Details for: PDC

Gene ID: 5132

Symbol: PDC

Ensembl ID: ENSG00000116703

Description: phosducin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 12.6806
    Cell Significance Index: 178.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 11.6568
    Cell Significance Index: 734.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1426
    Cell Significance Index: 29.3700
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.0229
    Cell Significance Index: 12.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3901
    Cell Significance Index: 9.4500
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.3837
    Cell Significance Index: 3.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2968
    Cell Significance Index: 4.3800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.2652
    Cell Significance Index: 2.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2217
    Cell Significance Index: 2.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1639
    Cell Significance Index: 10.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1319
    Cell Significance Index: 2.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1210
    Cell Significance Index: 24.2800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1180
    Cell Significance Index: 1.4300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1083
    Cell Significance Index: 4.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1004
    Cell Significance Index: 3.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0980
    Cell Significance Index: 2.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0889
    Cell Significance Index: 1.0600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0803
    Cell Significance Index: 1.3000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0513
    Cell Significance Index: 0.5800
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.0314
    Cell Significance Index: 0.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0293
    Cell Significance Index: 10.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0284
    Cell Significance Index: 4.1300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0182
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0169
    Cell Significance Index: 11.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0137
    Cell Significance Index: 0.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0136
    Cell Significance Index: 1.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0114
    Cell Significance Index: 17.5800
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.0088
    Cell Significance Index: 0.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0082
    Cell Significance Index: 0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0050
    Cell Significance Index: 6.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0035
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0010
    Cell Significance Index: 1.9700
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0031
    Cell Significance Index: -0.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0054
    Cell Significance Index: -1.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0055
    Cell Significance Index: -3.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0058
    Cell Significance Index: -2.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0065
    Cell Significance Index: -4.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0070
    Cell Significance Index: -3.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0133
    Cell Significance Index: -2.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0212
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0249
    Cell Significance Index: -0.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0290
    Cell Significance Index: -3.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0300
    Cell Significance Index: -0.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0313
    Cell Significance Index: -3.8500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0320
    Cell Significance Index: -0.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0324
    Cell Significance Index: -0.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0367
    Cell Significance Index: -1.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0400
    Cell Significance Index: -4.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0423
    Cell Significance Index: -4.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0423
    Cell Significance Index: -0.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0477
    Cell Significance Index: -1.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0480
    Cell Significance Index: -1.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0486
    Cell Significance Index: -2.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0491
    Cell Significance Index: -0.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0495
    Cell Significance Index: -2.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0514
    Cell Significance Index: -1.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0546
    Cell Significance Index: -0.7400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0614
    Cell Significance Index: -0.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0662
    Cell Significance Index: -3.4400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0671
    Cell Significance Index: -0.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0684
    Cell Significance Index: -3.1000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0715
    Cell Significance Index: -0.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0751
    Cell Significance Index: -2.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0774
    Cell Significance Index: -2.7100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0786
    Cell Significance Index: -1.0600
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.0787
    Cell Significance Index: -0.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0792
    Cell Significance Index: -3.7200
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0794
    Cell Significance Index: -0.7600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0806
    Cell Significance Index: -0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0812
    Cell Significance Index: -2.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0840
    Cell Significance Index: -2.9500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0888
    Cell Significance Index: -1.7600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0892
    Cell Significance Index: -1.7900
  • Cell Name: S cone cell (CL0003050)
    Fold Change: -0.0909
    Cell Significance Index: -1.0600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0936
    Cell Significance Index: -1.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0938
    Cell Significance Index: -2.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0967
    Cell Significance Index: -3.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0977
    Cell Significance Index: -1.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0994
    Cell Significance Index: -2.0800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1028
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1051
    Cell Significance Index: -3.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1061
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1124
    Cell Significance Index: -3.0600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1221
    Cell Significance Index: -1.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1244
    Cell Significance Index: -3.1100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1248
    Cell Significance Index: -3.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1268
    Cell Significance Index: -2.9300
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1300
    Cell Significance Index: -1.7800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1339
    Cell Significance Index: -1.7900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.1357
    Cell Significance Index: -1.6800
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: -0.1358
    Cell Significance Index: -1.4600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1372
    Cell Significance Index: -1.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Phosducin is a small, cytosolic protein that belongs to the phospholipase inhibitor family. It is characterized by its ability to inhibit phospholipase A2 (PLA2) activity, which is essential for the production of pro-inflammatory eicosanoids. Phosducin is specifically expressed in photoreceptor cells, erythrocytes, and immune cells, such as megakaryocytes and goblet cells. Its unique expression pattern highlights the protein's involvement in both visual perception and immune regulation. **Pathways and Functions:** Phosducin is intricately involved in various signaling pathways, including: 1. **G protein-coupled receptor signaling pathway:** Phosducin acts as a negative regulator of G protein-coupled receptors (GPCRs), which are critical for transducing signals in photoreceptor cells and immune cells. 2. **Phototransduction pathway:** Phosducin is essential for the regulation of phototransduction, a process that converts light into electrical signals in photoreceptor cells. 3. **Phospholipase inhibitor activity:** Phosducin inhibits PLA2 activity, which is involved in the production of pro-inflammatory eicosanoids, highlighting its role in immune regulation. 4. **Regulation of g protein-coupled receptor signaling pathway:** Phosducin modulates the activity of GPCRs, which are involved in various physiological processes, including immune response and visual perception. **Clinical Significance:** Phosducin's involvement in photoreceptor function and immune response has significant implications for various diseases: 1. **Retinal disorders:** Mutations in the PHOS_HUMAN gene have been associated with retinal degeneration and blindness, highlighting the protein's critical role in photoreceptor function. 2. **Immune disorders:** Phosducin's involvement in immune regulation suggests that dysregulation of this protein may contribute to autoimmune diseases, such as multiple sclerosis and lupus. 3. **Cancer:** Phosducin's expression in neoplastic cells and its role in regulating GPCR signaling pathways make it a potential target for cancer therapy. In conclusion, phosducin is a multifunctional protein that plays a critical role in photoreceptor function, immune response, and signal transduction pathways. Its unique expression pattern and involvement in various cellular processes make it an attractive target for further research and therapeutic interventions.

Genular Protein ID: 3283005760

Symbol: PHOS_HUMAN

Name: Phosducin

UniProtKB Accession Codes:

P20941 Q14816 Q9UP22 Q9UP23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2210381

Title: Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.

PubMed ID: 2210381

DOI: 10.1016/0378-1119(90)90090-e

PubMed ID: 2383274

Title: Isolation and analysis of the human MEKA gene encoding a retina-specific protein.

PubMed ID: 2383274

DOI: 10.1016/0006-291x(90)92183-z

PubMed ID: 10866677

Title: Modulation of CRX transactivation activity by phosducin isoforms.

PubMed ID: 10866677

DOI: 10.1128/mcb.20.14.5216-5226.2000

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 246
  • Mass: 28246
  • Checksum: DF59C2C7C3308C90
  • Sequence:
    • MEEAKSQSLE EDFEGQATHT GPKGVINDWR KFKLESQDSD SIPPSKKEIL RQMSSPQSRN 
GKDSKERVSR KMSIQEYELI HKEKEDENCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG 
KQFLETIEKE LKITTIVVHI YEDGIKGCDA LNSSLTCLAA EYPIVKFCKI KASNTGAGDR 
FSLDVLPTLL IYKGGELISN FISVAEQFAE EFFAGDVESF LNEYGLLPER EVHVLEHTKI 
EEEDVE

Genular Protein ID: 930866562

Symbol: Q52LP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q52LP8

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 6 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 201
  • Mass: 23213
  • Checksum: 6DA847BF385B41B5
  • Sequence:
    • KKEILRQMSS PQSRNGKDSK ERVSRKMSIQ EYELIHKEKE DENCLRKYRR QCMQDMHQKL 
SFGPRYGFVY ELETGKQFLE TIEKELKITT IVVHIYEDGI KGCDALNSSL TCLAAEYPIV 
KFCKIKASNT GAGDRFSLDV LPTLLIYKGG ELISNFISVA EQFAEEFFAG DVESFLNEYG 
LLPEREVHVL EHTKIEEEDV E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.