Details for: TEKT2

Gene ID: 27285

Symbol: TEKT2

Ensembl ID: ENSG00000092850

Description: tektin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.5620
    Cell Significance Index: -6.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.3813
    Cell Significance Index: -5.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9718
    Cell Significance Index: -6.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.7133
    Cell Significance Index: -4.5000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.0366
    Cell Significance Index: 10.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4753
    Cell Significance Index: 10.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4630
    Cell Significance Index: 252.8500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2380
    Cell Significance Index: 3.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1503
    Cell Significance Index: 1.2000
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1487
    Cell Significance Index: 1.6100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1154
    Cell Significance Index: 1.0600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.1124
    Cell Significance Index: 1.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0884
    Cell Significance Index: 10.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0485
    Cell Significance Index: 1.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0093
    Cell Significance Index: 0.5200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.0085
    Cell Significance Index: 0.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0024
    Cell Significance Index: 1.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0022
    Cell Significance Index: -0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0030
    Cell Significance Index: -5.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0034
    Cell Significance Index: -1.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0052
    Cell Significance Index: -8.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0061
    Cell Significance Index: -8.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0103
    Cell Significance Index: -2.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0115
    Cell Significance Index: -7.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0121
    Cell Significance Index: -2.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0181
    Cell Significance Index: -5.2100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0220
    Cell Significance Index: -0.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0267
    Cell Significance Index: -3.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0269
    Cell Significance Index: -4.8500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0270
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0278
    Cell Significance Index: -3.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0333
    Cell Significance Index: -5.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0345
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0350
    Cell Significance Index: -7.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0369
    Cell Significance Index: -5.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0371
    Cell Significance Index: -2.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0377
    Cell Significance Index: -4.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0496
    Cell Significance Index: -3.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0548
    Cell Significance Index: -5.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0605
    Cell Significance Index: -0.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0656
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0777
    Cell Significance Index: -0.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0814
    Cell Significance Index: -4.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0869
    Cell Significance Index: -5.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0885
    Cell Significance Index: -5.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0890
    Cell Significance Index: -2.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0913
    Cell Significance Index: -6.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1185
    Cell Significance Index: -6.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1200
    Cell Significance Index: -5.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1228
    Cell Significance Index: -2.5700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1358
    Cell Significance Index: -1.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1410
    Cell Significance Index: -6.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1410
    Cell Significance Index: -6.2400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1432
    Cell Significance Index: -3.5700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1432
    Cell Significance Index: -1.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1508
    Cell Significance Index: -6.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1577
    Cell Significance Index: -5.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1592
    Cell Significance Index: -8.2700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1612
    Cell Significance Index: -2.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1648
    Cell Significance Index: -6.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1658
    Cell Significance Index: -8.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1667
    Cell Significance Index: -5.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1668
    Cell Significance Index: -5.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1693
    Cell Significance Index: -2.7900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1738
    Cell Significance Index: -0.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1804
    Cell Significance Index: -5.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1886
    Cell Significance Index: -4.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2020
    Cell Significance Index: -5.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2044
    Cell Significance Index: -3.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2075
    Cell Significance Index: -7.2900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2089
    Cell Significance Index: -2.6400
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2122
    Cell Significance Index: -2.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2157
    Cell Significance Index: -5.7700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.2169
    Cell Significance Index: -2.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2184
    Cell Significance Index: -6.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2211
    Cell Significance Index: -6.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2235
    Cell Significance Index: -5.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2277
    Cell Significance Index: -6.1000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2298
    Cell Significance Index: -5.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2333
    Cell Significance Index: -5.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2344
    Cell Significance Index: -6.2600
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2357
    Cell Significance Index: -1.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2373
    Cell Significance Index: -6.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2388
    Cell Significance Index: -6.1000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2418
    Cell Significance Index: -4.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2419
    Cell Significance Index: -6.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2423
    Cell Significance Index: -5.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2490
    Cell Significance Index: -5.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2512
    Cell Significance Index: -5.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2539
    Cell Significance Index: -5.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2543
    Cell Significance Index: -6.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TEKT2 is a gene that encodes a protein essential for the assembly and function of cilia, flagella, and microtubule-based structures. The TEKT2 protein is a component of the dynein arm, a complex that binds to microtubules and generates force for ciliary movement. TEKT2 is also involved in the assembly of the axonemal microtubule, a structure composed of nine pairs of microtubules that are arranged in a specific pattern to generate the beat of cilia and flagella. The TEKT2 protein exhibits a high degree of homology with other tektin proteins, which are known to be involved in the assembly and function of cilia and flagella. **Pathways and Functions:** TEKT2 is involved in several cellular pathways that regulate ciliary function and cell signaling. The most notable pathways include: 1. **Axonemal microtubule assembly:** TEKT2 is required for the assembly of the axonemal microtubule, which is essential for the generation of ciliary movement. 2. **Cilium assembly:** TEKT2 is involved in the assembly of cilia, which are essential for various physiological processes such as cell motility, signaling, and development. 3. **Flagellated sperm motility:** TEKT2 is required for the assembly and function of flagella, which are essential for sperm motility. 4. **Inner dynein arm assembly:** TEKT2 is involved in the assembly of the inner dynein arm, a complex that generates force for ciliary movement. 5. **Microtubule cytoskeleton organization:** TEKT2 is involved in the organization of the microtubule cytoskeleton, which is essential for maintaining cell shape and motility. **Clinical Significance:** Dysregulation of TEKT2 has been implicated in various diseases, including: 1. **Primary ciliary dyskinesia (PCD):** PCD is a genetic disorder characterized by defective ciliary function, leading to respiratory and sinus infections, infertility, and other complications. 2. **Ciliary dysfunction:** TEKT2 mutations have been associated with ciliary dysfunction, leading to impaired ciliary movement and function. 3. **Neurological disorders:** TEKT2 mutations have been implicated in neurological disorders such as cerebral cortex GABAergic interneuron dysfunction, leading to impaired cognitive function and motor coordination. In conclusion, TEKT2 is a critical gene that plays a pivotal role in ciliary motility and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TEKT2 function and its role in human disease.

Genular Protein ID: 1761832241

Symbol: TEKT2_HUMAN

Name: Tektin-2

UniProtKB Accession Codes:

Q9UIF3 A6NIS6 O60638

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 2 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11751288

Title: Tektin B1 demonstrates flagellar localization in human sperm.

PubMed ID: 11751288

DOI: 10.1095/biolreprod66.1.241

PubMed ID: 12029069

Title: Cloning and characterization of the human tektin-t gene.

PubMed ID: 12029069

DOI: 10.1093/molehr/8.6.525

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

Sequence Information:

  • Length: 430
  • Mass: 49672
  • Checksum: BD7600E20624DD25
  • Sequence:
    • MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN NQTIWDEHDN 
RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE QNLQAKNLPL DVAIECLTLR 
ESRRDIDVVK DPVEDELHKE VEVIEATKKA LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM 
ETLEIDRGCL SLNLRSPNIS LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR 
EATALTIAET NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL 
EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ 
DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AERFVPEVDT FTRTTNSTLS 
PLKSCQLELA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.