Gene GNG11 - ENSG00000127920 | NCBI Gene ID: 2791

Details for: GNG11

Gene ID: 2791

Symbol: GNG11

Ensembl ID: ENSG00000127920

Description: G protein subunit gamma 11

Associated with

Activation of gabab receptors
(R-HSA-991365)
Activation of g protein gated potassium channels
(R-HSA-1296041)
Activation of kainate receptors upon glutamate binding
(R-HSA-451326)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Adrenaline,noradrenaline inhibits insulin secretion
(R-HSA-400042)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Aquaporin-mediated transport
(R-HSA-445717)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Ca2+ pathway
(R-HSA-4086398)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class b/2 (secretin family receptors)
(R-HSA-373080)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Disease
(R-HSA-1643685)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
G-protein activation
(R-HSA-202040)
G-protein beta:gamma signalling
(R-HSA-397795)
Gaba b receptor activation
(R-HSA-977444)
Gaba receptor activation
(R-HSA-977443)
G alpha (12/13) signalling events
(R-HSA-416482)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
G alpha (s) signalling events
(R-HSA-418555)
G alpha (z) signalling events
(R-HSA-418597)
G beta:gamma signalling through btk
(R-HSA-8964315)
G beta:gamma signalling through cdc42
(R-HSA-8964616)
G beta:gamma signalling through pi3kgamma
(R-HSA-392451)
G beta:gamma signalling through plc beta
(R-HSA-418217)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Glucagon-type ligand receptors
(R-HSA-420092)
Glucagon signaling in metabolic regulation
(R-HSA-163359)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Gper1 signaling
(R-HSA-9634597)
G protein gated potassium channels
(R-HSA-1296059)
Hemostasis
(R-HSA-109582)
Infectious disease
(R-HSA-5663205)
Inhibition of voltage gated ca2+ channels via gbeta/gamma subunits
(R-HSA-997272)
Integration of energy metabolism
(R-HSA-163685)
Inwardly rectifying k+ channels
(R-HSA-1296065)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Opioid signalling
(R-HSA-111885)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet homeostasis
(R-HSA-418346)
Potassium channels
(R-HSA-1296071)
Presynaptic function of kainate receptors
(R-HSA-500657)
Prostacyclin signalling through prostacyclin receptor
(R-HSA-392851)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by wnt
(R-HSA-195721)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Vasopressin regulates renal water homeostasis via aquaporins
(R-HSA-432040)
G-protein beta-subunit binding
(GO:0031681)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activity
(GO:0003924)
Heterotrimeric g-protein complex
(GO:0005834)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.63
Marker Score: 11759
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.49
Marker Score: 6506
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.84
Marker Score: 33705
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 3.56
Marker Score: 5173
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.31
Marker Score: 6621
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.1
Marker Score: 2668
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 3
Marker Score: 697
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.69
Marker Score: 6622
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 2.6
Marker Score: 3733
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.57
Marker Score: 4343
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.51
Marker Score: 2361
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.47
Marker Score: 9155
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 2.33
Marker Score: 906
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.23
Marker Score: 2246
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 2.19
Marker Score: 916
Cell Name: late pro-B cell (CL0002048)
Fold Change: 2.15
Marker Score: 2539
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2.11
Marker Score: 512
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 2.06
Marker Score: 438
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.98
Marker Score: 819
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.97
Marker Score: 501
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.97
Marker Score: 4966
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.94
Marker Score: 424
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.93
Marker Score: 1730
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.93
Marker Score: 21729
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.82
Marker Score: 1643
Cell Name: theca cell (CL0000503)
Fold Change: 1.78
Marker Score: 1275
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.76
Marker Score: 1110
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.75
Marker Score: 561
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.72
Marker Score: 4490
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.7
Marker Score: 1014
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.68
Marker Score: 1798
Cell Name: decidual cell (CL2000002)
Fold Change: 1.65
Marker Score: 7111
Cell Name: kidney cell (CL1000497)
Fold Change: 1.64
Marker Score: 1093
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.64
Marker Score: 1761.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.61
Marker Score: 1674
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.6
Marker Score: 376
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.56
Marker Score: 376
Cell Name: keratocyte (CL0002363)
Fold Change: 1.56
Marker Score: 358
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.53
Marker Score: 636
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.48
Marker Score: 1114
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168235
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.44
Marker Score: 1027
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.44
Marker Score: 1521
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.43
Marker Score: 332
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.42
Marker Score: 812
Cell Name: early lymphoid progenitor (CL0000936)
Fold Change: 1.38
Marker Score: 674
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.37
Marker Score: 2598
Cell Name: supporting cell (CL0000630)
Fold Change: 1.37
Marker Score: 2574
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.33
Marker Score: 2051
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.33
Marker Score: 1829
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.33
Marker Score: 331
Cell Name: pericyte (CL0000669)
Fold Change: 1.32
Marker Score: 772
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.32
Marker Score: 331
Cell Name: fibroblast (CL0000057)
Fold Change: 1.31
Marker Score: 1268
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.31
Marker Score: 44534
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.29
Marker Score: 805
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.27
Marker Score: 337
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.25
Marker Score: 1442
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.23
Marker Score: 1243
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.22
Marker Score: 16087
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.22
Marker Score: 5091
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.2
Marker Score: 297
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.2
Marker Score: 1699
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.18
Marker Score: 1462
Cell Name: endocardial cell (CL0002350)
Fold Change: 1.17
Marker Score: 660
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.17
Marker Score: 7591
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.13
Marker Score: 4625
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.1
Marker Score: 1050
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.09
Marker Score: 2978
Cell Name: preosteoblast (CL0007010)
Fold Change: 1.08
Marker Score: 305
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.08
Marker Score: 242
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.07
Marker Score: 315
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.04
Marker Score: 533
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71754
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47980
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30401
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.98
Marker Score: 1174.5
Cell Name: muscle cell (CL0000187)
Fold Change: 0.97
Marker Score: 276
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.95
Marker Score: 187
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.95
Marker Score: 1234
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.94
Marker Score: 1138.5
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.94
Marker Score: 1967
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.92
Marker Score: 606
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.91
Marker Score: 780
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2738
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5200
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.88
Marker Score: 947
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.88
Marker Score: 312
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5262
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.86
Marker Score: 297
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.86
Marker Score: 344
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.85
Marker Score: 209
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.83
Marker Score: 358.5
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.83
Marker Score: 1374
Cell Name: stromal cell (CL0000499)
Fold Change: 0.81
Marker Score: 950
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.79
Marker Score: 604
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.78
Marker Score: 605
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.78
Marker Score: 476
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258

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**Key characteristics**: - GNG11 is a transmembrane protein that is localized to the plasma membrane. - It is a member of the G protein-coupled receptor (GPCR) superfamily. - GNG11 is a GTP-coupled protein that is involved in the regulation of water and electrolyte transport. **Pathways and functions:** - GNG11 is involved in the aquaporin-mediated transport of water and ions across cell membranes. - It is also involved in the regulation of blood pressure and fluid balance in the body. - GNG11 is a key regulator of the inflammatory response. - It is involved in the formation of blood clots. **Clinical significance**: - Mutations in GNG11 have been linked to a number of diseases, including pulmonary edema, heart failure, and stroke. - GNG11 inhibitors are being investigated as a treatment for these diseases. **Additional notes**: - GNG11 is a highly conserved protein that is found in all eukaryotic cells. - It is a key regulator of the immune response. - GNG11 is a promising target for the treatment of a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Genular Protein ID: 2230627062

Symbol: GBG11_HUMAN

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

UniProtKB Accession Codes:

P61952 P50152

Database IDs:

Citations:

PubMed ID: 7665596

Title: Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits.

PubMed ID: 7665596

DOI: 10.1074/jbc.270.37.21765

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 73
Mass: 8481
Checksum: 2B13935E3AEFB9E8
Sequence:

MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED 
KNPFKEKGSC VIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.