Details for: BORCS8 MEF2B

Gene ID: 4207

Symbol: BORCS8 MEF2B

Ensembl ID: ENSG00000213999

Description: BORCS8-MEF2B readthrough

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 19.6181
    Cell Significance Index: -7.9700
  • Cell Name: centroblast (CL0009112)
    Fold Change: 18.5207
    Cell Significance Index: 43.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.4106
    Cell Significance Index: -8.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.9793
    Cell Significance Index: 351.3500
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 2.8509
    Cell Significance Index: 8.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.6120
    Cell Significance Index: 33.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0076
    Cell Significance Index: 29.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.8227
    Cell Significance Index: 50.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.5097
    Cell Significance Index: 7.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4387
    Cell Significance Index: 83.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4094
    Cell Significance Index: 14.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3534
    Cell Significance Index: 4.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3033
    Cell Significance Index: 18.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1820
    Cell Significance Index: 13.9700
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1701
    Cell Significance Index: 1.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1495
    Cell Significance Index: 8.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1370
    Cell Significance Index: 14.9000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.0965
    Cell Significance Index: 0.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0890
    Cell Significance Index: 80.3900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0752
    Cell Significance Index: 1.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0693
    Cell Significance Index: 13.9100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0670
    Cell Significance Index: 0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0645
    Cell Significance Index: 3.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0633
    Cell Significance Index: 7.7800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0633
    Cell Significance Index: 0.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0612
    Cell Significance Index: 11.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0517
    Cell Significance Index: 3.5800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0474
    Cell Significance Index: 0.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0452
    Cell Significance Index: 7.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0381
    Cell Significance Index: 3.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0346
    Cell Significance Index: 12.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0172
    Cell Significance Index: 0.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0168
    Cell Significance Index: 11.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0023
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0061
    Cell Significance Index: -9.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0094
    Cell Significance Index: -6.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0121
    Cell Significance Index: -6.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0123
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0135
    Cell Significance Index: -8.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0144
    Cell Significance Index: -7.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0154
    Cell Significance Index: -0.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0193
    Cell Significance Index: -8.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0236
    Cell Significance Index: -0.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0280
    Cell Significance Index: -3.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0290
    Cell Significance Index: -8.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0317
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0434
    Cell Significance Index: -9.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0457
    Cell Significance Index: -5.2300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0460
    Cell Significance Index: -0.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0488
    Cell Significance Index: -2.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0492
    Cell Significance Index: -1.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0562
    Cell Significance Index: -6.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0582
    Cell Significance Index: -8.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0660
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0679
    Cell Significance Index: -11.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0726
    Cell Significance Index: -4.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0768
    Cell Significance Index: -3.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0839
    Cell Significance Index: -8.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0988
    Cell Significance Index: -4.3700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1094
    Cell Significance Index: -1.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1273
    Cell Significance Index: -4.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1367
    Cell Significance Index: -3.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1445
    Cell Significance Index: -9.3200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1452
    Cell Significance Index: -1.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1477
    Cell Significance Index: -2.1200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1627
    Cell Significance Index: -3.7600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1768
    Cell Significance Index: -1.8400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1776
    Cell Significance Index: -2.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1784
    Cell Significance Index: -8.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1807
    Cell Significance Index: -6.3300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1955
    Cell Significance Index: -1.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1966
    Cell Significance Index: -1.8100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2050
    Cell Significance Index: -6.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2087
    Cell Significance Index: -10.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2117
    Cell Significance Index: -5.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2132
    Cell Significance Index: -6.9800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2175
    Cell Significance Index: -2.6900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2299
    Cell Significance Index: -2.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2333
    Cell Significance Index: -5.0400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2374
    Cell Significance Index: -3.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2574
    Cell Significance Index: -9.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2638
    Cell Significance Index: -6.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2665
    Cell Significance Index: -1.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2731
    Cell Significance Index: -6.8200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2794
    Cell Significance Index: -3.3700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2808
    Cell Significance Index: -8.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2858
    Cell Significance Index: -4.7100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2916
    Cell Significance Index: -3.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2968
    Cell Significance Index: -6.3000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3027
    Cell Significance Index: -6.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3035
    Cell Significance Index: -7.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3035
    Cell Significance Index: -8.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3086
    Cell Significance Index: -7.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3146
    Cell Significance Index: -9.2400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3162
    Cell Significance Index: -6.6000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3163
    Cell Significance Index: -6.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** The BORCS8-MEF2B gene is a transcriptional regulator that binds to specific DNA sequences, influencing the expression of target genes involved in cell differentiation, development, and immune responses. 2. **RNA Polymerase II Specificity:** The gene is specifically involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for transcribing most of the cell's genes. 3. **Cell Type Specificity:** The BORCS8-MEF2B gene is expressed in multiple cell types, including epithelial cells, immune cells, and stem cells, highlighting its role in diverse cellular processes. 4. **Disease Implications:** The dysregulation of the BORCS8-MEF2B gene has been linked to various diseases, including cancer and autoimmune disorders, underscoring its importance in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Cell Differentiation:** The BORCS8-MEF2B gene is involved in the regulation of cell differentiation, influencing the expression of genes involved in the development of various cell types. 2. **Developmental Biology:** The gene plays a crucial role in developmental processes, including heart development, muscle organ development, and myogenesis. 3. **Immune Response:** The BORCS8-MEF2B gene is expressed in immune cells, including B cells and T cells, and is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 4. **Chromatin Regulation:** The gene interacts with chromatin-modifying enzymes, influencing the structure and function of chromatin, which is essential for gene expression. **Clinical Significance:** 1. **Cancer:** The dysregulation of the BORCS8-MEF2B gene has been implicated in various cancers, including breast cancer, colon cancer, and lymphoma. 2. **Autoimmune Disorders:** The gene is also involved in autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. 3. **Developmental Disorders:** The BORCS8-MEF2B gene plays a crucial role in developmental processes, and its dysregulation can lead to developmental disorders, including heart defects and muscle abnormalities. 4. **Stem Cell Regulation:** The gene is expressed in stem cells, and its dysregulation can affect stem cell function, leading to abnormalities in tissue homeostasis. In conclusion, the BORCS8-MEF2B gene is a complex transcriptional regulator that plays a crucial role in various cellular processes, including cell differentiation, development, and immune responses. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and developmental disorders. Further research is necessary to fully understand the mechanisms by which the BORCS8-MEF2B gene regulates transcription and its implications in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.