQWLEWAV KEYGLPDVNI LLFQNIDGKE LCKMTKDDFQ 
    RLTPSYNADI LLSHLHYLRE TPLPHLTSDD VDKALQNSPR LMHARNTGGA AFIFPNTSVY 
    PEATQRITTR PDLPYEPPRR SAWTGHGHPT PQSKAAQPSP STVPKTEDQR PQLDPYQILG 
    PTSSRLANPG SGQIQLWQFL LELLSDSSNS SCITWEGTNG EFKMTDPDEV ARRWGERKSK 
    PNMNYDKLSR ALRYYYDKNI MTKVHGKRYA YKFDFHGIAQ ALQPHPPESS LYKYPSDLPY 
    MGSYHAHPQK MNFVAPHPPA LPVTSSSFFA APNPYWNSPT GGIYPNTRLP TSHMPSHLGT 
    YY

Genular Protein ID: 228784616

Symbol: A0A0C4DG41_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 387
  • Mass: 43974
  • Checksum: 6C19CE3D70C769EA
  • Sequence:
  • MVGSPDTVGM NYGSYMEEKH MPPPNMTTNE RRVIVPADPT LWSTDHVRQW LEWAVKEYGL 
    PDVNILLFQN IDGKELCKMT KDDFQRLTPS YNADILLSHL HYLRETPLPH LTSDDVDKAL 
    QNSPRLMHAR NTGGAAFIFP NTSVYPEATQ RITTRPDLPY EPPRRSAWTG HGHPTPQSKA 
    AQPSPSTVPK TEDQRPQLDP YQILGPTSSR LANPGSGQIQ LWQFLLELLS DSSNSSCITW 
    EGTNGEFKMT DPDEVARRWG ERKSKPNMNY DKLSRALRYY YDKNIMTKVH GKRYAYKFDF 
    HGIAQALQPH PPESSLYKYP SDLPYMGSYH AHPQKMNFVA PHPPALPVTS SSFFAAPNPY 
    WNSPTGGIYP NTRLPTSHMP SHLGTYY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.