Details for: RAG2

Gene ID: 5897

Symbol: RAG2

Ensembl ID: ENSG00000175097

Description: recombination activating 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 10.8650
    Cell Significance Index: -1.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.7417
    Cell Significance Index: -1.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.3869
    Cell Significance Index: -1.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8048
    Cell Significance Index: 19.5000
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.5999
    Cell Significance Index: 5.1100
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.4646
    Cell Significance Index: 4.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4527
    Cell Significance Index: 29.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3558
    Cell Significance Index: 5.1000
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.2853
    Cell Significance Index: 1.3400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2576
    Cell Significance Index: 6.5800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2244
    Cell Significance Index: 3.2700
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.1951
    Cell Significance Index: 1.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0471
    Cell Significance Index: 1.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0426
    Cell Significance Index: 0.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0321
    Cell Significance Index: 1.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0302
    Cell Significance Index: 0.3600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0242
    Cell Significance Index: 0.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0242
    Cell Significance Index: 1.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0199
    Cell Significance Index: 3.9900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0101
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0099
    Cell Significance Index: 1.9700
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0084
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0084
    Cell Significance Index: 15.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0060
    Cell Significance Index: 1.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0026
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0025
    Cell Significance Index: 3.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0020
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0008
    Cell Significance Index: 0.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0006
    Cell Significance Index: 0.8400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0023
    Cell Significance Index: -1.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0026
    Cell Significance Index: -1.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0054
    Cell Significance Index: -0.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0068
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0087
    Cell Significance Index: -1.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0097
    Cell Significance Index: -1.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0105
    Cell Significance Index: -0.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0106
    Cell Significance Index: -0.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0112
    Cell Significance Index: -1.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0112
    Cell Significance Index: -1.3200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0125
    Cell Significance Index: -0.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0152
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0154
    Cell Significance Index: -1.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0156
    Cell Significance Index: -1.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0163
    Cell Significance Index: -0.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0166
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0168
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0170
    Cell Significance Index: -0.4800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0187
    Cell Significance Index: -0.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0229
    Cell Significance Index: -1.2000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0230
    Cell Significance Index: -0.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0232
    Cell Significance Index: -0.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0258
    Cell Significance Index: -0.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0271
    Cell Significance Index: -0.9500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0285
    Cell Significance Index: -0.2700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0304
    Cell Significance Index: -0.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0306
    Cell Significance Index: -0.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0312
    Cell Significance Index: -0.9000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0317
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0324
    Cell Significance Index: -0.4700
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0334
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0347
    Cell Significance Index: -1.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0349
    Cell Significance Index: -0.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0350
    Cell Significance Index: -0.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0353
    Cell Significance Index: -0.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0370
    Cell Significance Index: -1.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0370
    Cell Significance Index: -1.8700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0386
    Cell Significance Index: -0.4700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0387
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0398
    Cell Significance Index: -0.5000
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: -0.0403
    Cell Significance Index: -0.3500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0429
    Cell Significance Index: -0.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0461
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0465
    Cell Significance Index: -1.9000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0467
    Cell Significance Index: -0.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0468
    Cell Significance Index: -0.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0471
    Cell Significance Index: -1.1500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0491
    Cell Significance Index: -0.5800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0506
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0506
    Cell Significance Index: -1.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0509
    Cell Significance Index: -1.1000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0514
    Cell Significance Index: -0.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0531
    Cell Significance Index: -1.0500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0548
    Cell Significance Index: -0.6900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0552
    Cell Significance Index: -1.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0561
    Cell Significance Index: -1.4300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0566
    Cell Significance Index: -0.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0573
    Cell Significance Index: -1.9900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0578
    Cell Significance Index: -1.2000
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0590
    Cell Significance Index: -0.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0592
    Cell Significance Index: -1.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0593
    Cell Significance Index: -1.3700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0612
    Cell Significance Index: -1.0300
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0612
    Cell Significance Index: -0.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RAG2 is a 45-kilodalton protein that is highly conserved across species, from mammals to birds and fish. It is a part of the RAG complex, which includes RAG1, RAG2, and other accessory proteins. RAG2 is characterized by its ability to recognize and bind to specific DNA sequences, facilitating the precise joining of V, D, and J gene segments during recombination. The RAG2 protein also exhibits a high degree of sequence specificity, allowing it to accurately recognize and bind to the correct gene segments. **Pathways and Functions:** RAG2 is involved in several key pathways, including: 1. **V(D)J Recombination:** RAG2 plays a central role in the process of V(D)J recombination, which generates the diversity of the immune system. This process involves the precise joining of V, D, and J gene segments during B cell and T cell development. 2. **B Cell Development:** RAG2 is essential for the development of B cells, which are critical for the adaptive immune response. The RAG complex is required for the accurate joining of V, D, and J gene segments during B cell development. 3. **T Cell Development:** RAG2 is also involved in the development of T cells, which are critical for the adaptive immune response. The RAG complex is required for the accurate joining of V, D, and J gene segments during T cell development. 4. **Immune System Function:** RAG2 is required for the proper functioning of the immune system, including the activation of immune cells and the production of antibodies. **Clinical Significance:** Mutations or deletions in RAG2 can lead to severe immunodeficiency and increased susceptibility to infections. Some of the clinical manifestations of RAG2 deficiency include: 1. **Severe Combined Immunodeficiency (SCID):** RAG2 deficiency can lead to SCID, a condition characterized by impaired T cell and B cell development. 2. **Increased Susceptibility to Infections:** Individuals with RAG2 deficiency are more susceptible to infections, particularly those caused by bacteria and viruses. 3. **Autoimmune Disorders:** RAG2 deficiency can also lead to autoimmune disorders, such as rheumatoid arthritis and lupus. In conclusion, RAG2 is a critical gene involved in the process of V(D)J recombination and immune system development. Its deficiency can lead to severe immunodeficiency and increased susceptibility to infections, highlighting the importance of RAG2 in maintaining immune system function.

Genular Protein ID: 121171324

Symbol: RAG2_HUMAN

Name: V(D)J recombination-activating protein 2

UniProtKB Accession Codes:

P55895 A8K9E9 Q8TBL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 26 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1428003

Title: Sequence and chromosome assignment to 11p13-p12 of human RAG genes.

PubMed ID: 1428003

DOI: 10.1016/0165-2478(92)90073-w

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1832998

Title: Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression.

PubMed ID: 1832998

PubMed ID: 8810255

Title: RAG mutations in human B cell-negative SCID.

PubMed ID: 8810255

DOI: 10.1126/science.274.5284.97

PubMed ID: 9630231

Title: Partial V(D)J recombination activity leads to Omenn syndrome.

PubMed ID: 9630231

DOI: 10.1016/s0092-8674(00)81448-8

PubMed ID: 18463379

Title: An immunodeficiency disease with RAG mutations and granulomas.

PubMed ID: 18463379

DOI: 10.1056/nejmoa073966

Sequence Information:

  • Length: 527
  • Mass: 59241
  • Checksum: 1CC4D0F88635BA87
  • Sequence:
    • MSLQMVTVSN NIALIQPGFS LMNFDGQVFF FGQKGWPKRS CPTGVFHLDV KHNHVKLKPT 
IFSKDSCYLP PLRYPATCTF KGSLESEKHQ YIIHGGKTPN NEVSDKIYVM SIVCKNNKKV 
TFRCTEKDLV GDVPEARYGH SINVVYSRGK SMGVLFGGRS YMPSTHRTTE KWNSVADCLP 
CVFLVDFEFG CATSYILPEL QDGLSFHVSI AKNDTIYILG GHSLANNIRP ANLYRIRVDL 
PLGSPAVNCT VLPGGISVSS AILTQTNNDE FVIVGGYQLE NQKRMICNII SLEDNKIEIR 
EMETPDWTPD IKHSKIWFGS NMGNGTVFLG IPGDNKQVVS EGFYFYMLKC AEDDTNEEQT 
TFTNSQTSTE DPGDSTPFED SEEFCFSAEA NSFDGDDEFD TYNEDDEEDE SETGYWITCC 
PTCDVDINTW VPFYSTELNK PAMIYCSHGD GHWVHAQCMD LAERTLIHLS AGSNKYYCNE 
HVEIARALHT PQRVLPLKKP PMKSLRKKGS GKILTPAKKS FLRRLFD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.