Details for: LIG4

Gene ID: 3981

Symbol: LIG4

Ensembl ID: ENSG00000174405

Description: DNA ligase 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.08
    Marker Score: 1302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71788
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5119
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.89
    Marker Score: 1045
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13609
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 312
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.86
    Marker Score: 1334
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1743
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1522.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1239
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.74
    Marker Score: 7692
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.74
    Marker Score: 6355
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.74
    Marker Score: 45445
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 654
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 430
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 544
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.71
    Marker Score: 6764
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2915
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.66
    Marker Score: 14128
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.65
    Marker Score: 1760.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.62
    Marker Score: 22954
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.59
    Marker Score: 177
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2267
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.58
    Marker Score: 2365
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.54
    Marker Score: 5073
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 318
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.49
    Marker Score: 1147
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.49
    Marker Score: 7256
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.47
    Marker Score: 408
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.47
    Marker Score: 2822
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.45
    Marker Score: 443
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.45
    Marker Score: 16941
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8700
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.43
    Marker Score: 326
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.43
    Marker Score: 1477
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.41
    Marker Score: 165
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4
    Marker Score: 396
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.4
    Marker Score: 103
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.4
    Marker Score: 1670
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.4
    Marker Score: 3052
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 259
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.38
    Marker Score: 144
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.37
    Marker Score: 891
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.37
    Marker Score: 1603
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.37
    Marker Score: 3183
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.36
    Marker Score: 147
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.36
    Marker Score: 377.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.36
    Marker Score: 875
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.35
    Marker Score: 2241
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 90
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.34
    Marker Score: 226
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.33
    Marker Score: 348.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 217
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 573
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.32
    Marker Score: 101
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.32
    Marker Score: 863
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.32
    Marker Score: 466
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.32
    Marker Score: 110
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.31
    Marker Score: 333
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.31
    Marker Score: 287.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.31
    Marker Score: 775
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3
    Marker Score: 1629
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.3
    Marker Score: 345
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.3
    Marker Score: 331
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 132
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.29
    Marker Score: 145
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.29
    Marker Score: 486
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.29
    Marker Score: 109
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.28
    Marker Score: 64
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.28
    Marker Score: 163
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.27
    Marker Score: 331
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.27
    Marker Score: 1786
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.27
    Marker Score: 185
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.27
    Marker Score: 384
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.27
    Marker Score: 278
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.26
    Marker Score: 68
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.26
    Marker Score: 108
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.26
    Marker Score: 264
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.26
    Marker Score: 134
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.26
    Marker Score: 112
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.26
    Marker Score: 146

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Other Information

**Key characteristics:** * The LIG4 gene is located on chromosome 15q26.1. * It is a large gene with a molecular weight of approximately 1.3 million base pairs. * It contains 13 exons and 12 introns. * The protein encoded by LIG4 is a transmembrane protein with a molecular weight of approximately 150 kDa. **Pathways and functions:** * LIG4 is involved in various cellular processes, including DNA repair, double-strand break repair, and viral infection pathways. * It is crucial for the maintenance of genomic integrity by repairing DNA damage caused by various agents, including viruses and environmental toxins. * It is also involved in the integration of viral proviruses into the host cell's genome. * LIG4 deficiency has been linked to an increased susceptibility to viral infection and cancer. **Clinical significance:** * Mutations in the LIG4 gene have been implicated in the pathogenesis of several human diseases, including cancer and viral infections. * Targeting LIG4 has emerged as a potential therapeutic strategy for these diseases. * Inhibitors of LIG4 have been shown to inhibit viral infection and tumor growth in preclinical models. **Additional notes:** * LIG4 is a key regulator of the early phase of HIV infection. * It is also involved in the regulation of the immune response to viral infection. * Mutations in LIG4 have been linked to the development of drug resistance in bacteria.

Genular Protein ID: 334589121

Symbol: DNLI4_HUMAN

Name: Polydeoxyribonucleotide synthase [ATP] 4

UniProtKB Accession Codes:

P49917 Q8IY66 Q8TEU5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTC 1 CTD 1 ChEBI 15 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 EMDB 15 EPD 1 Ensembl 16 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 47 PDBsum 23 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 15 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7760816

Title: Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination.

PubMed ID: 7760816

DOI: 10.1128/mcb.15.6.3206

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8798671

Title: DNA ligase IV from HeLa cell nuclei.

PubMed ID: 8798671

DOI: 10.1074/jbc.271.39.24257

PubMed ID: 9242410

Title: Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells.

PubMed ID: 9242410

DOI: 10.1038/41358

PubMed ID: 9809069

Title: DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes.

PubMed ID: 9809069

DOI: 10.1016/s1097-2765(00)80147-1

PubMed ID: 9259561

Title: Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV.

PubMed ID: 9259561

DOI: 10.1016/s0960-9822(06)00258-2

PubMed ID: 10854421

Title: Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase.

PubMed ID: 10854421

DOI: 10.1074/jbc.m000491200

PubMed ID: 12517771

Title: Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.

PubMed ID: 12517771

PubMed ID: 12547193

Title: Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

PubMed ID: 12547193

DOI: 10.1016/s0022-2836(02)01328-1

PubMed ID: 17290226

Title: XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps.

PubMed ID: 17290226

DOI: 10.1038/sj.emboj.7601559

PubMed ID: 17396150

Title: A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.

PubMed ID: 17396150

DOI: 10.1038/sj.emboj.7601663

PubMed ID: 19837014

Title: Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

PubMed ID: 19837014

DOI: 10.1016/j.dnarep.2009.09.007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21982441

Title: XRCC4 controls nuclear import and distribution of Ligase IV and exchanges faster at damaged DNA in complex with Ligase IV.

PubMed ID: 21982441

DOI: 10.1016/j.dnarep.2011.09.012

PubMed ID: 24984242

Title: DNA Ligase IV regulates XRCC4 nuclear localization.

PubMed ID: 24984242

DOI: 10.1016/j.dnarep.2014.05.010

PubMed ID: 25934149

Title: Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV.

PubMed ID: 25934149

DOI: 10.1016/j.bbrc.2015.04.093

PubMed ID: 25941166

Title: XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.

PubMed ID: 25941166

DOI: 10.1038/cdd.2015.22

PubMed ID: 25670504

Title: Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.

PubMed ID: 25670504

DOI: 10.1038/ncomms7233

PubMed ID: 25574025

Title: DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

PubMed ID: 25574025

DOI: 10.1126/science.1261971

PubMed ID: 11702069

Title: Crystal structure of an Xrcc4-DNA ligase IV complex.

PubMed ID: 11702069

DOI: 10.1038/nsb725

PubMed ID: 19332554

Title: Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.

PubMed ID: 19332554

DOI: 10.1128/mcb.01895-08

PubMed ID: 23219551

Title: Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining.

PubMed ID: 23219551

DOI: 10.1016/j.celrep.2012.11.004

PubMed ID: 22658747

Title: Structural insights into the role of domain flexibility in human DNA ligase IV.

PubMed ID: 22658747

DOI: 10.1016/j.str.2012.04.012

PubMed ID: 23523427

Title: Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair.

PubMed ID: 23523427

DOI: 10.1016/j.str.2013.02.014

PubMed ID: 29980672

Title: Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.

PubMed ID: 29980672

DOI: 10.1038/s41467-018-05024-8

PubMed ID: 34352203

Title: Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.

PubMed ID: 34352203

DOI: 10.1016/j.molcel.2021.07.005

PubMed ID: 33854234

Title: Structural basis of long-range to short-range synaptic transition in NHEJ.

PubMed ID: 33854234

DOI: 10.1038/s41586-021-03458-7

PubMed ID: 33586762

Title: Hypomorphic mutations in human DNA ligase IV lead to compromised DNA binding efficiency, hydrophobicity and thermal stability.

PubMed ID: 33586762

DOI: 10.1093/protein/gzab001

PubMed ID: 10395545

Title: Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient.

PubMed ID: 10395545

DOI: 10.1016/s0960-9822(99)80311-x

PubMed ID: 11349135

Title: Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity.

PubMed ID: 11349135

DOI: 10.1074/jbc.m103866200

PubMed ID: 11779494

Title: DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency.

PubMed ID: 11779494

DOI: 10.1016/s1097-2765(01)00408-7

PubMed ID: 12471202

Title: Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination.

PubMed ID: 12471202

DOI: 10.1136/jmg.39.12.900

PubMed ID: 16357942

Title: A new type of radiosensitive T-B-NK(+) severe combined immunodeficiency caused by a LIG4 mutation.

PubMed ID: 16357942

DOI: 10.1172/jci26121

PubMed ID: 25728776

Title: Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

PubMed ID: 25728776

DOI: 10.1016/j.ajhg.2015.01.013

Sequence Information:

  • Length: 911
  • Mass: 103971
  • Checksum: 2122813E1EFA63B9
  • Sequence:
    • MAASQTSQTV ASHVPFADLC STLERIQKSK GRAEKIRHFR EFLDSWRKFH DALHKNHKDV 
TDSFYPAMRL ILPQLERERM AYGIKETMLA KLYIELLNLP RDGKDALKLL NYRTPTGTHG 
DAGDFAMIAY FVLKPRCLQK GSLTIQQVND LLDSIASNNS AKRKDLIKKS LLQLITQSSA 
LEQKWLIRMI IKDLKLGVSQ QTIFSVFHND AAELHNVTTD LEKVCRQLHD PSVGLSDISI 
TLFSAFKPML AAIADIEHIE KDMKHQSFYI ETKLDGERMQ MHKDGDVYKY FSRNGYNYTD 
QFGASPTEGS LTPFIHNAFK ADIQICILDG EMMAYNPNTQ TFMQKGTKFD IKRMVEDSDL 
QTCYCVFDVL MVNNKKLGHE TLRKRYEILS SIFTPIPGRI EIVQKTQAHT KNEVIDALNE 
AIDKREEGIM VKQPLSIYKP DKRGEGWLKI KPEYVSGLMD ELDILIVGGY WGKGSRGGMM 
SHFLCAVAEK PPPGEKPSVF HTLSRVGSGC TMKELYDLGL KLAKYWKPFH RKAPPSSILC 
GTEKPEVYIE PCNSVIVQIK AAEIVPSDMY KTGCTLRFPR IEKIRDDKEW HECMTLDDLE 
QLRGKASGKL ASKHLYIGGD DEPQEKKRKA APKMKKVIGI IEHLKAPNLT NVNKISNIFE 
DVEFCVMSGT DSQPKPDLEN RIAEFGGYIV QNPGPDTYCV IAGSENIRVK NIILSNKHDV 
VKPAWLLECF KTKSFVPWQP RFMIHMCPST KEHFAREYDC YGDSYFIDTD LNQLKEVFSG 
IKNSNEQTPE EMASLIADLE YRYSWDCSPL SMFRRHTVYL DSYAVINDLS TKNEGTRLAI 
KALELRFHGA KVVSCLAEGV SHVIIGEDHS RVADFKAFRR TFKRKFKILK ESWVTDSIDK 
CELQEENQYL I

Genular Protein ID: 2090187688

Symbol: A8K8Q4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8Q4

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 1 DNASU 1 EC 1 EMBL 2 GO 8 Gene3D 5 GenomeRNAi 1 InterPro 12 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 2 SMART 1 SUPFAM 3

Sequence Information:

  • Length: 844
  • Mass: 96203
  • Checksum: 9BE5FF88F7E9ED4E
  • Sequence:
    • MRLILPQLER ERMAYGIKET MLAKLYIELL NLPRDGKDAL KLLNYRTPTG THGDAGDFAM 
IAYFVLKPRC LQKGSLTIQQ VNDLLDSIAS NNSAKRKDLI KKSLLQLITQ SSALEQKWLI 
RMIIKDLKLG VSQQTIFSVF HNDAAELHNV TTDLEKVCRQ LHDPSVGLSD ISITLFSAFK 
PMLAAIADIE HIEKDMKHQS FYIETKLDGE RMQMHKDGDV YKYFSRNGYN YTDQFGASPT 
EGSLTPFIHN AFKADIQICI LDGEMMAYNP NTQTFMQKGT KFDIKRMVED SDLQTCYCVF 
DVLMVNNKKL GHETLRKRYE ILSSIFTPIP GRIEIVQKTQ AHTKNEVIDA LNEAIDKREE 
GIMVKQPLSI YKPDKRGEGW LKIKPEYVSG LMDELDILIV GGYWGKGSRG GMMSHFLCAV 
AEKPPPGEKP SVFHTLSRVG SGCTMKELYD LGLKLAKYWK PFHRKAPPSS ILCGTEKPEV 
YIEPCNSVIV QIKAAEIVPS DMYKTGCTLR FPRIEKIRDD KEWHECMTLD DLEQLRGKAS 
GKLASKHLYI GGDDEPQEKK RKAAPKMKKV IGIIEHLKAP NLTNVNKISN IFEDVEFCVM 
SGTDSQPKPD LENRTAEFGG YIVQNPGPDT YCVIAGSENI RVKNIILSNK HDVVKPAWLL 
ECFKTKSFVP WQPRFMIHMC PSTKEHFARE YDCYGDSYFI DTDLNQLKEV FSGIKNSNEQ 
TPEEMASLIA DLEYRYSWDC SPLSMFRRHT VYLDSYAVIN DLSTKNEGTR LAIKALELRF 
HGAKVVSCLA EGVSHVIIGE DHSRVADFKA FRRTFKRKFK ILKESWVTDS IDKCELQEEN 
QYLI

Genular Protein ID: 3088259987

Symbol: A0A0C4DGV9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DGV9

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 EPD 2 Ensembl 4 GO 9 Gene3D 5 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 12 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 6 Pfam 5 Proteomes 2 RefSeq 2 RuleBase 2 SMART 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 844
  • Mass: 96215
  • Checksum: BB16F3B834E1B134
  • Sequence:
    • MRLILPQLER ERMAYGIKET MLAKLYIELL NLPRDGKDAL KLLNYRTPTG THGDAGDFAM 
IAYFVLKPRC LQKGSLTIQQ VNDLLDSIAS NNSAKRKDLI KKSLLQLITQ SSALEQKWLI 
RMIIKDLKLG VSQQTIFSVF HNDAAELHNV TTDLEKVCRQ LHDPSVGLSD ISITLFSAFK 
PMLAAIADIE HIEKDMKHQS FYIETKLDGE RMQMHKDGDV YKYFSRNGYN YTDQFGASPT 
EGSLTPFIHN AFKADIQICI LDGEMMAYNP NTQTFMQKGT KFDIKRMVED SDLQTCYCVF 
DVLMVNNKKL GHETLRKRYE ILSSIFTPIP GRIEIVQKTQ AHTKNEVIDA LNEAIDKREE 
GIMVKQPLSI YKPDKRGEGW LKIKPEYVSG LMDELDILIV GGYWGKGSRG GMMSHFLCAV 
AEKPPPGEKP SVFHTLSRVG SGCTMKELYD LGLKLAKYWK PFHRKAPPSS ILCGTEKPEV 
YIEPCNSVIV QIKAAEIVPS DMYKTGCTLR FPRIEKIRDD KEWHECMTLD DLEQLRGKAS 
GKLASKHLYI GGDDEPQEKK RKAAPKMKKV IGIIEHLKAP NLTNVNKISN IFEDVEFCVM 
SGTDSQPKPD LENRIAEFGG YIVQNPGPDT YCVIAGSENI RVKNIILSNK HDVVKPAWLL 
ECFKTKSFVP WQPRFMIHMC PSTKEHFARE YDCYGDSYFI DTDLNQLKEV FSGIKNSNEQ 
TPEEMASLIA DLEYRYSWDC SPLSMFRRHT VYLDSYAVIN DLSTKNEGTR LAIKALELRF 
HGAKVVSCLA EGVSHVIIGE DHSRVADFKA FRRTFKRKFK ILKESWVTDS IDKCELQEEN 
QYLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.