Details for: SFRP5

Gene ID: 6425

Symbol: SFRP5

Ensembl ID: ENSG00000120057

Description: secreted frizzled related protein 5

Associated with

  • Anatomical structure morphogenesis
    (GO:0009653)
  • Apoptotic process
    (GO:0006915)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cell differentiation
    (GO:0030154)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Establishment or maintenance of cell polarity
    (GO:0007163)
  • Extracellular space
    (GO:0005615)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of non-canonical wnt signaling pathway
    (GO:2000051)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of wnt signaling pathway
    (GO:0030178)
  • Non-canonical wnt signaling pathway
    (GO:0035567)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Signal transduction
    (GO:0007165)
  • Visual perception
    (GO:0007601)
  • Wnt-protein binding
    (GO:0017147)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.4518
    Cell Significance Index: -4.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5078
    Cell Significance Index: -4.3300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.6752
    Cell Significance Index: 23.1400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.6286
    Cell Significance Index: 9.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2648
    Cell Significance Index: 431.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.0796
    Cell Significance Index: -4.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9143
    Cell Significance Index: 54.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8787
    Cell Significance Index: 39.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7714
    Cell Significance Index: 22.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7657
    Cell Significance Index: 89.2300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.6399
    Cell Significance Index: 4.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4908
    Cell Significance Index: 15.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4899
    Cell Significance Index: 53.2900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4363
    Cell Significance Index: 6.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4190
    Cell Significance Index: 378.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3130
    Cell Significance Index: 21.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2996
    Cell Significance Index: 29.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1937
    Cell Significance Index: 31.5100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1672
    Cell Significance Index: 2.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1422
    Cell Significance Index: 3.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0981
    Cell Significance Index: 1.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0889
    Cell Significance Index: 1.3400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0604
    Cell Significance Index: 0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0598
    Cell Significance Index: 10.2100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0555
    Cell Significance Index: 0.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0328
    Cell Significance Index: 0.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0023
    Cell Significance Index: 1.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0023
    Cell Significance Index: 1.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0017
    Cell Significance Index: 3.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0005
    Cell Significance Index: 0.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0007
    Cell Significance Index: -0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0009
    Cell Significance Index: -0.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0021
    Cell Significance Index: -0.9300
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0036
    Cell Significance Index: -0.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0037
    Cell Significance Index: -2.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0039
    Cell Significance Index: -7.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0055
    Cell Significance Index: -1.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0059
    Cell Significance Index: -7.9800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0066
    Cell Significance Index: -0.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0076
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0078
    Cell Significance Index: -0.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0079
    Cell Significance Index: -1.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0088
    Cell Significance Index: -1.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0115
    Cell Significance Index: -0.1300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0121
    Cell Significance Index: -0.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0177
    Cell Significance Index: -0.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0179
    Cell Significance Index: -0.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0182
    Cell Significance Index: -1.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0184
    Cell Significance Index: -0.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0189
    Cell Significance Index: -0.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0215
    Cell Significance Index: -4.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0231
    Cell Significance Index: -4.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0260
    Cell Significance Index: -3.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0273
    Cell Significance Index: -1.9300
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0340
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0377
    Cell Significance Index: -4.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0383
    Cell Significance Index: -0.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0394
    Cell Significance Index: -4.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0422
    Cell Significance Index: -4.3100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0438
    Cell Significance Index: -0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0470
    Cell Significance Index: -1.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0497
    Cell Significance Index: -3.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0653
    Cell Significance Index: -4.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0671
    Cell Significance Index: -0.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0678
    Cell Significance Index: -5.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0684
    Cell Significance Index: -3.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0719
    Cell Significance Index: -1.2400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0720
    Cell Significance Index: -1.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0761
    Cell Significance Index: -4.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0826
    Cell Significance Index: -2.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0844
    Cell Significance Index: -5.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0852
    Cell Significance Index: -0.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0865
    Cell Significance Index: -1.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0903
    Cell Significance Index: -4.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0941
    Cell Significance Index: -5.2800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0958
    Cell Significance Index: -1.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1009
    Cell Significance Index: -2.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1011
    Cell Significance Index: -3.3100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1021
    Cell Significance Index: -1.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1069
    Cell Significance Index: -4.7300
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1074
    Cell Significance Index: -0.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1113
    Cell Significance Index: -3.9000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.1185
    Cell Significance Index: -0.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1204
    Cell Significance Index: -5.6600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1208
    Cell Significance Index: -1.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1246
    Cell Significance Index: -4.7200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1262
    Cell Significance Index: -4.0200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1263
    Cell Significance Index: -3.1500
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1291
    Cell Significance Index: -1.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1365
    Cell Significance Index: -3.4100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1378
    Cell Significance Index: -0.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1435
    Cell Significance Index: -3.8500
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1451
    Cell Significance Index: -0.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SFRP5 is a secreted protein belonging to the Frizzled-related protein family. It is characterized by its ability to bind to Wnt proteins, thereby inhibiting their interaction with Frizzled receptors and subsequent activation of downstream signaling pathways. SFRP5 is primarily expressed in epithelial tissues, including the colon, pancreas, and mesothelium, where it plays a crucial role in maintaining tissue homeostasis. Notably, SFRP5 has been shown to be expressed in various immune cells, including double-negative thymocytes and granulocyte-monocyte progenitors, which suggests its potential involvement in immune regulation. **Pathways and Functions:** SFRP5's primary function is to regulate the canonical Wnt signaling pathway, which is involved in various developmental and cellular processes. By binding to Wnt proteins, SFRP5 prevents their interaction with Frizzled receptors, thereby inhibiting the activation of downstream signaling components, including β-catenin, T-cell factor (TCF), and lymphoid enhancer-binding factor (LEF). This inhibition of Wnt signaling has been shown to regulate cell proliferation, differentiation, and survival in various tissues, including the colon, pancreas, and immune cells. Additionally, SFRP5 has been implicated in the regulation of non-canonical Wnt signaling pathways, including the planar cell polarity (PCP) and Wnt/Ca2+ signaling pathways. **Clinical Significance:** SFRP5 has been implicated in various disease contexts, including colorectal cancer, where its expression is often downregulated. Studies have shown that SFRP5 acts as a tumor suppressor by inhibiting Wnt signaling, which is frequently dysregulated in colorectal cancer. Furthermore, SFRP5 has been implicated in other diseases, including inflammatory bowel disease, where its expression is often altered. In the context of immunology, SFRP5 has been identified as a potential biomarker for various immune-related disorders, including autoimmune diseases and cancer. Its role in regulating Wnt signaling pathways suggests that it may be a useful therapeutic target for the treatment of diseases characterized by dysregulated Wnt signaling. In conclusion, SFRP5 is a critical regulator of Wnt signaling pathways, with significant implications for immunology and other biological processes. Further research is needed to fully elucidate the mechanisms by which SFRP5 regulates Wnt signaling and its role in various disease contexts.

Genular Protein ID: 2527655549

Symbol: SFRP5_HUMAN

Name: Secreted frizzled-related protein 5

UniProtKB Accession Codes:

Q5T4F7 O14780 Q86TH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9391078

Title: SARPs: a family of secreted apoptosis-related proteins.

PubMed ID: 9391078

DOI: 10.1073/pnas.94.25.13636

PubMed ID: 9642118

Title: Tissue restricted expression of two human Frzbs in preadipocytes and pancreas.

PubMed ID: 9642118

DOI: 10.1006/bbrc.1998.8784

PubMed ID: 10072424

Title: Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium.

PubMed ID: 10072424

DOI: 10.1093/hmg/8.4.575

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 317
  • Mass: 35563
  • Checksum: 4BF060F1161751F9
  • Sequence:
    • MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP PQCLDIPADL 
PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC HSDTQVFLCS LFAPVCLDRP 
IYPCRSLCEA VRAGCAPLME AYGFPWPEML HCHKFPLDND LCIAVQFGHL PATAPPVTKI 
CAQCEMEHSA DGLMEQMCSS DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT 
KRLVLHMKNG AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS 
YPCSLYYPFF YGAAEPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.