Details for: BTG4

Gene ID: 54766

Symbol: BTG4

Ensembl ID: ENSG00000137707

Description: BTG anti-proliferation factor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.5397
    Cell Significance Index: -1.4700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0887
    Cell Significance Index: 26.3700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5111
    Cell Significance Index: 7.4500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.2727
    Cell Significance Index: 6.8100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2357
    Cell Significance Index: 2.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1459
    Cell Significance Index: 1.5100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0851
    Cell Significance Index: 1.2000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0672
    Cell Significance Index: 0.6500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.0441
    Cell Significance Index: 0.5500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0356
    Cell Significance Index: 0.4500
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0256
    Cell Significance Index: 0.2500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0246
    Cell Significance Index: 0.3400
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0107
    Cell Significance Index: 0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0100
    Cell Significance Index: 6.3400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0092
    Cell Significance Index: 0.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0063
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0027
    Cell Significance Index: 5.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0026
    Cell Significance Index: 1.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0012
    Cell Significance Index: 0.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.6000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0020
    Cell Significance Index: -0.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0044
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0045
    Cell Significance Index: -0.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0045
    Cell Significance Index: -0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0058
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0063
    Cell Significance Index: -1.0700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0066
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0067
    Cell Significance Index: -1.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0073
    Cell Significance Index: -1.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0080
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0086
    Cell Significance Index: -0.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0099
    Cell Significance Index: -1.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0108
    Cell Significance Index: -0.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0125
    Cell Significance Index: -0.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0134
    Cell Significance Index: -0.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0136
    Cell Significance Index: -0.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0164
    Cell Significance Index: -1.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0190
    Cell Significance Index: -0.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0191
    Cell Significance Index: -0.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0192
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0192
    Cell Significance Index: -0.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0197
    Cell Significance Index: -0.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0198
    Cell Significance Index: -1.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0218
    Cell Significance Index: -0.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0226
    Cell Significance Index: -1.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0232
    Cell Significance Index: -1.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0261
    Cell Significance Index: -0.9900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0265
    Cell Significance Index: -0.2000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0266
    Cell Significance Index: -0.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0273
    Cell Significance Index: -0.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0274
    Cell Significance Index: -1.2900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0293
    Cell Significance Index: -0.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0293
    Cell Significance Index: -0.8400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0305
    Cell Significance Index: -0.6200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0306
    Cell Significance Index: -0.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0312
    Cell Significance Index: -0.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0317
    Cell Significance Index: -0.3700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0317
    Cell Significance Index: -0.4200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0318
    Cell Significance Index: -0.8100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0321
    Cell Significance Index: -0.3500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0326
    Cell Significance Index: -0.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0332
    Cell Significance Index: -0.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0333
    Cell Significance Index: -0.6500
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0335
    Cell Significance Index: -0.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0337
    Cell Significance Index: -0.4500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0338
    Cell Significance Index: -0.3500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0349
    Cell Significance Index: -0.7400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0359
    Cell Significance Index: -0.6200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0361
    Cell Significance Index: -0.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0364
    Cell Significance Index: -0.7300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0369
    Cell Significance Index: -0.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0369
    Cell Significance Index: -0.7700
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0390
    Cell Significance Index: -0.4600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0412
    Cell Significance Index: -0.5600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0422
    Cell Significance Index: -0.8300
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0422
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0423
    Cell Significance Index: -1.1300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0433
    Cell Significance Index: -1.0800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0434
    Cell Significance Index: -0.6400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0442
    Cell Significance Index: -0.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0442
    Cell Significance Index: -0.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0478
    Cell Significance Index: -0.6800
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0480
    Cell Significance Index: -0.5600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0482
    Cell Significance Index: -1.3800
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0490
    Cell Significance Index: -0.4500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0497
    Cell Significance Index: -0.5400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0497
    Cell Significance Index: -0.6300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0498
    Cell Significance Index: -0.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0500
    Cell Significance Index: -0.7600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0506
    Cell Significance Index: -0.7400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0513
    Cell Significance Index: -1.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0521
    Cell Significance Index: -0.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** BTG4 is widely expressed in various cell types, including progenitor cells, neurons, and endothelial cells, indicating its broad functional significance. 2. **Cellular Functions:** BTG4 regulates cellular proliferation, differentiation, and survival, suggesting its role as a key modulator of cellular behavior. 3. **Pathway Involvement:** BTG4 is implicated in multiple cellular pathways, including the negative regulation of cell population proliferation, mitotic cell cycle, and neuron differentiation, highlighting its complex functional profile. 4. **Protein Interactions:** BTG4 interacts with various proteins, including those involved in cell cycle regulation, differentiation, and survival, underscoring its multifunctional nature. **Pathways and Functions:** 1. **Negative Regulation of Cell Proliferation:** BTG4 inhibits cell population proliferation, preventing excessive cell growth and maintaining tissue homeostasis. 2. **Mitotic Cell Cycle Regulation:** BTG4 regulates the mitotic cell cycle, ensuring proper cell division and preventing aberrant cell growth. 3. **Neuron Differentiation:** BTG4 promotes neuron differentiation, guiding the development of neural cells and ensuring proper neural function. 4. **Maternal to Zygotic Transition:** BTG4 is involved in the maternal to zygotic transition, a critical process in development where maternal transcripts are degraded, and zygotic gene expression is established. 5. **M-decay:** BTG4 participates in the degradation of maternal mRNAs by maternally stored factors, ensuring the proper clearance of maternal transcripts and the establishment of zygotic gene expression. **Clinical Significance:** The dysregulation of BTG4 has been implicated in various diseases, including cancer, where its loss or inactivation can lead to uncontrolled cell growth and tumorigenesis. Additionally, BTG4's role in neuron differentiation and survival suggests its involvement in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Further studies on BTG4's functions and dysregulation will provide valuable insights into its potential as a therapeutic target for these diseases. In conclusion, BTG4 is a complex gene that plays a multifaceted role in regulating cellular proliferation, differentiation, and survival. Its involvement in various cellular pathways and its expression in multiple cell types highlight its importance in maintaining tissue homeostasis and preventing disease. Further research on BTG4's functions and dysregulation will provide valuable insights into its potential as a therapeutic target for various diseases.

Genular Protein ID: 1231611802

Symbol: BTG4_HUMAN

Name: Protein BTG4

UniProtKB Accession Codes:

Q9NY30 Q8NEH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10995567

Title: Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium.

PubMed ID: 10995567

DOI: 10.1006/geno.2000.6288

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32502391

Title: Homozygous mutations in BTG4 cause zygotic cleavage failure and female infertility.

PubMed ID: 32502391

DOI: 10.1016/j.ajhg.2020.05.010

Sequence Information:

  • Length: 223
  • Mass: 25970
  • Checksum: 7F78E134114D3E6E
  • Sequence:
    • MRDEIATTVF FVTRLVKKHD KLSKQQIEDF AEKLMTILFE TYRSHWHSDC PSKGQAFRCI 
RINNNQNKDP ILERACVESN VDFSHLGLPK EMTIWVDPFE VCCRYGEKNH PFTVASFKGR 
WEEWELYQQI SYAVSRASSD VSSGTSCDEE SCSKEPRVIP KVSNPKSIYQ VENLKQPFQS 
WLQIPRKKNV VDGRVGLLGN TYHGSQKHPK CYRPAMHRLD RIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.