Details for: HLA DOA

Gene ID: 3111

Symbol: HLA DOA

Ensembl ID: ENSG00000204252

Description: major histocompatibility complex, class II, DO alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.2818
    Cell Significance Index: -7.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 23.2610
    Cell Significance Index: -5.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.4304
    Cell Significance Index: -8.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.1073
    Cell Significance Index: -7.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.9153
    Cell Significance Index: 125.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.7580
    Cell Significance Index: 93.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.6285
    Cell Significance Index: 56.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9386
    Cell Significance Index: -7.6500
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.8731
    Cell Significance Index: 4.3700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.7172
    Cell Significance Index: 4.5300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4484
    Cell Significance Index: -3.1700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.3464
    Cell Significance Index: 20.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0788
    Cell Significance Index: 16.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9103
    Cell Significance Index: 24.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9092
    Cell Significance Index: 173.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8767
    Cell Significance Index: 103.3900
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.6775
    Cell Significance Index: 3.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5598
    Cell Significance Index: 55.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4816
    Cell Significance Index: 434.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4793
    Cell Significance Index: 30.9300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4745
    Cell Significance Index: 10.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3338
    Cell Significance Index: 36.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3220
    Cell Significance Index: 52.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2390
    Cell Significance Index: 14.3500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2068
    Cell Significance Index: 1.3200
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1854
    Cell Significance Index: 1.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1616
    Cell Significance Index: 11.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0792
    Cell Significance Index: 0.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0371
    Cell Significance Index: 16.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0309
    Cell Significance Index: 3.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0178
    Cell Significance Index: 3.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0097
    Cell Significance Index: 1.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0056
    Cell Significance Index: 4.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0039
    Cell Significance Index: -7.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0065
    Cell Significance Index: -0.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0073
    Cell Significance Index: -0.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0107
    Cell Significance Index: -7.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0117
    Cell Significance Index: -6.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0121
    Cell Significance Index: -7.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0136
    Cell Significance Index: -7.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0166
    Cell Significance Index: -3.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0187
    Cell Significance Index: -8.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0192
    Cell Significance Index: -6.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0243
    Cell Significance Index: -3.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0268
    Cell Significance Index: -7.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0276
    Cell Significance Index: -1.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0357
    Cell Significance Index: -7.1600
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0364
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0414
    Cell Significance Index: -7.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0439
    Cell Significance Index: -0.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0463
    Cell Significance Index: -1.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0475
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0492
    Cell Significance Index: -5.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0516
    Cell Significance Index: -7.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0593
    Cell Significance Index: -6.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0669
    Cell Significance Index: -4.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0673
    Cell Significance Index: -8.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0717
    Cell Significance Index: -7.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0745
    Cell Significance Index: -3.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0849
    Cell Significance Index: -3.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0953
    Cell Significance Index: -4.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0998
    Cell Significance Index: -5.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1063
    Cell Significance Index: -2.7200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1093
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1177
    Cell Significance Index: -9.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1187
    Cell Significance Index: -8.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1306
    Cell Significance Index: -3.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1383
    Cell Significance Index: -7.7600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1384
    Cell Significance Index: -2.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1401
    Cell Significance Index: -8.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1468
    Cell Significance Index: -7.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1546
    Cell Significance Index: -3.9800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1564
    Cell Significance Index: -2.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1600
    Cell Significance Index: -2.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1695
    Cell Significance Index: -5.8900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1750
    Cell Significance Index: -5.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1767
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1818
    Cell Significance Index: -8.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1907
    Cell Significance Index: -3.3700
  • Cell Name: centrocyte (CL0009111)
    Fold Change: -0.1946
    Cell Significance Index: -0.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1978
    Cell Significance Index: -7.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1996
    Cell Significance Index: -2.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2047
    Cell Significance Index: -7.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2142
    Cell Significance Index: -8.1100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2162
    Cell Significance Index: -4.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2227
    Cell Significance Index: -6.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2255
    Cell Significance Index: -3.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2286
    Cell Significance Index: -7.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2297
    Cell Significance Index: -7.3200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2414
    Cell Significance Index: -2.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2442
    Cell Significance Index: -6.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2446
    Cell Significance Index: -3.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2538
    Cell Significance Index: -3.1400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2577
    Cell Significance Index: -3.2700
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.2703
    Cell Significance Index: -2.7600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.2764
    Cell Significance Index: -1.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HLA-DOA is a non-coding gene that is part of the major histocompatibility complex (MHC) class II region. It encodes a 23-kDa protein that is expressed on the surface of antigen-presenting cells (APCs) and is involved in the assembly and loading of peptide antigens onto MHC class II molecules. The HLA-DOA protein interacts with several other MHC class II-associated proteins, including HLA-DRB1 and HLA-DM, to regulate the processing and presentation of exogenous peptides. **Pathways and Functions:** The HLA-DOA gene is involved in the following pathways and functions: 1. **Antigen processing and presentation of exogenous peptide antigen via MHC class II:** HLA-DOA plays a crucial role in the loading of peptide antigens onto MHC class II molecules, which are then presented to T-cells by APCs. 2. **Adaptive immune response:** The HLA-DOA gene is involved in the regulation of the adaptive immune response, including T-cell activation and differentiation. 3. **Negative regulation of antigen processing and presentation of peptide antigen via MHC class II:** HLA-DOA can inhibit the presentation of exogenous peptides by MHC class II molecules, which is important for preventing autoimmune responses. 4. **Positive regulation of immune response:** The HLA-DOA gene can enhance the presentation of endogenous peptides by MHC class II molecules, which is important for the activation of T-cells. **Significantly Expressed Cells:** The HLA-DOA gene is expressed in the following cells: 1. Myeloid dendritic cells 2. Colon goblet cells 3. T-helper 17 cells 4. Transit amplifying cells of small intestine 5. Enterocytes of epithelium of small intestine 6. Goblet cells 7. Transit amplifying cells of colon 8. IgG-negative class switched memory B cells 9. Fallopian tube secretory epithelial cells 10. Tonsil germinal center B cells **Clinical Significance:** Dysregulation of the HLA-DOA gene has been implicated in several autoimmune and inflammatory diseases, including: 1. **Rheumatoid arthritis:** The HLA-DOA gene has been associated with an increased risk of developing rheumatoid arthritis. 2. **Multiple sclerosis:** The HLA-DOA gene has been implicated in the pathogenesis of multiple sclerosis. 3. **Type 1 diabetes:** The HLA-DOA gene has been associated with an increased risk of developing type 1 diabetes. 4. **Autoimmune hepatitis:** The HLA-DOA gene has been implicated in the pathogenesis of autoimmune hepatitis. In conclusion, the HLA-DOA gene is a critical component of the MHC class II antigen presentation pathway and plays a pivotal role in the regulation of the adaptive immune response. Its dysregulation has been implicated in several autoimmune and inflammatory diseases, highlighting the importance of understanding the function of this gene in the context of human disease.

Genular Protein ID: 1341402464

Symbol: DOA_HUMAN

Name: HLA class II histocompatibility antigen, DO alpha chain

UniProtKB Accession Codes:

P06340 Q58HU0 Q58HU1 Q5STC7 Q9TQC6 Q9TQC7 Q9TQC8 Q9TQC9 Q9TQD0 Q9TQD1 Q9TQD2 Q9TQD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 26 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3000765

Title: The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.

PubMed ID: 3000765

DOI: 10.1002/j.1460-2075.1985.tb03919.x

PubMed ID: 2499532

Title: Human class II DNA and DOB genes display low sequence variability.

PubMed ID: 2499532

DOI: 10.1007/bf00375872

PubMed ID: 2370084

Title: The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript.

PubMed ID: 2370084

DOI: 10.1007/bf02115015

PubMed ID: 16101837

Title: Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing.

PubMed ID: 16101837

DOI: 10.1111/j.1399-0039.2005.00446.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10323340

Title: Limited polymorphism in the HLA-DOA gene.

PubMed ID: 10323340

DOI: 10.1034/j.1399-0039.1999.530406.x

PubMed ID: 10837054

Title: Nonclassical MHC class II molecules.

PubMed ID: 10837054

DOI: 10.1146/annurev.immunol.18.1.113

Sequence Information:

  • Length: 250
  • Mass: 27599
  • Checksum: FA9482197A02AC85
  • Sequence:
    • MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV 
DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK 
SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV 
PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII 
MGTYVSSVPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.