Details for: SLC22A6

Gene ID: 9356

Symbol: SLC22A6

Ensembl ID: ENSG00000197901

Description: solute carrier family 22 member 6

Associated with

Other Information

Genular Protein ID: 2532278410

Symbol: S22A6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9762842

Title: Cloning of a human renal p-aminohippurate transporter, hROAT1.

PubMed ID: 9762842

DOI: 10.1159/000025863

PubMed ID: 9887087

Title: Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney.

PubMed ID: 9887087

DOI: 10.1152/ajprenal.1999.276.1.f122

PubMed ID: 9950961

Title: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C.

PubMed ID: 9950961

DOI: 10.1152/ajprenal.1999.276.2.f295

PubMed ID: 10049739

Title: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3).

PubMed ID: 10049739

DOI: 10.1006/bbrc.1998.9978

PubMed ID: 10462545

Title: The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.

PubMed ID: 10462545

DOI: 10.1124/mol.56.3.570

PubMed ID: 10964714

Title: Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.

PubMed ID: 10964714

DOI: 10.1006/bbrc.2000.3230

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11907186

Title: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.

PubMed ID: 11907186

DOI: 10.1124/jpet.301.1.293

PubMed ID: 12538807

Title: Interaction of cysteine conjugates with human and rabbit organic anion transporter 1.

PubMed ID: 12538807

DOI: 10.1124/jpet.102.043455

PubMed ID: 11669456

Title: Characterization of ochratoxin A transport by human organic anion transporters.

PubMed ID: 11669456

DOI: 10.1016/s0024-3205(01)01296-6

PubMed ID: 14749323

Title: Role of glycosylation in the organic anion transporter OAT1.

PubMed ID: 14749323

DOI: 10.1074/jbc.m400197200

PubMed ID: 15145940

Title: Critical amino acid residues in transmembrane domain 1 of the human organic anion transporter hOAT1.

PubMed ID: 15145940

DOI: 10.1074/jbc.m404686200

PubMed ID: 14675047

Title: Characterization of uremic toxin transport by organic anion transporters in the kidney.

PubMed ID: 14675047

DOI: 10.1111/j.1523-1755.2004.00354.x

PubMed ID: 15644426

Title: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8).

PubMed ID: 15644426

DOI: 10.1124/jpet.104.080366

PubMed ID: 17038320

Title: A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.

PubMed ID: 17038320

DOI: 10.1074/jbc.m608834200

PubMed ID: 17502342

Title: Human organic anion transporters 1 (hOAT1/SLC22A6) and 3 (hOAT3/SLC22A8) transport edaravone (MCI-186; 3-methyl-1-phenyl-2-pyrazolin-5-one) and its sulfate conjugate.

PubMed ID: 17502342

DOI: 10.1124/dmd.106.013912

PubMed ID: 22108572

Title: Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.

PubMed ID: 22108572

DOI: 10.1016/j.phrs.2011.11.003

PubMed ID: 23832370

Title: Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3.

PubMed ID: 23832370

DOI: 10.1271/bbb.130178

PubMed ID: 26377792

Title: Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.

PubMed ID: 26377792

DOI: 10.1152/ajprenal.00140.2015

PubMed ID: 28534121

Title: Organic anion transporters, OAT1 and OAT3, are crucial biopterin transporters involved in bodily distribution of tetrahydrobiopterin and exclusion of its excess.

PubMed ID: 28534121

DOI: 10.1007/s11010-017-3060-7

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 15914676

Title: Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).

PubMed ID: 15914676

DOI: 10.1124/jpet.105.084301

PubMed ID: 16164626

Title: Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].

PubMed ID: 16164626

DOI: 10.1111/j.1523-1755.2005.00612.x

Sequence Information:

  • Length: 563
  • Mass: 61816
  • Checksum: 74AD3EA2678032E4
  • Sequence:
  • MAFNDLLQQV GGVGRFQQIQ VTLVVLPLLL MASHNTLQNF TAAIPTHHCR PPADANLSKN 
    GGLEVWLPRD RQGQPESCLR FTSPQWGLPF LNGTEANGTG ATEPCTDGWI YDNSTFPSTI 
    VTEWDLVCSH RALRQLAQSL YMVGVLLGAM VFGYLADRLG RRKVLILNYL QTAVSGTCAA 
    FAPNFPIYCA FRLLSGMALA GISLNCMTLN VEWMPIHTRA CVGTLIGYVY SLGQFLLAGV 
    AYAVPHWRHL QLLVSAPFFA FFIYSWFFIE SARWHSSSGR LDLTLRALQR VARINGKREE 
    GAKLSMEVLR ASLQKELTMG KGQASAMELL RCPTLRHLFL CLSMLWFATS FAYYGLVMDL 
    QGFGVSIYLI QVIFGAVDLP AKLVGFLVIN SLGRRPAQMA ALLLAGICIL LNGVIPQDQS 
    IVRTSLAVLG KGCLAASFNC IFLYTGELYP TMIRQTGMGM GSTMARVGSI VSPLVSMTAE 
    LYPSMPLFIY GAVPVAASAV TVLLPETLGQ PLPDTVQDLE SRWAPTQKEA GIYPRKGKQT 
    RQQQEHQKYM VPLQASAQEK NGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.