Details for: PDC

Gene ID: 5132

Symbol: PDC

Ensembl ID: ENSG00000116703

Description: phosducin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 4.74
    Marker Score: 2626
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.16
    Marker Score: 11867
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.91
    Marker Score: 868
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.4
    Marker Score: 2411
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.67
    Marker Score: 950
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.62
    Marker Score: 10792
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.54
    Marker Score: 1160
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169963
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.25
    Marker Score: 654
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.22
    Marker Score: 7419
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.22
    Marker Score: 3640
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.16
    Marker Score: 611
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 1.06
    Marker Score: 32707.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1524
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.8
    Marker Score: 336
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.8
    Marker Score: 730.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1228
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1427
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.69
    Marker Score: 287
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 427
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.64
    Marker Score: 1851
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9576
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.55
    Marker Score: 151
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.45
    Marker Score: 268
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.43
    Marker Score: 668
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.42
    Marker Score: 1047
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.42
    Marker Score: 5549
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.38
    Marker Score: 530
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.32
    Marker Score: 97
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.31
    Marker Score: 1880
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.31
    Marker Score: 293
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.3
    Marker Score: 1238
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.3
    Marker Score: 2543
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 138
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.27
    Marker Score: 340
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.27
    Marker Score: 794
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.27
    Marker Score: 110
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 531
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 114
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.25
    Marker Score: 2337
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.24
    Marker Score: 296.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 13920
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.2
    Marker Score: 475
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2
    Marker Score: 238
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.19
    Marker Score: 555.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.18
    Marker Score: 1738
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 294
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.17
    Marker Score: 75
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.17
    Marker Score: 223
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.16
    Marker Score: 33
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.16
    Marker Score: 41.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.16
    Marker Score: 655
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.15
    Marker Score: 5593
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 118
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.14
    Marker Score: 62
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.13
    Marker Score: 1350
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 51
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.12
    Marker Score: 267
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.12
    Marker Score: 144
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 99
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.11
    Marker Score: 2172
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.11
    Marker Score: 422
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.11
    Marker Score: 384
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 52
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.1
    Marker Score: 260.5
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1
    Marker Score: 401
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.1
    Marker Score: 3623
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.09
    Marker Score: 30

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Other Information

**Key characteristics:** * Phosducin is a protein of the phosducin family of proteins. * It is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed in high levels in the eye, particularly in retinal rod cells and photoreceptor cells. * It is a negative regulator of the G protein-coupled receptor signaling pathway. **Pathways and functions:** * Phosducin negatively regulates the G protein-coupled receptor signaling pathway. * This pathway is involved in a variety of cellular processes, including vision, blood pressure regulation, and inflammation. * When phosducin binds to its receptor, it inhibits the activity of the G protein. * This prevents the activation of downstream signaling pathways, which can lead to changes in cell behavior. **Clinical significance:** * Mutations in the PHOS gene have been linked to a number of eye diseases, including retinitis pigmentosa, age-related macular degeneration, and cataracts. * These diseases are characterized by the loss of photoreceptors, which are cells that are sensitive to light. * Phosducin is a potential therapeutic target for these eye diseases. **Additional information:** * Phosducin is a conserved protein that is found in organisms from yeast to humans. * It is a well-studied protein that has been extensively characterized in vitro and in vivo. * It is a promising target for the treatment of eye diseases.

Genular Protein ID: 3283005760

Symbol: PHOS_HUMAN

Name: Phosducin

UniProtKB Accession Codes:

P20941 Q14816 Q9UP22 Q9UP23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2210381

Title: Analysis of the human, bovine and rat 33-kDa proteins and cDNA in retina and pineal gland.

PubMed ID: 2210381

DOI: 10.1016/0378-1119(90)90090-e

PubMed ID: 2383274

Title: Isolation and analysis of the human MEKA gene encoding a retina-specific protein.

PubMed ID: 2383274

DOI: 10.1016/0006-291x(90)92183-z

PubMed ID: 10866677

Title: Modulation of CRX transactivation activity by phosducin isoforms.

PubMed ID: 10866677

DOI: 10.1128/mcb.20.14.5216-5226.2000

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 246
  • Mass: 28246
  • Checksum: DF59C2C7C3308C90
  • Sequence:
    • MEEAKSQSLE EDFEGQATHT GPKGVINDWR KFKLESQDSD SIPPSKKEIL RQMSSPQSRN 
GKDSKERVSR KMSIQEYELI HKEKEDENCL RKYRRQCMQD MHQKLSFGPR YGFVYELETG 
KQFLETIEKE LKITTIVVHI YEDGIKGCDA LNSSLTCLAA EYPIVKFCKI KASNTGAGDR 
FSLDVLPTLL IYKGGELISN FISVAEQFAE EFFAGDVESF LNEYGLLPER EVHVLEHTKI 
EEEDVE

Genular Protein ID: 930866562

Symbol: Q52LP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q52LP8

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 201
  • Mass: 23213
  • Checksum: 6DA847BF385B41B5
  • Sequence:
    • KKEILRQMSS PQSRNGKDSK ERVSRKMSIQ EYELIHKEKE DENCLRKYRR QCMQDMHQKL 
SFGPRYGFVY ELETGKQFLE TIEKELKITT IVVHIYEDGI KGCDALNSSL TCLAAEYPIV 
KFCKIKASNT GAGDRFSLDV LPTLLIYKGG ELISNFISVA EQFAEEFFAG DVESFLNEYG 
LLPEREVHVL EHTKIEEEDV E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.