Details for: LDHA

Gene ID: 3939

Symbol: LDHA

Ensembl ID: ENSG00000134333

Description: lactate dehydrogenase A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 880.2585
    Cell Significance Index: -136.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 414.8344
    Cell Significance Index: -105.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 342.6771
    Cell Significance Index: -141.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 324.8435
    Cell Significance Index: -131.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 299.2866
    Cell Significance Index: -141.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 273.2971
    Cell Significance Index: -140.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 211.2002
    Cell Significance Index: -141.7200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 114.2052
    Cell Significance Index: -140.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 36.4162
    Cell Significance Index: -143.7000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 31.8644
    Cell Significance Index: -97.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.6324
    Cell Significance Index: -82.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 26.3106
    Cell Significance Index: 656.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2548
    Cell Significance Index: -35.5800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.7583
    Cell Significance Index: 75.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.1548
    Cell Significance Index: 144.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 8.1186
    Cell Significance Index: 426.2600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 6.1924
    Cell Significance Index: 47.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.3488
    Cell Significance Index: 251.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.2160
    Cell Significance Index: 123.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.9433
    Cell Significance Index: 278.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7990
    Cell Significance Index: 79.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.7085
    Cell Significance Index: 42.1300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.6550
    Cell Significance Index: 10.8700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.4862
    Cell Significance Index: 37.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.4401
    Cell Significance Index: 256.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2818
    Cell Significance Index: 1792.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8555
    Cell Significance Index: 1262.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5836
    Cell Significance Index: 166.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5308
    Cell Significance Index: 326.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.2708
    Cell Significance Index: 311.8500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2452
    Cell Significance Index: 264.7800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.2067
    Cell Significance Index: 1992.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1939
    Cell Significance Index: 102.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9630
    Cell Significance Index: 53.4300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.7753
    Cell Significance Index: 12.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5075
    Cell Significance Index: 433.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4457
    Cell Significance Index: 185.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4215
    Cell Significance Index: 282.1000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3797
    Cell Significance Index: 36.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1887
    Cell Significance Index: 193.3300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1347
    Cell Significance Index: 68.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1177
    Cell Significance Index: 32.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0788
    Cell Significance Index: 132.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7604
    Cell Significance Index: 137.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6837
    Cell Significance Index: 17.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6784
    Cell Significance Index: 18.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5317
    Cell Significance Index: 106.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.4351
    Cell Significance Index: 329.3200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3672
    Cell Significance Index: 12.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3236
    Cell Significance Index: 20.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3087
    Cell Significance Index: 58.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2251
    Cell Significance Index: 38.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2160
    Cell Significance Index: 11.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1589
    Cell Significance Index: 293.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1395
    Cell Significance Index: 214.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1233
    Cell Significance Index: 167.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1177
    Cell Significance Index: 221.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0501
    Cell Significance Index: 31.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0394
    Cell Significance Index: 1.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0242
    Cell Significance Index: 0.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0110
    Cell Significance Index: -3.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0120
    Cell Significance Index: -0.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0218
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0267
    Cell Significance Index: -19.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0279
    Cell Significance Index: -0.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0392
    Cell Significance Index: -28.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1404
    Cell Significance Index: -63.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1980
    Cell Significance Index: -123.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2006
    Cell Significance Index: -113.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2826
    Cell Significance Index: -27.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2887
    Cell Significance Index: -60.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3901
    Cell Significance Index: -15.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4933
    Cell Significance Index: -56.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5598
    Cell Significance Index: -63.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5713
    Cell Significance Index: -83.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5864
    Cell Significance Index: -14.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7725
    Cell Significance Index: -90.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8304
    Cell Significance Index: -11.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8464
    Cell Significance Index: -10.0900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.8577
    Cell Significance Index: -3.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8630
    Cell Significance Index: -27.6400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8656
    Cell Significance Index: -5.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9877
    Cell Significance Index: -22.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9965
    Cell Significance Index: -21.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0294
    Cell Significance Index: -79.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0448
    Cell Significance Index: -19.3100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1266
    Cell Significance Index: -7.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1420
    Cell Significance Index: -30.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.2279
    Cell Significance Index: -15.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2604
    Cell Significance Index: -131.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2640
    Cell Significance Index: -70.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3855
    Cell Significance Index: -20.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4302
    Cell Significance Index: -113.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5511
    Cell Significance Index: -26.7400
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -1.5780
    Cell Significance Index: -27.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6289
    Cell Significance Index: -112.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7240
    Cell Significance Index: -105.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.9000
    Cell Significance Index: -86.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9108
    Cell Significance Index: -56.2800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0715
    Cell Significance Index: -17.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LDHA is a homodimeric enzyme composed of two identical subunits, each possessing a catalytic domain. The enzyme is primarily localized in the cytosol, with some expression in the mitochondria and nucleus. LDHA is highly expressed in various cell types, including glycinergic neurons, mature T cells, and mesenchymal stem cells, suggesting its widespread involvement in different physiological processes. The enzyme exhibits an identical protein binding capacity, allowing it to interact with various cytoplasmic and nuclear proteins. **Pathways and Functions:** LDHA is integral to the glycolytic process, catalyzing the interconversion of pyruvate and lactate. This reaction is crucial for energy metabolism, particularly in anaerobic conditions, where glycolysis provides a rapid source of ATP. Furthermore, LDHA is involved in lactate metabolic processes, including lactate production and degradation. The enzyme's activity is also linked to the regulation of pyruvate metabolism and the citric acid (TCA) cycle, highlighting its role in the coordination of energy metabolism and cellular homeostasis. In addition to its metabolic functions, LDHA has been implicated in various cellular processes, including cell proliferation, differentiation, and immune function. The enzyme's expression in glycinergic neurons and GABAergic amacrine cells suggests its involvement in neurotransmission and synaptic plasticity. In the context of immune function, LDHA has been shown to be expressed in mature T cells and decidual natural killer cells, highlighting its potential role in immune regulation and tolerance. **Clinical Significance:** LDHA's involvement in metabolic regulation and immune function has significant implications for various disease contexts. In cancer, altered LDHA expression has been linked to tumor progression, metastasis, and resistance to chemotherapy. The enzyme's role in energy metabolism has also been implicated in the pathogenesis of metabolic disorders, such as diabetes and obesity. Furthermore, LDHA's expression in immune cells has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. The enzyme's potential role in immune regulation and tolerance has sparked interest in its therapeutic applications, particularly in the development of immunomodulatory therapies. In conclusion, LDHA is a multifunctional enzyme with significant implications in metabolic regulation, immune function, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms by which LDHA regulates these processes and to explore its therapeutic potential in various disease contexts.

Genular Protein ID: 9112093

Symbol: LDHA_HUMAN

Name: Cell proliferation-inducing gene 19 protein

UniProtKB Accession Codes:

P00338 B4DKQ2 B7Z5E3 D3DQY3 F8W819 Q53G53 Q6IBM7 Q6ZNV1 Q9UDE8 Q9UDE9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CPTAC 3 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 20 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 43 PDBsum 43 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 3 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3838278

Title: Nucleotide sequences of the cDNA and an intronless pseudogene for human lactate dehydrogenase-A isozyme.

PubMed ID: 3838278

DOI: 10.1111/j.1432-1033.1985.tb08711.x

PubMed ID: 3000353

Title: Genomic organization of human lactate dehydrogenase-A gene.

PubMed ID: 3000353

DOI: 10.1042/bj2310537

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1953713

Title: Analysis of genetic mutations in human lactate dehydrogenase-A(M) deficiency using DNA conformation polymorphism in combination with polyacrylamide gradient gel and silver staining.

PubMed ID: 1953713

DOI: 10.1016/s0006-291x(05)81177-5

PubMed ID: 1959923

Title: Genotypic analysis of families with lactate dehydrogenase A (M) deficiency by selective DNA amplification.

PubMed ID: 1959923

DOI: 10.1007/bf00204925

PubMed ID: 2334430

Title: Molecular characterization of genetic mutation in human lactate dehydrogenase-A (M) deficiency.

PubMed ID: 2334430

DOI: 10.1016/0006-291x(90)92374-9

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33406399

Title: An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.

PubMed ID: 33406399

DOI: 10.1016/j.cmet.2020.12.008

PubMed ID: 33535099

Title:

PubMed ID: 33535099

DOI: 10.1016/j.cmet.2021.01.008

PubMed ID: 34381247

Title: The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect.

PubMed ID: 34381247

DOI: 10.1038/s41594-021-00633-2

PubMed ID: 11276087

Title: Structural basis for altered activity of M- and H-isozyme forms of human lactate dehydrogenase.

PubMed ID: 11276087

DOI: 10.1002/1097-0134(20010501)43:2<175::aid-prot1029>3.0.co;2-#

PubMed ID: 1445373

Title: Molecular analysis of genetic mutation in electrophoretic variant of human lactate dehydrogenase-A(M) subunit.

PubMed ID: 1445373

PubMed ID: 7908613

Title: Fast-type electrophoretic variant of lactate dehydrogenase M(A) and comparison with other missense mutations in lactate dehydrogenase M(A) and H(B) genes.

PubMed ID: 7908613

Sequence Information:

  • Length: 332
  • Mass: 36689
  • Checksum: 401E8604CEB7F908
  • Sequence:
    • MATLKDQLIY NLLKEEQTPQ NKITVVGVGA VGMACAISIL MKDLADELAL VDVIEDKLKG 
EMMDLQHGSL FLRTPKIVSG KDYNVTANSK LVIITAGARQ QEGESRLNLV QRNVNIFKFI 
IPNVVKYSPN CKLLIVSNPV DILTYVAWKI SGFPKNRVIG SGCNLDSARF RYLMGERLGV 
HPLSCHGWVL GEHGDSSVPV WSGMNVAGVS LKTLHPDLGT DKDKEQWKEV HKQVVESAYE 
VIKLKGYTSW AIGLSVADLA ESIMKNLRRV HPVSTMIKGL YGIKDDVFLS VPCILGQNGI 
SDLVKVTLTS EEEARLKKSA DTLWGIQKEL QF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.