Details for: TNR

Gene ID: 7143

Symbol: TNR

Ensembl ID: ENSG00000116147

Description: tenascin R

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.94
    Marker Score: 3638.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.74
    Marker Score: 21023
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.71
    Marker Score: 40452
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.61
    Marker Score: 7445
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.57
    Marker Score: 19377
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.56
    Marker Score: 5296
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.55
    Marker Score: 4283
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.21
    Marker Score: 83874.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.18
    Marker Score: 8412
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.11
    Marker Score: 77850
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.04
    Marker Score: 125176
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.9
    Marker Score: 18077.5
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.9
    Marker Score: 627
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.77
    Marker Score: 16657
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14757.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.65
    Marker Score: 522
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.65
    Marker Score: 3351
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.65
    Marker Score: 2542
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.6
    Marker Score: 6646
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.52
    Marker Score: 803
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.49
    Marker Score: 2094
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169887
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.48
    Marker Score: 15242
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.46
    Marker Score: 1261
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.32
    Marker Score: 730
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.25
    Marker Score: 753
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.25
    Marker Score: 24894
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18713.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.17
    Marker Score: 1119
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.17
    Marker Score: 365
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.16
    Marker Score: 474
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.14
    Marker Score: 4638
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.11
    Marker Score: 2543
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6985
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2528
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 675
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.85
    Marker Score: 1547
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 393
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.76
    Marker Score: 16289
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.68
    Marker Score: 3163
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.68
    Marker Score: 2856
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.67
    Marker Score: 459
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.62
    Marker Score: 161
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.61
    Marker Score: 1429.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.6
    Marker Score: 2520
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 471
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.57
    Marker Score: 254
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.5
    Marker Score: 326
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.49
    Marker Score: 188
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.48
    Marker Score: 548
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.47
    Marker Score: 463
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 231
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.43
    Marker Score: 399
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.43
    Marker Score: 191
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.42
    Marker Score: 244
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.42
    Marker Score: 462
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.41
    Marker Score: 168
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.41
    Marker Score: 782
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.4
    Marker Score: 204
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.4
    Marker Score: 431
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.39
    Marker Score: 937.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.39
    Marker Score: 136
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.39
    Marker Score: 2094
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.38
    Marker Score: 421
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 442
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.37
    Marker Score: 135
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.36
    Marker Score: 164
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.36
    Marker Score: 1883
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.35
    Marker Score: 505
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 329
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.3
    Marker Score: 3075
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 251
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.28
    Marker Score: 262
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 457
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.25
    Marker Score: 236.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.23
    Marker Score: 3103
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.22
    Marker Score: 110
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.22
    Marker Score: 124
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 259
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2
    Marker Score: 196

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Other Information

**Key Characteristics:** Tenascin R is a large, secreted glycoprotein with a complex structure, consisting of multiple domains that interact with various cell surface receptors and extracellular matrix components. Its expression is dynamically regulated during development, with high levels found in the CNS during embryonic stages and downregulated in adulthood. Tenascin R exhibits both adhesive and inhibitory properties, modulating cell-cell interactions and axon guidance during neural development. **Pathways and Functions:** Tenascin R is involved in various signaling pathways that regulate cell adhesion, migration, and synaptic transmission. Notably, it: 1. **Regulates axon guidance**: Tenascin R inhibits axon extension involved in regeneration and promotes axon guidance during neural development. 2. **Modulates cell-cell adhesion**: Tenascin R negatively regulates cell-cell adhesion, influencing the formation of perineuronal nets and regulating neuron projection development. 3. **Influences synaptic transmission**: Tenascin R positively regulates synaptic transmission, particularly in glutamatergic synapses, and negatively regulates long-term synaptic potentiation. 4. **Regulates cell migration**: Tenascin R is involved in regulating cell migration during neural development, including telencephalon cell migration and oligodendrocyte precursor cell migration. **Clinical Significance:** Dysregulation of the tenascin R gene has been implicated in various neurological and psychiatric disorders, including: 1. **Neurodevelopmental disorders**: Tenascin R mutations have been associated with autism spectrum disorder and schizophrenia. 2. **Neurodegenerative diseases**: Alterations in tenascin R expression have been linked to Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: Tenascin R is overexpressed in certain types of cancer, including glioblastoma and breast cancer, and has been implicated in tumor progression and metastasis. In conclusion, the tenascin R gene plays a critical role in regulating cell adhesion, migration, and synaptic transmission in the CNS and other tissues. Its dysregulation has been implicated in various neurological and psychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying tenascin R function and its potential as a therapeutic target.

Genular Protein ID: 1060388188

Symbol: TENR_HUMAN

Name: Tenascin-R

UniProtKB Accession Codes:

Q92752 C9J563 Q15568 Q5R3G0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 31 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8626505

Title: Human tenascin-R: complete primary structure, pre-mRNA alternative splicing and gene localization on chromosome 1q23-q24.

PubMed ID: 8626505

DOI: 10.1074/jbc.271.14.8157

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 32099069

Title: Loss of TNR causes a nonprogressive neurodevelopmental disorder with spasticity and transient opisthotonus.

PubMed ID: 32099069

DOI: 10.1038/s41436-020-0768-7

Sequence Information:

  • Length: 1358
  • Mass: 149562
  • Checksum: E4DE356B44D117E7
  • Sequence:
    • MGADGETVVL KNMLIGINLI LLGSMIKPSE CQLEVTTERV QRQSVEEEGG IANYNTSSKE 
QPVVFNHVYN INVPLDNLCS SGLEASAEQE VSAEDETLAE YMGQTSDHES QVTFTHRINF 
PKKACPCASS AQVLQELLSR IEMLEREVSV LRDQCNANCC QESAATGQLD YIPHCSGHGN 
FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS 
SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA 
CSGRGQCEEG LCVCEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM AVTEYVISYQ 
PTALGGLQLQ QRVPGDWSGV TITELEPGLT YNISVYAVIS NILSLPITAK VATHLSTPQG 
LQFKTITETT VEVQWEPFSF SFDGWEISFI PKNNEGGVIA QVPSDVTSFN QTGLKPGEEY 
IVNVVALKEQ ARSPPTSASV STVIDGPTQI LVRDVSDTVA FVEWIPPRAK VDFILLKYGL 
VGGEGGRTTF RLQPPLSQYS VQALRPGSRY EVSVSAVRGT NESDSATTQF TTEIDAPKNL 
RVGSRTATSL DLEWDNSEAE VQEYKVVYST LAGEQYHEVL VPRGIGPTTR ATLTDLVPGT 
EYGVGISAVM NSQQSVPATM NARTELDSPR DLMVTASSET SISLIWTKAS GPIDHYRITF 
TPSSGIASEV TVPKDRTSYT LTDLEPGAEY IISVTAERGR QQSLESTVDA FTGFRPISHL 
HFSHVTSSSV NITWSDPSPP ADRLILNYSP RDEEEEMMEV SLDATKRHAV LMGLQPATEY 
IVNLVAVHGT VTSEPIVGSI TTGIDPPKDI TISNVTKDSV MVSWSPPVAS FDYYRVSYRP 
TQVGRLDSSV VPNTVTEFTI TRLNPATEYE ISLNSVRGRE ESERICTLVH TAMDNPVDLI 
ATNITPTEAL LQWKAPVGEV ENYVIVLTHF AVAGETILVD GVSEEFRLVD LLPSTHYTAT 
MYATNGPLTS GTISTNFSTL LDPPANLTAS EVTRQSALIS WQPPRAEIEN YVLTYKSTDG 
SRKELIVDAE DTWIRLEGLL ENTDYTVLLQ AAQDTTWSSI TSTAFTTGGR VFPHPQDCAQ 
HLMNGDTLSG VYPIFLNGEL SQKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG 
FGNVEDEFWL GLDNIHRITS QGRYELRVDM RDGQEAAFAS YDRFSVEDSR NLYKLRIGSY 
NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY KNCHRTNLNG KYGESRHSQG 
INWYHWKGHE FSIPFVEMKM RPYNHRLMAG RKRQSLQF

Genular Protein ID: 2374363748

Symbol: A1L306_HUMAN

Name: N/A

UniProtKB Accession Codes:

A1L306

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 3 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 9 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 6 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1257
  • Mass: 138577
  • Checksum: C91D34380A00E43F
  • Sequence:
    • MGQTSDHESQ VTFTHRINFP KKACPCASSA QVLQELLSRI EMLEREVSVL RDQCNANCCQ 
ESAATGQLDY IPHCSGHGNF SFESCGCICN EGWFGKNCSE PYCPLGCSSR GVCVDGQCIC 
DSEYSGDDCS ELRCPTDCSS RGLCVDGECV CEEPYTGEDC RELRCPGDCS GKGRCANGTC 
LCEEGYVGED CGQRQCLNAC SGRGQCEEGL CVCEEGYQGP DCSAVAPPED LRVAGISDRS 
IELEWDGPMA VTEYVISYQP TALGGLQLQQ RVPGDWSGVT ITELEPGLTY NISVYAVISN 
ILSLPITAKV ATHLSTPQGL QFKTITETTV EVQWEPFSFS FDGWEISFIP KNNEGGVIAQ 
VPSDVTSFNQ TGLKPGEEYI VNVVALKEQA RSPPTSASVS TVIDGPTQIL VRDVSDTVAF 
VEWIPPRAKV DFILLKYGLV GGEGGRTTFR LQPPLSQYSV QALRPGSRYE VSVSAVRGTN 
ESDSATTQFT TEIDAPKNLR VGSRTATSLD LEWDNSEAEV QEYKVVYSTL AGEQYHEVLV 
PRGIGPTTRA TLTDLVPGTE YGVGISAVMN SQQSVPATMN ARTELDSPRD LMVTASSETS 
ISLIWTKASG PIDHYRITFT PSSGIASEVT VPKDRTSYTL TDLEPGAEYI ISVTAERGRQ 
QSLESTVDAF TGFRPISHLH FSHVTSSSVN ITWSDPSPPA DRLILNYSPR DEEEEMMEVS 
LDATKRHAVL MGLQPATEYI VNLVAVHGTV TSEPIVGSIT TGIDPPKDIT ISNVTKDSVM 
VSWSPPVASF DYYRVSYRPT QVGRLDSSVV PNTVTEFTIT RLNPATEYEI SLNSVRGREE 
SERICTLVHT AMDNPVDLIA TNITPTEALL QWKAPVGEVE NYVIVLTHFA VAGETILVDG 
VSEEFRLVDL LPSTHYTATM YATNGPLTSG TISTNFSTLL DPPANLTASE VTRQSALISW 
QPPRAEIENY VLTYKSTDGS RKELIVDAED TWIRLEGLLE NTDYTVLLQA AQDTTWSSIT 
STAFTTGGRV FPHPQDCAQH LMNGDTLSGV YPIFLNGELS QKLQVYCDMT TDGGGWIVFQ 
RRQNGQTDFF RKWADYRVGF GNVEDEFWLG LDNIHRITSQ GRYELRVDMR DGQEAAFASY 
DRFSVEDSRN LYKLRIGSYN GTAGDSLSYH QGRPFSTEDR DNDVAVTNCA MSYKGAWWYK 
NCHRTNLNGK YGESRHSQGI NWYHWKGHEF SIPFVEMKMR PYNHRLMAGR KRQSLQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.