Gene GEM - ENSG00000164949 | NCBI Gene ID: 2669

Details for: GEM

Gene ID: 2669

Symbol: GEM

Ensembl ID: ENSG00000164949

Description: GTP binding protein overexpressed in skeletal muscle

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Npas4 regulates expression of target genes
(R-HSA-9768919)
Rna polymerase ii transcription
(R-HSA-73857)
Transcriptional regulation by npas4
(R-HSA-9634815)
Calcium channel regulator activity
(GO:0005246)
Calmodulin binding
(GO:0005516)
Cell surface receptor signaling pathway
(GO:0007166)
Chromosome organization
(GO:0051276)
Cytoplasmic side of plasma membrane
(GO:0009898)
Gdp binding
(GO:0019003)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Immune response
(GO:0006955)
Magnesium ion binding
(GO:0000287)
Metaphase chromosome alignment
(GO:0051310)
Midbody
(GO:0030496)
Mitotic cell cycle
(GO:0000278)
Mitotic spindle
(GO:0072686)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Spindle midzone
(GO:0051233)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.29
Marker Score: 145943
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.6
Marker Score: 3072
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.23
Marker Score: 1343
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.05
Marker Score: 1313
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.6
Marker Score: 1482
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.36
Marker Score: 3076
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.35
Marker Score: 584
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.33
Marker Score: 584
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.32
Marker Score: 2474
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.6
Marker Score: 406
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.56
Marker Score: 4072
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.5
Marker Score: 945
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168891
Cell Name: muscle cell (CL0000187)
Fold Change: 1.37
Marker Score: 389
Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 1.36
Marker Score: 852.5
Cell Name: supporting cell (CL0000630)
Fold Change: 1.34
Marker Score: 2518
Cell Name: fibroblast (CL0000057)
Fold Change: 1.33
Marker Score: 1289
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.31
Marker Score: 4841
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.3
Marker Score: 490
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.25
Marker Score: 825
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.24
Marker Score: 1178
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.2
Marker Score: 2937.5
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.14
Marker Score: 5591
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.13
Marker Score: 1401
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.08
Marker Score: 16853
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.07
Marker Score: 315
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.06
Marker Score: 3763
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.06
Marker Score: 1731
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.05
Marker Score: 1437
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251755
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.02
Marker Score: 1421
Cell Name: decidual cell (CL2000002)
Fold Change: 1.02
Marker Score: 4416
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.01
Marker Score: 360
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71774
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47998
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.99
Marker Score: 1910
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30404
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.96
Marker Score: 2336
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.94
Marker Score: 247
Cell Name: pericyte (CL0000669)
Fold Change: 0.93
Marker Score: 542
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.92
Marker Score: 207
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.92
Marker Score: 205
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.91
Marker Score: 508
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: Unknown (CL0002371)
Fold Change: 0.91
Marker Score: 964
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.88
Marker Score: 5019
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.88
Marker Score: 5269
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.87
Marker Score: 619
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5267
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.86
Marker Score: 18446
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.86
Marker Score: 3607.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.85
Marker Score: 209
Cell Name: stromal cell (CL0000499)
Fold Change: 0.83
Marker Score: 975
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.81
Marker Score: 282
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.81
Marker Score: 900
Cell Name: B-2 B cell (CL0000822)
Fold Change: 0.79
Marker Score: 976
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.79
Marker Score: 406
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.79
Marker Score: 770
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1257
Cell Name: keratocyte (CL0002363)
Fold Change: 0.77
Marker Score: 178
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.77
Marker Score: 408
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 577
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.75
Marker Score: 1196
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.75
Marker Score: 356
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 0.74
Marker Score: 251
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.74
Marker Score: 9756
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.74
Marker Score: 1401
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 382
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.73
Marker Score: 722
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.72
Marker Score: 290
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.71
Marker Score: 2987.5
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.69
Marker Score: 361.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 629
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.68
Marker Score: 1589
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.66
Marker Score: 4276
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.65
Marker Score: 505
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.63
Marker Score: 1071
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.63
Marker Score: 1286
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.63
Marker Score: 889
Cell Name: reticular cell (CL0000432)
Fold Change: 0.62
Marker Score: 227
Cell Name: exhausted T cell (CL0011025)
Fold Change: 0.62
Marker Score: 355
Cell Name: lactocyte (CL0002325)
Fold Change: 0.62
Marker Score: 9899
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.6
Marker Score: 243
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.6
Marker Score: 275
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.59
Marker Score: 173
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.58
Marker Score: 1376
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.57
Marker Score: 12830
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.56
Marker Score: 369
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.56
Marker Score: 1138
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.55
Marker Score: 163
Cell Name: neural cell (CL0002319)
Fold Change: 0.54
Marker Score: 262
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.54
Marker Score: 326
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.54
Marker Score: 432
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.54
Marker Score: 223

Hover over a box to see details here...

**Key characteristics:** * The protein is a GTPase that is involved in the regulation of cell signaling pathways. * It is expressed in high levels in skeletal muscle cells, where it is thought to play a role in regulating muscle growth and differentiation. * It is also expressed in other cell types, including fibroblasts, immune cells, and smooth muscle cells. **Pathways and functions:** * The protein binds to GTP and activates it, which leads to the activation of downstream signaling pathways. * It is involved in the regulation of cell surface receptor signaling, calcium channel regulation, and transcription. * It is also involved in the regulation of cell cycle progression, migration, and differentiation. **Clinical significance:** * Mutations in the GEM gene have been linked to several human diseases, including breast cancer, prostate cancer, and cardiac disease. * Targeting the GEM protein has been investigated as a potential therapeutic strategy for these diseases. **Additional information:** * The gene is also known as GRP17. * It is a highly conserved protein, with a similar protein found in other vertebrates. * It is expressed in a variety of cell types, including muscle cells, endothelial cells, and immune cells.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GTP-binding protein GEM

Genular Protein ID: 3720937063

Symbol: GEM_HUMAN

Name: GTP-binding protein GEM

UniProtKB Accession Codes:

P55040 B2RA31

Database IDs:

Citations:

PubMed ID: 7912851

Title: Gem: an induced, immediate early protein belonging to the Ras family.

PubMed ID: 7912851

DOI: 10.1126/science.7912851

PubMed ID: 7809057

Title: Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.

PubMed ID: 7809057

DOI: 10.1073/pnas.91.26.12448

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115241

Title: Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II.

PubMed ID: 9115241

DOI: 10.1074/jbc.272.18.11832

PubMed ID: 11956230

Title: The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway.

PubMed ID: 11956230

DOI: 10.1083/jcb.200111026

Sequence Information:

Length: 296
Mass: 33949
Checksum: B7BB3F2CA96D338F
Sequence:

MTLNNVTMRQ GTVGMQPQQQ RWSIPADGRH LMVQKEPHQY SHRNRHSATP EDHCRRSWSS 
DSTDSVISSE SGNTYYRVVL IGEQGVGKST LANIFAGVHD SMDSDCEVLG EDTYERTLMV 
DGESATIILL DMWENKGENE WLHDHCMQVG DAYLIVYSIT DRASFEKASE LRIQLRRARQ 
TEDIPIILVG NKSDLVRCRE VSVSEGRACA VVFDCKFIET SAAVQHNVKE LFEGIVRQVR 
LRRDSKEKNE RRLAYQKRKE SMPRKARRFW GKIVAKNNKN MAFKLKSKSC HDLSVL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GEM

Associated with

Cells (max top 100)

Other Information

Gem: an induced, immediate early protein belonging to the Ras family. PubMed ID: 7912851

Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. PubMed ID: 7809057

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. PubMed ID: 9115241