Details for: IGLL1

Gene ID: 3543

Symbol: IGLL1

Ensembl ID: ENSG00000128322

Description: immunoglobulin lambda like polypeptide 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.31
    Marker Score: 3450
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.84
    Marker Score: 11632
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.75
    Marker Score: 3240.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.06
    Marker Score: 1555
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.95
    Marker Score: 5298
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.78
    Marker Score: 870
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.71
    Marker Score: 3342
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1172
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 857
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7682
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4820
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.13
    Marker Score: 289
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.13
    Marker Score: 552
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.13
    Marker Score: 770.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1
    Marker Score: 11175
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.02
    Marker Score: 615
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71833
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.76
    Marker Score: 481
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.72
    Marker Score: 552
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.69
    Marker Score: 503
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.61
    Marker Score: 154
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1115
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.57
    Marker Score: 199
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.49
    Marker Score: 158
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 449
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.46
    Marker Score: 228
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.46
    Marker Score: 122
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 231
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6805
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 849
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.38
    Marker Score: 784
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.38
    Marker Score: 378
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.34
    Marker Score: 408
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.34
    Marker Score: 146
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.32
    Marker Score: 273
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.29
    Marker Score: 131
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.28
    Marker Score: 97
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 183
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.24
    Marker Score: 67
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 110
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.21
    Marker Score: 142
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.21
    Marker Score: 115
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.2
    Marker Score: 219
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.17
    Marker Score: 101
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.15
    Marker Score: 69
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.15
    Marker Score: 100.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 229
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.15
    Marker Score: 153
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.14
    Marker Score: 173
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.14
    Marker Score: 85
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 130
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 319
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 148
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.13
    Marker Score: 60
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.13
    Marker Score: 134.5
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.13
    Marker Score: 63
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 48
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.1
    Marker Score: 34
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.1
    Marker Score: 31
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.09
    Marker Score: 67
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.09
    Marker Score: 18

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Other Information

**Key characteristics** * IGLL1 is a glycoprotein that is expressed on the surface of immune cells. * It is a type I transmembrane protein that is composed of 14 transmembrane domains. * IGLL1 is a ligand for CD69, a cell surface protein that is expressed on activated T cells and B cells. * It is involved in the regulation of T cell activation and antibody production. **Pathways and functions** * IGLL1 is involved in the regulation of T cell activation. * It binds to CD69 on T cells, which is expressed on activated T cells. * This binding activates T cells and promotes their activation. * IGLL1 also plays a role in the regulation of B cell activation. * It binds to CD40, a cell surface protein that is expressed on activated B cells. * This binding activates B cells and promotes their activation. **Clinical significance** Mutations in the IGLL1 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, lupus, and scleroderma. These diseases are characterized by inflammation and tissue damage. IGLL1 is thought to play a role in the inflammatory process in these diseases by regulating the activation of immune cells. **Other notable features** * IGLL1 is a highly conserved protein. * It is expressed in high levels in humans and other primates. * It is a well-studied protein that has been extensively characterized in research.

Genular Protein ID: 1509716872

Symbol: IGLL1_HUMAN

Name: Immunoglobulin lambda-like polypeptide 1

UniProtKB Accession Codes:

P15814 Q0P681

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2501791

Title: Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein.

PubMed ID: 2501791

DOI: 10.1073/pnas.86.14.5552

PubMed ID: 1703205

Title: Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution.

PubMed ID: 1703205

DOI: 10.1084/jem.173.2.305

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2128466

Title: The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene.

PubMed ID: 2128466

DOI: 10.1093/intimm/2.3.201

PubMed ID: 3003227

Title: Identification of three new Ig lambda-like genes in man.

PubMed ID: 3003227

DOI: 10.1084/jem.163.2.425

PubMed ID: 9419212

Title: Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.

PubMed ID: 9419212

DOI: 10.1084/jem.187.1.71

PubMed ID: 17431183

Title: Structural insight into pre-B cell receptor function.

PubMed ID: 17431183

DOI: 10.1126/science.1139412

Sequence Information:

  • Length: 213
  • Mass: 22963
  • Checksum: 9133A7742B943C79
  • Sequence:
    • MRPGTGQGGL EAPGEPGPNL RQRWPLLLLG LAVVTHGLLR PTAASQSRAL GPGAPGGSSR 
SSLRSRWGRF LLQRGSWTGP RCWPRGFQSK HNSVTHVFGS GTQLTVLSQP KATPSVTLFP 
PSSEELQANK ATLVCLMNDF YPGILTVTWK ADGTPITQGV EMTTPSKQSN NKYAASSYLS 
LTPEQWRSRR SYSCQVMHEG STVEKTVAPA ECS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.