Details for: HTR2C

Gene ID: 3358

Symbol: HTR2C

Ensembl ID: ENSG00000147246

Description: 5-hydroxytryptamine receptor 2C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 4.72
    Marker Score: 30407
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.56
    Marker Score: 872
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20614
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1509
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.79
    Marker Score: 3081.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.74
    Marker Score: 2411
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.52
    Marker Score: 4426
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.5
    Marker Score: 1679
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.4
    Marker Score: 629.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 872
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.28
    Marker Score: 3654
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.28
    Marker Score: 512
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7685
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2136
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.11
    Marker Score: 3180
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.03
    Marker Score: 983
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.02
    Marker Score: 38697
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.01
    Marker Score: 1565
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48026
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.99
    Marker Score: 1158
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5332
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1881
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 543
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.85
    Marker Score: 3454
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1333
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 476
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.71
    Marker Score: 472
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.7
    Marker Score: 1184
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.69
    Marker Score: 660
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.68
    Marker Score: 621
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.64
    Marker Score: 10085
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.63
    Marker Score: 505
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.63
    Marker Score: 184
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.61
    Marker Score: 1146.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.59
    Marker Score: 739
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.59
    Marker Score: 731
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.58
    Marker Score: 202
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.56
    Marker Score: 4746
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.52
    Marker Score: 831.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.51
    Marker Score: 312
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.51
    Marker Score: 295.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 203
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 148
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.46
    Marker Score: 185
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8753
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.43
    Marker Score: 454
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 240.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.42
    Marker Score: 3245
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.4
    Marker Score: 738
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.38
    Marker Score: 226
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.38
    Marker Score: 687
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 375
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.37
    Marker Score: 4878
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.35
    Marker Score: 121.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.35
    Marker Score: 1611
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.34
    Marker Score: 309
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.34
    Marker Score: 704
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.34
    Marker Score: 1299
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.32
    Marker Score: 355.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.32
    Marker Score: 3054
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 321.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.32
    Marker Score: 749
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.28
    Marker Score: 88
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.26
    Marker Score: 252
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.26
    Marker Score: 117
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.25
    Marker Score: 1616
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 62
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.24
    Marker Score: 697
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.23
    Marker Score: 303
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.22
    Marker Score: 102
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.22
    Marker Score: 120
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.21
    Marker Score: 51
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.21
    Marker Score: 120
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.2
    Marker Score: 72
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2
    Marker Score: 134
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.19
    Marker Score: 197
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.19
    Marker Score: 7085
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.19
    Marker Score: 89
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.17
    Marker Score: 111.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.17
    Marker Score: 1010
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.16
    Marker Score: 48
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 51

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Other Information

**Key characteristics:** - HTR2C is a G protein-coupled receptor. - It is a member of the G protein-coupled receptor superfamily. - It is expressed in high levels in the central nervous system. - It is involved in a variety of cellular processes, including neurotransmitter signaling, calcium signaling, and fear response. **Pathways and functions:** - HTR2C is a ligand for the G protein-coupled receptor 5-HT2C. - When HTR2C binds to 5-HT2C, it activates the G protein G alpha (q). - G alpha (q) signaling leads to the activation of the phospholipase c-activating g protein-coupled receptor (GPCR). - GPCR signaling downstream of HTR2C is involved in the regulation of neurotransmitter release and neuronal plasticity. **Clinical significance:** - Mutations in the HTR2C gene have been linked to a number of psychiatric disorders, including schizophrenia and depression. - HTR2C inhibitors are being investigated as potential treatments for these disorders.

Genular Protein ID: 1219963304

Symbol: 5HT2C_HUMAN

Name: 5-hydroxytryptamine receptor 1C

UniProtKB Accession Codes:

P28335 B1AMW4 Q5VUF8 Q9NP28

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 81 DrugCentral 1 EMBL 10 EMDB 4 Ensembl 3 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1722404

Title: Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes.

PubMed ID: 1722404

DOI: 10.1016/0006-291x(91)92105-s

PubMed ID: 7895773

Title: Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor.

PubMed ID: 7895773

DOI: 10.1016/0922-4106(94)90042-6

PubMed ID: 8812491

Title: The human serotonin 5-HT2C receptor: complete cDNA, genomic structure, and alternatively spliced variant.

PubMed ID: 8812491

DOI: 10.1006/geno.1996.0397

PubMed ID: 9928237

Title: Identification and characterization of RNA editing events within the 5-HT2C receptor.

PubMed ID: 9928237

DOI: 10.1111/j.1749-6632.1998.tb10171.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11150294

Title: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1.

PubMed ID: 11150294

DOI: 10.1074/jbc.m008089200

PubMed ID: 12970106

Title: Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy.

PubMed ID: 12970106

DOI: 10.1038/sj.bjp.0705437

PubMed ID: 14988405

Title: The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.

PubMed ID: 14988405

DOI: 10.1074/jbc.m312106200

PubMed ID: 16319069

Title: A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.

PubMed ID: 16319069

DOI: 10.1074/jbc.m508074200

PubMed ID: 16914526

Title: Opposite effects of PSD-95 and MPP3 PDZ proteins on serotonin 5-hydroxytryptamine2C receptor desensitization and membrane stability.

PubMed ID: 16914526

DOI: 10.1091/mbc.e06-03-0218

PubMed ID: 18703043

Title: Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.

PubMed ID: 18703043

DOI: 10.1016/j.ejphar.2008.07.040

PubMed ID: 19057895

Title: Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors.

PubMed ID: 19057895

DOI: 10.1007/s00210-008-0378-4

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 22497996

Title: The N-terminal region of the human 5-HT(2)C receptor has as a cleavable signal peptide.

PubMed ID: 22497996

DOI: 10.1016/j.ejphar.2012.03.043

PubMed ID: 7557992

Title: Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C).

PubMed ID: 7557992

DOI: 10.1006/geno.1995.1042

PubMed ID: 10206230

Title: Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability.

PubMed ID: 10206230

DOI: 10.1002/(sici)1096-8628(19990416)88:2<126::aid-ajmg6>3.3.co;2-d

PubMed ID: 10581480

Title: Unified approach to the analysis of genetic variation in serotonergic pathways.

PubMed ID: 10581480

DOI: 10.1002/(sici)1096-8628(19991215)88:6<621::aid-ajmg9>3.0.co;2-h

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 458
  • Mass: 51805
  • Checksum: 0622E8F8AE55696D
  • Sequence:
    • MVNLRNAVHS FLVHLIGLLV WQSDISVSPV AAIVTDIFNT SDGGRFKFPD GVQNWPALSI 
VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW 
PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRYVAIRNPI EHSRFNSRTK AIMKIAIVWA 
ISIGVSVPIP VIGLRDEEKV FVNNTTCVLN DPNFVLIGSF VAFFIPLTIM VITYCLTIYV 
LRRQALMLLH GHTEEPPGLS LDFLKCCKRN TAEEENSANP NQDQNARRRK KKERRPRGTM 
QAINNERKAS KVLGIVFFVF LIMWCPFFIT NILSVLCEKS CNQKLMEKLL NVFVWIGYVC 
SGINPLVYTL FNKIYRRAFS NYLRCNYKVE KKPPVRQIPR VAATALSGRE LNVNIYRHTN 
EPVIEKASDN EPGIEMQVEN LELPVNPSSV VSERISSV

Genular Protein ID: 3936945406

Symbol: K9J958_HUMAN

Name: N/A

UniProtKB Accession Codes:

K9J958

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 2 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 248
  • Mass: 28055
  • Checksum: 8A8C81B80DA6B59E
  • Sequence:
    • MVNLRNAVHS FLVHLIGLLV WQCDISVSPV AAIVTDIFNT SDGGRFKFPD GVQNWPALSI 
VIIIIMTIGG NILVIMAVSM EKKLHNATNY FLMSLAIADM LVGLLVMPLS LLAILYDYVW 
PLPRYLCPVW ISLDVLFSTA SIMHLCAISL DRCISSYPCD WTEGRRKGVR EQHDVRAQRP 
KFRSYWVLRS FLHTADDYGD YVLPDHLRSA PTSFDVTARP HRGTAWTKSG FPEVLQEEYG 
RGRELCKP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.