Details for: TCF3

Gene ID: 6929

Symbol: TCF3

Ensembl ID: ENSG00000071564

Description: transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.8406
    Cell Significance Index: -11.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.1345
    Cell Significance Index: -15.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.5316
    Cell Significance Index: -16.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.9784
    Cell Significance Index: -16.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.6420
    Cell Significance Index: -16.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6110
    Cell Significance Index: -17.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6071
    Cell Significance Index: -18.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2065
    Cell Significance Index: -12.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5121
    Cell Significance Index: 162.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6232
    Cell Significance Index: 1465.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3889
    Cell Significance Index: 151.0800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1.3652
    Cell Significance Index: 7.7600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1265
    Cell Significance Index: 15.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0672
    Cell Significance Index: 55.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8996
    Cell Significance Index: 106.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8745
    Cell Significance Index: 25.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8376
    Cell Significance Index: 166.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7067
    Cell Significance Index: 48.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5762
    Cell Significance Index: 12.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5300
    Cell Significance Index: 29.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4782
    Cell Significance Index: 10.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4695
    Cell Significance Index: 21.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4599
    Cell Significance Index: 5.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4579
    Cell Significance Index: 164.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4445
    Cell Significance Index: 23.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4429
    Cell Significance Index: 241.8700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4410
    Cell Significance Index: 71.7300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4262
    Cell Significance Index: 11.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3240
    Cell Significance Index: 39.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3082
    Cell Significance Index: 42.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2882
    Cell Significance Index: 127.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2841
    Cell Significance Index: 51.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2423
    Cell Significance Index: 8.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2258
    Cell Significance Index: 45.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1863
    Cell Significance Index: 35.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1796
    Cell Significance Index: 11.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1738
    Cell Significance Index: 4.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1599
    Cell Significance Index: 10.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1528
    Cell Significance Index: 2.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1436
    Cell Significance Index: 10.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1258
    Cell Significance Index: 2.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1207
    Cell Significance Index: 5.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1145
    Cell Significance Index: 5.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1143
    Cell Significance Index: 155.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1017
    Cell Significance Index: 2.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1015
    Cell Significance Index: 156.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0884
    Cell Significance Index: 2.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0855
    Cell Significance Index: 1.8200
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.0793
    Cell Significance Index: 0.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0788
    Cell Significance Index: 145.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0415
    Cell Significance Index: 5.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0221
    Cell Significance Index: 10.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0210
    Cell Significance Index: 2.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0177
    Cell Significance Index: 33.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0140
    Cell Significance Index: 0.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0016
    Cell Significance Index: 1.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0016
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0081
    Cell Significance Index: -0.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0148
    Cell Significance Index: -10.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0157
    Cell Significance Index: -2.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0227
    Cell Significance Index: -16.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0228
    Cell Significance Index: -3.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0298
    Cell Significance Index: -16.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0317
    Cell Significance Index: -19.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0371
    Cell Significance Index: -0.9900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0469
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0521
    Cell Significance Index: -14.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0527
    Cell Significance Index: -5.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0653
    Cell Significance Index: -2.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0702
    Cell Significance Index: -2.2500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0711
    Cell Significance Index: -1.0800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0794
    Cell Significance Index: -2.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0814
    Cell Significance Index: -6.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0881
    Cell Significance Index: -10.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0894
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0945
    Cell Significance Index: -19.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0967
    Cell Significance Index: -11.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1058
    Cell Significance Index: -1.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1350
    Cell Significance Index: -3.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1358
    Cell Significance Index: -14.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1384
    Cell Significance Index: -5.2400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.1426
    Cell Significance Index: -0.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1459
    Cell Significance Index: -3.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1584
    Cell Significance Index: -3.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1664
    Cell Significance Index: -11.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1687
    Cell Significance Index: -4.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2020
    Cell Significance Index: -16.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2608
    Cell Significance Index: -15.9900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2901
    Cell Significance Index: -6.2000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3000
    Cell Significance Index: -1.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3125
    Cell Significance Index: -6.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3265
    Cell Significance Index: -7.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3288
    Cell Significance Index: -3.9200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3322
    Cell Significance Index: -4.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3361
    Cell Significance Index: -8.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3476
    Cell Significance Index: -18.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor**: TCF3 is a transcription factor that binds to specific DNA sequences, thereby regulating the expression of target genes. 2. **B Cell Differentiation**: TCF3 is essential for the development of B cells, from early pro-B cells to mature B cell populations. 3. **Chromatin Remodeling**: TCF3 interacts with chromatin remodeling complexes, influencing gene expression and chromatin structure. 4. **DNA Binding**: TCF3 binds to specific DNA sequences, including E-box and vitamin D response elements, to regulate gene expression. 5. **Protein-Protein Interactions**: TCF3 interacts with various proteins, including Runx1 and TFE2, to regulate transcriptional processes. **Pathways and Functions:** 1. **B Cell Differentiation**: TCF3 regulates the expression of genes involved in B cell development, including immunoglobulin heavy chain (IgH) genes. 2. **Transcriptional Regulation**: TCF3 binds to specific DNA sequences, influencing the expression of target genes involved in immune cell development and function. 3. **Chromatin Remodeling**: TCF3 interacts with chromatin remodeling complexes, influencing gene expression and chromatin structure. 4. **DNA Binding**: TCF3 binds to specific DNA sequences, including E-box and vitamin D response elements, to regulate gene expression. 5. **Protein-Protein Interactions**: TCF3 interacts with various proteins, including Runx1 and TFE2, to regulate transcriptional processes. **Clinical Significance:** 1. **Immunodeficiency Disorders**: TCF3 mutations have been associated with immunodeficiency disorders, including X-linked agammaglobulinemia (XLA) and X-linked lymphoproliferative disease (XLP). 2. **Autoimmune Diseases**: TCF3 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: TCF3 has been identified as a potential target for cancer therapy, particularly in lymphoid malignancies. 4. **Vaccine-Associated Immune Responses**: TCF3 plays a critical role in regulating the immune response to vaccines, highlighting its importance in vaccine development and efficacy. In conclusion, TCF3 is a critical regulator of immune cell development and function, influencing various cellular processes, including transcriptional regulation, chromatin remodeling, and DNA binding. Its dysregulation has been associated with immunodeficiency disorders, autoimmune diseases, and cancer, highlighting the need for further research into TCF3's role in immune homeostasis and disease.

Genular Protein ID: 651299786

Symbol: TFE2_HUMAN

Name: Transcription factor E2-alpha

UniProtKB Accession Codes:

P15923 P15883 Q14208 Q14635 Q14636 Q2TB39 Q2TB40 Q9UPI9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1967983

Title: A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

PubMed ID: 1967983

DOI: 10.1016/0092-8674(90)90658-2

PubMed ID: 1967982

Title: Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

PubMed ID: 1967982

DOI: 10.1016/0092-8674(90)90657-z

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2493990

Title: A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.

PubMed ID: 2493990

DOI: 10.1016/0092-8674(89)90682-x

PubMed ID: 2308859

Title: Sequence of the cDNA encoding ITF-1, a positive-acting transcription factor.

PubMed ID: 2308859

DOI: 10.1093/nar/18.3.677

PubMed ID: 1818757

Title: Sequence of a HeLa cDNA provides the DNA binding domain and carboxy terminus of HE47: a human helix-loop-helix protein related to the enhancer binding factor E47.

PubMed ID: 1818757

DOI: 10.3109/10425179109039690

PubMed ID: 2105528

Title: Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.

PubMed ID: 2105528

DOI: 10.1126/science.2105528

PubMed ID: 2112746

Title: Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.

PubMed ID: 2112746

DOI: 10.1073/pnas.87.12.4722

PubMed ID: 1671560

Title: The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias.

PubMed ID: 1671560

PubMed ID: 1386162

Title: Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.

PubMed ID: 1386162

DOI: 10.1126/science.1386162

PubMed ID: 9409784

Title: The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors.

PubMed ID: 9409784

DOI: 10.1016/s0378-1119(97)00444-7

PubMed ID: 10086727

Title: Identification of a novel molecular partner of the E2A gene in childhood leukemia.

PubMed ID: 10086727

DOI: 10.1038/sj.leu.2401338

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 15044608

Title: Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary.

PubMed ID: 15044608

DOI: 10.1093/molehr/gah056

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25466284

Title: Mutations affecting the BHLHA9 DNA-binding domain cause MSSD, mesoaxial synostotic syndactyly with phalangeal reduction, Malik-Percin type.

PubMed ID: 25466284

DOI: 10.1016/j.ajhg.2014.10.012

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31696227

Title: Atonal homolog 7 (ATOH7) loss-of-function mutations in predominant bilateral optic nerve hypoplasia.

PubMed ID: 31696227

DOI: 10.1093/hmg/ddz268

PubMed ID: 8433970

Title: Proposed structure for the DNA-binding domain of the helix-loop-helix family of eukaryotic gene regulatory proteins.

PubMed ID: 8433970

DOI: 10.1093/protein/6.1.41

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 24216514

Title: A recurrent dominant negative E47 mutation causes agammaglobulinemia and BCR(-) B cells.

PubMed ID: 24216514

DOI: 10.1172/jci71927

PubMed ID: 28532655

Title: Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia.

PubMed ID: 28532655

DOI: 10.1016/j.jaci.2017.04.037

PubMed ID: 30063982

Title: Autosomal Recessive Agammaglobulinemia - first case with a novel TCF3 mutation from Pakistan.

PubMed ID: 30063982

DOI: 10.1016/j.clim.2018.07.016

Sequence Information:

  • Length: 654
  • Mass: 67600
  • Checksum: 52F5E3DE1890AE13
  • Sequence:
    • MNQPQRMAPV GTDKELSDLL DFSMMFPLPV TNGKGRPASL AGAQFGGSGL EDRPSSGSWG 
SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG KSGERGAYAS FGRDAGVGGL 
TQAGFLSGEL ALNSPGPLSP SGMKGTSQYY PSYSGSSRRR AADGSLDTQP KKVRKVPPGL 
PSSVYPPSSG EDYGRDATAY PSAKTPSSTY PAPFYVADGS LHPSAELWSP PGQAGFGPML 
GGGSSPLPLP PGSGPVGSSG SSSTFGGLHQ HERMGYQLHG AEVNGGLPSA SSFSSAPGAT 
YGGVSSHTPP VSGADSLLGS RGTTAGSSGD ALGKALASIY SPDHSSNNFS SSPSTPVGSP 
QGLAGTSQWP RAGAPGALSP SYDGGLHGLQ SKIEDHLDEA IHVLRSHAVG TAGDMHTLLP 
GHGALASGFT GPMSLGGRHA GLVGGSHPED GLAGSTSLMH NHAALPSQPG TLPDLSRPPD 
SYSGLGRAGA TAAASEIKRE EKEDEENTSA ADHSEEEKKE LKAPRARTSP DEDEDDLLPP 
EQKAEREKER RVANNARERL RVRDINEAFK ELGRMCQLHL NSEKPQTKLL ILHQAVSVIL 
NLEQQVRERN LNPKAACLKR REEEKVSGVV GDPQMVLSAP HPGLSEAHNP AGHM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.