Details for: LDHA

Gene ID: 3939

Symbol: LDHA

Ensembl ID: ENSG00000134333

Description: lactate dehydrogenase A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.41
    Marker Score: 5321
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 4.01
    Marker Score: 3785
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.99
    Marker Score: 39557
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.6
    Marker Score: 5547
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.54
    Marker Score: 1305
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.43
    Marker Score: 26754.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.39
    Marker Score: 9354
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.29
    Marker Score: 6687
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.26
    Marker Score: 2782
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.21
    Marker Score: 1710
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.18
    Marker Score: 1992
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.13
    Marker Score: 7643
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.12
    Marker Score: 1055
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.11
    Marker Score: 3324
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.11
    Marker Score: 36128
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.1
    Marker Score: 9746
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.07
    Marker Score: 3206.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.05
    Marker Score: 6094
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.04
    Marker Score: 4302
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.03
    Marker Score: 1582.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.03
    Marker Score: 1774
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.02
    Marker Score: 12937
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3
    Marker Score: 5085
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.96
    Marker Score: 974
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.96
    Marker Score: 1686
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.94
    Marker Score: 943
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.92
    Marker Score: 99380
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.92
    Marker Score: 9216.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.9
    Marker Score: 5189.5
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.88
    Marker Score: 2176
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.87
    Marker Score: 2419
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.87
    Marker Score: 151797
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.87
    Marker Score: 99271
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.86
    Marker Score: 11036
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.86
    Marker Score: 37736
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.85
    Marker Score: 2895
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.85
    Marker Score: 13675.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.82
    Marker Score: 7124
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.81
    Marker Score: 2031
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.8
    Marker Score: 3618
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.8
    Marker Score: 1165
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.78
    Marker Score: 23931
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.77
    Marker Score: 4596
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.77
    Marker Score: 1192
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.76
    Marker Score: 1009
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.76
    Marker Score: 4391
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.75
    Marker Score: 11859
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.74
    Marker Score: 7827
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.72
    Marker Score: 7132
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.71
    Marker Score: 7899
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.71
    Marker Score: 1810
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.7
    Marker Score: 4347
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7
    Marker Score: 17285
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.7
    Marker Score: 1215
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.7
    Marker Score: 11033
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.69
    Marker Score: 13206
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.67
    Marker Score: 26899.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.66
    Marker Score: 1753
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.66
    Marker Score: 6063
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.66
    Marker Score: 1938
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.65
    Marker Score: 2086
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.64
    Marker Score: 1079
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.64
    Marker Score: 4963
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.63
    Marker Score: 4665
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.63
    Marker Score: 7149
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.62
    Marker Score: 627
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.62
    Marker Score: 4289
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.61
    Marker Score: 145921
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.59
    Marker Score: 16889
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.58
    Marker Score: 2312
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.58
    Marker Score: 16765
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.57
    Marker Score: 1067
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.56
    Marker Score: 970
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.56
    Marker Score: 2928.5
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.56
    Marker Score: 13446
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.55
    Marker Score: 2003
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.55
    Marker Score: 561
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.55
    Marker Score: 3928.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.55
    Marker Score: 1311
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.54
    Marker Score: 2389
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.54
    Marker Score: 986
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.53
    Marker Score: 2442
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.53
    Marker Score: 752.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.52
    Marker Score: 1091
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.52
    Marker Score: 4603
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.52
    Marker Score: 7060
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.52
    Marker Score: 3458
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.52
    Marker Score: 607
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.51
    Marker Score: 1152
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.51
    Marker Score: 2643
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.5
    Marker Score: 2414
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.49
    Marker Score: 3442
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.49
    Marker Score: 1952
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.49
    Marker Score: 4846
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.48
    Marker Score: 859
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.48
    Marker Score: 2177
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.47
    Marker Score: 5812
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.47
    Marker Score: 2653
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.46
    Marker Score: 608
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.46
    Marker Score: 2675

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Other Information

**Key characteristics:** * The gene is located on chromosome 15q21.1. * It encodes a protein of 131 amino acids. * It is a glycoprotein that is expressed in both soluble and membrane forms. * The soluble form of LDHA is localized to the cytoplasm, while the membrane form is found in the mitochondria. **Pathways and functions:** * LDHA is involved in multiple metabolic pathways, including the citric acid (tca) cycle and respiratory electron transport. * In the citric acid cycle, LDHA catalyzes the transfer of a phosphate group from L-lactate to oxaloacetate, forming pyruvate. * In the respiratory electron transport chain, LDHA is involved in the transfer of electrons to oxygen, generating ATP. * It also plays a role in the regulation of blood glucose metabolism, as it can be induced by high blood glucose levels. **Clinical significance:** * Mutations in the LDHA gene have been linked to certain neurological disorders, including amyotrophic lateral sclerosis (ALS), lactic acidosis, and diabetic ketoacidosis. * LDHA inhibitors are being investigated as potential treatments for these disorders. **Additional notes:** * LDHA is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a key regulatory protein in the regulation of blood glucose metabolism. * It is a promising target for the treatment of various diseases.

Genular Protein ID: 9112093

Symbol: LDHA_HUMAN

Name: Cell proliferation-inducing gene 19 protein

UniProtKB Accession Codes:

P00338 B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CPTAC 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EC 1 EMBL 20 EPD 1 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 46 PDBsum 42 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3838278

Title: Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme.

PubMed ID: 3838278

DOI: 10.1111/j.1432-1033.1985.tb08711.x

PubMed ID: 3000353

Title: Genomic organization of human lactate dehydrogenase-A gene.

PubMed ID: 3000353

DOI: 10.1042/bj2310537

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1953713

Title: Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining.

PubMed ID: 1953713

DOI: 10.1016/s0006-291x(05)81177-5

PubMed ID: 1959923

Title: Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification.

PubMed ID: 1959923

DOI: 10.1007/bf00204925

PubMed ID: 2334430

Title: Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.

PubMed ID: 2334430

DOI: 10.1016/0006-291x(90)92374-9

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33406399

Title: An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.

PubMed ID: 33406399

DOI: 10.1016/j.cmet.2020.12.008

PubMed ID: 33535099

Title:

PubMed ID: 33535099

DOI: 10.1016/j.cmet.2021.01.008

PubMed ID: 34381247

Title: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.

PubMed ID: 34381247

DOI: 10.1038/s41594-021-00633-2

PubMed ID: 11276087

Title: Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.

PubMed ID: 11276087

DOI: 10.1002/1097-0134(20010501)43:2<175::aid-prot1029>3.0.co;2-#

PubMed ID: 1445373

Title: Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.

PubMed ID: 1445373

PubMed ID: 7908613

Title: Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes.

PubMed ID: 7908613

Sequence Information:

  • Length: 332
  • Mass: 36689
  • Checksum: 401E8604CEB7F908
  • Sequence:
    • MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE 
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI 
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.