Details for: GPR143

Gene ID: 4935

Symbol: GPR143

Ensembl ID: ENSG00000101850

Description: G protein-coupled receptor 143

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4373
    Cell Significance Index: 34.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8891
    Cell Significance Index: 169.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8050
    Cell Significance Index: 79.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4690
    Cell Significance Index: 423.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4472
    Cell Significance Index: 11.9400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4031
    Cell Significance Index: 4.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3995
    Cell Significance Index: 43.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3963
    Cell Significance Index: 64.4500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3723
    Cell Significance Index: 5.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3598
    Cell Significance Index: 18.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3280
    Cell Significance Index: 14.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3259
    Cell Significance Index: 19.5700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3172
    Cell Significance Index: 12.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2768
    Cell Significance Index: 521.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2077
    Cell Significance Index: 30.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1807
    Cell Significance Index: 5.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1732
    Cell Significance Index: 11.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1458
    Cell Significance Index: 28.9300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1384
    Cell Significance Index: 1.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1092
    Cell Significance Index: 4.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1015
    Cell Significance Index: 1.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0957
    Cell Significance Index: 2.1000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0804
    Cell Significance Index: 0.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0609
    Cell Significance Index: 0.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0571
    Cell Significance Index: 31.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0545
    Cell Significance Index: 1.1800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0498
    Cell Significance Index: 1.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0492
    Cell Significance Index: 21.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0459
    Cell Significance Index: 1.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0457
    Cell Significance Index: 6.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0437
    Cell Significance Index: 1.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0392
    Cell Significance Index: 2.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0385
    Cell Significance Index: 1.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0306
    Cell Significance Index: 5.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0301
    Cell Significance Index: 0.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0295
    Cell Significance Index: 3.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0252
    Cell Significance Index: 0.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0238
    Cell Significance Index: 1.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0237
    Cell Significance Index: 0.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0213
    Cell Significance Index: 0.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0169
    Cell Significance Index: 1.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0082
    Cell Significance Index: 0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0076
    Cell Significance Index: 4.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0074
    Cell Significance Index: 1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0061
    Cell Significance Index: 9.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0045
    Cell Significance Index: 8.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0037
    Cell Significance Index: 5.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0001
    Cell Significance Index: 0.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0057
    Cell Significance Index: -4.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0079
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0081
    Cell Significance Index: -4.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0082
    Cell Significance Index: -3.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0083
    Cell Significance Index: -2.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0089
    Cell Significance Index: -3.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0094
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0120
    Cell Significance Index: -1.3800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0128
    Cell Significance Index: -0.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0130
    Cell Significance Index: -1.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0154
    Cell Significance Index: -2.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0183
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0186
    Cell Significance Index: -3.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0198
    Cell Significance Index: -2.0200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0205
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0254
    Cell Significance Index: -5.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0281
    Cell Significance Index: -3.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0303
    Cell Significance Index: -2.0400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0336
    Cell Significance Index: -0.4300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0348
    Cell Significance Index: -0.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0426
    Cell Significance Index: -0.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0431
    Cell Significance Index: -3.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0464
    Cell Significance Index: -0.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0470
    Cell Significance Index: -1.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0497
    Cell Significance Index: -0.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0541
    Cell Significance Index: -0.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0546
    Cell Significance Index: -2.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0626
    Cell Significance Index: -0.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0698
    Cell Significance Index: -5.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0724
    Cell Significance Index: -3.4100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0725
    Cell Significance Index: -1.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0726
    Cell Significance Index: -0.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0732
    Cell Significance Index: -5.8000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0735
    Cell Significance Index: -1.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0749
    Cell Significance Index: -4.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0831
    Cell Significance Index: -5.1100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0840
    Cell Significance Index: -1.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0861
    Cell Significance Index: -3.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0873
    Cell Significance Index: -5.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0896
    Cell Significance Index: -2.6400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0903
    Cell Significance Index: -0.6900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0924
    Cell Significance Index: -1.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1010
    Cell Significance Index: -4.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1046
    Cell Significance Index: -5.4500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1047
    Cell Significance Index: -0.8900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.1060
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1173
    Cell Significance Index: -4.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GPR143 exhibits several distinct characteristics that set it apart from other GPCRs: 1. **Ligand specificity**: GPR143 is activated by L-dopa, a precursor to dopamine, and other related compounds, such as tyrosine and dopamine. 2. **Melanosome association**: GPR143 is closely linked to melanosome formation, transport, and organization, highlighting its role in melanocyte biology. 3. **Visual perception**: GPR143's expression in retinal bipolar neurons suggests a potential involvement in visual processing and perception. 4. **Calcium-mediated signaling**: GPR143's signaling pathway is mediated by intracellular calcium sources, which are critical for various cellular processes. **Pathways and Functions** GPR143's signaling pathway is intricately linked to various cellular processes, including: 1. **Melanosome organization**: GPR143 regulates melanosome formation, transport, and organization, ensuring proper melanin distribution and pigment synthesis. 2. **Visual perception**: GPR143's expression in retinal bipolar neurons suggests a role in visual processing and perception, potentially modulating the response to light and color. 3. **Calcium-mediated signaling**: GPR143's signaling pathway is mediated by intracellular calcium sources, which regulate various cellular processes, including muscle contraction, neurotransmitter release, and cell proliferation. 4. **Neurotransmitter signaling**: GPR143's interaction with L-dopa and other ligands may influence neurotransmitter release and signaling, particularly in the context of melanocyte biology. **Clinical Significance** GPR143's dysregulation has been implicated in various diseases, including: 1. **Albinism**: Mutations in GPR143 have been linked to albinism, a condition characterized by impaired melanin production and vision. 2. **Neurodegenerative disorders**: GPR143's involvement in visual perception and neurotransmitter signaling suggests a potential role in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. 3. **Cancer**: GPR143's expression in certain cancer cells, such as melanoma and colon cancer, highlights its potential as a therapeutic target. In conclusion, GPR143 is a complex receptor with far-reaching implications for melanosome biology, visual perception, and neurotransmitter signaling. Further research into GPR143's mechanisms and clinical significance will provide valuable insights into the molecular basis of various diseases and potentially lead to the development of novel therapeutic strategies.

Genular Protein ID: 72543013

Symbol: GP143_HUMAN

Name: G-protein coupled receptor 143

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7647783

Title: Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome.

PubMed ID: 7647783

DOI: 10.1038/ng0595-13

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10094567

Title: Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.

PubMed ID: 10094567

DOI: 10.1002/(sici)1098-1004(1999)13:2<99::aid-humu2>3.0.co;2-c

PubMed ID: 10471510

Title: Ocular albinism: evidence for a defect in an intracellular signal transduction system.

PubMed ID: 10471510

DOI: 10.1038/12715

PubMed ID: 11115845

Title: Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1.

PubMed ID: 11115845

DOI: 10.1093/hmg/9.20.3011

PubMed ID: 11793467

Title: New insights into ocular albinism type 1 (OA1): mutations and polymorphisms of the OA1 gene.

PubMed ID: 11793467

DOI: 10.1002/humu.10034

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 16621890

Title: An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1.

PubMed ID: 16621890

DOI: 10.1242/jcs.02930

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16524428

Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.

PubMed ID: 16524428

DOI: 10.1111/j.1600-0749.2006.00292.x

PubMed ID: 18697795

Title: The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells.

PubMed ID: 18697795

DOI: 10.1093/hmg/ddn241

PubMed ID: 18828673

Title: L-DOPA is an endogenous ligand for OA1.

PubMed ID: 18828673

DOI: 10.1371/journal.pbio.0060236

PubMed ID: 19717472

Title: The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.

PubMed ID: 19717472

DOI: 10.1093/hmg/ddp415

PubMed ID: 8634705

Title: Analysis of the OA1 gene reveals mutations in only one-third of patients with X-linked ocular albinism.

PubMed ID: 8634705

DOI: 10.1093/hmg/4.12.2319

PubMed ID: 9529334

Title: OA1 mutations and deletions in X-linked ocular albinism.

PubMed ID: 9529334

DOI: 10.1086/301776

PubMed ID: 9887374

Title: X-linked ocular albinism: prevalence and mutations -- a national study.

PubMed ID: 9887374

DOI: 10.1038/sj.ejhg.5200226

PubMed ID: 11214907

Title: Diverse prevalence of large deletions within the OA1 gene in ocular albinism type 1 patients from Europe and North America.

PubMed ID: 11214907

DOI: 10.1007/s004390000440

PubMed ID: 16646960

Title: Eight previously unidentified mutations found in the OA1 ocular albinism gene.

PubMed ID: 16646960

DOI: 10.1186/1471-2350-7-41

PubMed ID: 17822861

Title: New mutations identified in the ocular albinism type 1 gene.

PubMed ID: 17822861

DOI: 10.1016/j.gene.2007.07.020

PubMed ID: 17516023

Title: Identification of a novel GPR143 mutation in a large Chinese family with congenital nystagmus as the most prominent and consistent manifestation.

PubMed ID: 17516023

DOI: 10.1007/s10038-007-0152-3

PubMed ID: 17960122

Title: Identification of two novel mutations in families with X-linked ocular albinism.

PubMed ID: 17960122

PubMed ID: 18978956

Title: Novel GPR143 mutations and clinical characteristics in six Chinese families with X-linked ocular albinism.

PubMed ID: 18978956

Sequence Information:

  • Length: 404
  • Mass: 43878
  • Checksum: 20DEB20E80CC0E1D
  • Sequence:
  • MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR LALGLLQLLP GRRPAGPGSP 
    ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD SVSDMNHTEI WPAAFCVGSA 
    MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM AWGLATLLCV EGAAMLYYPS 
    VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV ASLLKGRQGI YTENERRMGA 
    VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS LKPVRTAAKT TWFIMGILNP 
    AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA HPSPLMPHEN PASGKVSQVG 
    GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT HGDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.