Details for: FADS3

Gene ID: 3995

Symbol: FADS3

Ensembl ID: ENSG00000221968

Description: fatty acid desaturase 3

Associated with

  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Lipid metabolic process
    (GO:0006629)
  • Membrane
    (GO:0016020)
  • Molecular_function
    (GO:0003674)
  • Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
    (GO:0016717)
  • Protein binding
    (GO:0005515)
  • Sphingolipid metabolic process
    (GO:0006665)
  • Unsaturated fatty acid biosynthetic process
    (GO:0006636)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.9038
    Cell Significance Index: -25.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.3915
    Cell Significance Index: -25.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.0493
    Cell Significance Index: -25.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.4699
    Cell Significance Index: -20.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9745
    Cell Significance Index: -20.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.9334
    Cell Significance Index: -25.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1830
    Cell Significance Index: -24.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5648
    Cell Significance Index: -25.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.6623
    Cell Significance Index: -14.3200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2106
    Cell Significance Index: 39.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.4538
    Cell Significance Index: 17.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2356
    Cell Significance Index: 35.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1998
    Cell Significance Index: 141.4900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.1726
    Cell Significance Index: 14.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0431
    Cell Significance Index: 22.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9878
    Cell Significance Index: 44.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8946
    Cell Significance Index: 57.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8251
    Cell Significance Index: 165.5200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.7833
    Cell Significance Index: 3.4100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7737
    Cell Significance Index: 59.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5975
    Cell Significance Index: 37.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5553
    Cell Significance Index: 26.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5473
    Cell Significance Index: 75.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4631
    Cell Significance Index: 418.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.4206
    Cell Significance Index: 2.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3553
    Cell Significance Index: 8.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3218
    Cell Significance Index: 52.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2750
    Cell Significance Index: 52.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2741
    Cell Significance Index: 35.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2673
    Cell Significance Index: 29.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2441
    Cell Significance Index: 133.3000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.2328
    Cell Significance Index: 2.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2325
    Cell Significance Index: 83.4100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2269
    Cell Significance Index: 1.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2161
    Cell Significance Index: 6.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1915
    Cell Significance Index: 34.5300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1892
    Cell Significance Index: 22.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1884
    Cell Significance Index: 11.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1351
    Cell Significance Index: 10.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1324
    Cell Significance Index: 0.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1166
    Cell Significance Index: 7.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1165
    Cell Significance Index: 15.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1099
    Cell Significance Index: 2.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0895
    Cell Significance Index: 61.8800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0805
    Cell Significance Index: 4.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0771
    Cell Significance Index: 2.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0553
    Cell Significance Index: 10.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0522
    Cell Significance Index: 5.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0483
    Cell Significance Index: 89.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0400
    Cell Significance Index: 25.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0329
    Cell Significance Index: 61.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0256
    Cell Significance Index: 39.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0156
    Cell Significance Index: 6.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0046
    Cell Significance Index: -0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0127
    Cell Significance Index: -0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0261
    Cell Significance Index: -19.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0289
    Cell Significance Index: -21.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0304
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0353
    Cell Significance Index: -26.1300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0371
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0415
    Cell Significance Index: -7.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0422
    Cell Significance Index: -1.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0452
    Cell Significance Index: -0.6500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0461
    Cell Significance Index: -26.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0715
    Cell Significance Index: -20.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0728
    Cell Significance Index: -7.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0783
    Cell Significance Index: -11.3800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0786
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0871
    Cell Significance Index: -9.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0959
    Cell Significance Index: -4.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1173
    Cell Significance Index: -8.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1189
    Cell Significance Index: -4.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1278
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1374
    Cell Significance Index: -28.9400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1681
    Cell Significance Index: -3.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1721
    Cell Significance Index: -3.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1963
    Cell Significance Index: -13.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2108
    Cell Significance Index: -11.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2118
    Cell Significance Index: -11.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2243
    Cell Significance Index: -6.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2291
    Cell Significance Index: -23.8600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2655
    Cell Significance Index: -3.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2711
    Cell Significance Index: -11.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2780
    Cell Significance Index: -7.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2862
    Cell Significance Index: -6.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2966
    Cell Significance Index: -23.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3103
    Cell Significance Index: -9.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3117
    Cell Significance Index: -11.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3220
    Cell Significance Index: -19.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3641
    Cell Significance Index: -20.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4015
    Cell Significance Index: -10.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4088
    Cell Significance Index: -10.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4194
    Cell Significance Index: -11.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4222
    Cell Significance Index: -5.7600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4458
    Cell Significance Index: -7.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4496
    Cell Significance Index: -9.4100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4973
    Cell Significance Index: -11.9300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5087
    Cell Significance Index: -16.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FADS3 is a membrane-bound enzyme that operates in the endoplasmic reticulum, where it catalyzes the desaturation of fatty acids. The enzyme exhibits oxidoreductase activity, specifically targeting paired donors and reducing molecular oxygen to two molecules of water. FADS3 is also characterized by its ability to bind to proteins and participate in sphingolipid metabolism, further highlighting its multifaceted role in cellular processes. **Pathways and Functions:** FADS3 is involved in several critical pathways, including: 1. **Lipid Metabolic Process**: FADS3 plays a vital role in the biosynthesis of unsaturated fatty acids, which are essential for various cellular functions, including membrane fluidity, signaling, and hormone regulation. 2. **Endoplasmic Reticulum Membrane**: As a membrane-bound enzyme, FADS3 is strategically positioned to regulate fatty acid metabolism and lipid homeostasis within the endoplasmic reticulum. 3. **Sphingolipid Metabolic Process**: FADS3's ability to bind to proteins and participate in sphingolipid metabolism highlights its involvement in the regulation of cell signaling and membrane dynamics. **Clinical Significance:** Dysregulation of FADS3 has been implicated in various diseases, including: 1. **Atherosclerosis**: Altered FADS3 expression and activity have been linked to the development of atherosclerosis, a condition characterized by the buildup of fatty deposits in arteries. 2. **Inflammatory Disorders**: FADS3's role in immune response and lipid metabolism suggests its involvement in inflammatory disorders, such as rheumatoid arthritis and asthma. 3. **Cancer**: Aberrant FADS3 expression has been observed in various types of cancer, including breast and colon cancer, highlighting its potential as a biomarker or therapeutic target. In conclusion, FADS3 is a vital enzyme that plays a critical role in lipid metabolism, immune response, and overall health. Further research is necessary to fully elucidate the mechanisms underlying FADS3's function and its clinical significance, but its importance as a therapeutic target and biomarker is already evident.

Genular Protein ID: 2187950495

Symbol: FADS3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y5Q0 O60426

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 42 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 Rhea 24 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10860662

Title: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family.

PubMed ID: 10860662

DOI: 10.1006/geno.2000.6196

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19752397

Title: The fatty acid desaturase 3 gene encodes for different FADS3 protein isoforms in mammalian tissues.

PubMed ID: 19752397

DOI: 10.1194/jlr.m000588

PubMed ID: 31916624

Title: Biosynthesis of the anti-lipid-microdomain sphingoid base 4,14-sphingadiene by the ceramide desaturase FADS3.

PubMed ID: 31916624

DOI: 10.1096/fj.201902645r

PubMed ID: 31862735

Title: FADS3 is a Delta14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome.

PubMed ID: 31862735

DOI: 10.1074/jbc.ac119.011883

PubMed ID: 37209771

Title: Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS3.

PubMed ID: 37209771

DOI: 10.1016/j.bbalip.2023.159335

Sequence Information:

  • Length: 445
  • Mass: 51145
  • Checksum: 7840EF6BE055111D
  • Sequence:
    • MGGVGEPGPR EGPAQPGAPL PTFCWEQIRA HDQPGDKWLV IERRVYDISR WAQRHPGGSR 
LIGHHGAEDA TDAFRAFHQD LNFVRKFLQP LLIGELAPEE PSQDGPLNAQ LVEDFRALHQ 
AAEDMKLFDA SPTFFAFLLG HILAMEVLAW LLIYLLGPGW VPSALAAFIL AISQAQSWCL 
QHDLGHASIF KKSWWNHVAQ KFVMGQLKGF SAHWWNFRHF QHHAKPNIFH KDPDVTVAPV 
FLLGESSVEY GKKKRRYLPY NQQHLYFFLI GPPLLTLVNF EVENLAYMLV CMQWADLLWA 
ASFYARFFLS YLPFYGVPGV LLFFVAVRVL ESHWFVWITQ MNHIPKEIGH EKHRDWVSSQ 
LAATCNVEPS LFTNWFSGHL NFQIEHHLFP RMPRHNYSRV APLVKSLCAK HGLSYEVKPF 
LTALVDIVRS LKKSGDIWLD AYLHQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.