Details for: HLA DOA

Gene ID: 3111

Symbol: HLA DOA

Ensembl ID: ENSG00000204252

Description: major histocompatibility complex, class II, DO alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.28
    Marker Score: 1385
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1154
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.41
    Marker Score: 927
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 477
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4794
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7191
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.07
    Marker Score: 493
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.04
    Marker Score: 1025
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251787
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.03
    Marker Score: 3063
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.02
    Marker Score: 914
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.01
    Marker Score: 954
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.99
    Marker Score: 2065
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.97
    Marker Score: 2525
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.94
    Marker Score: 713
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 631.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.93
    Marker Score: 23724
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5279
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.92
    Marker Score: 218
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 365
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.9
    Marker Score: 208
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.83
    Marker Score: 984.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.82
    Marker Score: 938
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.78
    Marker Score: 1366
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.78
    Marker Score: 384
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 698
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.74
    Marker Score: 447
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.74
    Marker Score: 803
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.7
    Marker Score: 485
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.7
    Marker Score: 248
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.7
    Marker Score: 424
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.7
    Marker Score: 211
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.67
    Marker Score: 1095
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.6
    Marker Score: 725
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.59
    Marker Score: 1679
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.59
    Marker Score: 3581
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.55
    Marker Score: 5570
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 477
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.49
    Marker Score: 288
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.49
    Marker Score: 147
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.49
    Marker Score: 2561
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.48
    Marker Score: 506
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.48
    Marker Score: 487.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.48
    Marker Score: 316
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.47
    Marker Score: 330
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.46
    Marker Score: 439
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.46
    Marker Score: 107
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.43
    Marker Score: 108
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.43
    Marker Score: 110
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.43
    Marker Score: 314
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.42
    Marker Score: 423
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 668
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.41
    Marker Score: 2703
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.4
    Marker Score: 273
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.4
    Marker Score: 287
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.39
    Marker Score: 1070
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.37
    Marker Score: 90
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.37
    Marker Score: 237
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.37
    Marker Score: 96
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.36
    Marker Score: 125
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.36
    Marker Score: 91
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.35
    Marker Score: 394
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.35
    Marker Score: 202
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.35
    Marker Score: 88
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.35
    Marker Score: 500
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.34
    Marker Score: 552
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.34
    Marker Score: 81
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.33
    Marker Score: 636
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.32
    Marker Score: 85
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 319
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.32
    Marker Score: 166
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.31
    Marker Score: 85
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.3
    Marker Score: 164
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 200
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.3
    Marker Score: 3505
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3
    Marker Score: 94
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.3
    Marker Score: 268
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 92
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.28
    Marker Score: 124
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.28
    Marker Score: 256
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.26
    Marker Score: 118
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.26
    Marker Score: 69
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.26
    Marker Score: 256
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 107

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Other Information

**Key characteristics:** - DOA is a glycoprotein with a molecular weight of approximately 45 kDa. - It is expressed in high levels on myeloid dendritic cells, T-helper 17 cells, and certain epithelial cells. - DOA is a member of the HLA class II family of cell surface proteins, which are responsible for the recognition of MHC class I molecules. - DOA is a heterodimeric protein, with two identical heavy chain subunits and two identical light chain subunits. **Pathways and functions:** - DOA is expressed on the surface of APCs, where it is presented with peptide antigens derived from extracellular proteins. - DOA binds to MHC class II molecules bound to peptide antigens, initiating the adaptive immune response. - The interaction between DOA and MHC class II molecules is a critical step in the activation of T cells. - DOA also regulates the activation of T cells through the regulation of MHC class I-mediated antigen presentation. **Clinical significance:** - Mutations in the DOA gene have been linked to the development of several autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and asthma. - DOA is a potential therapeutic target for autoimmune diseases that are characterized by the overactivation of T cells. - By blocking the interaction between DOA and MHC class II molecules, it is possible to inhibit T cell activation and suppress the autoimmune response.

Genular Protein ID: 1341402464

Symbol: DOA_HUMAN

Name: HLA class II histocompatibility antigen, DO alpha chain

UniProtKB Accession Codes:

P06340 Q58HU0 Q58HU1 Q5STC7 Q9TQC6 Q9TQC7 Q9TQC8 Q9TQC9 Q9TQD0 Q9TQD1 Q9TQD2 Q9TQD3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 26 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3000765

Title: The human HLA class II alpha chain gene DZ alpha is distinct from genes in the DP, DQ and DR subregions.

PubMed ID: 3000765

DOI: 10.1002/j.1460-2075.1985.tb03919.x

PubMed ID: 2499532

Title: Human class II DNA and DOB genes display low sequence variability.

PubMed ID: 2499532

DOI: 10.1007/bf00375872

PubMed ID: 2370084

Title: The HLA-DNA (DZA) gene is correctly expressed as a 1.1 kb mature mRNA transcript.

PubMed ID: 2370084

DOI: 10.1007/bf02115015

PubMed ID: 16101837

Title: Identification of four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, by sequence-based typing.

PubMed ID: 16101837

DOI: 10.1111/j.1399-0039.2005.00446.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10323340

Title: Limited polymorphism in the HLA-DOA gene.

PubMed ID: 10323340

DOI: 10.1034/j.1399-0039.1999.530406.x

PubMed ID: 10837054

Title: Nonclassical MHC class II molecules.

PubMed ID: 10837054

DOI: 10.1146/annurev.immunol.18.1.113

Sequence Information:

  • Length: 250
  • Mass: 27599
  • Checksum: FA9482197A02AC85
  • Sequence:
    • MALRAGLVLG FHTLMTLLSP QEAGATKADH MGSYGPAFYQ SYGASGQFTH EFDEEQLFSV 
DLKKSEAVWR LPEFGDFARF DPQGGLAGIA AIKAHLDILV ERSNRSRAIN VPPRVTVLPK 
SRVELGQPNI LICIVDNIFP PVINITWLRN GQTVTEGVAQ TSFYSQPDHL FRKFHYLPFV 
PSAEDVYDCQ VEHWGLDAPL LRHWELQVPI PPPDAMETLV CALGLAIGLV GFLVGTVLII 
MGTYVSSVPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.