Details for: GABRB1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 270.0248
Cell Significance Index: -68.4900 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 5.7252
Cell Significance Index: 80.0600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.3837
Cell Significance Index: 193.9000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.2770
Cell Significance Index: 161.9600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.2182
Cell Significance Index: 283.6400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 4.1719
Cell Significance Index: 1496.4000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 3.4464
Cell Significance Index: 98.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.2810
Cell Significance Index: 658.1600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 3.1084
Cell Significance Index: 2149.8700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.4146
Cell Significance Index: 108.5600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.1937
Cell Significance Index: 73.3700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.1080
Cell Significance Index: 14.7800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.6697
Cell Significance Index: 16.0600 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.5660
Cell Significance Index: 7.3400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5235
Cell Significance Index: 472.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3730
Cell Significance Index: 169.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2762
Cell Significance Index: 54.8200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.1387
Cell Significance Index: 1.3200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1342
Cell Significance Index: 13.2800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1296
Cell Significance Index: 24.6600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0503
Cell Significance Index: 8.1900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0058
Cell Significance Index: -0.1000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0160
Cell Significance Index: -0.6900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0240
Cell Significance Index: -0.8500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0311
Cell Significance Index: -58.4900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0363
Cell Significance Index: -66.8600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0388
Cell Significance Index: -0.6700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0414
Cell Significance Index: -1.3300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0439
Cell Significance Index: -67.6500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0532
Cell Significance Index: -72.3300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0973
Cell Significance Index: -71.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1104
Cell Significance Index: -70.1500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.1111
Cell Significance Index: -84.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1142
Cell Significance Index: -84.6200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1288
Cell Significance Index: -3.7100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.1309
Cell Significance Index: -57.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1446
Cell Significance Index: -90.3000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1505
Cell Significance Index: -84.8500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1994
Cell Significance Index: -57.3600 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2194
Cell Significance Index: -2.3900 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.2515
Cell Significance Index: -27.3600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.3496
Cell Significance Index: -63.0300 - Cell Name: neural cell (CL0002319)
Fold Change: -0.3532
Cell Significance Index: -4.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3662
Cell Significance Index: -10.2400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3816
Cell Significance Index: -9.5400 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3870
Cell Significance Index: -7.7700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.3949
Cell Significance Index: -17.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4017
Cell Significance Index: -84.6100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4592
Cell Significance Index: -66.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4606
Cell Significance Index: -47.9600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4684
Cell Significance Index: -60.0400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4758
Cell Significance Index: -81.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.4982
Cell Significance Index: -68.4100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.4994
Cell Significance Index: -10.6000 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.5044
Cell Significance Index: -7.6600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.5294
Cell Significance Index: -65.1000 - Cell Name: astrocyte (CL0000127)
Fold Change: -0.5391
Cell Significance Index: -6.1700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.6085
Cell Significance Index: -78.6100 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.6093
Cell Significance Index: -8.5400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7065
Cell Significance Index: -48.8600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7082
Cell Significance Index: -83.5200 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7353
Cell Significance Index: -14.5400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.7475
Cell Significance Index: -16.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7497
Cell Significance Index: -85.8900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.7552
Cell Significance Index: -10.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.7982
Cell Significance Index: -81.5400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8242
Cell Significance Index: -26.2500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.8363
Cell Significance Index: -59.1500 - Cell Name: neuron (CL0000540)
Fold Change: -0.8925
Cell Significance Index: -8.4600 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8948
Cell Significance Index: -53.7200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9067
Cell Significance Index: -55.5900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9297
Cell Significance Index: -30.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9581
Cell Significance Index: -75.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0504
Cell Significance Index: -55.1500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -1.0549
Cell Significance Index: -78.6200 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -1.0985
Cell Significance Index: -8.7400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1138
Cell Significance Index: -24.1300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -1.1257
Cell Significance Index: -28.0800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.1538
Cell Significance Index: -40.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.2237
Cell Significance Index: -68.6700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.2799
Cell Significance Index: -82.5800 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -1.3107
Cell Significance Index: -16.5400 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -1.3170
Cell Significance Index: -15.7500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.3743
Cell Significance Index: -86.6200 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -1.5650
Cell Significance Index: -23.1100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.6365
Cell Significance Index: -76.9200 - Cell Name: mature astrocyte (CL0002627)
Fold Change: -1.6585
Cell Significance Index: -18.4300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.6654
Cell Significance Index: -77.6500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.7601
Cell Significance Index: -91.4300 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.7681
Cell Significance Index: -11.9800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.9071
Cell Significance Index: -39.5600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.9262
Cell Significance Index: -70.7100 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.9337
Cell Significance Index: -38.0600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.9724
Cell Significance Index: -50.7000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -1.9851
Cell Significance Index: -41.4300 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -2.0248
Cell Significance Index: -22.3400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -2.2439
Cell Significance Index: -44.7500 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -2.3403
Cell Significance Index: -30.0100 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.3846
Cell Significance Index: -75.4200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -2.4904
Cell Significance Index: -54.5300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 196012313
Symbol: GBRB1_HUMAN
Name: Gamma-aminobutyric acid receptor subunit beta-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2465923
Title: Sequence and expression of human GABAA receptor alpha 1 and beta 1 subunits.
PubMed ID: 2465923
PubMed ID: 1655634
Title: Isolation, characterization, and localization of human genomic DNA encoding the beta 1 subunit of the GABAA receptor (GABRB1).
PubMed ID: 1655634
PubMed ID: 24722188
Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
PubMed ID: 24722188
DOI: 10.1038/ncomms4650
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2160058
Title: Differential expression of gamma-aminobutyric acidA receptor subunits.
PubMed ID: 2160058
PubMed ID: 8178835
Title: Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia.
PubMed ID: 8178835
PubMed ID: 10449790
Title: Theta, a novel gamma-aminobutyric acid type A receptor subunit.
PubMed ID: 10449790
PubMed ID: 16412217
Title: Impact of epsilon and theta subunits on pharmacological properties of alpha3beta1 GABAA receptors expressed in Xenopus oocytes.
PubMed ID: 16412217
PubMed ID: 23934111
Title: De novo mutations in epileptic encephalopathies.
PubMed ID: 23934111
DOI: 10.1038/nature12439
PubMed ID: 27273810
Title: A second patient with a de novo GABRB1 mutation and epileptic encephalopathy.
PubMed ID: 27273810
DOI: 10.1002/ana.24699
PubMed ID: 26950270
Title: Epileptic encephalopathy de novo GABRB mutations impair GABAA receptor function.
PubMed ID: 26950270
DOI: 10.1002/ana.24631
Sequence Information:
- Length: 474
- Mass: 54235
- Checksum: 05DA70F6FCD04E54
- Sequence:
MWTVQNRESL GLLSFPVMIT MVCCAHSTNE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE KNKLEMNKVQ VDAHGNILLS TLEIRNETSG SEVLTSVSDP KATMYSYDSA SIQYRKPLSS REAYGRALDR HGVPSKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.