Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 852.3566
Cell Significance Index: -132.5800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 523.4515
Cell Significance Index: -132.7700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 354.9966
Cell Significance Index: -146.2400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 318.3698
Cell Significance Index: -129.3400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 302.8874
Cell Significance Index: -143.0000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 271.7030
Cell Significance Index: -139.7600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 213.6740
Cell Significance Index: -143.3800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 136.3089
Cell Significance Index: -130.1400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 113.1833
Cell Significance Index: -139.5500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 47.1805
Cell Significance Index: -126.3900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 46.6570
Cell Significance Index: -143.3100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 36.6721
Cell Significance Index: -144.7100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.6212
Cell Significance Index: -62.6400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 15.8741
Cell Significance Index: 293.4000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 4.7446
Cell Significance Index: 249.1100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.7353
Cell Significance Index: 512.9600 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.3722
Cell Significance Index: 432.3000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 3.2305
Cell Significance Index: 86.2600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.5184
Cell Significance Index: 66.2200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.3966
Cell Significance Index: 68.7000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3901
Cell Significance Index: 178.1300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2963
Cell Significance Index: 413.9500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.0512
Cell Significance Index: 1120.2300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.0469
Cell Significance Index: 251.6800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.0144
Cell Significance Index: 93.9200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9179
Cell Significance Index: 384.7300 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.5357
Cell Significance Index: 198.4000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3959
Cell Significance Index: 277.0200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3887
Cell Significance Index: 498.0900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.3219
Cell Significance Index: 25.8000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.2970
Cell Significance Index: 60.9600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.2142
Cell Significance Index: 32.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.0123
Cell Significance Index: 447.5500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.9683
Cell Significance Index: 165.3400 - Cell Name: theca cell (CL0000503)
Fold Change: 0.8970
Cell Significance Index: 5.2700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.6273
Cell Significance Index: 11.0900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5944
Cell Significance Index: 30.9600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.4460
Cell Significance Index: 12.1400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.4056
Cell Significance Index: 27.2700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3037
Cell Significance Index: 8.7500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2291
Cell Significance Index: 14.0800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1846
Cell Significance Index: 135.3400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1748
Cell Significance Index: 28.4300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1241
Cell Significance Index: 233.6400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1033
Cell Significance Index: 3.5900 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0957
Cell Significance Index: 9.7800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0776
Cell Significance Index: 49.2600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0510
Cell Significance Index: 38.6300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0329
Cell Significance Index: 3.2500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0487
Cell Significance Index: -0.8200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0500
Cell Significance Index: -92.2200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0621
Cell Significance Index: -46.0000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0699
Cell Significance Index: -107.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0738
Cell Significance Index: -100.3500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0774
Cell Significance Index: -3.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1302
Cell Significance Index: -2.8200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1366
Cell Significance Index: -85.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1848
Cell Significance Index: -104.2200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1976
Cell Significance Index: -89.6900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.2075
Cell Significance Index: -39.4900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2266
Cell Significance Index: -26.7200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2452
Cell Significance Index: -17.3400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2495
Cell Significance Index: -3.2000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3105
Cell Significance Index: -65.3900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3518
Cell Significance Index: -3.2400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4462
Cell Significance Index: -128.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4509
Cell Significance Index: -65.5400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5043
Cell Significance Index: -57.5600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.5426
Cell Significance Index: -19.0700 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -0.5842
Cell Significance Index: -3.6300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.6696
Cell Significance Index: -10.3600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6877
Cell Significance Index: -80.1400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.7331
Cell Significance Index: -83.9900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7585
Cell Significance Index: -39.4000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7963
Cell Significance Index: -61.1100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.8975
Cell Significance Index: -15.3800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.9440
Cell Significance Index: -52.9700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0011
Cell Significance Index: -64.5900 - Cell Name: kidney cell (CL1000497)
Fold Change: -1.0546
Cell Significance Index: -8.4200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.3159
Cell Significance Index: -137.0200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.3541
Cell Significance Index: -33.8500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.3695
Cell Significance Index: -40.2200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.5685
Cell Significance Index: -44.7600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.5866
Cell Significance Index: -125.6600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.5952
Cell Significance Index: -70.5600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.6124
Cell Significance Index: -43.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.6209
Cell Significance Index: -45.3000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.8132
Cell Significance Index: -125.4000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.8707
Cell Significance Index: -39.8400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.8713
Cell Significance Index: -117.9500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.0852
Cell Significance Index: -78.9600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.3249
Cell Significance Index: -142.5400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.4056
Cell Significance Index: -58.7000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -2.5416
Cell Significance Index: -53.2000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.5633
Cell Significance Index: -65.4900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -2.5656
Cell Significance Index: -61.5300 - Cell Name: peg cell (CL4033014)
Fold Change: -2.6087
Cell Significance Index: -60.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.8534
Cell Significance Index: -91.3900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.9290
Cell Significance Index: -34.9200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.0841
Cell Significance Index: -90.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2006958043
Symbol: SAP_HUMAN
Name: Prosaposin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2515150
Title: Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats.
PubMed ID: 2515150
PubMed ID: 2498298
Title: Structure of full-length cDNA coding for sulfatide activator, a Co-beta-glucosidase and two other homologous proteins: two alternate forms of the sulfatide activator.
PubMed ID: 2498298
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2842863
Title: Coding of two sphingolipid activator proteins (SAP-1 and SAP-2) by same genetic locus.
PubMed ID: 2842863
PubMed ID: 1612590
Title: Structure and evolution of the human prosaposin chromosomal gene.
PubMed ID: 1612590
PubMed ID: 8323276
Title: Isolation, characterization, and proteolysis of human prosaposin, the precursor of saposins (sphingolipid activator proteins).
PubMed ID: 8323276
PubMed ID: 1958198
Title: Isolation and characterization of prosaposin from human milk.
PubMed ID: 1958198
PubMed ID: 2013321
Title: The organization of the gene for the human cerebroside sulfate activator protein.
PubMed ID: 2013321
PubMed ID: 2717620
Title: Saposin A: second cerebrosidase activator protein.
PubMed ID: 2717620
PubMed ID: 8370464
Title: Storage of saposins A and D in infantile neuronal ceroid-lipofuscinosis.
PubMed ID: 8370464
PubMed ID: 2825202
Title: Nucleotide sequence of cloned cDNA for human sphingolipid activator protein 1 precursor.
PubMed ID: 2825202
PubMed ID: 2868718
Title: Molecular cloning of the sphingolipid activator protein-1 (SAP-1), the sulfatide sulfatase activator.
PubMed ID: 2868718
PubMed ID: 3242555
Title: Complete amino-acid sequence of the naturally occurring A2 activator protein for enzymic sphingomyelin degradation: identity to the sulfatide activator protein (SAP-1).
PubMed ID: 3242555
PubMed ID: 2209618
Title: The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein.
PubMed ID: 2209618
PubMed ID: 3442600
Title: Complete amino-acid sequence and carbohydrate content of the naturally occurring glucosylceramide activator protein (A1 activator) absent from a new human Gaucher disease variant.
PubMed ID: 3442600
PubMed ID: 2845979
Title: Saposin D: a sphingomyelinase activator.
PubMed ID: 2845979
PubMed ID: 3048308
Title: The precursor of sulfatide activator protein is processed to three different proteins.
PubMed ID: 3048308
PubMed ID: 10562467
Title: Preparation of the cerebroside sulfate activator (CSAct or saposin B) from human urine.
PubMed ID: 10562467
PubMed ID: 7730378
Title: Structural analysis of saposin C and B. Complete localization of disulfide bridges.
PubMed ID: 7730378
PubMed ID: 10383054
Title: Prosaposin: a myelinotrophic protein that promotes expression of myelin constituents and is secreted after nerve injury.
PubMed ID: 10383054
DOI: 10.1002/(sici)1098-1136(199906)26:4<353::aid-glia9>3.3.co;2-7
PubMed ID: 10510427
Title: Cerebroside sulfate activator protein (Saposin B): chromatographic and electrospray mass spectrometric properties.
PubMed ID: 10510427
DOI: 10.1002/(sici)1096-9888(199910)34:10<1040::aid-jms863>3.0.co;2-x
PubMed ID: 11180632
Title: Structure of the asparagine-linked sugar chains of porcine kidney and human urine cerebroside sulfate activator protein.
PubMed ID: 11180632
DOI: 10.1002/1096-9888(200012)35:12<1416::aid-jms75>3.0.co;2-k
PubMed ID: 10406958
Title: Structural and membrane-binding properties of saposin D.
PubMed ID: 10406958
PubMed ID: 14657016
Title: The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.
PubMed ID: 14657016
DOI: 10.1093/emboj/cdg629
PubMed ID: 12510003
Title: Expression, purification, crystallization, and preliminary X-ray analysis of recombinant human saposin B.
PubMed ID: 12510003
PubMed ID: 19167329
Title: Cotranslational and posttranslational N-glycosylation of polypeptides by distinct mammalian OST isoforms.
PubMed ID: 19167329
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21835174
Title: Prosaposin sorting is mediated by oligomerization.
PubMed ID: 21835174
PubMed ID: 22431521
Title: The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.
PubMed ID: 22431521
DOI: 10.1128/mcb.06726-11
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26370502
Title: Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
PubMed ID: 26370502
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 12518053
Title: Crystal structure of saposin B reveals a dimeric shell for lipid binding.
PubMed ID: 12518053
PubMed ID: 7866401
Title: Molecular genetics of metachromatic leukodystrophy.
PubMed ID: 7866401
PubMed ID: 2302219
Title: Detection of a point mutation in sphingolipid activator protein-1 mRNA in patients with a variant form of metachromatic leukodystrophy.
PubMed ID: 2302219
PubMed ID: 2320574
Title: Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect.
PubMed ID: 2320574
PubMed ID: 2019586
Title: Sulfatide activator protein. Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease.
PubMed ID: 2019586
PubMed ID: 1371116
Title: Simultaneous deficiency of sphingolipid activator proteins 1 and 2 is caused by a mutation in the initiation codon of their common gene.
PubMed ID: 1371116
PubMed ID: 2060627
Title: Mutation in the sphingolipid activator protein 2 in a patient with a variant of Gaucher disease.
PubMed ID: 2060627
PubMed ID: 10196694
Title: An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity.
PubMed ID: 10196694
PubMed ID: 10682309
Title: A non-glycosylated and functionally deficient mutant (N215H) of the sphingolipid activator protein B (SAP-B) in a novel case of metachromatic leukodystrophy (MLD).
PubMed ID: 10682309
PubMed ID: 11309366
Title: A novel mutation in the coding region of the prosaposin gene leads to a complete deficiency of prosaposin and saposins, and is associated with a complex sphingolipidosis dominated by lactosylceramide accumulation.
PubMed ID: 11309366
DOI: 10.1093/hmg/10.9.927
PubMed ID: 15773042
Title: A mutation in the saposin A coding region of the prosaposin gene in an infant presenting as Krabbe disease: first report of saposin A deficiency in humans.
PubMed ID: 15773042
PubMed ID: 17919309
Title: Non-neuronopathic Gaucher disease due to saposin C deficiency.
PubMed ID: 17919309
PubMed ID: 32201884
Title: Variants in saposin D domain of prosaposin gene linked to Parkinson's disease.
PubMed ID: 32201884
Sequence Information:
- Length: 524
- Mass: 58113
- Checksum: 71977F7A8C9E1533
- Sequence:
MYALFLLASL LGAALAGPVL GLKECTRGSA VWCQNVKTAS DCGAVKHCLQ TVWNKPTVKS LPCDICKDVV TAAGDMLKDN ATEEEILVYL EKTCDWLPKP NMSASCKEIV DSYLPVILDI IKGEMSRPGE VCSALNLCES LQKHLAELNH QKQLESNKIP ELDMTEVVAP FMANIPLLLY PQDGPRSKPQ PKDNGDVCQD CIQMVTDIQT AVRTNSTFVQ ALVEHVKEEC DRLGPGMADI CKNYISQYSE IAIQMMMHMQ PKEICALVGF CDEVKEMPMQ TLVPAKVASK NVIPALELVE PIKKHEVPAK SDVYCEVCEF LVKEVTKLID NNKTEKEILD AFDKMCSKLP KSLSEECQEV VDTYGSSILS ILLEEVSPEL VCSMLHLCSG TRLPALTVHV TQPKDGGFCE VCKKLVGYLD RNLEKNSTKQ EILAALEKGC SFLPDPYQKQ CDQFVAEYEP VLIEILVEVM DPSFVCLKIG ACPSAHKPLL GTEKCIWGPS YWCQNTETAA QCNAVEHCKR HVWN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.