Details for: SLC8A1

Gene ID: 6546

Symbol: SLC8A1

Ensembl ID: ENSG00000183023

Description: solute carrier family 8 member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 10.71
    Marker Score: 64344
  • Cell Name: granule cell (CL0000120)
    Fold Change: 7.16
    Marker Score: 53961
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.16
    Marker Score: 109418
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 5.9
    Marker Score: 31711
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 5.85
    Marker Score: 13439
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 5.53
    Marker Score: 4777
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 5.48
    Marker Score: 122365
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 5.32
    Marker Score: 22171
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.11
    Marker Score: 7188
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.06
    Marker Score: 1827
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.68
    Marker Score: 15695
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 4.23
    Marker Score: 22191
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.18
    Marker Score: 3148
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 4.17
    Marker Score: 14809.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.04
    Marker Score: 53745
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.71
    Marker Score: 1782
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.7
    Marker Score: 1839
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 3.32
    Marker Score: 2561
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 3.19
    Marker Score: 1431
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.16
    Marker Score: 1834
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.06
    Marker Score: 971
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.99
    Marker Score: 5016
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57886
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.86
    Marker Score: 2723
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.84
    Marker Score: 42531
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.79
    Marker Score: 12927
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.74
    Marker Score: 92503
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.73
    Marker Score: 5255.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.68
    Marker Score: 20551
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.51
    Marker Score: 7166
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.46
    Marker Score: 1334
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.36
    Marker Score: 906
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.35
    Marker Score: 9076
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.28
    Marker Score: 2821
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.2
    Marker Score: 3110
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.19
    Marker Score: 20639
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.19
    Marker Score: 9071
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.18
    Marker Score: 80525
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.14
    Marker Score: 897
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.12
    Marker Score: 722
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.08
    Marker Score: 688
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.08
    Marker Score: 608
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.08
    Marker Score: 21439
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.07
    Marker Score: 127399
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.05
    Marker Score: 1081
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.97
    Marker Score: 8235
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18318
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.92
    Marker Score: 6802.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.91
    Marker Score: 7793
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.89
    Marker Score: 480
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16138
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.88
    Marker Score: 618
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.88
    Marker Score: 1878
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.82
    Marker Score: 2270
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.75
    Marker Score: 2181
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.72
    Marker Score: 650
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.7
    Marker Score: 947
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.7
    Marker Score: 949
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2539
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.62
    Marker Score: 1870
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.6
    Marker Score: 898
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.6
    Marker Score: 436
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.58
    Marker Score: 3980
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.52
    Marker Score: 2764
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1508
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.5
    Marker Score: 3056
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.49
    Marker Score: 1578
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.49
    Marker Score: 451
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.46
    Marker Score: 2846
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.46
    Marker Score: 3518
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.45
    Marker Score: 3405.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.45
    Marker Score: 2937
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.44
    Marker Score: 1734
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.4
    Marker Score: 510
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.38
    Marker Score: 357
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.36
    Marker Score: 1559
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21290
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.35
    Marker Score: 1446
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.35
    Marker Score: 1272.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.33
    Marker Score: 1458
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.31
    Marker Score: 409
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.3
    Marker Score: 924
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.29
    Marker Score: 72278
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.29
    Marker Score: 481
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.29
    Marker Score: 48842
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.28
    Marker Score: 1549
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 742
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.22
    Marker Score: 3171
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.18
    Marker Score: 446
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.18
    Marker Score: 30167
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.17
    Marker Score: 1196
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.16
    Marker Score: 373
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.15
    Marker Score: 810
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.14
    Marker Score: 747
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.12
    Marker Score: 294
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1
    Marker Score: 620
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.09
    Marker Score: 23356
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.07
    Marker Score: 638
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.06
    Marker Score: 393

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key Characteristics:** The SLC8A1 gene exhibits the following key characteristics: 1. **Transmembrane protein**: The NCX1 protein is a transmembrane protein that spans the plasma membrane, allowing it to interact with both the cytosol and the extracellular environment. 2. **Sodium/calcium exchanger**: The NCX1 protein facilitates the exchange of sodium and calcium ions across cell membranes, regulating the concentration of calcium ions within cells. 3. **Calcium homeostasis**: The NCX1 protein plays a crucial role in maintaining calcium homeostasis in various tissues, including the heart, neurons, and smooth muscle cells. 4. **Regulation of cardiac conduction**: The NCX1 protein is involved in regulating cardiac conduction by controlling the concentration of calcium ions within cardiac muscle cells. 5. **Neuronal signaling**: The NCX1 protein is also involved in neuronal signaling, regulating the concentration of calcium ions within neurons. **Pathways and Functions:** The SLC8A1 gene is involved in various pathways and functions, including: 1. **Calcium ion homeostasis**: The NCX1 protein regulates the concentration of calcium ions within cells, maintaining calcium homeostasis in various tissues. 2. **Cardiac conduction**: The NCX1 protein is involved in regulating cardiac conduction by controlling the concentration of calcium ions within cardiac muscle cells. 3. **Neuronal signaling**: The NCX1 protein regulates the concentration of calcium ions within neurons, facilitating neuronal signaling. 4. **Smooth muscle contraction**: The NCX1 protein is involved in regulating smooth muscle contraction by controlling the concentration of calcium ions within smooth muscle cells. 5. **Gene expression**: The NCX1 protein regulates gene expression by controlling the concentration of calcium ions within cells. **Clinical Significance:** Dysregulation of the SLC8A1 gene has been implicated in various cardiovascular and neurological disorders, including: 1. **Hypertrophic cardiomyopathy**: Mutations in the SLC8A1 gene have been associated with hypertrophic cardiomyopathy, a condition characterized by abnormal cardiac muscle growth. 2. **Arrhythmias**: Dysregulation of the NCX1 protein has been implicated in arrhythmias, including atrial fibrillation and ventricular tachycardia. 3. **Neurodegenerative diseases**: Mutations in the SLC8A1 gene have been associated with neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Smooth muscle disorders**: Dysregulation of the NCX1 protein has been implicated in smooth muscle disorders, including hypertension and atherosclerosis. In conclusion, the SLC8A1 gene plays a critical role in regulating calcium homeostasis in various tissues, including the heart, neurons, and smooth muscle cells. Dysregulation of the SLC8A1 gene has been implicated in various cardiovascular and neurological disorders, highlighting the importance of this gene in maintaining cellular homeostasis.

Genular Protein ID: 1615937725

Symbol: NAC1_HUMAN

Name: Sodium/calcium exchanger 1

UniProtKB Accession Codes:

P32418 A8K6N1 D6W595 O95849 Q4QQG6 Q587I6 Q59GN4 Q9UBL8 Q9UD55 Q9UDN1 Q9UDN2 Q9UKX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChEBI 29 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 ELM 1 EMBL 17 EPD 1 Ensembl 9 ExpressionAtlas 1 GO 55 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 3 RefSeq 23 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1374913

Title: Molecular cloning and characterization of the human cardiac Na+/Ca2+ exchanger cDNA.

PubMed ID: 1374913

DOI: 10.1073/pnas.89.10.4769

PubMed ID: 11241183

Title: NCX1 Na/Ca exchanger splice variants in pancreatic islet cells.

PubMed ID: 11241183

DOI: 10.1677/joe.0.1680517

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 10908415

Title: Na+/Ca2+ exchanger isoforms of rat odontoblasts and osteoblasts.

PubMed ID: 10908415

DOI: 10.1007/s00223001098

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8048567

Title: Functional expression of human renal Na+/Ca2+ exchanger in insect cells.

PubMed ID: 8048567

DOI: 10.1152/ajprenal.1994.267.1.f70

PubMed ID: 1476165

Title: Expression of the Na-Ca exchanger in diverse tissues: a study using the cloned human cardiac Na-Ca exchanger.

PubMed ID: 1476165

DOI: 10.1152/ajpcell.1992.263.6.c1241

PubMed ID: 23376057

Title: The topology of the cardiac Na(+)/Ca(2)(+) exchanger, NCX1.

PubMed ID: 23376057

DOI: 10.1016/j.yjmcc.2013.01.010

PubMed ID: 23506867

Title: The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.

PubMed ID: 23506867

DOI: 10.1016/j.mam.2012.07.003

Sequence Information:

  • Length: 973
  • Mass: 108547
  • Checksum: 17DFC1B1F15921D8
  • Sequence:
    • MYNMRRLSLS PTFSMGFHLL VTVSLLFSHV DHVIAETEME GEGNETGECT GSYYCKKGVI 
LPIWEPQDPS FGDKIARATV YFVAMVYMFL GVSIIADRFM SSIEVITSQE KEITIKKPNG 
ETTKTTVRIW NETVSNLTLM ALGSSAPEIL LSVIEVCGHN FTAGDLGPST IVGSAAFNMF 
IIIALCVYVV PDGETRKIKH LRVFFVTAAW SIFAYTWLYI ILSVISPGVV EVWEGLLTFF 
FFPICVVFAW VADRRLLFYK YVYKRYRAGK QRGMIIEHEG DRPSSKTEIE MDGKVVNSHV 
ENFLDGALVL EVDERDQDDE EARREMARIL KELKQKHPDK EIEQLIELAN YQVLSQQQKS 
RAFYRIQATR LMTGAGNILK RHAADQARKA VSMHEVNTEV TENDPVSKIF FEQGTYQCLE 
NCGTVALTII RRGGDLTNTV FVDFRTEDGT ANAGSDYEFT EGTVVFKPGD TQKEIRVGII 
DDDIFEEDEN FLVHLSNVKV SSEASEDGIL EANHVSTLAC LGSPSTATVT IFDDDHAGIF 
TFEEPVTHVS ESIGIMEVKV LRTSGARGNV IVPYKTIEGT ARGGGEDFED TCGELEFQND 
EIVKTISVKV IDDEEYEKNK TFFLEIGEPR LVEMSEKKAL LLNELGGFTI TGKYLFGQPV 
FRKVHAREHP ILSTVITIAD EYDDKQPLTS KEEEERRIAE MGRPILGEHT KLEVIIEESY 
EFKSTVDKLI KKTNLALVVG TNSWREQFIE AITVSAGEDD DDDECGEEKL PSCFDYVMHF 
LTVFWKVLFA FVPPTEYWNG WACFIVSILM IGLLTAFIGD LASHFGCTIG LKDSVTAVVF 
VALGTSVPDT FASKVAATQD QYADASIGNV TGSNAVNVFL GIGVAWSIAA IYHAANGEQF 
KVSPGTLAFS VTLFTIFAFI NVGVLLYRRR PEIGGELGGP RTAKLLTSCL FVLLWLLYIF 
FSSLEAYCHI KGF

Genular Protein ID: 3556124666

Symbol: Q4QQH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4QQH3

Database IDs:

ARBA 20 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 2 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 384
  • Mass: 42734
  • Checksum: 759F0B6C87D899AF
  • Sequence:
    • DTCGELEFQN DEIVKTISVK VIDDEEYEKN KTFFLEIGEP RLVEMSEKKA LLLNELGGFT 
ITGKYLFGQP VFRKVHAREH PILSTVITIA DEYDDKQPLT SKEEEERRIA EMGRPILGEH 
TKLEVIIEES YEFKSTVDKL IKKTNLALVV GTNSWREQFI EAITVSAGED DDDDECGEEK 
LPSCFDYVMH FLTVFWKVLF AFVPPTEYWN GWACFIVSIL MIGLLTAFIG DLASHFGCTI 
GLKDSVTAVV FVALGTSVPD TFASKVAATQ DQYADASIGN VTGSNAVNVF LGIGVAWSIA 
AIYHAANGEQ FKVSPGTLAF SVTLFTIFAF INVGVLLYRR RPEIGGELGG PRTAKLLTSC 
LFVLLWLLYI FFSSLEAYCH IKGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.