Details for: IMPG1

Gene ID: 3617

Symbol: IMPG1

Ensembl ID: ENSG00000112706

Description: interphotoreceptor matrix proteoglycan 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.74
    Marker Score: 4287
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.19
    Marker Score: 1810
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.14
    Marker Score: 8955
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.94
    Marker Score: 4062
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.62
    Marker Score: 782
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.25
    Marker Score: 1184
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2232
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.82
    Marker Score: 1371
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.77
    Marker Score: 3673
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.46
    Marker Score: 612
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.39
    Marker Score: 2631
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7397
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.07
    Marker Score: 560
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2065
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.84
    Marker Score: 503
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12767
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.81
    Marker Score: 535
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.76
    Marker Score: 401
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.67
    Marker Score: 598
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.66
    Marker Score: 210
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.62
    Marker Score: 697
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.6
    Marker Score: 670
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.55
    Marker Score: 245
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1259
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.51
    Marker Score: 1470.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.46
    Marker Score: 147
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 207
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.37
    Marker Score: 97
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.35
    Marker Score: 205
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.33
    Marker Score: 99
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.31
    Marker Score: 497
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.27
    Marker Score: 80
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.27
    Marker Score: 119
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.26
    Marker Score: 326
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 156
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.26
    Marker Score: 71
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 89
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 208
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.22
    Marker Score: 131
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.21
    Marker Score: 43
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.2
    Marker Score: 283
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2
    Marker Score: 44
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.2
    Marker Score: 255
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.19
    Marker Score: 181
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.19
    Marker Score: 86
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.19
    Marker Score: 142
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.17
    Marker Score: 45
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.16
    Marker Score: 184
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 149
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 94
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.15
    Marker Score: 45
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 0.15
    Marker Score: 44
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.14
    Marker Score: 125
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.14
    Marker Score: 40
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.14
    Marker Score: 50
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.14
    Marker Score: 1164
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 0.13
    Marker Score: 45
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.13
    Marker Score: 145
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.13
    Marker Score: 380
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.12
    Marker Score: 287
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 85
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.12
    Marker Score: 72
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 718
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.12
    Marker Score: 45
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.11
    Marker Score: 142
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.11
    Marker Score: 27

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Other Information

**Key characteristics:** * IMPG1 is a large protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including erythrocytes, megakaryocytes, retinal rod cells, double-negative thymocytes, eye photoreceptor cells, hematopoietic stem cells, blood vessel endothelial cells, and photoreceptor cells. * It is a highly glycosylated protein, with a complex structure that includes both transmembrane and extracellular portions. * The extracellular domain of IMPG1 is responsible for its interaction with hyaluronic acid and heparin. * The transmembrane domain of IMPG1 is responsible for its interaction with the ECM proteins fibronectin and collagen. **Pathways and functions:** * IMPG1 is involved in the assembly and organization of the ECM. * It is a key component of the cell adhesion complex, which is responsible for the adhesion of cells to the ECM. * It is also involved in the migration of cells through the ECM. * IMPG1 is a regulator of cell migration, differentiation, and signaling. * It is involved in the development of the eye and the maintenance of the integrity of the blood-eye barrier. **Clinical significance:** * Mutations in the IMPG1 gene have been linked to a number of eye diseases, including age-related macular degeneration (AMD), diabetic retinopathy, and retinal detachment. * IMPG1 is a promising target for the treatment of these diseases. * By blocking the interaction between IMPG1 and its ligands, it is possible to prevent the formation of the ECM and to slow the progression of eye diseases.

Genular Protein ID: 3700912254

Symbol: IMPG1_HUMAN

Name: Interphotoreceptor matrix proteoglycan 1

UniProtKB Accession Codes:

Q17R60 A6NNZ6 O43686 O95094 Q68D53 Q9BWZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 29 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9691169

Title: Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies.

PubMed ID: 9691169

DOI: 10.1159/000015001

PubMed ID: 10601738

Title: Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan.

PubMed ID: 10601738

DOI: 10.1016/s0945-053x(99)00043-8

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9813076

Title: SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan.

PubMed ID: 9813076

DOI: 10.1074/jbc.273.47.31599

PubMed ID: 9719680

Title: Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis.

PubMed ID: 9719680

DOI: 10.1093/glycob/8.10.997

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 14691150

Title: The benign concentric annular macular dystrophy locus maps to 6p12.3-q16.

PubMed ID: 14691150

DOI: 10.1167/iovs.03-0392

PubMed ID: 23993198

Title: Mutations in IMPG1 cause vitelliform macular dystrophies.

PubMed ID: 23993198

DOI: 10.1016/j.ajhg.2013.07.018

PubMed ID: 25085631

Title: Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes.

PubMed ID: 25085631

DOI: 10.1016/j.ophtha.2014.06.028

PubMed ID: 28644393

Title: Mutations in the Genes for Interphotoreceptor Matrix Proteoglycans, IMPG1 and IMPG2, in Patients with Vitelliform Macular Lesions.

PubMed ID: 28644393

DOI: 10.3390/genes8070170

PubMed ID: 32817297

Title: Pathogenic variants in IMPG1 cause autosomal dominant and autosomal recessive retinitis pigmentosa.

PubMed ID: 32817297

DOI: 10.1136/jmedgenet-2020-107150

PubMed ID: 30688845

Title: Unusual early-onset vitelliform dystrophy possibly linked to the interphotoreceptor matrix proteoglycan-1 p.Leu154Pro mutation.

PubMed ID: 30688845

DOI: 10.1097/icb.0000000000000843

Sequence Information:

  • Length: 797
  • Mass: 89387
  • Checksum: D017ED090C78D521
  • Sequence:
    • MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK MYKMSTMRRI 
FDLAKHRTKR SAFFPTGVKV CPQESMKQIL DSLQAYYRLR VCQEAVWEAY RIFLDRIPDT 
GEYQDWVSIC QQETFCLFDI GKNFSNSQEH LDLLQQRIKQ RSFPDRKDEI SAEKTLGEPG 
ETIVISTDVA NVSLGPFPLT PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV 
SLVNQKFKAE LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST 
EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL TATDLKRLIS 
KALEEEQSLD VGTIQFTDEI AGSLPAFGPD TQSELPTSFA VITEDATLSP ELPPVEPQLE 
TVDGAEHGLP DTSWSPPAMA STSLSEAPPF FMASSIFSLT DQGTTDTMAT DQTMLVPGLT 
IPTSDYSAIS QLALGISHPP ASSDDSRSSA GGEDMVRHLD EMDLSDTPAP SEVPELSEYV 
SVPDHFLEDT TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA 
LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT KAVHGVLEDF 
RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV KNERTEEAEC RCKPGYDSQG 
SLDGLEPGLC GPGTKECEVL QGKGAPCRLP DHSENQAYKT SVKKFQNQQN NKVISKRNSE 
LLTVEYEEFN HQDWEGN

Genular Protein ID: 3045516207

Symbol: A0A087WYL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYL3

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 719
  • Mass: 80147
  • Checksum: 547304511C058F3A
  • Sequence:
    • MYLETRRAIF VFWIFLQVQG TKVCQEAVWE AYRIFLDRIP DTGEYQDWVS ICQQETFCLF 
DIGKNFSNSQ EHLDLLQQRI KQRSFPDRKD EISAEKTLGE PGETIVISTD VANVSLGPFP 
LTPDDTLLNE ILDNTLNDTK MPTTERETEF AVLEEQRVEL SVSLVNQKFK AELADSQSPY 
YQELAGKSQL QMQKIFKKLP GFKKIHVLGF RPKKEKDGSS STEMQLTAIF KRHSAEAKSP 
ASDLLSFDSN KIESEEVYHG TMEEDKQPEI YLTATDLKRL ISKALEEEQS LDVGTIQFTD 
EIAGSLPAFG PDTQSELPTS FAVITEDATL SPELPPVEPQ LETVDGAEHG LPDTSWSPPA 
MASTSLSEAP PFFMASSIFS LTDQGTTDTM ATDQTMLVPG LTIPTSDYSA ISQLALGISH 
PPASSDDSRS SAGGEDMVRH LDEMDLSDTP APSEVPELSE YVSVPDHFLE DTTPVSALQY 
ITTSSMTIAP KGRELVVFFS LRVANMAFSN DLFNKSSLEY RALEQQFTQL LVPYLRSNLT 
GFKQLEILNF RNGSVIVNSK MKFAKSVPYN LTKAVHGVLE DFRSAAAQQL HLEIDSYSLN 
IEPADQADPC KFLACGEFAQ CVKNERTEEA ECRCKPGYDS QGSLDGLEPG LCGPGTKECE 
VLQGKGAPCR LPDHSENQAY KTSVKKFQNQ QNNKVISKRN SELLTVEYEE FNHQDWEGN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.