Details for: GHR
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 68.26rCSI 87.65%PRS 84.73
-
CSI 28.75rCSI 51.46%PRS 90.5
-
CSI 26.19rCSI 32.59%PRS 78.11
-
CSI 25.12rCSI 81.74%PRS 89.48
-
CSI 24.76rCSI 38.25%PRS 90.22
-
CSI 17.87rCSI 55.9%PRS 83.29
-
CSI 16.61rCSI 26.49%PRS 85.09
-
CSI 16.15rCSI 61.03%PRS 80.49
-
CSI 16.03rCSI 82.09%PRS 93.63
-
CSI 15.68rCSI 28.49%PRS 86.16
-
CSI 15.07rCSI 47.09%PRS 81.58
-
CSI 14.28rCSI 17.05%PRS 80.34
-
CSI 13.28rCSI 19.06%PRS 84.64
-
CSI 12.79rCSI 22.13%PRS 87.12
-
CSI 11.66rCSI 18.75%PRS 81.33
-
CSI 11.41rCSI 36.5%PRS 90.8
-
CSI 9.99rCSI 14.25%PRS 91.89
-
CSI 9.44rCSI 21.79%PRS 83.82
-
CSI 9.41rCSI 32.22%PRS 80.4
-
CSI 8.24rCSI 10.62%PRS 81.41
-
CSI 7.79rCSI 45.88%PRS 80.73
-
CSI 7.76rCSI 41.25%PRS 85.44
-
CSI 7.59rCSI 13.31%PRS 88.86
-
CSI 7.59rCSI 18.45%PRS 78.15
-
CSI 7.52rCSI 11.95%PRS 87.83
-
CSI 7.47rCSI 27.97%PRS 88.19
-
CSI 7.47rCSI 19.46%PRS 93.5
-
CSI 7.13rCSI 24.15%PRS 88.71
-
CSI 6.86rCSI 16.76%PRS 86.16
-
CSI 6.71rCSI 13.79%PRS 81.17
-
CSI 6.68rCSI 18.99%PRS 88.7
-
CSI 6.64rCSI 19.61%PRS 91.68
-
CSI 6.06rCSI 9.93%PRS 85.77
-
CSI 6.05rCSI 16.68%PRS 89.71
-
CSI 6.05rCSI 10.15%PRS 80.29
-
CSI 6.03rCSI 14.4%PRS 93.82
-
CSI 5.74rCSI 12.68%PRS 82.59
-
CSI 5.54rCSI 5.16%PRS 93.16
-
CSI 5.41rCSI 33.79%PRS 86.23
-
CSI 5.28rCSI 20.64%PRS 77.26
-
CSI 5.24rCSI 7.26%PRS 88.89
-
CSI 5.19rCSI 17.37%PRS 79.72
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CSI 5rCSI 10.38%PRS 90.44
-
CSI 4.92rCSI 7.86%PRS 93.79
-
CSI 4.77rCSI 17.16%PRS 78.4
-
CSI 4.75rCSI 22.72%PRS 88.83
-
CSI 4.71rCSI 11.28%PRS 82.58
-
CSI 4.31rCSI 16.75%PRS 88.91
-
CSI 4.16rCSI 12.06%PRS 84.32
-
CSI 4.16rCSI 23.17%PRS 93.02
-
CSI 4.05rCSI 7.15%PRS 79.75
-
CSI 4.05rCSI 8.13%PRS 86.55
-
CSI 4.04rCSI 7.13%PRS 94.4
-
CSI 3.86rCSI 18.48%PRS 92.78
-
CSI 3.84rCSI 3.03%PRS 85.77
-
CSI 3.67rCSI 14.82%PRS 92.55
-
CSI 3.58rCSI 15.93%PRS 92.2
-
CSI 3.57rCSI 9.26%PRS 91.28
-
CSI 3.55rCSI 8.34%PRS 89.39
-
CSI 3.52rCSI 9.3%PRS 95.15
-
CSI 3.5rCSI 9.36%PRS 87.42
-
CSI 3.47rCSI 7.77%PRS 80.61
-
CSI 3.44rCSI 8.28%PRS 92.86
-
CSI 3.4rCSI 8.62%PRS 86.68
-
CSI 3.38rCSI 7.72%PRS 92.79
-
CSI 3.37rCSI 3.69%PRS 93.43
-
CSI 3.3rCSI 4.41%PRS 89.47
-
CSI 3.13rCSI 8.15%PRS 86.42
-
CSI 2.98rCSI 7.75%PRS 94.24
-
CSI 2.93rCSI 3.51%PRS 90.87
-
CSI 2.92rCSI 7.5%PRS 88.57
-
CSI 2.69rCSI 3.42%PRS 94.85
-
CSI 2.66rCSI 8.55%PRS 88.66
-
CSI 2.6rCSI 16.27%PRS 73.2
-
CSI 2.54rCSI 3.88%PRS 90.85
-
CSI 2.54rCSI 18.64%PRS 84.52
-
CSI 2.49rCSI 21.47%PRS 86.94
-
CSI 2.45rCSI 5.84%PRS 92.01
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CSI 2.32rCSI 6.52%PRS 88.48
-
CSI 2.29rCSI 5.97%PRS 88.05
-
CSI 2.24rCSI 6.55%PRS 96.49
-
CSI 2.13rCSI 8.31%PRS 84.89
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CSI 1.95rCSI 4.92%PRS 93.78
-
CSI 1.9rCSI 2.6%PRS 85.35
-
CSI 1.89rCSI 2.34%PRS 91.49
-
CSI 1.85rCSI 6.08%PRS 81.43
-
CSI 1.8rCSI 14.68%PRS 89.9
-
CSI 1.59rCSI 2.51%PRS 92.81
-
CSI 1.46rCSI 5.94%PRS 95.78
-
CSI 1.39rCSI 4.27%PRS 93.26
-
CSI 1.13rCSI 12.9%PRS 80.67
-
CSI 1.08rCSI 9.07%PRS 79.29
-
CSI 0.98rCSI 6.91%PRS 86.2
-
CSI 0.91rCSI 12.94%PRS 85.29
-
CSI 0.84rCSI 8.9%PRS 88.56
-
CSI 0.64rCSI 15.35%PRS 78.23
-
CSI 0.63rCSI 15.05%PRS 78.1
-
CSI 0.54rCSI 11.03%PRS 84.88
-
CSI 0.5rCSI 10.18%PRS 84.16
-
CSI 0.34rCSI 2.94%PRS 84.56
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2708394047
Symbol: GHR_HUMAN
Name: Somatotropin receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2825030
Title: Growth hormone receptor and serum binding protein: purification, cloning and expression.
PubMed ID: 2825030
DOI: 10.1038/330537a0
PubMed ID: 2813379
Title: Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism.
PubMed ID: 2813379
PubMed ID: 1569971
Title: Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript.
PubMed ID: 1569971
PubMed ID: 8855247
Title: Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein.
PubMed ID: 8855247
PubMed ID: 9360546
Title: A membrane-fixed, truncated isoform of the human growth hormone receptor.
PubMed ID: 9360546
PubMed ID: 9058373
Title: A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein.
PubMed ID: 9058373
PubMed ID: 8360189
Title: Functional characterization of the alternatively spliced, placental human growth hormone receptor.
PubMed ID: 8360189
PubMed ID: 10764769
Title: Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution.
PubMed ID: 10764769
PubMed ID: 2406245
Title: The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain.
PubMed ID: 2406245
PubMed ID: 11785980
Title: Identification of a region critical for proteolysis of the human growth hormone receptor.
PubMed ID: 11785980
PubMed ID: 15690087
Title: SOCS2 negatively regulates growth hormone action in vitro and in vivo.
PubMed ID: 15690087
DOI: 10.1172/jci22710
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 21980433
Title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
PubMed ID: 21980433
PubMed ID: 25505247
Title: Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
PubMed ID: 25505247
PubMed ID: 34857742
Title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
PubMed ID: 34857742
PubMed ID: 1549776
Title: Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
PubMed ID: 1549776
PubMed ID: 8943276
Title: Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution.
PubMed ID: 8943276
PubMed ID: 31182716
Title: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.
PubMed ID: 31182716
PubMed ID: 2779634
Title: Laron dwarfism and mutations of the growth hormone-receptor gene.
PubMed ID: 2779634
PubMed ID: 8421103
Title: Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome.
PubMed ID: 8421103
PubMed ID: 8504296
Title: Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome.
PubMed ID: 8504296
DOI: 10.1093/hmg/2.4.355
PubMed ID: 8450064
Title: Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.
PubMed ID: 8450064
DOI: 10.1172/jci116304
PubMed ID: 8137822
Title: A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization.
PubMed ID: 8137822
PubMed ID: 7565946
Title: Mutations of the growth hormone receptor in children with idiopathic short stature.
PubMed ID: 7565946
PubMed ID: 9024232
Title: Nine novel growth hormone receptor gene mutations in patients with Laron syndrome.
PubMed ID: 9024232
PubMed ID: 9661642
Title: A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue.
PubMed ID: 9661642
PubMed ID: 9814495
Title: Growth hormone receptor mutations in children with idiopathic short stature.
PubMed ID: 9814495
PubMed ID: 9851797
Title: Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor.
PubMed ID: 9851797
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 10870033
Title: Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation.
PubMed ID: 10870033
PubMed ID: 12910492
Title: Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred.
PubMed ID: 12910492
DOI: 10.1002/ajmg.a.20172
PubMed ID: 14678285
Title: The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration.
PubMed ID: 14678285
Sequence Information:
- Length: 638
- Mass: 71500
- Checksum: EAF77EADE4787822
- Sequence:
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI DEPDEKTEES DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN ANDIHEGTSE VAQPQRLKGE ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ AEKNKPQPLP TEGAESTHQA AHIQLSNPSS LSNIDFYAQV SDITPAGSVV LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA KKCIPVAPHI KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP
Genular Protein ID: 3168471881
Symbol: A0A087X0H5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 645
- Mass: 72243
- Checksum: D757356B10C5D250
- Sequence:
MNWGPTGMDL WQLLLTLALA GSSDAFSGSE ATAAILSRAP WSLQSVNPGL KTNSSKEPKF TKCRSPERET FSCHWTDEVH HGTKNLGPIQ LFYTRRNTQE WTQEWKECPD YVSAGENSCY FNSSFTSIWI PYCIKLTSNG GTVDEKCFSV DEIVQPDPPI ALNWTLLNVS LTGIHADIQV RWEAPRNADI QKGWMVLEYE LQYKEVNETK WKMMDPILTT SVPVYSLKVD KEYEVRVRSK QRNSGNYGEF SEVLYVTLPQ MSQFTCEEDF YFPWLLIIIF GIFGLTVMLF VFLFSKQQRI KMLILPPVPV PKIKGIDPDL LKEGKLEEVN TILAIHDSYK PEFHSDDSWV EFIELDIDEP DEKTEESDTD RLLSSDHEKS HSNLGVKDGD SGRTSCCEPD ILETDFNAND IHEGTSEVAQ PQRLKGEADL LCLDQKNQNN SPYHDACPAT QQPSVIQAEK NKPQPLPTEG AESTHQAAHI QLSNPSSLSN IDFYAQVSDI TPAGSVVLSP GQKNKAGMSQ CDMHPEMVSL CQENFLMDNA YFCEADAKKC IPVAPHIKVE SHIQPSLNQE DIYITTESLT TAAGRPGTGE HVPGSEMPVP DYTSIHIVQS PQGLILNATA LPLPDKEFLS SCGYVSTDQL NKIMP
Genular Protein ID: 3147290305
Symbol: A0A087X162_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 295
- Mass: 34045
- Checksum: 98B1DD31AAC8F6FD
- Sequence:
MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRKEN