Details for: COL14A1

Gene ID: 7373

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: COL14A1

Ensembl ID: ENSG00000187955

Description: collagen type XIV alpha 1 chain

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • chondrocyte CL0000138
    CSI 15.14
    rCSI 24.08%
    PRS 86.47
  • bronchus fibroblast of lung CL2000093
    CSI 10.82
    rCSI 8.79%
    PRS 90.46
  • microcirculation associated smooth muscle cell CL0008035
    CSI 10.78
    rCSI 31.2%
    PRS 90.31
  • skin fibroblast CL0002620
    CSI 8.63
    rCSI 7.44%
    PRS 90.55
  • stromal cell of ovary CL0002132
    CSI 8.38
    rCSI 23.04%
    PRS 93.88
  • fibroblast of lung CL0002553
    CSI 8.32
    rCSI 7.74%
    PRS 92.24
  • stromal cell CL0000499
    CSI 7.94
    rCSI 22.32%
    PRS 87.25
  • perivascular cell CL4033054
    CSI 7.69
    rCSI 10.51%
    PRS 93.82
  • keratocyte CL0002363
    CSI 6.7
    rCSI 16.12%
    PRS 92.07
  • adventitial cell CL0002503
    CSI 6.12
    rCSI 14.61%
    PRS 93.01
  • neural crest cell CL0011012
    CSI 6.08
    rCSI 4.8%
    PRS 84.35
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6
    rCSI 6.57%
    PRS 92.35
  • myofibroblast cell CL0000186
    CSI 5.89
    rCSI 8.16%
    PRS 87.89
  • adipocyte CL0000136
    CSI 5.88
    rCSI 7.55%
    PRS 83.19
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 5.69
    rCSI 8.07%
    PRS 88.83
  • fibroblast of breast CL4006000
    CSI 5.68
    rCSI 23.86%
    PRS 92.71
  • hepatic stellate cell CL0000632
    CSI 5.48
    rCSI 20.51%
    PRS 86.57
  • alveolar adventitial fibroblast CL4028006
    CSI 5.45
    rCSI 8.62%
    PRS 91.8
  • myeloid leukocyte CL0000766
    CSI 4.91
    rCSI 4.53%
    PRS 92.01
  • Schwann cell CL0002573
    CSI 4.82
    rCSI 13.72%
    PRS 87.51
  • mesenchymal cell CL0008019
    CSI 4.62
    rCSI 11.74%
    PRS 86.21
  • vascular associated smooth muscle cell CL0000359
    CSI 4.26
    rCSI 13.83%
    PRS 89.34
  • lung pericyte CL0009089
    CSI 3.95
    rCSI 10.42%
    PRS 94.46
  • smooth muscle cell CL0000192
    CSI 3.91
    rCSI 9.33%
    PRS 85.32
  • enteric smooth muscle cell CL0002504
    CSI 3.59
    rCSI 5.13%
    PRS 91.1
  • kidney interstitial fibroblast CL1000692
    CSI 3.53
    rCSI 18.74%
    PRS 84.29
  • mononuclear phagocyte CL0000113
    CSI 3.49
    rCSI 7.69%
    PRS 93.17
  • mesodermal cell CL0000222
    CSI 3.44
    rCSI 4.13%
    PRS 89.96
  • fibroblast CL0000057
    CSI 3.41
    rCSI 9.81%
    PRS 81.3
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.38
    rCSI 6.4%
    PRS 95.81
  • intestinal epithelial cell CL0002563
    CSI 3.3
    rCSI 3.45%
    PRS 88.7
  • tracheobronchial smooth muscle cell CL0019019
    CSI 3.14
    rCSI 5.54%
    PRS 93.45
  • basal cell CL0000646
    CSI 3.13
    rCSI 4.19%
    PRS 88.52
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.9
    rCSI 3.61%
    PRS 76.41
  • placental villous trophoblast CL2000060
    CSI 2.89
    rCSI 4.47%
    PRS 89.23
  • fibroblast of cardiac tissue CL0002548
    CSI 2.81
    rCSI 13.48%
    PRS 91.74
  • renal interstitial pericyte CL1001318
    CSI 2.74
    rCSI 7.55%
    PRS 88.32
  • contractile cell CL0000183
    CSI 2.56
    rCSI 7.57%
    PRS 90.09
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.5
    rCSI 3.23%
    PRS 79.65
  • tendon cell CL0000388
    CSI 2.38
    rCSI 6.19%
    PRS 93.54
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.24
    rCSI 2.67%
    PRS 78.62
  • myoepithelial cell CL0000185
    CSI 2.08
    rCSI 5.27%
    PRS 93.23
  • mesenchymal stem cell CL0000134
    CSI 1.97
    rCSI 21.57%
    PRS 92.79
  • blood vessel smooth muscle cell CL0019018
    CSI 1.92
    rCSI 15.59%
    PRS 88.33
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.8
    rCSI 3.03%
    PRS 78.57
  • endocardial cell CL0002350
    CSI 1.68
    rCSI 8.03%
    PRS 87.37
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.66
    rCSI 4.29%
    PRS 88.33
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 1.65
    rCSI 12.67%
    PRS 91.56
  • smooth muscle cell of prostate CL1000487
    CSI 0.96
    rCSI 5.62%
    PRS 93.77
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.73
    rCSI 6.3%
    PRS 85.71
  • pancreatic stellate cell CL0002410
    CSI 0.66
    rCSI 3.86%
    PRS 92.32
  • L6b glutamatergic cortical neuron CL4023038
    CSI 0.6
    rCSI 1.87%
    PRS 79.88
  • kidney interstitial cell CL1000500
    CSI 0.54
    rCSI 8.86%
    PRS 92.77
  • mesenchymal lymphangioblast CL0005021
    CSI 0.4
    rCSI 10.5%
    PRS 94.03
  • central nervous system neuron CL2000029
    CSI 0.38
    rCSI 2.81%
    PRS 83
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.29
    rCSI 3.08%
    PRS 87.15
  • medium spiny neuron CL1001474
    CSI 0.2
    rCSI 1.75%
    PRS 83.36

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [COL14A1](/details-gene/7373) (collagen type XIV alpha 1 chain) encodes a member of the fibril-associated collagens with interrupted triple helices (FACIT) family. This protein is a crucial component of the extracellular matrix (ECM), where it is involved in organizing collagen fibrils and maintaining tissue integrity, a function supported by studies on its structure and stability ([Link](https://doi.org/10.1016/0945-053x(94)90194-5)). Its primary structure was first detailed by Brown et al. ([Link](https://doi.org/10.1016/s0167-4781(97)00131-0)). Also known as undulin, it is associated with the surface of type I collagen fibrils and is thought to mediate interactions between the ECM and cells ([Link](https://doi.org/10.1016/s0021-9258(19)38962-8), [Link](https://doi.org/10.1016/s0021-9258(19)47377-8)). Expression data indicates that **Overall**, [COL14A1](/details-gene/7373) is most significantly expressed in mesenchymal-derived cells such as [chondrocyte](/details-cell/CL0000138)s and various fibroblast populations, highlighting its central role in the formation and maintenance of connective tissues. Clinically, it is associated with an entry in OMIM ([120324](https://omim.org/entry/120324)). ## Cellular Roles and Expression Landscape The expression profile of [COL14A1](/details-gene/7373) underscores its fundamental role in synthesizing and structuring the extracellular matrix. **Overall**, the gene shows the highest significance in cells responsible for building and maintaining connective tissue architecture. Its most significant expression is observed in [chondrocyte](/details-cell/CL0000138) (CSI: 15.14), the primary cell type in cartilage, which is consistent with a role in cartilage homeostasis and mechanics. A strong signal is also seen across multiple fibroblast populations, including [bronchus fibroblast of lung](/details-cell/CL2000093) (CSI: 10.82), [skin fibroblast](/details-cell/CL0002620) (CSI: 8.63), and [fibroblast of lung](/details-cell/CL0002553) (CSI: 8.32), suggesting a widespread function in providing structural support to diverse organs. Furthermore, its high significance in [microcirculation associated smooth muscle cell](/details-cell/CL0008035) (CSI: 10.78), [perivascular cell](/details-cell/CL4033054) (CSI: 7.69), and [adventitial cell](/details-cell/CL0002503) (CSI: 6.12) points to an important function in vascular structure and integrity. The gene's activity in various stromal cells, such as [stromal cell of ovary](/details-cell/CL0002132) (CSI: 8.38) and the broader [stromal cell](/details-cell/CL0000499) category (CSI: 7.94), further solidifies its identity as a key contributor to the supportive tissue framework throughout the body. ## Pathways and Molecular Function The functions of [COL14A1](/details-gene/7373) are tightly linked to the organization and maintenance of the extracellular space. Gene Ontology annotations classify it as an '[extracellular matrix structural constituent](https://www.ebi.ac.uk/QuickGO/term/GO:0005201)' that participates in '[collagen fibril organization](https://www.ebi.ac.uk/QuickGO/term/GO:0030199)' and '[extracellular matrix organization](https://www.ebi.ac.uk/QuickGO/term/GO:0030198)'. These roles are consistent with its high expression in ECM-producing cells like [fibroblast of lung](/details-cell/CL0002553) and [chondrocyte](/details-cell/CL0000138). Reactome pathway analysis further refines this role, placing [COL14A1](/details-gene/7373) in key processes such as '[Collagen formation](https://reactome.org/content/detail/R-HSA-1474290)', '[Assembly of collagen fibrils and other multimeric structures](https://reactome.org/content/detail/R-HSA-2022090)', and '[Extracellular matrix organization](https://reactome.org/content/detail/R-HSA-1474244)'. Its molecular function also includes '[collagen binding](https://www.ebi.ac.uk/QuickGO/term/GO:0005518)', which enables it to act as an adaptor molecule linking different components of the ECM. In addition to its structural roles, a GO annotation for '[Rna binding](https://www.ebi.ac.uk/QuickGO/term/GO:0003723)' suggests potential intracellular functions that are less characterized. The gene's involvement in '[regulation of cell growth involved in cardiac muscle cell development](https://www.ebi.ac.uk/QuickGO/term/GO:0061050)' points towards specialized roles in organogenesis beyond general tissue maintenance. ## Research Directions Based on its well-defined role in ECM biology and its specific cellular expression patterns, several avenues for future research can be proposed. **Proposed Hypotheses:** 1. Given its high expression in various fibroblast populations (e.g., [bronchus fibroblast of lung](/details-cell/CL2000093), [skin fibroblast](/details-cell/CL0002620)) and its central role in '[collagen fibril organization](https://www.ebi.ac.uk/QuickGO/term/GO:0030199)', dysregulation of [COL14A1](/details-gene/7373) may be a key driver of pathological fibrosis. Overexpression or altered function of [COL14A1](/details-gene/7373) could lead to excessive collagen deposition and tissue stiffening in diseases like idiopathic pulmonary fibrosis or scleroderma. 2. The significant expression of [COL14A1](/details-gene/7373) in [chondrocyte](/details-cell/CL0000138)s suggests that its depletion or functional impairment could compromise the structural integrity of articular cartilage, potentially accelerating the onset or progression of osteoarthritis by disrupting the organization of the collagenous network. 3. The specific annotation for '[regulation of cell growth involved in cardiac muscle cell development](https://www.ebi.ac.uk/QuickGO/term/GO:0061050)' suggests that [COL14A1](/details-gene/7373) may play a critical, non-structural signaling role during heart development, perhaps by modulating growth factor availability or cell-matrix adhesion to guide cardiomyocyte proliferation and alignment. **Key Experimental Approach:** To test the hypothesis that [COL14A1](/details-gene/7373) is a critical regulator of pulmonary fibrosis, a robust experimental plan could be implemented. A conditional knockout of `Col14a1` in murine lung fibroblasts could be generated. These mice, alongside wild-type controls, would be subjected to a bleomycin-induced lung injury model. The progression of fibrosis would be assessed at multiple time points using histology (Masson's trichrome and Picro-Sirius Red staining), quantification of total lung collagen content via hydroxyproline assay, and functional assessment with lung mechanics measurements. Furthermore, single-cell RNA sequencing of lung tissue would allow for a detailed analysis of how the loss of [COL14A1](/details-gene/7373) affects fibroblast activation, differentiation into myofibroblasts, and crosstalk with immune and epithelial cells during the fibrotic response. **Therapeutic Potential:** As an extracellular protein central to tissue structure, [COL14A1](/details-gene/7373) presents an intriguing but challenging therapeutic target. In the context of fibrotic diseases, where its expression may be elevated, [COL14A1](/details-gene/7373) could be a target for inhibitory therapies. A monoclonal antibody designed to block the interaction of [COL14A1](/details-gene/7373) with type I collagen or other ECM components could potentially disrupt the formation of the rigid, cross-linked matrix that characterizes fibrotic tissue. Such a strategy would aim to normalize ECM architecture rather than simply block its production. Conversely, in conditions involving tissue atrophy or poor healing, targeted delivery of recombinant [COL14A1](/details-gene/7373) or therapies that upregulate its expression could be explored to promote constructive tissue remodeling.

Genular Protein ID: 2911924718

Symbol: COEA1_HUMAN

Name: Collagen alpha-1(XIV) chain

UniProtKB Accession Codes:

Q05707 B2RU07 O00260 O00261 O00262 Q05708 Q5XJ18 Q96C67 Q9UDF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 2 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 4 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427527

Title: Complete primary structure of human collagen type XIV (undulin).

PubMed ID: 9427527

DOI: 10.1016/s0167-4781(97)00131-0

PubMed ID: 1716629

Title: Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins.

PubMed ID: 1716629

DOI: 10.1016/s0021-9258(19)47377-8

PubMed ID: 7827751

Title: Structure and stability of the triple-helical domains of human collagen XIV.

PubMed ID: 7827751

DOI: 10.1016/0945-053x(94)90194-5

PubMed ID: 2187872

Title: Undulin, an extracellular matrix glycoprotein associated with collagen fibrils.

PubMed ID: 2187872

DOI: 10.1016/s0021-9258(19)38962-8

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1796
  • Mass: 193515
  • Checksum: 30A72F6E2CC07F70
  • Sequence:
    • MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW KAPRGKFGGY 
KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII AYNKDKESKP AQGQFRIKDL 
EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV CQTPAIADIV ILVDGSWSIG RFNFRLVRHF 
LENLVTAFDV GSEKTRIGLA QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA 
LNYIFENSFK PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN 
ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH AITGPPTELI 
TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV DGTVSSTVLK NLMSLTEYQI 
AVFAIYAHTA SEGLRGTETT LALPMASDLL LYDVTENSMR VKWDAVPGAS GYLILYAPLT 
EGLAGDEKEM KIGETHTDIE LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN 
LRISNVGSNS ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT 
IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD EGLHKLMWIP 
VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG SESEVVTAVG TTLDSFWTEP 
ATTIVPTTSV TSVFQTGIRN LVVGDETTSS LRVKWDISDS DVQQFRVTYM TAQGDPEEEV 
IGTVMVPGSQ NNLLLKPLLP DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE 
WYNRLRITWD PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF 
ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV VIESLQDRQK 
QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS IMEKTQSLPT RPPTFPPTIP 
PAKEVCKAAK ADLVFMVDGS WSIGDENFNK IISFLYSTVG ALNKIGTDGT QVAMVQFTDD 
PRTEFKLNAY KTKETLLDAI KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV 
ITDGRSQDDV NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK 
IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS MEPGTFNVFP 
CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ EPFALWEILN KNSDPLVGVI 
LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR KIFYGSFHKL HIVVSETLVK VVIDCKQVGE 
KAMNASANIT SDGVEVLGKM VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD 
DESCPDLPHS CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ 
GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP GQRGLPGKDG 
SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA KGERGERGDL QSQAMVRSVA 
RQVCEQLIQS HMARYTAILN QIPSHSSSIR TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP 
GNAGVPGTPG ERGLTGIKGE KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP 
PGHLGVPGPQ GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV