Details for: FADS3

Gene ID: 3995

Symbol: FADS3

Ensembl ID: ENSG00000221968

Description: fatty acid desaturase 3

Associated with

  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Lipid metabolic process
    (GO:0006629)
  • Membrane
    (GO:0016020)
  • Molecular_function
    (GO:0003674)
  • Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
    (GO:0016717)
  • Protein binding
    (GO:0005515)
  • Sphingolipid metabolic process
    (GO:0006665)
  • Unsaturated fatty acid biosynthetic process
    (GO:0006636)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.06
    Marker Score: 752
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.95
    Marker Score: 2431
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.67
    Marker Score: 594
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.52
    Marker Score: 1628
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.5
    Marker Score: 1804
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.44
    Marker Score: 4274.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.36
    Marker Score: 46144
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.35
    Marker Score: 30176
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.32
    Marker Score: 28191
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.25
    Marker Score: 11869
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.25
    Marker Score: 19525
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.25
    Marker Score: 6119
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2485
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.21
    Marker Score: 1191
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.19
    Marker Score: 10252
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.19
    Marker Score: 666
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.19
    Marker Score: 4225.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.15
    Marker Score: 483
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.14
    Marker Score: 69894
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.13
    Marker Score: 557
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.13
    Marker Score: 1906
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.08
    Marker Score: 1666.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.06
    Marker Score: 4298
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.01
    Marker Score: 10239
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71751
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47974.5
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.99
    Marker Score: 482
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.99
    Marker Score: 653
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.97
    Marker Score: 336
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.93
    Marker Score: 2534
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 438
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.92
    Marker Score: 501
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.92
    Marker Score: 1241
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.91
    Marker Score: 556
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.91
    Marker Score: 409
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9
    Marker Score: 3520
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4975
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.86
    Marker Score: 817
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.86
    Marker Score: 1610
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.85
    Marker Score: 5103
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.84
    Marker Score: 3635
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 713
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.82
    Marker Score: 7706
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.81
    Marker Score: 230
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8
    Marker Score: 9009
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8
    Marker Score: 238
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.78
    Marker Score: 212
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.77
    Marker Score: 368
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.77
    Marker Score: 192
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.77
    Marker Score: 437
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.77
    Marker Score: 684
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1243
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.76
    Marker Score: 192
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.76
    Marker Score: 193
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.76
    Marker Score: 870
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.75
    Marker Score: 782
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3137.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.74
    Marker Score: 196
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.74
    Marker Score: 310
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.74
    Marker Score: 217
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.73
    Marker Score: 214
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1698
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.72
    Marker Score: 165
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.7
    Marker Score: 478
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.7
    Marker Score: 499
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.69
    Marker Score: 4075
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 411
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.68
    Marker Score: 1140
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.67
    Marker Score: 1196
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.67
    Marker Score: 844
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.67
    Marker Score: 509
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.67
    Marker Score: 322.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.67
    Marker Score: 627
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.66
    Marker Score: 1397
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.66
    Marker Score: 257
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.65
    Marker Score: 9792.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.65
    Marker Score: 21987
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.65
    Marker Score: 6683
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.65
    Marker Score: 713
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.64
    Marker Score: 642
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.64
    Marker Score: 4878
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.63
    Marker Score: 2644
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 279
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.63
    Marker Score: 761
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.62
    Marker Score: 23638
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.62
    Marker Score: 139
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.62
    Marker Score: 406
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.61
    Marker Score: 718
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.6
    Marker Score: 581

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Other Information

**Key Characteristics:** 1. **Subcellular localization:** FADS3 is primarily localized to the endoplasmic reticulum (ER) membrane, where it is involved in the desaturation of fatty acids. 2. **Enzymatic activity:** FADS3 possesses oxidoreductase activity, catalyzing the reduction of molecular oxygen to water while introducing double bonds into fatty acid chains. 3. **Expression pattern:** FADS3 is highly expressed in subcutaneous fat cells, cardiac neurons, and mammary gland epithelial cells, among other cell types. 4. **Function:** FADS3 is essential for the biosynthesis of unsaturated fatty acids, which are critical components of cellular membranes, influencing membrane fluidity, signaling, and other cellular processes. **Pathways and Functions:** 1. **Lipid metabolism:** FADS3 is involved in the desaturation of fatty acids, a crucial step in the biosynthesis of unsaturated fatty acids. 2. **Endoplasmic reticulum membrane:** FADS3 is localized to the ER membrane, where it interacts with other proteins to regulate membrane structure and function. 3. **Sphingolipid metabolism:** FADS3 has been implicated in the regulation of sphingolipid metabolism, which is essential for cellular signaling and membrane trafficking. 4. **Oxidoreductase activity:** FADS3 possesses oxidoreductase activity, allowing it to catalyze the reduction of molecular oxygen to water while introducing double bonds into fatty acid chains. **Clinical Significance:** Dysregulation of FADS3 has been linked to various diseases and conditions, including: 1. **Metabolic disorders:** Abnormal fatty acid profiles have been associated with metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 2. **Cardiovascular disease:** Alterations in FADS3 expression and activity have been linked to cardiovascular disease, including atherosclerosis and cardiac arrhythmias. 3. **Cancer:** FADS3 has been implicated in the regulation of lipid metabolism in cancer cells, influencing tumor growth and progression. 4. **Neurological disorders:** Dysregulation of FADS3 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, FADS3 is a critical enzyme in lipid metabolism, playing a key role in the biosynthesis of unsaturated fatty acids. Its dysregulation has been linked to various diseases and conditions, highlighting the importance of FADS3 in maintaining cellular homeostasis and overall health. Further research is needed to elucidate the mechanisms underlying FADS3-mediated lipid metabolism and its clinical significance in human diseases.

Genular Protein ID: 2187950495

Symbol: FADS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y5Q0 O60426

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 42 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 24 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10860662

Title: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.

PubMed ID: 10860662

DOI: 10.1006/geno.2000.6196

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19752397

Title: The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.

PubMed ID: 19752397

DOI: 10.1194/jlr.m000588

PubMed ID: 31916624

Title: Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3.

PubMed ID: 31916624

DOI: 10.1096/fj.201902645r

PubMed ID: 31862735

Title: FADS3 is a Delta14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.

PubMed ID: 31862735

DOI: 10.1074/jbc.ac119.011883

PubMed ID: 37209771

Title: Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS3.

PubMed ID: 37209771

DOI: 10.1016/j.bbalip.2023.159335

Sequence Information:

  • Length: 445
  • Mass: 51145
  • Checksum: 7840EF6BE055111D
  • Sequence:
    • MGGVGEPGPR EGPAQPGAPL PTFCWEQIRA HDQPGDKWLV IERRVYDISR WAQRHPGGSR 
LIGHHGAEDA TDAFRAFHQD LNFVRKFLQP LLIGELAPEE PSQDGPLNAQ LVEDFRALHQ 
AAEDMKLFDA SPTFFAFLLG HILAMEVLAW LLIYLLGPGW VPSALAAFIL AISQAQSWCL 
QHDLGHASIF KKSWWNHVAQ KFVMGQLKGF SAHWWNFRHF QHHAKPNIFH KDPDVTVAPV 
FLLGESSVEY GKKKRRYLPY NQQHLYFFLI GPPLLTLVNF EVENLAYMLV CMQWADLLWA 
ASFYARFFLS YLPFYGVPGV LLFFVAVRVL ESHWFVWITQ MNHIPKEIGH EKHRDWVSSQ 
LAATCNVEPS LFTNWFSGHL NFQIEHHLFP RMPRHNYSRV APLVKSLCAK HGLSYEVKPF 
LTALVDIVRS LKKSGDIWLD AYLHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.