Details for: CEROX1

Gene ID: 115804232

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: CEROX1

Ensembl ID: ENSG00000260807

Description: cytoplasmic endogenous regulator of oxidative phosphorylation 1

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • progenitor cell CL0011026
    CSI 6.48
    rCSI 13.78%
    PRS 97.38
  • Mueller cell CL0000636
    CSI 4.63
    rCSI 10.57%
    PRS 97.69
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 2.88
    rCSI 8.5%
    PRS 99.07
  • Schwann cell CL0002573
    CSI 2.86
    rCSI 8.12%
    PRS 98.13
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 2.61
    rCSI 6.35%
    PRS 96
  • GABAergic amacrine cell CL4030027
    CSI 2.45
    rCSI 8.41%
    PRS 95.15
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.34
    rCSI 8.43%
    PRS 96.41
  • retinal pigment epithelial cell CL0002586
    CSI 2.33
    rCSI 4.62%
    PRS 98.18
  • forebrain radial glial cell CL0013000
    CSI 1.33
    rCSI 4.28%
    PRS 99.1
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 1.07
    rCSI 4.03%
    PRS 96.43

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary **[CEROX1](/details-gene/115804232)** (cytoplasmic endogenous regulator of oxidative phosphorylation 1) is a non-coding RNA gene located on chromosome 16p13.3. Its nomenclature suggests a primary function in the regulation of cellular energy metabolism. **Overall** expression data highlight its significant role within the nervous system and in developmental contexts. It is most prominently expressed in [progenitor cell](/details-cell/CL0011026)s, as well as various specialized glial and neuronal cell types, including [Mueller cell](/details-cell/CL0000636)s of the retina, [cerebral cortex GABAergic interneuron](/details-cell/CL0010011)s, and [Schwann cell](/details-cell/CL0002573)s, indicating its potential importance in both neural development and the maintenance of mature neural circuits. ## Cellular Roles and Expression Landscape The expression pattern of **[CEROX1](/details-gene/115804232)** points to a specialized function in cells with high metabolic demands or critical developmental roles, particularly within the neuro-glial axis. - **Progenitor and Developmental Cells:** The highest significance score for **[CEROX1](/details-gene/115804232)** is observed in [progenitor cell](/details-cell/CL0011026)s (CSI: 6.48), with notable expression also found in [forebrain radial glial cell](/details-cell/CL0013000)s. This suggests a potential role in regulating the metabolic state required for cell proliferation and differentiation during development. - **Glial and Support Cells:** The gene is a significant marker in several glial populations. Its high expression in [Mueller cell](/details-cell/CL0000636)s and [retinal pigment epithelial cell](/details-cell/CL0002586)s suggests a role in maintaining retinal homeostasis, a highly energy-intensive process. Similarly, its prominence in [Schwann cell](/details-cell/CL0002573)s points to a function in supporting the metabolic health of peripheral nervous system axons. - **Neuronal Subtypes:** **[CEROX1](/details-gene/115804232)** is also significantly expressed across a diverse range of neurons, including both inhibitory ([cerebral cortex GABAergic interneuron](/details-cell/CL0010011), [GABAergic amacrine cell](/details-cell/CL4030027)) and excitatory ([L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040), [L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041)) subtypes. This broad neuronal expression is consistent with a fundamental role in managing the high energy demands associated with synaptic transmission and maintaining ion gradients. ## Pathways and Molecular Function While detailed functional annotations are not provided, the gene's name, "cytoplasmic endogenous regulator of oxidative phosphorylation 1," strongly implies its involvement in cellular metabolism. Oxidative phosphorylation is the primary mechanism for ATP production in most eukaryotic cells and is particularly crucial for the function of neurons, glia, and proliferating progenitor cells. As a non-coding RNA, **[CEROX1](/details-gene/115804232)** likely functions post-transcriptionally, possibly by interacting with mRNAs of metabolic enzymes or with components of the mitochondrial machinery to modulate their activity or expression. Its high expression in the nervous system is consistent with a role in fine-tuning energy production to meet the dynamic needs of neural activity and maintenance. ## Research Directions The specific expression profile of **[CEROX1](/details-gene/115804232)** in neural and progenitor cells, combined with its putative role in metabolic regulation, opens several avenues for future investigation. **Proposed Hypotheses:** 1. **[CEROX1](/details-gene/115804232)** is a critical regulator of the metabolic switch from glycolysis to oxidative phosphorylation that accompanies the differentiation of neural progenitor cells. Its downregulation may impair proper neuronal and glial development by disrupting this metabolic transition. 2. In mature glial cells like [Mueller cell](/details-cell/CL0000636)s and [Schwann cell](/details-cell/CL0002573)s, **[CEROX1](/details-gene/115804232)** controls metabolic flux to provide essential energy substrates, such as lactate, to neighboring neurons, thereby playing a key role in metabolic coupling and neuronal support. 3. Dysregulation of **[CEROX1](/details-gene/115804232)** contributes to the pathology of neurodevelopmental or neurodegenerative diseases characterized by mitochondrial dysfunction, as its absence or malfunction would directly impact cellular energy production in vulnerable neural populations. **Suggested Experimental Approach:** To test the hypothesis that **[CEROX1](/details-gene/115804232)** is essential for the metabolic maturation of neural progenitors (Hypothesis 1), one could perform a loss-of-function study in a human induced pluripotent stem cell (iPSC) model. Differentiating iPSCs into neural progenitor cells (NPCs), followed by CRISPRi-mediated knockdown of **[CEROX1](/details-gene/115804232)**, would allow for a direct assessment of its role. The experimental readout would involve parallel analysis of differentiation efficiency (via immunofluorescence for markers like Tuj1 and GFAP) and metabolic function using a Seahorse XF Analyzer to measure the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR). A failure of knockdown cells to upregulate OCR during differentiation would provide strong evidence for its role in the metabolic switch. **Therapeutic Potential:** As a non-coding RNA, **[CEROX1](/details-gene/115804232)** represents a non-traditional therapeutic target. Its high expression in progenitor cells suggests it could be a target for inhibition in diseases involving uncontrolled proliferation of neural-like progenitors, such as glioblastoma. In this context, therapies based on antisense oligonucleotides (ASOs) or siRNAs could be developed to specifically target and degrade **[CEROX1](/details-gene/115804232)** transcripts, thereby disrupting tumor cell metabolism. Conversely, if its loss is implicated in neurodegenerative diseases, developing strategies to restore its function would be therapeutically relevant, though technically more challenging.