Details for: PMEL

Gene ID: 6490

Symbol: PMEL

Ensembl ID: ENSG00000185664

Description: premelanosome protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.7446
    Cell Significance Index: -4.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.7164
    Cell Significance Index: -4.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.4389
    Cell Significance Index: -4.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2105
    Cell Significance Index: 30.1600
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: 2.1428
    Cell Significance Index: 15.4200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.6013
    Cell Significance Index: 3.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6899
    Cell Significance Index: -1.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6636
    Cell Significance Index: 126.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.6519
    Cell Significance Index: 9.3400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5226
    Cell Significance Index: 7.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4458
    Cell Significance Index: 23.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4411
    Cell Significance Index: 43.6300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.4000
    Cell Significance Index: 3.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3238
    Cell Significance Index: 292.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3037
    Cell Significance Index: 18.2300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2856
    Cell Significance Index: 31.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2415
    Cell Significance Index: 39.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2258
    Cell Significance Index: 6.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2196
    Cell Significance Index: 13.8400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2115
    Cell Significance Index: 3.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2058
    Cell Significance Index: 2.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1944
    Cell Significance Index: 1.7900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1687
    Cell Significance Index: 317.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1374
    Cell Significance Index: 9.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1152
    Cell Significance Index: 5.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1096
    Cell Significance Index: 21.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1095
    Cell Significance Index: 19.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1076
    Cell Significance Index: 12.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1019
    Cell Significance Index: 45.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.0971
    Cell Significance Index: 10.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0869
    Cell Significance Index: 3.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0855
    Cell Significance Index: 2.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0827
    Cell Significance Index: 2.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0739
    Cell Significance Index: 1.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0725
    Cell Significance Index: 1.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0559
    Cell Significance Index: 1.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0555
    Cell Significance Index: 1.4600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.0406
    Cell Significance Index: 0.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0338
    Cell Significance Index: 0.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0167
    Cell Significance Index: 0.7800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.0149
    Cell Significance Index: 0.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0119
    Cell Significance Index: 0.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0111
    Cell Significance Index: 7.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0076
    Cell Significance Index: 4.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0072
    Cell Significance Index: 0.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0052
    Cell Significance Index: 1.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0048
    Cell Significance Index: 2.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0046
    Cell Significance Index: 7.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0025
    Cell Significance Index: 4.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0017
    Cell Significance Index: 0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0013
    Cell Significance Index: 0.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0025
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0027
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0068
    Cell Significance Index: -4.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0086
    Cell Significance Index: -2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0094
    Cell Significance Index: -1.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0100
    Cell Significance Index: -1.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0142
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0190
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0207
    Cell Significance Index: -4.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0210
    Cell Significance Index: -1.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0214
    Cell Significance Index: -1.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0224
    Cell Significance Index: -2.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0286
    Cell Significance Index: -2.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0319
    Cell Significance Index: -0.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0344
    Cell Significance Index: -4.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0400
    Cell Significance Index: -0.3800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0402
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0409
    Cell Significance Index: -3.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0445
    Cell Significance Index: -1.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0447
    Cell Significance Index: -0.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0455
    Cell Significance Index: -3.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0477
    Cell Significance Index: -3.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0482
    Cell Significance Index: -0.9400
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0483
    Cell Significance Index: -0.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0619
    Cell Significance Index: -3.1300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0621
    Cell Significance Index: -0.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0626
    Cell Significance Index: -2.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0645
    Cell Significance Index: -4.1600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0727
    Cell Significance Index: -1.0200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0731
    Cell Significance Index: -1.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0750
    Cell Significance Index: -1.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0784
    Cell Significance Index: -1.9000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0795
    Cell Significance Index: -0.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0807
    Cell Significance Index: -1.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0861
    Cell Significance Index: -4.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0873
    Cell Significance Index: -3.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0905
    Cell Significance Index: -3.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0910
    Cell Significance Index: -1.9100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0916
    Cell Significance Index: -3.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PMEL is a 32-kDa protein that is primarily localized to the endoplasmic reticulum (ER) and Golgi apparatus, where it is involved in the assembly and transport of melanosomes, organelles responsible for melanin production. The protein exhibits a unique structure with multiple transmembrane domains, allowing it to interact with various cellular components. PMEL is also characterized by its ability to bind to other proteins, modulating their activity and localization. **Pathways and Functions:** PMEL is involved in several cellular processes, including: 1. **Melanin biosynthetic process:** PMEL plays a key role in the assembly and transport of melanosomes, which are essential for melanin production. The protein interacts with other proteins, such as tyrosinase, to regulate melanin synthesis. 2. **Golgi apparatus and ER membrane:** PMEL is localized to the Golgi apparatus and ER membrane, where it interacts with other proteins involved in protein transport and modification. 3. **Extracellular exosome and multivesicular body:** PMEL is also involved in the formation and function of extracellular exosomes and multivesicular bodies, which are involved in cellular communication and waste management. 4. **Protein binding and regulation:** PMEL interacts with other proteins, modulating their activity and localization. This interaction is crucial for regulating various cellular processes, including immune responses and cellular differentiation. **Significantly Expressed Cells:** PMEL is expressed in various cell types, including: 1. **Melanocytes:** PMEL is a hallmark of melanocytes, where it plays a critical role in melanin production. 2. **Kidney cells:** PMEL is expressed in kidney cells, where it is involved in the regulation of melanin biosynthesis and immune responses. 3. **Immune cells:** PMEL is also expressed in immune cells, including mononuclear cells and immature innate lymphoid cells, where it regulates immune responses and cellular differentiation. 4. **Cardiac cells:** PMEL is expressed in cardiac cells, where it plays a role in regulating melanin biosynthesis and cardiac function. **Clinical Significance:** Dysregulation of PMEL has been implicated in various diseases, including: 1. **Albinism:** Mutations in the PMEL gene have been associated with albinism, a condition characterized by reduced melanin production. 2. **Neurodegenerative diseases:** PMEL has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates melanin biosynthesis and immune responses. 3. **Cancer:** PMEL has been identified as a potential biomarker for cancer, where it regulates melanin biosynthesis and immune responses. In conclusion, PMEL is a multifunctional protein that plays a critical role in melanin biosynthesis, cellular differentiation, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this protein.

Genular Protein ID: 3079798567

Symbol: PMEL_HUMAN

Name: Melanocyte protein PMEL

UniProtKB Accession Codes:

P40967 B3KS57 B7Z6D7 Q12763 Q14448 Q14817 Q16565

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 17 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1924386

Title: A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.

PubMed ID: 1924386

DOI: 10.1073/pnas.88.20.9228

PubMed ID: 8179825

Title: Cloning and expression of the gene for the melanoma-associated ME20 antigen.

PubMed ID: 8179825

DOI: 10.1089/dna.1994.13.87

PubMed ID: 7519602

Title: Molecular characterization of the melanocyte lineage-specific antigen gp100.

PubMed ID: 7519602

DOI: 10.1016/s0021-9258(17)32136-1

PubMed ID: 8022805

Title: Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

PubMed ID: 8022805

DOI: 10.1073/pnas.91.14.6458

PubMed ID: 8592076

Title: Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus.

PubMed ID: 8592076

DOI: 10.1111/1523-1747.ep12326976

PubMed ID: 8739560

Title: Genomic organization and FISH mapping of human Pmel 17, the putative silver locus.

PubMed ID: 8739560

DOI: 10.1111/j.1600-0749.1996.tb00085.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14632201

Title: A novel splice variant of Pmel17 expressed by human melanocytes and melanoma cells lacking some of the internal repeats.

PubMed ID: 14632201

DOI: 10.1046/j.1523-1747.2003.12474.x

PubMed ID: 7706734

Title: Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

PubMed ID: 7706734

PubMed ID: 11694580

Title: Pmel17 initiates premelanosome morphogenesis within multivesicular bodies.

PubMed ID: 11694580

DOI: 10.1091/mbc.12.11.3451

PubMed ID: 12732614

Title: Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis.

PubMed ID: 12732614

DOI: 10.1083/jcb.200302072

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 15096515

Title: Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment.

PubMed ID: 15096515

DOI: 10.1074/jbc.m401269200

PubMed ID: 15695812

Title: MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.

PubMed ID: 15695812

DOI: 10.1074/jbc.m413692200

PubMed ID: 16682408

Title: The repeat domain of the melanosomal matrix protein PMEL17/GP100 is required for the formation of organellar fibers.

PubMed ID: 16682408

DOI: 10.1074/jbc.m601643200

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16760433

Title: Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17.

PubMed ID: 16760433

DOI: 10.1091/mbc.e06-01-0081

PubMed ID: 17991747

Title: Premelanosome amyloid-like fibrils are composed of only Golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.

PubMed ID: 17991747

DOI: 10.1074/jbc.m708007200

PubMed ID: 19047044

Title: Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase.

PubMed ID: 19047044

DOI: 10.1074/jbc.m808904200

PubMed ID: 21962903

Title: The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis.

PubMed ID: 21962903

DOI: 10.1016/j.devcel.2011.08.019

PubMed ID: 23754390

Title: BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

PubMed ID: 23754390

DOI: 10.1073/pnas.1220748110

PubMed ID: 26387950

Title: Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells.

PubMed ID: 26387950

DOI: 10.1016/j.celrep.2015.08.057

PubMed ID: 26694611

Title: The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.

PubMed ID: 26694611

DOI: 10.1074/jbc.m115.692442

PubMed ID: 28272432

Title: Melanosomal formation of PMEL core amyloid is driven by aromatic residues.

PubMed ID: 28272432

DOI: 10.1038/srep44064

PubMed ID: 30988362

Title: Repeat domain-associated O-glycans govern PMEL fibrillar sheet architecture.

PubMed ID: 30988362

DOI: 10.1038/s41598-019-42571-6

Sequence Information:

  • Length: 661
  • Mass: 70255
  • Checksum: 8A904FAB16715653
  • Sequence:
    • MDLVLKRCLL HLAVIGALLA VGATKVPRNQ DWLGVSRQLR TKAWNRQLYP EWTEAQRLDC 
WRGGQVSLKV SNDGPTLIGA NASFSIALNF PGSQKVLPDG QVIWVNNTII NGSQVWGGQP 
VYPQETDDAC IFPDGGPCPS GSWSQKRSFV YVWKTWGQYW QVLGGPVSGL SIGTGRAMLG 
THTMEVTVYH RRGSRSYVPL AHSSSAFTIT DQVPFSVSVS QLRALDGGNK HFLRNQPLTF 
ALQLHDPSGY LAEADLSYTW DFGDSSGTLI SRALVVTHTY LEPGPVTAQV VLQAAIPLTS 
CGSSPVPGTT DGHRPTAEAP NTTAGQVPTT EVVGTTPGQA PTAEPSGTTS VQVPTTEVIS 
TAPVQMPTAE STGMTPEKVP VSEVMGTTLA EMSTPEATGM TPAEVSIVVL SGTTAAQVTT 
TEWVETTARE LPIPEPEGPD ASSIMSTESI TGSLGPLLDG TATLRLVKRQ VPLDCVLYRY 
GSFSVTLDIV QGIESAEILQ AVPSGEGDAF ELTVSCQGGL PKEACMEISS PGCQPPAQRL 
CQPVLPSPAC QLVLHQILKG GSGTYCLNVS LADTNSLAVV STQLIMPGQE AGLGQVPLIV 
GILLVLMAVV LASLIYRRRL MKQDFSVPQL PHSSSHWLRL PRIFCSCPIG ENSPLLSGQQ 
V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.