Gene CASP6 - ENSG00000138794 | NCBI Gene ID: 839

Details for: CASP6

Gene ID: 839

Symbol: CASP6

Ensembl ID: ENSG00000138794

Description: caspase 6

Associated with

Apoptosis
(R-HSA-109581)
Apoptotic cleavage of cellular proteins
(R-HSA-111465)
Apoptotic execution phase
(R-HSA-75153)
Breakdown of the nuclear lamina
(R-HSA-352238)
Caspase-mediated cleavage of cytoskeletal proteins
(R-HSA-264870)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Programmed cell death
(R-HSA-5357801)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates transcription of caspase activators and caspases
(R-HSA-6803207)
Tp53 regulates transcription of cell death genes
(R-HSA-5633008)
Transcriptional regulation by tp53
(R-HSA-3700989)
Activation of innate immune response
(GO:0002218)
Apoptotic process
(GO:0006915)
Cellular response to staurosporine
(GO:0072734)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic process
(GO:0097153)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epithelial cell differentiation
(GO:0030855)
Execution phase of apoptosis
(GO:0097194)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of necroptotic process
(GO:0060545)
Positive regulation of neuron apoptotic process
(GO:0043525)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Pyroptosis
(GO:0070269)
Regulation of programmed cell death
(GO:0043067)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.51
Marker Score: 1206
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168478
Cell Name: stem cell (CL0000034)
Fold Change: 1.42
Marker Score: 3362
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 1.26
Marker Score: 3957
Cell Name: enterocyte (CL0000584)
Fold Change: 1.22
Marker Score: 5875.5
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.1
Marker Score: 606
Cell Name: proerythroblast (CL0000547)
Fold Change: 1.1
Marker Score: 745
Cell Name: pro-T cell (CL0000827)
Fold Change: 1.06
Marker Score: 4351
Cell Name: Unknown (CL0002371)
Fold Change: 1.04
Marker Score: 1105
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.04
Marker Score: 35876
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.02
Marker Score: 326
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71728
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47953
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.99
Marker Score: 9917
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.95
Marker Score: 2579
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 481
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 437
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5261
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1475
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2710
Cell Name: germ cell (CL0000586)
Fold Change: 0.88
Marker Score: 1538
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.87
Marker Score: 328
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.87
Marker Score: 1275
Cell Name: Sertoli cell (CL0000216)
Fold Change: 0.87
Marker Score: 5132.5
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.87
Marker Score: 3203
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 309
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.81
Marker Score: 811
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.8
Marker Score: 836
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.79
Marker Score: 1659
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.79
Marker Score: 573
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.79
Marker Score: 755
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.78
Marker Score: 785
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.78
Marker Score: 4970
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.77
Marker Score: 818
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 582
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.75
Marker Score: 300
Cell Name: kidney cell (CL1000497)
Fold Change: 0.74
Marker Score: 494
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.74
Marker Score: 389
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.73
Marker Score: 159
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.73
Marker Score: 4754
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.73
Marker Score: 255
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 374
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.72
Marker Score: 356
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.71
Marker Score: 4542
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.71
Marker Score: 668
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.68
Marker Score: 711
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2868
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.68
Marker Score: 1153
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.68
Marker Score: 731
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.68
Marker Score: 1592
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.67
Marker Score: 502
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 602
Cell Name: plasmablast (CL0000980)
Fold Change: 0.66
Marker Score: 871
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.65
Marker Score: 8580
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.65
Marker Score: 269.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.64
Marker Score: 599
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.64
Marker Score: 149
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.63
Marker Score: 977
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.63
Marker Score: 1435
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.63
Marker Score: 1119
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.63
Marker Score: 167
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.63
Marker Score: 2461
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.62
Marker Score: 168
Cell Name: osteoclast (CL0000092)
Fold Change: 0.6
Marker Score: 301
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.6
Marker Score: 155
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.59
Marker Score: 406
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.59
Marker Score: 2465
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.59
Marker Score: 631
Cell Name: precursor cell (CL0011115)
Fold Change: 0.59
Marker Score: 143
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.59
Marker Score: 1385
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.59
Marker Score: 269
Cell Name: common lymphoid progenitor (CL0000051)
Fold Change: 0.58
Marker Score: 395
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.58
Marker Score: 699
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.58
Marker Score: 213
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.57
Marker Score: 513
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.57
Marker Score: 376
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 0.57
Marker Score: 284
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.56
Marker Score: 5832
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.56
Marker Score: 8804
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.56
Marker Score: 2177
Cell Name: neural cell (CL0002319)
Fold Change: 0.56
Marker Score: 268
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.55
Marker Score: 171
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.55
Marker Score: 33827
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.54
Marker Score: 157
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.54
Marker Score: 385.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 428
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.54
Marker Score: 154
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.53
Marker Score: 1128
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.53
Marker Score: 1886
Cell Name: osteoblast (CL0000062)
Fold Change: 0.53
Marker Score: 285
Cell Name: Unknown (CL0000548)
Fold Change: 0.53
Marker Score: 383
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 0.52
Marker Score: 562
Cell Name: peptic cell (CL0000155)
Fold Change: 0.51
Marker Score: 214
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.51
Marker Score: 144
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.51
Marker Score: 263

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**Key characteristics:** - CASP6 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a key regulator of apoptosis, and its activity is critical for the initiation and execution of this process. - CASP6 is also involved in the regulation of cell cycle progression and differentiation. **Pathways and functions:** - CASP6 is involved in the apoptotic pathway, a multi-step process that leads to cell death. - It is one of the first proteins to be activated during apoptosis, and its activation triggers a cascade of events that leads to the activation of other caspases. - CASP6 also plays a role in the regulation of cell cycle progression and differentiation. - It is involved in the regulation of epithelial cell migration and differentiation. **Clinical significance:** - Mutations in CASP6 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. - Caspase inhibitors are being developed as cancer drugs, and CASP6 is a promising target for these drugs. **Additional notes:** - CASP6 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a member of the caspase family of proteinases, which are responsible for the activation of other caspases. - CASP6 is a relatively new protein, and there is still much that is unknown about its function.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CASP6_HUMAN

Genular Protein ID: 721924699

Symbol: CASP6_HUMAN

Name: N/A

UniProtKB Accession Codes:

P55212 Q9BQE7

Database IDs:

Citations:

PubMed ID: 7796396

Title: Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.

PubMed ID: 7796396

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8900201

Title: The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32.

PubMed ID: 8900201

DOI: 10.1074/jbc.271.43.27099

PubMed ID: 8663580

Title: The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.

PubMed ID: 8663580

PubMed ID: 9463409

Title: Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis.

PubMed ID: 9463409

DOI: 10.1084/jem.187.4.587

PubMed ID: 10559921

Title: Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop.

PubMed ID: 10559921

DOI: 10.1038/12050

PubMed ID: 11953316

Title: Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

PubMed ID: 11953316

DOI: 10.1093/emboj/21.8.1967

PubMed ID: 14657026

Title: Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration.

PubMed ID: 14657026

DOI: 10.1093/emboj/cdg615

PubMed ID: 15200957

Title: Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.

PubMed ID: 15200957

DOI: 10.1016/j.molcel.2004.05.018

PubMed ID: 15273717

Title: Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

PubMed ID: 15273717

DOI: 10.1038/sj.onc.1207963

PubMed ID: 16123779

Title: Caspase-1 activation of caspase-6 in human apoptotic neurons.

PubMed ID: 16123779

DOI: 10.1038/sj.cdd.4401753

PubMed ID: 17401638

Title: Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification.

PubMed ID: 17401638

DOI: 10.1007/s11373-007-9165-3

PubMed ID: 18155731

Title: Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection.

PubMed ID: 18155731

DOI: 10.1016/j.jmb.2007.11.081

PubMed ID: 19133298

Title: Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.

PubMed ID: 19133298

DOI: 10.1016/j.bbamcr.2008.12.004

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22858542

Title: Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.

PubMed ID: 22858542

DOI: 10.1038/cdd.2012.98

PubMed ID: 27032039

Title: Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition.

PubMed ID: 27032039

DOI: 10.1021/acschembio.5b00971

PubMed ID: 27911442

Title: Palmitoylation of caspase-6 by HIP14 regulates its activation.

PubMed ID: 27911442

DOI: 10.1038/cdd.2016.139

PubMed ID: 28154009

Title: Caspase-6 undergoes a distinct helix-strand interconversion upon substrate binding.

PubMed ID: 28154009

DOI: 10.1074/jbc.m116.773499

PubMed ID: 28864531

Title: Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.

PubMed ID: 28864531

DOI: 10.1073/pnas.1704640114

PubMed ID: 30420425

Title: Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.

PubMed ID: 30420425

DOI: 10.1074/jbc.ra118.005914

PubMed ID: 32298652

Title: Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense.

PubMed ID: 32298652

DOI: 10.1016/j.cell.2020.03.040

PubMed ID: 32029622

Title: An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

PubMed ID: 32029622

DOI: 10.1126/science.aay0542

PubMed ID: 35922005

Title: Coronaviruses exploit a host cysteine-aspartic protease for replication.

PubMed ID: 35922005

DOI: 10.1038/s41586-022-05148-4

PubMed ID: 19694615

Title: The crystal structure of caspase-6, a selective effector of axonal degeneration.

PubMed ID: 19694615

DOI: 10.1042/bj20090540

PubMed ID: 20890311

Title: Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation.

PubMed ID: 20890311

DOI: 10.1038/embor.2010.141

PubMed ID: 22433863

Title: Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.

PubMed ID: 22433863

DOI: 10.1074/jbc.m112.351213

PubMed ID: 23227217

Title: Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

PubMed ID: 23227217

DOI: 10.1371/journal.pone.0050864

PubMed ID: 22483120

Title: Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.

PubMed ID: 22483120

DOI: 10.1016/j.str.2012.02.003

Sequence Information:

Length: 293
Mass: 33310
Checksum: 0738AE4F9791EBD7
Sequence:

MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF NHERFFWHLT 
LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI HEVSTVSHAD ADCFVCVFLS 
HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS LVGKPKIFII QACRGNQHDV PVIPLDVVDN 
QTEKLDTNIT EVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG 
SSLEFTELLT LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CASP6

Associated with

Cells (max top 100)

Other Information

Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. PubMed ID: 7796396

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32. PubMed ID: 8900201

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A. PubMed ID: 8663580

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis. PubMed ID: 9463409

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop. PubMed ID: 10559921

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation. PubMed ID: 11953316

Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. PubMed ID: 14657026

Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase. PubMed ID: 15200957

Regulation of caspase-6 and FLIP by the AMPK family member ARK5. PubMed ID: 15273717

Caspase-1 activation of caspase-6 in human apoptotic neurons. PubMed ID: 16123779

Apoptotic cleavage of NuMA at the C-terminal end is related to nuclear disruption and death amplification. PubMed ID: 17401638

Cell type-specific cleavage of nucleocapsid protein by effector caspases during SARS coronavirus infection. PubMed ID: 18155731

Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells. PubMed ID: 19133298

Initial characterization of the human central proteome. PubMed ID: 21269460

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6. PubMed ID: 22858542

Reprogramming caspase-7 specificity by regio-specific mutations and selection provides alternate solutions for substrate recognition. PubMed ID: 27032039

Palmitoylation of caspase-6 by HIP14 regulates its activation. PubMed ID: 27911442

Caspase-6 undergoes a distinct helix-strand interconversion upon substrate binding. PubMed ID: 28154009

Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. PubMed ID: 28864531

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. PubMed ID: 30420425

Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense. PubMed ID: 32298652

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. PubMed ID: 32029622

Coronaviruses exploit a host cysteine-aspartic protease for replication. PubMed ID: 35922005

The crystal structure of caspase-6, a selective effector of axonal degeneration. PubMed ID: 19694615

Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. PubMed ID: 20890311

Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays. PubMed ID: 22433863

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PubMed ID: 23227217

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. PubMed ID: 22483120