Details for: FBP2

Gene ID: 8789

Symbol: FBP2

Ensembl ID: ENSG00000130957

Description: fructose-bisphosphatase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.8061
    Cell Significance Index: 12.7100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.6004
    Cell Significance Index: 9.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0509
    Cell Significance Index: 64.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9412
    Cell Significance Index: 20.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9153
    Cell Significance Index: 22.1700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7883
    Cell Significance Index: 12.7200
  • Cell Name: duodenum glandular cell (CL1001589)
    Fold Change: 0.7636
    Cell Significance Index: 5.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6873
    Cell Significance Index: 41.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6459
    Cell Significance Index: 122.9200
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.6256
    Cell Significance Index: 2.9800
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.5245
    Cell Significance Index: 2.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4835
    Cell Significance Index: 21.9200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4001
    Cell Significance Index: 10.8900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3855
    Cell Significance Index: 8.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3809
    Cell Significance Index: 41.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.3252
    Cell Significance Index: 6.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2964
    Cell Significance Index: 43.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.2935
    Cell Significance Index: 7.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2565
    Cell Significance Index: 7.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2433
    Cell Significance Index: 24.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2070
    Cell Significance Index: 5.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1821
    Cell Significance Index: 12.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1482
    Cell Significance Index: 24.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1316
    Cell Significance Index: 118.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1025
    Cell Significance Index: 11.9500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0838
    Cell Significance Index: 1.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0718
    Cell Significance Index: 1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0667
    Cell Significance Index: 0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0530
    Cell Significance Index: 10.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0498
    Cell Significance Index: 93.7400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.0464
    Cell Significance Index: 0.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0279
    Cell Significance Index: 0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0234
    Cell Significance Index: 6.7300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.0179
    Cell Significance Index: 0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0168
    Cell Significance Index: 3.3700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0160
    Cell Significance Index: 0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0121
    Cell Significance Index: 2.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0083
    Cell Significance Index: 0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0059
    Cell Significance Index: 1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0047
    Cell Significance Index: 1.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0037
    Cell Significance Index: 2.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0032
    Cell Significance Index: -1.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0033
    Cell Significance Index: -1.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0038
    Cell Significance Index: -2.1500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0060
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0076
    Cell Significance Index: -0.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0092
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0104
    Cell Significance Index: -2.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0105
    Cell Significance Index: -1.0700
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.0123
    Cell Significance Index: -0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0124
    Cell Significance Index: -0.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0150
    Cell Significance Index: -1.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0151
    Cell Significance Index: -2.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0199
    Cell Significance Index: -0.3000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0234
    Cell Significance Index: -0.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0252
    Cell Significance Index: -1.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0286
    Cell Significance Index: -1.9200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0294
    Cell Significance Index: -0.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0307
    Cell Significance Index: -1.3600
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.0349
    Cell Significance Index: -0.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0357
    Cell Significance Index: -1.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0359
    Cell Significance Index: -1.1500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0361
    Cell Significance Index: -0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0371
    Cell Significance Index: -2.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0433
    Cell Significance Index: -2.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0435
    Cell Significance Index: -1.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0450
    Cell Significance Index: -0.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0451
    Cell Significance Index: -0.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0472
    Cell Significance Index: -2.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0480
    Cell Significance Index: -1.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0512
    Cell Significance Index: -1.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0512
    Cell Significance Index: -1.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0515
    Cell Significance Index: -2.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0520
    Cell Significance Index: -2.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0543
    Cell Significance Index: -1.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0545
    Cell Significance Index: -2.8600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0565
    Cell Significance Index: -0.7400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0609
    Cell Significance Index: -0.7800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0627
    Cell Significance Index: -2.3000
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0632
    Cell Significance Index: -0.6800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0633
    Cell Significance Index: -0.4800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0642
    Cell Significance Index: -1.0800
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0674
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0715
    Cell Significance Index: -2.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0725
    Cell Significance Index: -1.2200
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0730
    Cell Significance Index: -0.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0749
    Cell Significance Index: -1.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0757
    Cell Significance Index: -2.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0761
    Cell Significance Index: -0.5200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0762
    Cell Significance Index: -1.9000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0769
    Cell Significance Index: -1.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0774
    Cell Significance Index: -2.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FBP2 is a bifunctional enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, a rate-limiting step in gluconeogenesis and glycolysis. This enzyme is highly expressed in various tissues, including the liver, kidney, and small intestine, where it plays a critical role in maintaining glucose homeostasis. **Pathways and Functions:** FBP2 is involved in several metabolic pathways, including: 1. **Gluconeogenesis:** FBP2 is essential for the generation of glucose from non-carbohydrate sources, such as amino acids and lactate. This pathway is crucial for maintaining energy homeostasis during periods of fasting or low glucose availability. 2. **Glucose Metabolism:** FBP2 regulates the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, a key step in glycolysis. This enzyme also participates in the regulation of glucose production in the liver. 3. **Fructose Metabolism:** FBP2 is involved in the metabolism of fructose, a simple sugar that is absorbed from the diet. This enzyme regulates the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate, a critical step in fructose metabolism. 4. **Cellular Regulation:** FBP2 is also involved in the regulation of cellular processes, including cell growth, differentiation, and survival. This enzyme is highly expressed in neural cells, where it plays a role in the development and maintenance of the central nervous system. **Clinical Significance:** Dysregulation of FBP2 has been implicated in various diseases, including: 1. **Diabetes:** Abnormalities in FBP2 expression and activity have been linked to impaired glucose regulation and insulin resistance. 2. **Metabolic Syndrome:** FBP2 dysregulation has been associated with metabolic syndrome, a cluster of conditions that increase the risk of developing type 2 diabetes and cardiovascular disease. 3. **Neurological Disorders:** FBP2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where it plays a role in the regulation of glucose metabolism and neuronal function. In conclusion, FBP2 is a multifunctional enzyme that plays a critical role in various metabolic pathways, including gluconeogenesis, glucose metabolism, and fructose metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis and overall health.

Genular Protein ID: 839023354

Symbol: F16P2_HUMAN

Name: Fructose-1,6-bisphosphatase isozyme 2

UniProtKB Accession Codes:

O00757 Q17R39 Q6FI53

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 17 DEPOD 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIRSF 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9678974

Title: Isolation and characterization of an allelic cDNA for human muscle fructose-1,6-bisphosphatase.

PubMed ID: 9678974

DOI: 10.1016/s0378-1119(98)00181-4

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12507293

Title: Immunohistochemical localization of human fructose-1,6-bisphosphatase in subcellular structures of myocytes.

PubMed ID: 12507293

DOI: 10.14670/hh-18.135

PubMed ID: 16213487

Title: The origin of the high sensitivity of muscle fructose 1,6-bisphosphatase towards AMP.

PubMed ID: 16213487

DOI: 10.1016/j.febslet.2005.09.021

PubMed ID: 17350621

Title: Glu 69 is essential for the high sensitivity of muscle fructose-1,6-bisphosphatase inhibition by calcium ions.

PubMed ID: 17350621

DOI: 10.1016/j.febslet.2007.02.051

PubMed ID: 18214967

Title: Evolutionary conserved N-terminal region of human muscle fructose 1,6-bisphosphatase regulates its activity and the interaction with aldolase.

PubMed ID: 18214967

DOI: 10.1002/prot.21909

PubMed ID: 19626708

Title: Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence.

PubMed ID: 19626708

DOI: 10.1002/prot.22506

PubMed ID: 22120740

Title: Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase.

PubMed ID: 22120740

DOI: 10.1107/s090744491104385x

PubMed ID: 24086250

Title: Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway.

PubMed ID: 24086250

DOI: 10.1371/journal.pone.0071242

PubMed ID: 33977262

Title: A novel remitting leukodystrophy associated with a variant in FBP2.

PubMed ID: 33977262

DOI: 10.1093/braincomms/fcab036

Sequence Information:

  • Length: 339
  • Mass: 36743
  • Checksum: 196B06D744710BC4
  • Sequence:
    • MTDRSPFETD MLTLTRYVME KGRQAKGTGE LTQLLNSMLT AIKAISSAVR KAGLAHLYGI 
AGSVNVTGDE VKKLDVLSNS LVINMVQSSY STCVLVSEEN KDAIITAKEK RGKYVVCFDP 
LDGSSNIDCL ASIGTIFAIY RKTSEDEPSE KDALQCGRNI VAAGYALYGS ATLVALSTGQ 
GVDLFMLDPA LGEFVLVEKD VKIKKKGKIY SLNEGYAKYF DAATTEYVQK KKFPEDGSAP 
YGARYVGSMV ADVHRTLVYG GIFLYPANQK SPKGKLRLLY ECNPVAYIIE QAGGLATTGT 
QPVLDVKPEA IHQRVPLILG SPEDVQEYLT CVQKNQAGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.