Details for: HSD17B2

Gene ID: 3294

Symbol: HSD17B2

Ensembl ID: ENSG00000086696

Description: hydroxysteroid 17-beta dehydrogenase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.0492
    Cell Significance Index: -8.8900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 20.1482
    Cell Significance Index: -8.3000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 15.6475
    Cell Significance Index: 118.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 13.9265
    Cell Significance Index: -9.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.8319
    Cell Significance Index: 302.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 5.3097
    Cell Significance Index: 32.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6699
    Cell Significance Index: -12.5100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 4.2668
    Cell Significance Index: 16.0700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.9475
    Cell Significance Index: 16.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.5989
    Cell Significance Index: 77.9700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.0003
    Cell Significance Index: 50.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2919
    Cell Significance Index: 31.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1979
    Cell Significance Index: 63.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.6701
    Cell Significance Index: 242.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6277
    Cell Significance Index: 73.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.4702
    Cell Significance Index: 22.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4610
    Cell Significance Index: 158.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4011
    Cell Significance Index: 252.5700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.3709
    Cell Significance Index: 13.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1782
    Cell Significance Index: 233.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1168
    Cell Significance Index: 52.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1115
    Cell Significance Index: 2092.8600
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.9704
    Cell Significance Index: 5.8200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.9203
    Cell Significance Index: 5.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8135
    Cell Significance Index: 94.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8107
    Cell Significance Index: 99.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7704
    Cell Significance Index: 53.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7206
    Cell Significance Index: 15.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7045
    Cell Significance Index: 17.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6016
    Cell Significance Index: 382.0500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5243
    Cell Significance Index: 8.6400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.4787
    Cell Significance Index: 2.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4605
    Cell Significance Index: 415.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4566
    Cell Significance Index: 21.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4180
    Cell Significance Index: 67.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3845
    Cell Significance Index: 38.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2735
    Cell Significance Index: 504.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2480
    Cell Significance Index: 28.3100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.2338
    Cell Significance Index: 2.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2114
    Cell Significance Index: 287.4900
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.2088
    Cell Significance Index: 2.0600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1990
    Cell Significance Index: 1.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1980
    Cell Significance Index: 25.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1747
    Cell Significance Index: 5.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1630
    Cell Significance Index: 2.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1333
    Cell Significance Index: 25.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1218
    Cell Significance Index: 13.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0870
    Cell Significance Index: 47.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0802
    Cell Significance Index: 123.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0794
    Cell Significance Index: 2.7900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0758
    Cell Significance Index: 0.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0711
    Cell Significance Index: 1.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0601
    Cell Significance Index: 37.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0583
    Cell Significance Index: 0.8600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0429
    Cell Significance Index: 0.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0382
    Cell Significance Index: 16.8800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0019
    Cell Significance Index: 0.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0079
    Cell Significance Index: -1.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0097
    Cell Significance Index: -7.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.4100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0175
    Cell Significance Index: -0.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0185
    Cell Significance Index: -6.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0226
    Cell Significance Index: -3.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0253
    Cell Significance Index: -1.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0287
    Cell Significance Index: -1.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0309
    Cell Significance Index: -3.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0357
    Cell Significance Index: -10.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0360
    Cell Significance Index: -7.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0647
    Cell Significance Index: -4.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0693
    Cell Significance Index: -4.9000
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.0729
    Cell Significance Index: -0.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0774
    Cell Significance Index: -7.9100
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0908
    Cell Significance Index: -0.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0927
    Cell Significance Index: -2.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0984
    Cell Significance Index: -6.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0988
    Cell Significance Index: -6.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1283
    Cell Significance Index: -8.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1314
    Cell Significance Index: -10.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1320
    Cell Significance Index: -2.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1329
    Cell Significance Index: -2.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1341
    Cell Significance Index: -1.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1421
    Cell Significance Index: -7.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1527
    Cell Significance Index: -11.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1682
    Cell Significance Index: -3.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1710
    Cell Significance Index: -8.9100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1740
    Cell Significance Index: -1.8400
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.1836
    Cell Significance Index: -1.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1880
    Cell Significance Index: -5.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1897
    Cell Significance Index: -9.9600
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.1898
    Cell Significance Index: -1.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1913
    Cell Significance Index: -11.7600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2042
    Cell Significance Index: -6.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2069
    Cell Significance Index: -9.1500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2141
    Cell Significance Index: -7.8600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2494
    Cell Significance Index: -2.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2541
    Cell Significance Index: -8.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B2 is a member of the hydroxysteroid dehydrogenase family, which catalyzes the reduction and oxidation of hydroxysteroid hormones. This enzyme is specifically expressed in various tissues, including the placenta, liver, and reproductive organs. Notably, HSD17B2 is primarily localized to the endoplasmic reticulum and is involved in the conversion of estradiol to estrone, a process that has significant implications for estrogen homeostasis. **Pathways and Functions:** HSD17B2 plays a critical role in the metabolism of steroid hormones, particularly estrogen and testosterone. The enzyme catalyzes the reduction of 17-keto steroid hormones to their corresponding 17-hydroxysteroid hormones. This process is essential for the regulation of various physiological processes, including: 1. **Estrogen biosynthesis:** HSD17B2 is involved in the conversion of estradiol to estrone, which has significant implications for estrogen homeostasis and the regulation of reproductive functions. 2. **Androgen metabolism:** The enzyme also plays a role in the metabolism of testosterone, converting it to 17-hydroxytestosterone, which is then further metabolized to other androgenic compounds. 3. **Intracellular signaling:** HSD17B2 can modulate intracellular signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance:** HSD17B2 has significant clinical implications, particularly in the context of reproductive health and immune regulation. Abnormalities in HSD17B2 expression have been associated with various disorders, including: 1. **Reproductive disorders:** Altered HSD17B2 expression has been linked to reproductive disorders, such as polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). 2. **Cancer:** Abnormal HSD17B2 expression has been implicated in the development and progression of certain cancers, including breast and prostate cancer. 3. **Immune regulation:** HSD17B2 has been shown to modulate immune responses, particularly in the context of autoimmune disorders, such as rheumatoid arthritis. In conclusion, HSD17B2 is a multifaceted enzyme involved in the metabolism of steroid hormones and has significant implications for immune regulation and reproductive health. Further research is necessary to fully elucidate the role of HSD17B2 in these processes and to explore its potential as a therapeutic target for various disorders.

Genular Protein ID: 3448144085

Symbol: DHB2_HUMAN

Name: 20 alpha-hydroxysteroid dehydrogenase

UniProtKB Accession Codes:

P37059 B2R7T4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 2 EMBL 11 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8099587

Title: Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity.

PubMed ID: 8099587

DOI: 10.1016/s0021-9258(18)31480-7

PubMed ID: 7546291

Title: The human type II 17 beta-hydroxysteroid dehydrogenase gene encodes two alternatively spliced mRNA species.

PubMed ID: 7546291

DOI: 10.1089/dna.1995.14.849

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10385431

Title: Characterization of molecular and catalytic properties of intact and truncated human 17beta-hydroxysteroid dehydrogenase type 2 enzymes: intracellular localization of the wild-type enzyme in the endoplasmic reticulum.

PubMed ID: 10385431

DOI: 10.1210/endo.140.7.6861

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11940569

Title: Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2.

PubMed ID: 11940569

DOI: 10.1074/jbc.m111726200

Sequence Information:

  • Length: 387
  • Mass: 42785
  • Checksum: EDE5606EA041042B
  • Sequence:
    • MSTFFSDTAW ICLAVPTVLC GTVFCKYKKS SGQLWSWMVC LAGLCAVCLL ILSPFWGLIL 
FSVSCFLMYT YLSGQELLPV DQKAVLVTGG DCGLGHALCK YLDELGFTVF AGVLNENGPG 
AEELRRTCSP RLSVLQMDIT KPVQIKDAYS KVAAMLQDRG LWAVINNAGV LGFPTDGELL 
LMTDYKQCMA VNFFGTVEVT KTFLPLLRKS KGRLVNVSSM GGGAPMERLA SYGSSKAAVT 
MFSSVMRLEL SKWGIKVASI QPGGFLTNIA GTSDKWEKLE KDILDHLPAE VQEDYGQDYI 
LAQRNFLLLI NSLASKDFSP VLRDIQHAIL AKSPFAYYTP GKGAYLWICL AHYLPIGIYD 
YFAKRHFGQD KPMPRALRMP NYKKKAT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.