Details for: GPR143
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 1.4373
Cell Significance Index: 34.8200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.8891
Cell Significance Index: 169.2000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8050
Cell Significance Index: 79.6400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4690
Cell Significance Index: 423.4500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4472
Cell Significance Index: 11.9400 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.4031
Cell Significance Index: 4.5100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3995
Cell Significance Index: 43.4600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3963
Cell Significance Index: 64.4500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.3723
Cell Significance Index: 5.0800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3598
Cell Significance Index: 18.6900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.3280
Cell Significance Index: 14.5100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3259
Cell Significance Index: 19.5700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.3172
Cell Significance Index: 12.0100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2768
Cell Significance Index: 521.2500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.2077
Cell Significance Index: 30.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1807
Cell Significance Index: 5.0500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1732
Cell Significance Index: 11.9800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1458
Cell Significance Index: 28.9300 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.1384
Cell Significance Index: 1.9200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1092
Cell Significance Index: 4.9500 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.1015
Cell Significance Index: 1.5300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0957
Cell Significance Index: 2.1000 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.0804
Cell Significance Index: 0.9400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.0609
Cell Significance Index: 0.7800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0571
Cell Significance Index: 31.1700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0545
Cell Significance Index: 1.1800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0498
Cell Significance Index: 1.7300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0492
Cell Significance Index: 21.7600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0459
Cell Significance Index: 1.1800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0457
Cell Significance Index: 6.2700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0437
Cell Significance Index: 1.1700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.0392
Cell Significance Index: 2.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0385
Cell Significance Index: 1.1100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0306
Cell Significance Index: 5.5200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0301
Cell Significance Index: 0.6400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0295
Cell Significance Index: 3.6300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0252
Cell Significance Index: 0.6900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0238
Cell Significance Index: 1.1100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0237
Cell Significance Index: 0.7600 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.0213
Cell Significance Index: 0.1700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0180
Cell Significance Index: 0.4500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0169
Cell Significance Index: 1.9700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0082
Cell Significance Index: 0.4600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0076
Cell Significance Index: 4.8400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0074
Cell Significance Index: 1.4900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0061
Cell Significance Index: 9.3800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0045
Cell Significance Index: 8.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0037
Cell Significance Index: 0.1300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0037
Cell Significance Index: 5.0600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0001
Cell Significance Index: 0.0500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0057
Cell Significance Index: -4.1600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0057
Cell Significance Index: -4.2400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0068
Cell Significance Index: -5.1800 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0079
Cell Significance Index: -0.1100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0081
Cell Significance Index: -4.5600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0082
Cell Significance Index: -3.7200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0083
Cell Significance Index: -2.3900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0089
Cell Significance Index: -3.1800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0094
Cell Significance Index: -5.8600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0120
Cell Significance Index: -1.3800 - Cell Name: melanocyte (CL0000148)
Fold Change: -0.0128
Cell Significance Index: -0.1200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0130
Cell Significance Index: -1.6700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0154
Cell Significance Index: -2.0000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0183
Cell Significance Index: -1.9100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0186
Cell Significance Index: -3.1700 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0198
Cell Significance Index: -2.0200 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0200
Cell Significance Index: -0.1900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0205
Cell Significance Index: -0.5400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0254
Cell Significance Index: -5.3600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0281
Cell Significance Index: -3.3100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0303
Cell Significance Index: -2.0400 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.0336
Cell Significance Index: -0.4300 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0348
Cell Significance Index: -0.3600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0426
Cell Significance Index: -0.7300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0431
Cell Significance Index: -3.2100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0464
Cell Significance Index: -0.6600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0470
Cell Significance Index: -1.0100 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.0497
Cell Significance Index: -0.4100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0541
Cell Significance Index: -0.7800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0546
Cell Significance Index: -2.8700 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0626
Cell Significance Index: -0.8900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0698
Cell Significance Index: -5.3600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0724
Cell Significance Index: -3.4100 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0725
Cell Significance Index: -1.1500 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0726
Cell Significance Index: -0.9100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0732
Cell Significance Index: -5.8000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0735
Cell Significance Index: -1.2700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0749
Cell Significance Index: -4.5900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0831
Cell Significance Index: -5.1100 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0840
Cell Significance Index: -1.0600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0861
Cell Significance Index: -3.5300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0873
Cell Significance Index: -5.6300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0896
Cell Significance Index: -2.6400 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0903
Cell Significance Index: -0.6900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0924
Cell Significance Index: -1.0500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1010
Cell Significance Index: -4.3900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1046
Cell Significance Index: -5.4500 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1047
Cell Significance Index: -0.8900 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.1060
Cell Significance Index: -1.3700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1173
Cell Significance Index: -4.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 72543013
Symbol: GP143_HUMAN
Name: G-protein coupled receptor 143
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7647783
Title: Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome.
PubMed ID: 7647783
DOI: 10.1038/ng0595-13
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10094567
Title: Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism.
PubMed ID: 10094567
DOI: 10.1002/(sici)1098-1004(1999)13:2<99::aid-humu2>3.0.co;2-c
PubMed ID: 10471510
Title: Ocular albinism: evidence for a defect in an intracellular signal transduction system.
PubMed ID: 10471510
DOI: 10.1038/12715
PubMed ID: 11115845
Title: Defective intracellular transport and processing of OA1 is a major cause of ocular albinism type 1.
PubMed ID: 11115845
PubMed ID: 11793467
Title: New insights into ocular albinism type 1 (OA1): mutations and polymorphisms of the OA1 gene.
PubMed ID: 11793467
DOI: 10.1002/humu.10034
PubMed ID: 12643545
Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.
PubMed ID: 12643545
DOI: 10.1021/pr025562r
PubMed ID: 16621890
Title: An unconventional dileucine-based motif and a novel cytosolic motif are required for the lysosomal and melanosomal targeting of OA1.
PubMed ID: 16621890
DOI: 10.1242/jcs.02930
PubMed ID: 17081065
Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
PubMed ID: 17081065
DOI: 10.1021/pr060363j
PubMed ID: 16524428
Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.
PubMed ID: 16524428
PubMed ID: 18697795
Title: The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells.
PubMed ID: 18697795
DOI: 10.1093/hmg/ddn241
PubMed ID: 18828673
Title: L-DOPA is an endogenous ligand for OA1.
PubMed ID: 18828673
PubMed ID: 19717472
Title: The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.
PubMed ID: 19717472
DOI: 10.1093/hmg/ddp415
PubMed ID: 8634705
Title: Analysis of the OA1 gene reveals mutations in only one-third of patients with X-linked ocular albinism.
PubMed ID: 8634705
PubMed ID: 9529334
Title: OA1 mutations and deletions in X-linked ocular albinism.
PubMed ID: 9529334
DOI: 10.1086/301776
PubMed ID: 9887374
Title: X-linked ocular albinism: prevalence and mutations -- a national study.
PubMed ID: 9887374
PubMed ID: 11214907
Title: Diverse prevalence of large deletions within the OA1 gene in ocular albinism type 1 patients from Europe and North America.
PubMed ID: 11214907
PubMed ID: 16646960
Title: Eight previously unidentified mutations found in the OA1 ocular albinism gene.
PubMed ID: 16646960
PubMed ID: 17822861
Title: New mutations identified in the ocular albinism type 1 gene.
PubMed ID: 17822861
PubMed ID: 17516023
Title: Identification of a novel GPR143 mutation in a large Chinese family with congenital nystagmus as the most prominent and consistent manifestation.
PubMed ID: 17516023
PubMed ID: 17960122
Title: Identification of two novel mutations in families with X-linked ocular albinism.
PubMed ID: 17960122
PubMed ID: 18978956
Title: Novel GPR143 mutations and clinical characteristics in six Chinese families with X-linked ocular albinism.
PubMed ID: 18978956
Sequence Information:
- Length: 404
- Mass: 43878
- Checksum: 20DEB20E80CC0E1D
- Sequence:
MASPRLGTFC CPTRDAATQL VLSFQPRAFH ALCLGSGGLR LALGLLQLLP GRRPAGPGSP ATSPPASVRI LRAAAACDLL GCLGMVIRST VWLGFPNFVD SVSDMNHTEI WPAAFCVGSA MWIQLLYSAC FWWLFCYAVD AYLVIRRSAG LSTILLYHIM AWGLATLLCV EGAAMLYYPS VSRCERGLDH AIPHYVTMYL PLLLVLVANP ILFQKTVTAV ASLLKGRQGI YTENERRMGA VIKIRFFKIM LVLIICWLSN IINESLLFYL EMQTDINGGS LKPVRTAAKT TWFIMGILNP AQGFLLSLAF YGWTGCSLGF QSPRKEIQWE SLTTSAAEGA HPSPLMPHEN PASGKVSQVG GQTSDEALSM LSEGSDASTI EIHTASESCN KNEGDPALPT HGDL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.