Details for: NUDT1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: embryonic stem cell (CL0002322)
Fold Change: 63.2119
Cell Significance Index: -26.0400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 51.4909
Cell Significance Index: -24.3100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 50.2391
Cell Significance Index: -20.4100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 45.8411
Cell Significance Index: -23.5800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 45.5364
Cell Significance Index: -11.5500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 21.6603
Cell Significance Index: -20.6800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 16.9430
Cell Significance Index: -20.8900 - Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 16.4582
Cell Significance Index: -2.5600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.2746
Cell Significance Index: -24.7600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 5.8913
Cell Significance Index: -18.1000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.4463
Cell Significance Index: -14.5900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 4.7807
Cell Significance Index: 127.8800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.0522
Cell Significance Index: -6.6800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.1025
Cell Significance Index: 135.6400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.4871
Cell Significance Index: 173.3100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3829
Cell Significance Index: 83.0200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.3265
Cell Significance Index: 156.4400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3227
Cell Significance Index: 14.3800 - Cell Name: germ cell (CL0000586)
Fold Change: 1.1853
Cell Significance Index: 8.9500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.0915
Cell Significance Index: 32.0600 - Cell Name: basophilic erythroblast (CL0000549)
Fold Change: 0.9003
Cell Significance Index: 0.4100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7532
Cell Significance Index: 333.0300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.6774
Cell Significance Index: 46.8500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.6483
Cell Significance Index: 13.5700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5972
Cell Significance Index: 42.2400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5120
Cell Significance Index: 50.6500 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.4869
Cell Significance Index: 4.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4834
Cell Significance Index: 264.0000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3997
Cell Significance Index: 13.8900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3806
Cell Significance Index: 10.9700 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 0.3771
Cell Significance Index: 3.2400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2949
Cell Significance Index: 15.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.2817
Cell Significance Index: 38.6800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.2688
Cell Significance Index: 8.6100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2647
Cell Significance Index: 12.4400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2580
Cell Significance Index: 6.4500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2376
Cell Significance Index: 29.2100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2345
Cell Significance Index: 3.2000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2204
Cell Significance Index: 41.9400 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.2057
Cell Significance Index: 26.5800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2031
Cell Significance Index: 4.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1804
Cell Significance Index: 23.1300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1750
Cell Significance Index: 31.5500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1661
Cell Significance Index: 8.6500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1568
Cell Significance Index: 7.3100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.1547
Cell Significance Index: 2.8600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1288
Cell Significance Index: 5.8400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0512
Cell Significance Index: 1.8000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0419
Cell Significance Index: 8.3200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0307
Cell Significance Index: 0.8200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0164
Cell Significance Index: 0.3500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0060
Cell Significance Index: 0.1000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0038
Cell Significance Index: -0.3900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0093
Cell Significance Index: -17.4300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0130
Cell Significance Index: -9.8200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0162
Cell Significance Index: -1.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0168
Cell Significance Index: -31.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0204
Cell Significance Index: -31.4200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0236
Cell Significance Index: -3.8500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0240
Cell Significance Index: -17.6200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0246
Cell Significance Index: -33.5000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0305
Cell Significance Index: -21.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0333
Cell Significance Index: -21.1500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0370
Cell Significance Index: -27.4200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0391
Cell Significance Index: -1.0000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.0428
Cell Significance Index: -0.6500 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0441
Cell Significance Index: -0.3600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0458
Cell Significance Index: -25.8300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0536
Cell Significance Index: -24.3200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0571
Cell Significance Index: -35.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0662
Cell Significance Index: -23.7600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0740
Cell Significance Index: -21.2900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0772
Cell Significance Index: -2.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0872
Cell Significance Index: -17.5000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0895
Cell Significance Index: -2.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0927
Cell Significance Index: -15.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1155
Cell Significance Index: -7.2800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1360
Cell Significance Index: -7.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1448
Cell Significance Index: -30.5000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1586
Cell Significance Index: -23.0600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1602
Cell Significance Index: -18.3600 - Cell Name: glioblast (CL0000030)
Fold Change: -0.1799
Cell Significance Index: -1.1300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2265
Cell Significance Index: -12.7100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2276
Cell Significance Index: -13.9900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.2359
Cell Significance Index: -2.6800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2403
Cell Significance Index: -25.0200 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.2620
Cell Significance Index: -1.6400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2722
Cell Significance Index: -21.5600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2873
Cell Significance Index: -4.3300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3093
Cell Significance Index: -18.9600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3312
Cell Significance Index: -8.7100 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3516
Cell Significance Index: -26.9800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3675
Cell Significance Index: -24.7100 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3743
Cell Significance Index: -10.7300 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3846
Cell Significance Index: -8.8900 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.4245
Cell Significance Index: -6.3600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4334
Cell Significance Index: -12.7700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.5110
Cell Significance Index: -5.2900 - Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.5231
Cell Significance Index: -3.4700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5448
Cell Significance Index: -24.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1409335412
Symbol: 8ODP_HUMAN
Name: 2-hydroxy-dATP diphosphatase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8226881
Title: Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.
PubMed ID: 8226881
PubMed ID: 7713500
Title: Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.
PubMed ID: 7713500
PubMed ID: 9211940
Title: Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products.
PubMed ID: 9211940
PubMed ID: 10536140
Title: Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.
PubMed ID: 10536140
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 12853948
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7782328
Title: Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.
PubMed ID: 7782328
PubMed ID: 10373420
Title: The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.
PubMed ID: 10373420
PubMed ID: 10608900
Title: Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins.
PubMed ID: 10608900
PubMed ID: 11139615
Title: Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.
PubMed ID: 11139615
DOI: 10.1093/nar/29.2.449
PubMed ID: 11756418
Title: A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.
PubMed ID: 11756418
PubMed ID: 12857738
Title: An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress.
PubMed ID: 12857738
PubMed ID: 16607562
Title: The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.
PubMed ID: 16607562
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22556419
Title: Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.
PubMed ID: 22556419
PubMed ID: 26238318
Title: Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.
PubMed ID: 26238318
DOI: 10.1038/ncomms8871
PubMed ID: 15133035
Title: Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.
PubMed ID: 15133035
PubMed ID: 17142918
Title: Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.
PubMed ID: 17142918
PubMed ID: 21787772
Title: Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.
PubMed ID: 21787772
PubMed ID: 24695224
Title: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
PubMed ID: 24695224
DOI: 10.1038/nature13181
PubMed ID: 24695225
Title: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
PubMed ID: 24695225
DOI: 10.1038/nature13194
PubMed ID: 26999531
Title: MTH1 Substrate Recognition--An Example of Specific Promiscuity.
PubMed ID: 26999531
PubMed ID: 28679043
Title: Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
PubMed ID: 28679043
PubMed ID: 28035004
Title: Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.
PubMed ID: 28035004
PubMed ID: 30304478
Title: MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
PubMed ID: 30304478
DOI: 10.1093/nar/gky896
PubMed ID: 32144205
Title: MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
PubMed ID: 32144205
PubMed ID: 15516784
Title: Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus.
PubMed ID: 15516784
PubMed ID: 16774934
Title: Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk.
PubMed ID: 16774934
Sequence Information:
- Length: 156
- Mass: 17952
- Checksum: B9FB669FF0ACFF5F
- Sequence:
MGASRLYTLV LVLQPQRVLL GMKKRGFGAG RWNGFGGKVQ EGETIEDGAR RELQEESGLT VDALHKVGQI VFEFVGEPEL MDVHVFCTDS IQGTPVESDE MRPCWFQLDQ IPFKDMWPDD SYWFPLLLQK KKFHGYFKFQ GQDTILDYTL REVDTV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.