Details for: RGR

Gene ID: 5995

Symbol: RGR

Ensembl ID: ENSG00000148604

Description: retinal G protein coupled receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.3990
    Cell Significance Index: 26.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1676
    Cell Significance Index: 9.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9052
    Cell Significance Index: 10.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4757
    Cell Significance Index: 29.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4350
    Cell Significance Index: 22.8400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3909
    Cell Significance Index: 5.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1864
    Cell Significance Index: 2.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1802
    Cell Significance Index: 26.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1519
    Cell Significance Index: 2.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0504
    Cell Significance Index: 1.2200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0240
    Cell Significance Index: 0.4200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0238
    Cell Significance Index: 0.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0194
    Cell Significance Index: 1.0900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.0112
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0041
    Cell Significance Index: -2.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0059
    Cell Significance Index: -2.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0090
    Cell Significance Index: -4.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0093
    Cell Significance Index: -5.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0142
    Cell Significance Index: -4.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0164
    Cell Significance Index: -3.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0175
    Cell Significance Index: -3.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0216
    Cell Significance Index: -4.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0251
    Cell Significance Index: -5.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0293
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0296
    Cell Significance Index: -5.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0300
    Cell Significance Index: -0.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0308
    Cell Significance Index: -4.2300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0322
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0332
    Cell Significance Index: -4.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0353
    Cell Significance Index: -0.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0358
    Cell Significance Index: -1.8100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0383
    Cell Significance Index: -0.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0443
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0451
    Cell Significance Index: -5.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0456
    Cell Significance Index: -1.8700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0497
    Cell Significance Index: -0.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0512
    Cell Significance Index: -5.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0585
    Cell Significance Index: -4.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0607
    Cell Significance Index: -3.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0645
    Cell Significance Index: -0.9800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0696
    Cell Significance Index: -0.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0720
    Cell Significance Index: -4.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0793
    Cell Significance Index: -1.5500
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0812
    Cell Significance Index: -0.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0837
    Cell Significance Index: -4.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0839
    Cell Significance Index: -6.4400
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0850
    Cell Significance Index: -0.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0880
    Cell Significance Index: -3.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0889
    Cell Significance Index: -4.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0927
    Cell Significance Index: -4.1000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0952
    Cell Significance Index: -1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0974
    Cell Significance Index: -4.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0981
    Cell Significance Index: -2.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1099
    Cell Significance Index: -4.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1150
    Cell Significance Index: -4.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1179
    Cell Significance Index: -3.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1207
    Cell Significance Index: -4.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1228
    Cell Significance Index: -3.9100
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.1271
    Cell Significance Index: -1.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1294
    Cell Significance Index: -1.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1382
    Cell Significance Index: -4.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1388
    Cell Significance Index: -4.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1484
    Cell Significance Index: -3.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1517
    Cell Significance Index: -4.3500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1579
    Cell Significance Index: -1.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1600
    Cell Significance Index: -4.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1645
    Cell Significance Index: -3.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1682
    Cell Significance Index: -4.4900
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1698
    Cell Significance Index: -2.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1701
    Cell Significance Index: -5.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1762
    Cell Significance Index: -4.2300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1763
    Cell Significance Index: -5.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1771
    Cell Significance Index: -4.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1814
    Cell Significance Index: -4.8600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1839
    Cell Significance Index: -1.2500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1852
    Cell Significance Index: -4.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1857
    Cell Significance Index: -3.9700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1904
    Cell Significance Index: -4.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1914
    Cell Significance Index: -3.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1921
    Cell Significance Index: -2.8000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1941
    Cell Significance Index: -1.9200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1961
    Cell Significance Index: -3.9900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.1980
    Cell Significance Index: -2.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2062
    Cell Significance Index: -4.4600
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.2088
    Cell Significance Index: -2.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2101
    Cell Significance Index: -4.4600
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2155
    Cell Significance Index: -2.2500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.2158
    Cell Significance Index: -1.1300
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.2163
    Cell Significance Index: -2.4800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2177
    Cell Significance Index: -4.3700
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.2184
    Cell Significance Index: -0.9500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2240
    Cell Significance Index: -9.7400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2256
    Cell Significance Index: -4.4600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2266
    Cell Significance Index: -3.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RGR gene is a member of the GPCR family, which is characterized by its ability to respond to ligands and activate downstream signaling pathways. The RGR receptor is specifically expressed in the retina, where it is thought to play a role in the detection of visible light. The receptor is also found in other tissues, such as the cerebral cortex and intestinal crypt stem cells, indicating its broader functional significance. The RGR receptor is part of the class a/1 rhodopsin-like receptors, which are specifically involved in phototransduction, the process by which light is converted into electrical signals in the retina. **Pathways and Functions** The RGR gene is involved in several signaling pathways, including: 1. **G alpha (i) signaling events**: The RGR receptor activates G alpha (i) proteins, which are part of the larger GPCR signaling pathway. These proteins play a crucial role in modulating various cellular processes, including ion channel activity, gene expression, and cell proliferation. 2. **G protein-coupled photoreceptor activity**: The RGR receptor is specifically involved in phototransduction, the process by which light is converted into electrical signals in the retina. This process involves the activation of transducin, a G protein that regulates the activity of cGMP phosphodiesterase, leading to the hyperpolarization of photoreceptor cells. 3. **G protein-coupled receptor signaling pathway**: The RGR receptor is part of the larger GPCR signaling pathway, which involves the activation of various downstream signaling molecules, including G proteins, ion channels, and transcription factors. 4. **Opsins**: The RGR receptor is part of the opsin family, which are GPCRs that respond to light. Opsins are specifically involved in phototransduction, and the RGR receptor is thought to play a role in the detection of visible light. **Clinical Significance** The RGR gene has several clinical implications, including: 1. **Visual impairment**: Alterations in the RGR gene have been associated with visual impairment, including retinitis pigmentosa, a genetic disorder that affects the retina and leads to progressive vision loss. 2. **Photoreceptor degeneration**: The RGR receptor is thought to play a role in the regulation of photoreceptor cell survival and death. Alterations in the RGR gene have been associated with photoreceptor degeneration, a process that contributes to visual impairment. 3. **Neurological disorders**: The RGR receptor is also expressed in other tissues, including the cerebral cortex and intestinal crypt stem cells. Alterations in the RGR gene have been associated with various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: The RGR receptor has been found to be overexpressed in certain types of cancer, including colorectal cancer. This overexpression is thought to contribute to tumorigenesis and cancer progression. In conclusion, the RGR gene plays a critical role in the visual system, particularly in the detection of visible light. The receptor is part of the larger GPCR family and is involved in multiple signaling pathways, including phototransduction, G alpha (i) signaling events, and G protein-coupled receptor signaling pathway. Alterations in the RGR gene have been associated with visual impairment, photoreceptor degeneration, neurological disorders, and cancer, highlighting its clinical significance.

Genular Protein ID: 2645391783

Symbol: RGR_HUMAN

Name: RPE-retinal G protein-coupled receptor

UniProtKB Accession Codes:

P47804 A6NKK7 Q96FC5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7947717

Title: A human opsin-related gene that encodes a retinaldehyde-binding protein.

PubMed ID: 7947717

DOI: 10.1021/bi00248a022

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10581022

Title: Mutations in RGR, encoding a light-sensitive opsin homologue, in patients with retinitis pigmentosa.

PubMed ID: 10581022

DOI: 10.1038/70496

Sequence Information:

  • Length: 291
  • Mass: 31874
  • Checksum: 85AB087E09719E88
  • Sequence:
    • MAETSALPTG FGELEVLAVG MVLLVEALSG LSLNTLTIFS FCKTPELRTP CHLLVLSLAL 
ADSGISLNAL VAATSSLLRR WPYGSDGCQA HGFQGFVTAL ASICSSAAIA WGRYHHYCTR 
SQLAWNSAVS LVLFVWLSSA FWAALPLLGW GHYDYEPLGT CCTLDYSKGD RNFTSFLFTM 
SFFNFAMPLF ITITSYSLME QKLGKSGHLQ VNTTLPARTL LLGWGPYAIL YLYAVIADVT 
SISPKLQMVP ALIAKMVPTI NAINYALGNE MVCRGIWQCL SPQKREKDRT K

Genular Protein ID: 4004312042

Symbol: A0A0S2Z498_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z498

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 295
  • Mass: 32354
  • Checksum: 4224150E95726B6D
  • Sequence:
    • MAETSALPTG FGELEVLAVG MVLLVEALSG LSLNTLTIFS FCKTPELRTP CHLLVLSLAL 
ADSGISLNAL VAATSSLLRV SHRRWPYGSD GCQAHGFQGF VTALASICSS AAIAWGRYHH 
YCTRSQLAWN SAVSLVLFVW LSSAFWAALP LLGWGHYDYE PLGTCCTLDY SKGDRNFTSF 
LFTMSFFNFA MPLFITITSY SLMEQKLGKS GHLQVNTTLP ARTLLLGWGP YAILYLYAVI 
ADVTSISPKL QMVPALIAKM VPTINAINYA LGNEMVCRGI WQCLSPQKRE KDRTK

Genular Protein ID: 2812149553

Symbol: A0A0S2Z494_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z494

Database IDs:

ARBA 11 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 253
  • Mass: 27728
  • Checksum: 4D610689536B5767
  • Sequence:
    • MAETSALPTG FGELEVLAVG MVLLVEALSG LSLNTLTIFS FCKTPELRTP CHLLVLSLAL 
ADSGISLNAL VAATSSLLRR WPYGSDGCQA HGFQGFVTAL ASICSSAAIA WGRYHHYCTR 
SQLAWNSAVS LVLFVWLSSA FWAALPLLGW GHYDYEPLGT CCTLDYSKGD RNFTSFLFTM 
SFFNFAMPLF ITITSYSLME QKLGKSGHLQ VPALIAKMVP TINAINYALG NEMVCRGIWQ 
CLSPQKREKD RTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.