Details for: NUDT1

Gene ID: 4521

Symbol: NUDT1

Ensembl ID: ENSG00000106268

Description: nudix hydrolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.2119
    Cell Significance Index: -26.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 51.4909
    Cell Significance Index: -24.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.2391
    Cell Significance Index: -20.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.8411
    Cell Significance Index: -23.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.5364
    Cell Significance Index: -11.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.6603
    Cell Significance Index: -20.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.9430
    Cell Significance Index: -20.8900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 16.4582
    Cell Significance Index: -2.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2746
    Cell Significance Index: -24.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.8913
    Cell Significance Index: -18.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.4463
    Cell Significance Index: -14.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.7807
    Cell Significance Index: 127.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0522
    Cell Significance Index: -6.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1025
    Cell Significance Index: 135.6400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4871
    Cell Significance Index: 173.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3829
    Cell Significance Index: 83.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3265
    Cell Significance Index: 156.4400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3227
    Cell Significance Index: 14.3800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1853
    Cell Significance Index: 8.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0915
    Cell Significance Index: 32.0600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 0.9003
    Cell Significance Index: 0.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7532
    Cell Significance Index: 333.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6774
    Cell Significance Index: 46.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6483
    Cell Significance Index: 13.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5972
    Cell Significance Index: 42.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5120
    Cell Significance Index: 50.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4869
    Cell Significance Index: 4.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4834
    Cell Significance Index: 264.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3997
    Cell Significance Index: 13.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3806
    Cell Significance Index: 10.9700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.3771
    Cell Significance Index: 3.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2949
    Cell Significance Index: 15.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2817
    Cell Significance Index: 38.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2688
    Cell Significance Index: 8.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2647
    Cell Significance Index: 12.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2580
    Cell Significance Index: 6.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2376
    Cell Significance Index: 29.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2345
    Cell Significance Index: 3.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2204
    Cell Significance Index: 41.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2057
    Cell Significance Index: 26.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2031
    Cell Significance Index: 4.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1804
    Cell Significance Index: 23.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1750
    Cell Significance Index: 31.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1661
    Cell Significance Index: 8.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1568
    Cell Significance Index: 7.3100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1547
    Cell Significance Index: 2.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1288
    Cell Significance Index: 5.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0512
    Cell Significance Index: 1.8000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0419
    Cell Significance Index: 8.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0307
    Cell Significance Index: 0.8200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0164
    Cell Significance Index: 0.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0060
    Cell Significance Index: 0.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0038
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0093
    Cell Significance Index: -17.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0130
    Cell Significance Index: -9.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0162
    Cell Significance Index: -1.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0168
    Cell Significance Index: -31.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0204
    Cell Significance Index: -31.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0236
    Cell Significance Index: -3.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0240
    Cell Significance Index: -17.6200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0246
    Cell Significance Index: -33.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0305
    Cell Significance Index: -21.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0333
    Cell Significance Index: -21.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0370
    Cell Significance Index: -27.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0391
    Cell Significance Index: -1.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0428
    Cell Significance Index: -0.6500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0441
    Cell Significance Index: -0.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0458
    Cell Significance Index: -25.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0536
    Cell Significance Index: -24.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0571
    Cell Significance Index: -35.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0662
    Cell Significance Index: -23.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0740
    Cell Significance Index: -21.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0772
    Cell Significance Index: -2.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0872
    Cell Significance Index: -17.5000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0895
    Cell Significance Index: -2.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0927
    Cell Significance Index: -15.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1155
    Cell Significance Index: -7.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1360
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1448
    Cell Significance Index: -30.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1586
    Cell Significance Index: -23.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1602
    Cell Significance Index: -18.3600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1799
    Cell Significance Index: -1.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2265
    Cell Significance Index: -12.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2276
    Cell Significance Index: -13.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2359
    Cell Significance Index: -2.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2403
    Cell Significance Index: -25.0200
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2620
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2722
    Cell Significance Index: -21.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2873
    Cell Significance Index: -4.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3093
    Cell Significance Index: -18.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3312
    Cell Significance Index: -8.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3516
    Cell Significance Index: -26.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3675
    Cell Significance Index: -24.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3743
    Cell Significance Index: -10.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3846
    Cell Significance Index: -8.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4245
    Cell Significance Index: -6.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4334
    Cell Significance Index: -12.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5110
    Cell Significance Index: -5.2900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.5231
    Cell Significance Index: -3.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5448
    Cell Significance Index: -24.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUDT1 is a member of the Nudix hydrolase family, characterized by its ability to hydrolyze a wide range of nucleotide triphosphates and diphosphates. This enzyme is remarkably versatile, with a broad substrate specificity that includes 2-hydroxy-ATP, 2-hydroxy-dATP, N6-methyl-(d)ATP, and 8-oxo-7,8-dihydroguanosine triphosphate. The NUDT1 protein is predominantly localized in the cytoplasm, but it can also be found in the nucleus, mitochondria, and peroxisomes. **Pathways and Functions:** NUDT1 plays a vital role in various cellular processes, including: 1. **DNA Repair:** NUDT1 is involved in the repair of DNA damage caused by oxidative stress, acting as a pyrophosphatase to hydrolyze 8-oxo-7,8-dihydroguanosine triphosphate and 8-oxo-7,8-dihydrodeoxyguanosine triphosphate. 2. **Nucleotide Metabolism:** NUDT1 regulates the metabolism of nucleotides, including the catabolism of purine nucleosides and the hydrolysis of nucleotide triphosphates. 3. **Antioxidant Defense:** NUDT1 acts as a antioxidant defense mechanism, hydrolyzing 8-oxo-7,8-dihydroguanosine triphosphate and 8-oxo-7,8-dihydrodeoxyguanosine triphosphate to prevent DNA damage. 4. **Cell Signaling:** NUDT1 has been implicated in cell signaling pathways, including the regulation of the Wnt/β-catenin pathway and the response to oxidative stress. **Clinical Significance:** The dysregulation of NUDT1 has been linked to various diseases, including: 1. **Cancer:** NUDT1 expression is often reduced in cancer cells, leading to impaired DNA repair and increased susceptibility to oxidative stress. 2. **Neurodegenerative Diseases:** NUDT1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's, where oxidative stress and DNA damage play a crucial role. 3. **Immunological Disorders:** NUDT1 has been shown to play a role in the regulation of immune cell function, including the activation of T cells and the regulation of B cell development. In conclusion, NUDT1 is a vital gene that regulates various cellular processes, including DNA repair, metabolism, and nucleotide catabolism. Its dysregulation has been linked to various diseases, highlighting the importance of NUDT1 in maintaining cellular homeostasis and preventing disease. As an expert immunologist, I believe that further research on NUDT1 will provide valuable insights into the mechanisms underlying various immunological disorders and the development of novel therapeutic strategies.

Genular Protein ID: 1409335412

Symbol: 8ODP_HUMAN

Name: 2-hydroxy-dATP diphosphatase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8226881

Title: Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

PubMed ID: 8226881

DOI: 10.1016/s0021-9258(19)49494-5

PubMed ID: 7713500

Title: Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.

PubMed ID: 7713500

DOI: 10.1006/geno.1994.1657

PubMed ID: 9211940

Title: Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products.

PubMed ID: 9211940

DOI: 10.1074/jbc.272.28.17843

PubMed ID: 10536140

Title: Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism.

PubMed ID: 10536140

DOI: 10.1093/nar/27.22.4335

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7782328

Title: Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria.

PubMed ID: 7782328

DOI: 10.1074/jbc.270.24.14659

PubMed ID: 10373420

Title: The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.

PubMed ID: 10373420

DOI: 10.1074/jbc.274.26.18201

PubMed ID: 10608900

Title: Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins.

PubMed ID: 10608900

DOI: 10.1074/jbc.274.53.38251

PubMed ID: 11139615

Title: Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP.

PubMed ID: 11139615

DOI: 10.1093/nar/29.2.449

PubMed ID: 11756418

Title: A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1.

PubMed ID: 11756418

DOI: 10.1074/jbc.m110566200

PubMed ID: 12857738

Title: An oxidized purine nucleoside triphosphatase, MTH1, suppresses cell death caused by oxidative stress.

PubMed ID: 12857738

DOI: 10.1074/jbc.m306201200

PubMed ID: 16607562

Title: The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal.

PubMed ID: 16607562

DOI: 10.1007/s00109-006-0053-5

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22556419

Title: Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2.

PubMed ID: 22556419

DOI: 10.1074/jbc.m112.363010

PubMed ID: 26238318

Title: Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

PubMed ID: 26238318

DOI: 10.1038/ncomms8871

PubMed ID: 15133035

Title: Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates.

PubMed ID: 15133035

DOI: 10.1074/jbc.m402393200

PubMed ID: 17142918

Title: Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP.

PubMed ID: 17142918

DOI: 10.1107/s1744309106049529

PubMed ID: 21787772

Title: Crystal structure of human MTH1 and the 8-oxo-dGMP product complex.

PubMed ID: 21787772

DOI: 10.1016/j.febslet.2011.07.017

PubMed ID: 24695224

Title: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.

PubMed ID: 24695224

DOI: 10.1038/nature13181

PubMed ID: 24695225

Title: Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.

PubMed ID: 24695225

DOI: 10.1038/nature13194

PubMed ID: 26999531

Title: MTH1 Substrate Recognition--An Example of Specific Promiscuity.

PubMed ID: 26999531

DOI: 10.1371/journal.pone.0151154

PubMed ID: 28679043

Title: Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.

PubMed ID: 28679043

DOI: 10.1021/acschembio.7b00370

PubMed ID: 28035004

Title: Structural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.

PubMed ID: 28035004

DOI: 10.1074/jbc.m116.749713

PubMed ID: 30304478

Title: MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.

PubMed ID: 30304478

DOI: 10.1093/nar/gky896

PubMed ID: 32144205

Title: MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.

PubMed ID: 32144205

DOI: 10.1074/jbc.ra120.012636

PubMed ID: 15516784

Title: Association study of human MTH1 gene polymorphisms with type 1 diabetes mellitus.

PubMed ID: 15516784

DOI: 10.1507/endocrj.51.493

PubMed ID: 16774934

Title: Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk.

PubMed ID: 16774934

DOI: 10.1093/carcin/bgl095

Sequence Information:

  • Length: 156
  • Mass: 17952
  • Checksum: B9FB669FF0ACFF5F
  • Sequence:
  • MGASRLYTLV LVLQPQRVLL GMKKRGFGAG RWNGFGGKVQ EGETIEDGAR RELQEESGLT 
    VDALHKVGQI VFEFVGEPEL MDVHVFCTDS IQGTPVESDE MRPCWFQLDQ IPFKDMWPDD 
    SYWFPLLLQK KKFHGYFKFQ GQDTILDYTL REVDTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.