Details for: HSD17B2

Gene ID: 3294

Symbol: HSD17B2

Ensembl ID: ENSG00000086696

Description: hydroxysteroid 17-beta dehydrogenase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.59
    Marker Score: 10839.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.46
    Marker Score: 11816
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.08
    Marker Score: 2798
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.01
    Marker Score: 587
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.83
    Marker Score: 2817
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.81
    Marker Score: 5689
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.72
    Marker Score: 5624
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.59
    Marker Score: 2344
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.5
    Marker Score: 878
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.37
    Marker Score: 5930
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.36
    Marker Score: 3334
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.3
    Marker Score: 315
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.29
    Marker Score: 6916.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.27
    Marker Score: 508
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.26
    Marker Score: 1306
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.23
    Marker Score: 7928
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.08
    Marker Score: 1305
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Marker Score: 6526
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.06
    Marker Score: 305
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.04
    Marker Score: 266
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251799
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.02
    Marker Score: 254
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1850
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.97
    Marker Score: 2294
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1540
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.92
    Marker Score: 1766
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.91
    Marker Score: 2072
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.85
    Marker Score: 754.5
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.83
    Marker Score: 831
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.83
    Marker Score: 6172
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.78
    Marker Score: 285.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 307
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.73
    Marker Score: 276
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 667
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.73
    Marker Score: 4627
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.72
    Marker Score: 146
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.72
    Marker Score: 491
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.71
    Marker Score: 205
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.71
    Marker Score: 240
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1423
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2806
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.66
    Marker Score: 209
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.61
    Marker Score: 587
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.57
    Marker Score: 164
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.57
    Marker Score: 686
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1249
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.53
    Marker Score: 564
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5
    Marker Score: 529
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.46
    Marker Score: 540
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.45
    Marker Score: 169
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.45
    Marker Score: 232
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.45
    Marker Score: 168
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.43
    Marker Score: 112
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6581
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.41
    Marker Score: 245
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.4
    Marker Score: 87
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.39
    Marker Score: 107
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.38
    Marker Score: 177
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.36
    Marker Score: 114
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.35
    Marker Score: 143.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.33
    Marker Score: 366
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.33
    Marker Score: 151
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.32
    Marker Score: 318
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.31
    Marker Score: 90
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 401
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.3
    Marker Score: 351
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 142
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.29
    Marker Score: 257
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.29
    Marker Score: 141
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.29
    Marker Score: 198
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.28
    Marker Score: 505
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.28
    Marker Score: 391
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.28
    Marker Score: 137
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.27
    Marker Score: 109
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.27
    Marker Score: 484.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.26
    Marker Score: 413
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.26
    Marker Score: 224
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 112
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.24
    Marker Score: 111
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 75
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.23
    Marker Score: 220
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.22
    Marker Score: 608

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Other Information

**Key characteristics:** - DHB2 is a multi-functional enzyme that can be found in various cellular locations, including the liver, kidney, and prostate. - It is responsible for the metabolism of steroid hormones, including estrogen and testosterone. - DHB2 is also involved in the biosynthesis of androgens, which are responsible for the development of male reproductive characteristics. - It is a key enzyme in the production of estradiol, a hormone that regulates the menstrual cycle and breast development. **Pathways and functions:** - DHB2 is involved in the following pathways: - Estrogen biosynthesis - Androgen metabolic process - Steroid metabolic process - Metabolism of steroids - It plays a crucial role in the production of estradiol, which is responsible for the development of female reproductive characteristics. - DHB2 is also involved in the metabolism of androgens, which can lead to the development of male reproductive characteristics. **Clinical significance:** - Mutations in the HSD17B2 gene have been linked to certain human diseases, including breast cancer, prostate cancer, and infertility. - Overexpression of DHB2 has been linked to the development of breast cancer. - Inhibition of DHB2 has been shown to inhibit the growth of cancer cells. **Additional notes:** - DHB2 is a highly regulated gene, with its expression being influenced by a variety of factors, including sex hormones, growth factors, and cytokines. - Mutations in the HSD17B2 gene can lead to the production of a defective protein that is unable to perform its normal functions. - These mutations can increase the risk of developing certain types of cancer.

Genular Protein ID: 3448144085

Symbol: DHB2_HUMAN

Name: 20 alpha-hydroxysteroid dehydrogenase

UniProtKB Accession Codes:

P37059 B2R7T4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 2 EMBL 11 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8099587

Title: Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.

PubMed ID: 8099587

DOI: 10.1016/s0021-9258(18)31480-7

PubMed ID: 7546291

Title: The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species.

PubMed ID: 7546291

DOI: 10.1089/dna.1995.14.849

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10385431

Title: Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum.

PubMed ID: 10385431

DOI: 10.1210/endo.140.7.6861

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11940569

Title: Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2.

PubMed ID: 11940569

DOI: 10.1074/jbc.m111726200

Sequence Information:

  • Length: 387
  • Mass: 42785
  • Checksum: EDE5606EA041042B
  • Sequence:
    • MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL 
FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG 
AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL 
LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT 
MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI 
LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD 
YFAKRHFGQD KPMPRALRMP NYKKKAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.