Details for: NXPH1

Gene ID: 30010

Symbol: NXPH1

Ensembl ID: ENSG00000122584

Description: neurexophilin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 8.0408
    Cell Significance Index: 192.8400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 7.7506
    Cell Significance Index: 100.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 6.6213
    Cell Significance Index: 406.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 6.0595
    Cell Significance Index: 2173.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.8248
    Cell Significance Index: 82.4800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 3.7406
    Cell Significance Index: 48.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.6519
    Cell Significance Index: 1834.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.6436
    Cell Significance Index: 32.5000
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 1.6082
    Cell Significance Index: 12.9900
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: 0.2244
    Cell Significance Index: 2.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0861
    Cell Significance Index: 17.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0482
    Cell Significance Index: 0.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0405
    Cell Significance Index: 0.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0211
    Cell Significance Index: -39.7400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0284
    Cell Significance Index: -0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0298
    Cell Significance Index: -40.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0325
    Cell Significance Index: -60.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0398
    Cell Significance Index: -61.3000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0518
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0655
    Cell Significance Index: -48.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0866
    Cell Significance Index: -54.0700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0889
    Cell Significance Index: -56.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0924
    Cell Significance Index: -52.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0957
    Cell Significance Index: -18.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0991
    Cell Significance Index: -1.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1186
    Cell Significance Index: -3.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1274
    Cell Significance Index: -3.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1296
    Cell Significance Index: -58.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1389
    Cell Significance Index: -39.9600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1413
    Cell Significance Index: -3.5300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1838
    Cell Significance Index: -3.9700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2074
    Cell Significance Index: -3.1500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2290
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2516
    Cell Significance Index: -53.0000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2597
    Cell Significance Index: -3.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2734
    Cell Significance Index: -49.2900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.3087
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3315
    Cell Significance Index: -56.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3815
    Cell Significance Index: -55.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.4108
    Cell Significance Index: -50.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4437
    Cell Significance Index: -46.2000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4524
    Cell Significance Index: -3.0700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.4775
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4937
    Cell Significance Index: -56.5700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5053
    Cell Significance Index: -4.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5544
    Cell Significance Index: -34.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5659
    Cell Significance Index: -11.8100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5791
    Cell Significance Index: -9.3800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.5830
    Cell Significance Index: -5.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6569
    Cell Significance Index: -44.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7387
    Cell Significance Index: -56.6900
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7923
    Cell Significance Index: -10.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8297
    Cell Significance Index: -43.5600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9217
    Cell Significance Index: -22.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9539
    Cell Significance Index: -53.5300
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.9957
    Cell Significance Index: -11.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0106
    Cell Significance Index: -44.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.0677
    Cell Significance Index: -50.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1147
    Cell Significance Index: -39.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1263
    Cell Significance Index: -51.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.2136
    Cell Significance Index: -56.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2228
    Cell Significance Index: -46.3100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2356
    Cell Significance Index: -31.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2618
    Cell Significance Index: -41.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.3160
    Cell Significance Index: -25.7300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.3222
    Cell Significance Index: -12.5800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3498
    Cell Significance Index: -42.9900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.4046
    Cell Significance Index: -28.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5415
    Cell Significance Index: -43.9900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -1.5525
    Cell Significance Index: -3.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.5965
    Cell Significance Index: -39.8300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.6326
    Cell Significance Index: -33.2200
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -1.6457
    Cell Significance Index: -3.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6910
    Cell Significance Index: -33.9500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.6964
    Cell Significance Index: -53.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.6984
    Cell Significance Index: -29.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.7213
    Cell Significance Index: -45.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.7509
    Cell Significance Index: -44.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.7761
    Cell Significance Index: -62.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7979
    Cell Significance Index: -48.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.8225
    Cell Significance Index: -35.8700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -1.8972
    Cell Significance Index: -28.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.8981
    Cell Significance Index: -49.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.9101
    Cell Significance Index: -37.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.9873
    Cell Significance Index: -28.9700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -1.9905
    Cell Significance Index: -26.0700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0097
    Cell Significance Index: -59.2000
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -2.0308
    Cell Significance Index: -21.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.0433
    Cell Significance Index: -42.7700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -2.0925
    Cell Significance Index: -24.2200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -2.1436
    Cell Significance Index: -22.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1550
    Cell Significance Index: -36.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1637
    Cell Significance Index: -62.3400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -2.3058
    Cell Significance Index: -27.9500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -2.3496
    Cell Significance Index: -20.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -2.3703
    Cell Significance Index: -50.6700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -2.4089
    Cell Significance Index: -25.5900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.4596
    Cell Significance Index: -35.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.4926
    Cell Significance Index: -54.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.5015
    Cell Significance Index: -62.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NXPH1 is a small, non-coding RNA gene that is primarily expressed in cells of the nervous system and hematopoietic system. The gene is part of the neurexophilin family, which is characterized by its extracellular region and signaling receptor binding capabilities. NXPH1 is significantly expressed in various cell types, including erythrocytes, double negative thymocytes, chromaffin cells, hematopoietic stem cells, inhibitory interneurons, and oligodendrocyte precursor cells. This widespread expression pattern suggests a potential role in regulating cellular processes in multiple tissues. **Pathways and Functions** NXPH1 is involved in several signaling pathways, including extracellular region and signaling receptor binding. The gene's extracellular region is thought to interact with various receptors, modulating cellular responses to external stimuli. In the context of the nervous system, NXPH1 may play a role in regulating neuronal communication and synaptic plasticity. In the hematopoietic system, NXPH1 may influence the development and function of hematopoietic stem cells. Furthermore, NXPH1 has been shown to interact with other genes involved in neuronal development and function, including those involved in GABAergic transmission. The gene's expression in inhibitory interneurons suggests a potential role in regulating inhibitory neurotransmission and synaptic plasticity. **Clinical Significance** The clinical significance of NXPH1 is still largely unknown. However, the gene's involvement in the nervous system and hematopoietic system suggests potential implications for neurological and hematological disorders. For example, NXPH1 may play a role in regulating the development of autoimmune diseases, such as multiple sclerosis, or hematological disorders, such as leukemia. Furthermore, NXPH1 may have implications for the treatment of neurological disorders, such as epilepsy or Parkinson's disease. The gene's interaction with other genes involved in neuronal development and function may provide a new target for therapeutic interventions. In conclusion, NXPH1 is a fascinating gene that plays a crucial role in the development and function of the nervous system and hematopoietic system. Further research is needed to fully understand the gene's clinical significance and potential implications for human disease.

Genular Protein ID: 579062175

Symbol: NXPH1_HUMAN

Name: Neurexophilin-1

UniProtKB Accession Codes:

P58417 Q8NB31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 12880961

Title: Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma.

PubMed ID: 12880961

DOI: 10.1016/s0304-3835(03)00085-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 271
  • Mass: 31082
  • Checksum: 140C6C7DE1126B27
  • Sequence:
    • MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS 
QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG 
WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ 
QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI 
YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.