Details for: SCHIP1

Gene ID: 29970

Symbol: SCHIP1

Ensembl ID: ENSG00000151967

Description: schwannomin interacting protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 75.6050
    Cell Significance Index: -11.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 42.3429
    Cell Significance Index: -10.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5462
    Cell Significance Index: -11.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8351
    Cell Significance Index: 48.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7464
    Cell Significance Index: 17.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6549
    Cell Significance Index: 50.2600
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.6529
    Cell Significance Index: 4.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6330
    Cell Significance Index: 38.9100
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.6104
    Cell Significance Index: 7.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5924
    Cell Significance Index: 118.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2916
    Cell Significance Index: 83.9100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.2629
    Cell Significance Index: 1.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1946
    Cell Significance Index: 2.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1767
    Cell Significance Index: 3.8700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0784
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0666
    Cell Significance Index: 23.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0637
    Cell Significance Index: 0.9400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0451
    Cell Significance Index: 0.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0012
    Cell Significance Index: 0.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0052
    Cell Significance Index: -0.6400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0065
    Cell Significance Index: -12.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0089
    Cell Significance Index: -16.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0103
    Cell Significance Index: -5.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0106
    Cell Significance Index: -16.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0120
    Cell Significance Index: -16.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0146
    Cell Significance Index: -9.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0151
    Cell Significance Index: -1.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0164
    Cell Significance Index: -12.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0213
    Cell Significance Index: -3.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0241
    Cell Significance Index: -13.5800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0242
    Cell Significance Index: -0.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0249
    Cell Significance Index: -11.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0278
    Cell Significance Index: -3.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0281
    Cell Significance Index: -1.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0294
    Cell Significance Index: -2.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0387
    Cell Significance Index: -0.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0471
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0472
    Cell Significance Index: -2.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0586
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0649
    Cell Significance Index: -13.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0653
    Cell Significance Index: -9.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0799
    Cell Significance Index: -10.9800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0823
    Cell Significance Index: -1.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0836
    Cell Significance Index: -8.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0889
    Cell Significance Index: -15.1800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0959
    Cell Significance Index: -1.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1183
    Cell Significance Index: -9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1195
    Cell Significance Index: -14.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1230
    Cell Significance Index: -14.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1301
    Cell Significance Index: -9.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1312
    Cell Significance Index: -8.2700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1328
    Cell Significance Index: -6.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1352
    Cell Significance Index: -3.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1478
    Cell Significance Index: -6.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1626
    Cell Significance Index: -4.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1629
    Cell Significance Index: -10.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1629
    Cell Significance Index: -3.4100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1750
    Cell Significance Index: -2.5500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1902
    Cell Significance Index: -1.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1927
    Cell Significance Index: -9.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2060
    Cell Significance Index: -4.9900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2072
    Cell Significance Index: -4.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2080
    Cell Significance Index: -12.7500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2099
    Cell Significance Index: -1.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2099
    Cell Significance Index: -3.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2258
    Cell Significance Index: -6.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2265
    Cell Significance Index: -7.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2392
    Cell Significance Index: -10.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2451
    Cell Significance Index: -7.2200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.2770
    Cell Significance Index: -2.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2772
    Cell Significance Index: -4.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2786
    Cell Significance Index: -9.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2798
    Cell Significance Index: -8.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2872
    Cell Significance Index: -10.0600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2937
    Cell Significance Index: -3.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3036
    Cell Significance Index: -3.3000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3052
    Cell Significance Index: -4.3500
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: -0.3093
    Cell Significance Index: -2.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3104
    Cell Significance Index: -5.3200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3110
    Cell Significance Index: -6.7200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3164
    Cell Significance Index: -4.5000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3220
    Cell Significance Index: -5.6900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3266
    Cell Significance Index: -1.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3322
    Cell Significance Index: -5.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3345
    Cell Significance Index: -9.5900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3505
    Cell Significance Index: -8.7400
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3531
    Cell Significance Index: -4.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3643
    Cell Significance Index: -10.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3657
    Cell Significance Index: -9.9600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3725
    Cell Significance Index: -7.9100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3727
    Cell Significance Index: -5.9100
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.3754
    Cell Significance Index: -4.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3799
    Cell Significance Index: -9.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3815
    Cell Significance Index: -9.7500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3842
    Cell Significance Index: -3.7600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4010
    Cell Significance Index: -8.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4061
    Cell Significance Index: -8.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SCHIP1 shares homology with schwannomin, a protein involved in the development and function of Schwann cells, which are crucial for the myelination of neurons. The high expression of SCHIP1 in oligodendrocytes and neurons suggests a potential role in the development and maintenance of the nervous system. Additionally, SCHIP1's association with cell junctions and plasma membranes indicates its involvement in cellular adhesion and signaling processes. **Pathways and Functions:** SCHIP1 is implicated in several signaling pathways, including the positive regulation of the Hippo signaling pathway. This pathway is crucial for regulating cell growth, proliferation, and apoptosis. SCHIP1's interaction with other proteins, such as schwannomin, may also influence cellular processes, including protein binding and regulation of cellular localization. Furthermore, SCHIP1's expression in epithelial cells and stem cells suggests its involvement in cell differentiation, proliferation, and maintenance. **Clinical Significance:** The clinical significance of SCHIP1 is not yet fully understood. However, its expression in specific cell types, such as oligodendrocytes and neurons, suggests potential involvement in neurological disorders, such as multiple sclerosis or neurodegenerative diseases. Additionally, SCHIP1's role in cell differentiation and proliferation may be relevant to the development of certain cancers. Further research is necessary to elucidate the clinical significance of SCHIP1 and its potential as a therapeutic target. **Conclusion:** SCHIP1 is a multifaceted gene that plays a crucial role in various cellular processes, including cell signaling, adhesion, and differentiation. Further research is necessary to fully elucidate the mechanisms by which SCHIP1 regulates cellular processes and to explore its potential as a therapeutic target in neurological and cancer disorders.

Genular Protein ID: 3782616777

Symbol: SCHI1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P0DPB3 B3KRM0 O75543 Q00P30 Q00P31 Q7Z3Y3 Q8IY83 Q9P0W3 Q9P0W4 Q9P0W5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioMuta 1 CCDS 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RefSeq 4 SMR 1 SignaLink 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10669747

Title: Cloning and characterization of SCHIP-1, a novel protein interacting specifically with spliced isoforms and naturally occurring mutant NF2 proteins.

PubMed ID: 10669747

DOI: 10.1128/mcb.20.5.1699-1712.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17045569

Title: IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.

PubMed ID: 17045569

DOI: 10.1016/j.bbrc.2006.09.136

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25950943

Title: CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

PubMed ID: 25950943

DOI: 10.1111/jnc.13158

Sequence Information:

  • Length: 487
  • Mass: 53480
  • Checksum: 86F86EDD64A475BF
  • Sequence:
    • MERSGQRVTT WDCDQGKHSD SDYREDGMDL GSDAGSSSSS SRASSQSNST KVTPCSECKS 
SSSPGGSLDL VSALEDYEEP FPVYQKKVID EWAPEEDGEE EEEEDERDQR GYRDDRSPAR 
EPGDVSARTR SGGGGGRSAT TAMPPPVPNG NLHQHDPQDL RHNGNVVVAG RPSCSRGPRR 
AIQKPQPAGG RRSGRGPAAG GLCLQPPDGG TCVPEEPPVP PMDWEALEKH LAGLQFREQE 
VRNQGQARTN STSAQKNERE SIRQKLALGS FFDDGPGIYT SCSKSGKPSL SSRLQSGMNL 
QICFVNDSGS DKDSDADDSK TETSLDTPLS PMSKQSSSYS DRDTTEEESE SLDDMDFLTR 
QKKLQAEAKM ALAMAKPMAK MQVEVEKQNR KKSPVADLLP HMPHISECLM KRSLKPTDLR 
DMTIGQLQVI VNDLHSQIES LNEELVQLLL IRDELHTEQD AMLVDIEDLT RHAESQQKHM 
AEKMPAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.