Details for: CLUL1

Gene ID: 27098

Symbol: CLUL1

Ensembl ID: ENSG00000079101

Description: clusterin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.8273
    Cell Significance Index: -5.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 10.3789
    Cell Significance Index: 654.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 8.2118
    Cell Significance Index: 97.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.9408
    Cell Significance Index: 62.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7958
    Cell Significance Index: 38.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.5107
    Cell Significance Index: 33.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.2209
    Cell Significance Index: -3.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5488
    Cell Significance Index: 104.4400
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.4445
    Cell Significance Index: 3.1000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.3582
    Cell Significance Index: 5.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2984
    Cell Significance Index: 6.3600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2949
    Cell Significance Index: 42.8600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2877
    Cell Significance Index: 17.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2384
    Cell Significance Index: 23.5800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2228
    Cell Significance Index: 24.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2193
    Cell Significance Index: 198.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1925
    Cell Significance Index: 4.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1460
    Cell Significance Index: 1.8700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1411
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1401
    Cell Significance Index: 22.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1282
    Cell Significance Index: 25.7200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1111
    Cell Significance Index: 1.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1068
    Cell Significance Index: 1.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1050
    Cell Significance Index: 1.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0939
    Cell Significance Index: 6.5000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0802
    Cell Significance Index: 4.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0641
    Cell Significance Index: 4.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0606
    Cell Significance Index: 1.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0585
    Cell Significance Index: 11.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0560
    Cell Significance Index: 20.0800
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0534
    Cell Significance Index: 0.4700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0498
    Cell Significance Index: 2.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0492
    Cell Significance Index: 1.0200
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.0392
    Cell Significance Index: 0.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0252
    Cell Significance Index: 2.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0189
    Cell Significance Index: 10.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0110
    Cell Significance Index: 20.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0061
    Cell Significance Index: 4.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0059
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0056
    Cell Significance Index: 0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0041
    Cell Significance Index: 0.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0040
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0033
    Cell Significance Index: 2.1100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0018
    Cell Significance Index: 0.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0010
    Cell Significance Index: 1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0003
    Cell Significance Index: 0.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0002
    Cell Significance Index: -0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0014
    Cell Significance Index: -1.8800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0029
    Cell Significance Index: -0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0044
    Cell Significance Index: -0.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0069
    Cell Significance Index: -1.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0074
    Cell Significance Index: -4.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0093
    Cell Significance Index: -4.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0099
    Cell Significance Index: -6.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0117
    Cell Significance Index: -1.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0117
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0139
    Cell Significance Index: -1.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0160
    Cell Significance Index: -2.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0181
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0191
    Cell Significance Index: -1.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0194
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0247
    Cell Significance Index: -5.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0271
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0296
    Cell Significance Index: -4.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0335
    Cell Significance Index: -3.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0421
    Cell Significance Index: -1.8600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0431
    Cell Significance Index: -0.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0474
    Cell Significance Index: -2.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0476
    Cell Significance Index: -1.3300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0480
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0487
    Cell Significance Index: -1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0524
    Cell Significance Index: -0.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0532
    Cell Significance Index: -1.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0554
    Cell Significance Index: -5.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0556
    Cell Significance Index: -2.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0615
    Cell Significance Index: -4.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0842
    Cell Significance Index: -6.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0865
    Cell Significance Index: -0.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0867
    Cell Significance Index: -2.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0888
    Cell Significance Index: -4.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0921
    Cell Significance Index: -5.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0922
    Cell Significance Index: -3.0200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0957
    Cell Significance Index: -2.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0996
    Cell Significance Index: -5.1900
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1007
    Cell Significance Index: -0.7600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1034
    Cell Significance Index: -1.4500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1067
    Cell Significance Index: -1.2100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1109
    Cell Significance Index: -1.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1153
    Cell Significance Index: -4.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1191
    Cell Significance Index: -3.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1201
    Cell Significance Index: -4.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1247
    Cell Significance Index: -3.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural similarity to clusterin**: CLUL1 exhibits a high degree of sequence homology with clusterin, suggesting a conserved evolutionary pathway. 2. **Secretion and extracellular localization**: CLUL1 is secreted by various cell types, including immune cells, and is found in the extracellular space, where it may interact with other molecules and influence cellular signaling. 3. **Cell type-specific expression**: CLUL1 is highly expressed in retinal rod cells, eye photoreceptor cells, colon goblet cells, granulocyte monocyte progenitor cells, intestinal crypt stem cells, and other cell types, indicating its involvement in maintaining cellular homeostasis and immune regulation. 4. **Misfolded protein binding**: CLUL1 interacts with misfolded proteins, suggesting its role in protein quality control and cellular stress response. **Pathways and Functions:** CLUL1 is involved in several cellular pathways, including: 1. **Extracellular space regulation**: CLUL1 influences the extracellular environment by modulating the activity of various proteins and signaling molecules. 2. **Protein quality control**: CLUL1 interacts with misfolded proteins, helping to maintain protein homeostasis and prevent protein aggregation. 3. **Immune regulation**: CLUL1 modulates immune responses by interacting with immune cells and influencing the activity of immune-related proteins. 4. **Neuroprotection**: CLUL1 may play a role in protecting neurons from stress and injury, as it is highly expressed in neural cells. **Clinical Significance:** The study of CLUL1 has significant implications for our understanding of various diseases, including: 1. **Neurodegenerative disorders**: CLUL1's role in neuroprotection suggests its potential as a therapeutic target for neurodegenerative diseases, such as Alzheimer's and Parkinson's. 2. **Immune-related disorders**: CLUL1's involvement in immune regulation implies its potential as a therapeutic target for immune-related disorders, such as autoimmune diseases. 3. **Cancer**: CLUL1's expression in cancer cells suggests its potential as a biomarker or therapeutic target for cancer treatment. 4. **Retinal diseases**: CLUL1's high expression in retinal cells suggests its potential as a therapeutic target for retinal diseases, such as age-related macular degeneration. In conclusion, CLUL1 is a multifunctional protein that plays a crucial role in maintaining cellular homeostasis, regulating immune responses, and protecting against cellular stress. Further research is needed to fully elucidate the mechanisms of CLUL1 and its potential therapeutic applications.

Genular Protein ID: 1277431016

Symbol: CLUL1_HUMAN

Name: Clusterin-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14507903

Title: Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene.

PubMed ID: 14507903

DOI: 10.1167/iovs.02-1202

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17286855

Title: Mapping of transcription start sites of human retina expressed genes.

PubMed ID: 17286855

DOI: 10.1186/1471-2164-8-42

Sequence Information:

  • Length: 466
  • Mass: 54215
  • Checksum: 41A603D0FD6439C4
  • Sequence:
  • MKPPLLVFIV CLLWLKDSHC APTWKDKTAI SENLKSFSEV GEIDADEEVK KALTGIKQMK 
    IMMERKEKEH TNLMSTLKKC REEKQEALKL LNEVQEHLEE EERLCRESLA DSWGECRSCL 
    ENNCMRIYTT CQPSWSSVKN KIERFFRKIY QFLFPFHEDN EKDLPISEKL IEEDAQLTQM 
    EDVFSQLTVD VNSLFNRSFN VFRQMQQEFD QTFQSHFISD TDLTEPYFFP AFSKEPMTKA 
    DLEQCWDIPN FFQLFCNFSV SIYESVSETI TKMLKAIEDL PKQDKAPDHG GLISKMLPGQ 
    DRGLCGELDQ NLSRCFKFHE KCQKCQAHLS EDCPDVPALH TELDEAIRLV NVSNQQYGQI 
    LQMTRKHLED TAYLVEKMRG QFGWVSELAN QAPETEIIFN SIQVVPRIHE GNISKQDETM 
    MTDLSILPSS NFTLKIPLEE SAESSNFIGY VVAKALQHFK EHFKTW

Genular Protein ID: 3752226661

Symbol: B7Z5R4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 518
  • Mass: 60135
  • Checksum: 6351284B46D00C25
  • Sequence:
  • MRTWDYRWSL ALVAQTGVHC CDLSSLQPLP PRFKRFSCLS LSSGWDYSNS GNMKPPLLVF 
    IVCLLWLKDS HCAPTWKDKT AISENLKSFS EVGEIDADEE VKKALTGIKQ MKIMMERKEK 
    EHTNLMSTLK KCREEKQEAL KLLNEVQEHL EEEERLCRES LADSWGECRS CLENNCMRIY 
    TTCQPSWSSV KNKIERFFRK IYQFLFPFHE DNEKDLPISE KLIEEDAQLT QMEDVFSQLT 
    VDVNSLFNRS FNVFRQMQQE FDQTFQSHFI SDTDLTEPYF FPAFSKEPMT KADLEQCWDI 
    PNFFQLFCNF SVSIYESVSE TITKMLKAIE DLPKQDKAPD HGGLISKMLP GQDRGLCGEL 
    DQNLSRCFKF HEKCQKCQAH LSEDCPDVPA LHTELDEAIR LVNVSNQQYG QILQMTRKHL 
    EDTAYLVEKM RGQFGWVSEL ANQAPETEII FNSIQVVPRI HEGNISKQDE TMMTDLSILP 
    SSNFTLKIPL EESAESSNFI GYVVAKALQH FKEHFKTW

Genular Protein ID: 2306086754

Symbol: F5GWQ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 518
  • Mass: 60135
  • Checksum: C1289326F00B6193
  • Sequence:
  • MRTWDYRWSL ALVAQTGVHC CNLSSLQPLP PRFKRFSCLS LSSGWDYSNS GNMKPPLLVF 
    IVCLLWLKDS HCAPTWKDKT AISENLKSFS EVGEIDADEE VKKALTGIKQ MKIMMERKEK 
    EHTNLMSTLK KCREEKQEAL KLLNEVQEHL EEEERLCRES LADSWGECRS CLENNCMRIY 
    TTCQPSWSSV KNKIERFFRK IYQFLFPFHE DNEKDLPISE KLIEEDAQLT QMEDVFSQLT 
    VDVNSLFNRS FNVFRQMQQE FDQTFQSHFI SDTDLTEPYF FPAFSKEPMT KADLEQCWDI 
    PNFFQLFCNF SVSIYESVSE TITKMLKAIE DLPKQDKAPD HGGLISKMLP GQDRGLCGEL 
    DQNLSRCFKF HEKCQKCQAH LSEDCPDVPA LHTELDEAIR LVNVSNQQYG QILQMTRKHL 
    EDTAYLVEKM RGQFGWVSEL ANQAPETEII FNSIQVVPRI HEGNISKQDE TMMTDLSILP 
    SSNFTLKIPL EESAESSNFI GYVVAKALQH FKEHFKTW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.