Details for: NID1

Gene ID: 4811

Symbol: NID1

Ensembl ID: ENSG00000116962

Description: nidogen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 145.2311
    Cell Significance Index: -22.5900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 56.8762
    Cell Significance Index: -23.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.7683
    Cell Significance Index: -22.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.3125
    Cell Significance Index: -25.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.3500
    Cell Significance Index: -22.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.3675
    Cell Significance Index: -22.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.4110
    Cell Significance Index: -22.7000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 14.9465
    Cell Significance Index: 101.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6588
    Cell Significance Index: -22.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 4.0943
    Cell Significance Index: 58.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.1886
    Cell Significance Index: 40.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.0458
    Cell Significance Index: 87.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9806
    Cell Significance Index: 95.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.7791
    Cell Significance Index: 54.2400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.5959
    Cell Significance Index: 16.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9443
    Cell Significance Index: 385.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9321
    Cell Significance Index: 148.2700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.5406
    Cell Significance Index: 19.4000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.4689
    Cell Significance Index: 8.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.4628
    Cell Significance Index: 24.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3941
    Cell Significance Index: 191.4500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.3489
    Cell Significance Index: 21.4000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.3237
    Cell Significance Index: 10.4500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.2657
    Cell Significance Index: 6.6600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.1146
    Cell Significance Index: 16.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9854
    Cell Significance Index: 49.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.9618
    Cell Significance Index: 50.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.7862
    Cell Significance Index: 4.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6038
    Cell Significance Index: 114.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5696
    Cell Significance Index: 25.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5136
    Cell Significance Index: 184.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4873
    Cell Significance Index: 62.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4452
    Cell Significance Index: 3.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3621
    Cell Significance Index: 35.8200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.3564
    Cell Significance Index: 1.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3531
    Cell Significance Index: 543.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3392
    Cell Significance Index: 7.1000
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.3075
    Cell Significance Index: 1.4200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2647
    Cell Significance Index: 238.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2514
    Cell Significance Index: 3.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2213
    Cell Significance Index: 100.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1959
    Cell Significance Index: 31.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1882
    Cell Significance Index: 3.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1578
    Cell Significance Index: 290.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1217
    Cell Significance Index: 13.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1193
    Cell Significance Index: 75.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1091
    Cell Significance Index: 13.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0544
    Cell Significance Index: 9.8100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0382
    Cell Significance Index: 0.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0195
    Cell Significance Index: 0.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0176
    Cell Significance Index: 33.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0150
    Cell Significance Index: 0.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0071
    Cell Significance Index: 9.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0059
    Cell Significance Index: -0.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0083
    Cell Significance Index: -0.1400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0093
    Cell Significance Index: -0.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0112
    Cell Significance Index: -8.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0115
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0135
    Cell Significance Index: -8.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0153
    Cell Significance Index: -6.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0168
    Cell Significance Index: -11.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0211
    Cell Significance Index: -11.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0213
    Cell Significance Index: -3.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0249
    Cell Significance Index: -13.6200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0332
    Cell Significance Index: -24.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0344
    Cell Significance Index: -0.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0396
    Cell Significance Index: -4.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0515
    Cell Significance Index: -10.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0612
    Cell Significance Index: -12.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0615
    Cell Significance Index: -10.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0638
    Cell Significance Index: -4.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0747
    Cell Significance Index: -4.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0759
    Cell Significance Index: -21.8500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0867
    Cell Significance Index: -1.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0878
    Cell Significance Index: -5.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0932
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1294
    Cell Significance Index: -14.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1442
    Cell Significance Index: -16.8000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1631
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1769
    Cell Significance Index: -20.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1901
    Cell Significance Index: -24.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1916
    Cell Significance Index: -19.5800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2093
    Cell Significance Index: -1.3100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2116
    Cell Significance Index: -2.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2271
    Cell Significance Index: -26.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2433
    Cell Significance Index: -17.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2823
    Cell Significance Index: -18.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2893
    Cell Significance Index: -17.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3081
    Cell Significance Index: -14.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3091
    Cell Significance Index: -24.4800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.3736
    Cell Significance Index: -3.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3911
    Cell Significance Index: -25.2300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4076
    Cell Significance Index: -18.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4274
    Cell Significance Index: -22.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4339
    Cell Significance Index: -22.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4541
    Cell Significance Index: -15.7800
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4658
    Cell Significance Index: -5.6700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.4753
    Cell Significance Index: -5.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NID1 is a proteoglycan that consists of a core protein domain and a highly glycosylated protein backbone. Its unique structure allows it to interact with various extracellular matrix components, including collagen, laminin, and proteoglycans, thereby modulating cell-matrix adhesion and signaling. The presence of NID1 has been linked to the maintenance of basement membrane integrity, cell-substrate adhesion, and the regulation of integrin-mediated signaling pathways. Moreover, NID1 has been implicated in the development and organization of various tissues, including the glomerular basement membrane, skin, and muscle. **Pathways and Functions:** NID1 is involved in several key signaling pathways, including canonical Wnt signaling, which regulates cell proliferation, differentiation, and survival. Its interactions with Wnt proteins have been shown to modulate the activity of Wnt receptors, thereby influencing downstream signaling events. Additionally, NID1 has been implicated in the regulation of cell-substrate adhesion, integrin-mediated signaling, and muscle cell differentiation. The gene's expression in various cell types suggests its role in tissue homeostasis and development, particularly in the formation and maintenance of basement membranes. **Clinical Significance:** Dysregulation of NID1 has been implicated in various diseases, including fibrosis, cancer, and neurological disorders. For instance, mutations in the NID1 gene have been linked to fibrosis in various organs, including the skin, lungs, and kidneys. Furthermore, alterations in NID1 expression have been observed in cancer, where it may contribute to tumor progression and metastasis. In the nervous system, NID1 has been implicated in the development and maintenance of the glomerular basement membrane, and its dysregulation may contribute to neurological disorders, such as multiple sclerosis. Overall, further research is needed to elucidate the complex functions of NID1 and its role in human disease. In conclusion, NID1 is a multifunctional gene that plays a critical role in the organization and integrity of the basement membrane. Its interactions with various extracellular matrix components and signaling pathways highlight its importance in tissue homeostasis and development. Further research is necessary to fully understand the complexities of NID1 and its role in human disease, but its significance in the field of immunology and tissue biology is undeniable.

Genular Protein ID: 1377206553

Symbol: NID1_HUMAN

Name: Nidogen-1

UniProtKB Accession Codes:

P14543 Q14942 Q59FL2 Q5TAF2 Q5TAF3 Q86XD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 26 Ensembl 2 GO 23 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 10 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2574658

Title: Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene.

PubMed ID: 2574658

DOI: 10.1089/dna.1989.8.581

PubMed ID: 7557988

Title: Genomic sequences and structural organization of the human nidogen gene (NID).

PubMed ID: 7557988

DOI: 10.1006/geno.1995.1038

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1906509

Title: Human nidogen gene: structural and functional characterization of the 5'-flanking region.

PubMed ID: 1906509

DOI: 10.1111/1523-1747.ep12480380

PubMed ID: 2471408

Title: Human nidogen: cDNA cloning, cellular expression, and mapping of the gene to chromosome 1q43.

PubMed ID: 2471408

PubMed ID: 16574105

Title: Identification of the basement membrane protein nidogen as a candidate ligand for tumor endothelial marker 7 in vitro and in vivo.

PubMed ID: 16574105

DOI: 10.1016/j.febslet.2006.03.033

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1247
  • Mass: 136377
  • Checksum: FCC839416525CD48
  • Sequence:
    • MLASSSRIRA AWTRALLLPL LLAGPVGCLS RQELFPFGPG QGDLELEDGD DFVSPALELS 
GALRFYDRSD IDAVYVTTNG IIATSEPPAK ESHPGLFPPT FGAVAPFLAD LDTTDGLGKV 
YYREDLSPSI TQRAAECVHR GFPEISFQPS SAVVVTWESV APYQGPSRDP DQKGKRNTFQ 
AVLASSDSSS YAIFLYPEDG LQFHTTFSKK ENNQVPAVVA FSQGSVGFLW KSNGAYNIFA 
NDRESVENLA KSSNSGQQGV WVFEIGSPAT TNGVVPADVI LGTEDGAEYD DEDEDYDLAT 
TRLGLEDVGT TPFSYKALRR GGADTYSVPS VLSPRRAATE RPLGPPTERT RSFQLAVETF 
HQQHPQVIDV DEVEETGVVF SYNTDSRQTC ANNRHQCSVH AECRDYATGF CCSCVAGYTG 
NGRQCVAEGS PQRVNGKVKG RIFVGSSQVP IVFENTDLHS YVVMNHGRSY TAISTIPETV 
GYSLLPLAPV GGIIGWMFAV EQDGFKNGFS ITGGEFTRQA EVTFVGHPGN LVIKQRFSGI 
DEHGHLTIDT ELEGRVPQIP FGSSVHIEPY TELYHYSTSV ITSSSTREYT VTEPERDGAS 
PSRIYTYQWR QTITFQECVH DDSRPALPST QQLSVDSVFV LYNQEEKILR YALSNSIGPV 
REGSPDALQN PCYIGTHGCD TNAACRPGPR TQFTCECSIG FRGDGRTCYD IDECSEQPSV 
CGSHTICNNH PGTFRCECVE GYQFSDEGTC VAVVDQRPIN YCETGLHNCD IPQRAQCIYT 
GGSSYTCSCL PGFSGDGQAC QDVDECQPSR CHPDAFCYNT PGSFTCQCKP GYQGDGFRCV 
PGEVEKTRCQ HEREHILGAA GATDPQRPIP PGLFVPECDA HGHYAPTQCH GSTGYCWCVD 
RDGREVEGTR TRPGMTPPCL STVAPPIHQG PAVPTAVIPL PPGTHLLFAQ TGKIERLPLE 
GNTMRKTEAK AFLHVPAKVI IGLAFDCVDK MVYWTDITEP SIGRASLHGG EPTTIIRQDL 
GSPEGIAVDH LGRNIFWTDS NLDRIEVAKL DGTQRRVLFE TDLVNPRGIV TDSVRGNLYW 
TDWNRDNPKI ETSYMDGTNR RILVQDDLGL PNGLTFDAFS SQLCWVDAGT NRAECLNPSQ 
PSRRKALEGL QYPFAVTSYG KNLYFTDWKM NSVVALDLAI SKETDAFQPH KQTRLYGITT 
ALSQCPQGHN YCSVNNGGCT HLCLATPGSR TCRCPDNTLG VDCIEQK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.