Details for: VPREB1

Gene ID: 7441

Symbol: VPREB1

Ensembl ID: ENSG00000169575

Description: V-set pre-B cell surrogate light chain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 8.5827
    Cell Significance Index: -1.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.1966
    Cell Significance Index: 399.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 3.6477
    Cell Significance Index: 93.1900
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.2496
    Cell Significance Index: 5.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.1152
    Cell Significance Index: -1.3800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9580
    Cell Significance Index: 25.6300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4467
    Cell Significance Index: 5.6600
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1535
    Cell Significance Index: 1.6500
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.1253
    Cell Significance Index: 0.8000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0906
    Cell Significance Index: 1.1000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0446
    Cell Significance Index: 0.6500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0419
    Cell Significance Index: 0.5300
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0340
    Cell Significance Index: 0.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0157
    Cell Significance Index: 0.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0048
    Cell Significance Index: 0.5700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0041
    Cell Significance Index: -0.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0069
    Cell Significance Index: -1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0120
    Cell Significance Index: -0.5600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0210
    Cell Significance Index: -0.2800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0215
    Cell Significance Index: -0.2200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0216
    Cell Significance Index: -0.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0265
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0287
    Cell Significance Index: -3.2900
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: -0.0339
    Cell Significance Index: -0.2700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0368
    Cell Significance Index: -0.4400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0384
    Cell Significance Index: -0.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0388
    Cell Significance Index: -1.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0403
    Cell Significance Index: -1.3200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0412
    Cell Significance Index: -0.5900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0506
    Cell Significance Index: -0.3600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0516
    Cell Significance Index: -0.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0530
    Cell Significance Index: -1.4200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0561
    Cell Significance Index: -0.5700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0561
    Cell Significance Index: -0.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0601
    Cell Significance Index: -3.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0602
    Cell Significance Index: -1.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0605
    Cell Significance Index: -1.2900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0610
    Cell Significance Index: -0.7600
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0611
    Cell Significance Index: -0.5300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0615
    Cell Significance Index: -0.3800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0627
    Cell Significance Index: -1.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0628
    Cell Significance Index: -1.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0640
    Cell Significance Index: -1.3400
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.0688
    Cell Significance Index: -0.5100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0706
    Cell Significance Index: -0.8300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0737
    Cell Significance Index: -1.0700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0754
    Cell Significance Index: -2.6200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0787
    Cell Significance Index: -0.9300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0831
    Cell Significance Index: -0.5100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0852
    Cell Significance Index: -2.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0915
    Cell Significance Index: -1.2200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0916
    Cell Significance Index: -1.5600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0922
    Cell Significance Index: -1.3800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0923
    Cell Significance Index: -0.9900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0949
    Cell Significance Index: -1.2800
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0976
    Cell Significance Index: -1.1800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0998
    Cell Significance Index: -1.1300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1036
    Cell Significance Index: -1.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1054
    Cell Significance Index: -1.3300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1063
    Cell Significance Index: -1.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1080
    Cell Significance Index: -1.4100
  • Cell Name: podocyte (CL0000653)
    Fold Change: -0.1081
    Cell Significance Index: -1.2400
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1085
    Cell Significance Index: -1.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1093
    Cell Significance Index: -3.2200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1187
    Cell Significance Index: -1.3100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.1191
    Cell Significance Index: -1.3700
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1197
    Cell Significance Index: -1.5800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.1197
    Cell Significance Index: -1.3000
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1234
    Cell Significance Index: -0.7200
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.1242
    Cell Significance Index: -1.6000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1247
    Cell Significance Index: -2.0200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1263
    Cell Significance Index: -1.8100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1278
    Cell Significance Index: -1.3300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1293
    Cell Significance Index: -1.3500
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1320
    Cell Significance Index: -1.3700
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.1326
    Cell Significance Index: -1.3400
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1334
    Cell Significance Index: -1.4300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1338
    Cell Significance Index: -3.2400
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1343
    Cell Significance Index: -1.7900
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.1347
    Cell Significance Index: -1.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1400
    Cell Significance Index: -3.7500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1404
    Cell Significance Index: -2.4000
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: -0.1406
    Cell Significance Index: -1.2300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1422
    Cell Significance Index: -2.3800
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.1429
    Cell Significance Index: -1.7900
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.1436
    Cell Significance Index: -1.2800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1442
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1450
    Cell Significance Index: -1.5400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.1457
    Cell Significance Index: -1.4400
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1471
    Cell Significance Index: -1.5600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1493
    Cell Significance Index: -1.1600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1509
    Cell Significance Index: -2.9500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1513
    Cell Significance Index: -1.5500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1593
    Cell Significance Index: -2.1900
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.1683
    Cell Significance Index: -2.2900
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.1718
    Cell Significance Index: -1.6100
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: -0.1719
    Cell Significance Index: -1.5400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1741
    Cell Significance Index: -1.1600
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: -0.1748
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.1761
    Cell Significance Index: -1.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The VPREB1 gene exhibits several key characteristics that are essential for its function: 1. **Location**: The VPREB1 gene is located on chromosome 22q11.23, a region known for its high density of genes involved in immune system development. 2. **Expression**: VPREB1 is significantly expressed in various cell types, including thymocytes, oligodendrocyte precursor cells, microglial cells, and early pro-B cells, indicating its widespread involvement in immune system development. 3. **Protein structure**: The VPREB1 protein is a member of the V-set domain family, which is characterized by a unique structure consisting of a V-set domain and a C-terminal domain. 4. **Function**: VPREB1 plays a critical role in the development of the B cell receptor (BCR) on B cells, specifically in the formation of the light chain portion of the BCR. **Pathways and Functions** The VPREB1 gene is involved in several key pathways and functions, including: 1. **Immune response**: VPREB1 plays a critical role in the development of the B cell receptor (BCR) on B cells, which is essential for the activation of B cells in response to antigens. 2. **Immunoglobulin production**: VPREB1 is involved in the production of immunoglobulins, which are essential for the development of adaptive immunity. 3. **Cell surface interactions**: VPREB1 is expressed on the surface of various cell types, including thymocytes, oligodendrocyte precursor cells, and microglial cells, highlighting its role in cell surface interactions and immune system development. 4. **Endoplasmic reticulum**: VPREB1 is also involved in the endoplasmic reticulum (ER) pathway, which is essential for the proper folding and processing of proteins. **Clinical Significance** Dysregulation or mutations in the VPREB1 gene have been associated with several immune-related disorders, including: 1. **Immunodeficiency**: Mutations in VPREB1 can lead to impaired B cell development and function, resulting in impaired immune response and increased susceptibility to infections. 2. **Autoimmune diseases**: Dysregulation of VPREB1 can also contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: VPREB1 has been implicated in the development of certain types of cancer, including B cell lymphoma and multiple myeloma. In conclusion, the VPREB1 gene plays a critical role in the development of the B cell receptor (BCR) on B cells and is involved in various key pathways and functions, including immune response, immunoglobulin production, and cell surface interactions. Dysregulation or mutations in VPREB1 can have significant clinical implications, including impaired immune function and increased susceptibility to infections and autoimmune diseases.

Genular Protein ID: 2173721523

Symbol: VPREB_HUMAN

Name: Immunoglobulin iota chain

UniProtKB Accession Codes:

P12018 B5MCG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7935499

Title: The human pre-B cell receptor: structural constraints for a tentative model of the pseudo-light (psi L) chain.

PubMed ID: 7935499

DOI: 10.1016/0161-5890(94)90105-8

PubMed ID: 9074928

Title: One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

PubMed ID: 9074928

DOI: 10.1101/gr.7.3.250

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 3258819

Title: Structure and pre-B lymphocyte restricted expression of the VpreB in humans and conservation of its structure in other mammalian species.

PubMed ID: 3258819

DOI: 10.1002/j.1460-2075.1988.tb02789.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 17431183

Title: Structural insight into pre-B cell receptor function.

PubMed ID: 17431183

DOI: 10.1126/science.1139412

PubMed ID: 18287279

Title: Engineering and characterization of a single chain surrogate light chain variable domain.

PubMed ID: 18287279

DOI: 10.1110/ps.073269808

Sequence Information:

  • Length: 145
  • Mass: 16605
  • Checksum: 197665B13AF64D46
  • Sequence:
    • MSWAPVLLML FVYCTGCGPQ PVLHQPPAMS SALGTTIRLT CTLRNDHDIG VYSVYWYQQR 
PGHPPRFLLR YFSQSDKSQG PQVPPRFSGS KDVARNRGYL SISELQPEDE AMYYCAMGAR 
SSEKEERERE WEEEMEPTAA RTRVP

Genular Protein ID: 92672318

Symbol: F8W8C9_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8W8C9

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18477386

Title: Finishing the finished human chromosome 22 sequence.

PubMed ID: 18477386

DOI: 10.1186/gb-2008-9-5-r78

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 42
  • Mass: 4576
  • Checksum: 4F058B994626C637
  • Sequence:
    • MSWAPVLLML FVYCTAGAAS AAGHVLGPWN HNPPHLHPEE RP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.