Details for: COL14A1

Gene ID: 7373

Symbol: COL14A1

Ensembl ID: ENSG00000187955

Description: collagen type XIV alpha 1 chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 91.8218
    Cell Significance Index: -23.2900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.3939
    Cell Significance Index: -23.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.8977
    Cell Significance Index: -23.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.7001
    Cell Significance Index: 53.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0724
    Cell Significance Index: -13.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7779
    Cell Significance Index: -22.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.1020
    Cell Significance Index: 65.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.3317
    Cell Significance Index: 95.5100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 3.0213
    Cell Significance Index: 13.9500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.5250
    Cell Significance Index: 49.2800
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 2.2351
    Cell Significance Index: 13.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6519
    Cell Significance Index: 226.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3430
    Cell Significance Index: 35.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.2310
    Cell Significance Index: 19.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1435
    Cell Significance Index: 30.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0380
    Cell Significance Index: 52.4600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.9992
    Cell Significance Index: 4.7800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.9315
    Cell Significance Index: 15.0300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8041
    Cell Significance Index: 19.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6373
    Cell Significance Index: 13.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3578
    Cell Significance Index: 10.0000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3568
    Cell Significance Index: 3.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2180
    Cell Significance Index: 3.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1650
    Cell Significance Index: 2.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1564
    Cell Significance Index: 31.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0818
    Cell Significance Index: 56.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0736
    Cell Significance Index: 32.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0660
    Cell Significance Index: 1.1100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0536
    Cell Significance Index: 0.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0445
    Cell Significance Index: 8.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0162
    Cell Significance Index: 0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0027
    Cell Significance Index: 1.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0096
    Cell Significance Index: -17.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0125
    Cell Significance Index: -19.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0126
    Cell Significance Index: -17.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0234
    Cell Significance Index: -8.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0303
    Cell Significance Index: -19.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0311
    Cell Significance Index: -22.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0323
    Cell Significance Index: -24.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0353
    Cell Significance Index: -26.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0418
    Cell Significance Index: -18.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0418
    Cell Significance Index: -26.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0467
    Cell Significance Index: -26.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0526
    Cell Significance Index: -6.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0589
    Cell Significance Index: -16.9600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0636
    Cell Significance Index: -0.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0743
    Cell Significance Index: -13.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1042
    Cell Significance Index: -15.1400
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1104
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1228
    Cell Significance Index: -25.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1262
    Cell Significance Index: -21.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1280
    Cell Significance Index: -9.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1295
    Cell Significance Index: -15.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1330
    Cell Significance Index: -3.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1683
    Cell Significance Index: -19.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1756
    Cell Significance Index: -22.6800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1926
    Cell Significance Index: -3.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2039
    Cell Significance Index: -20.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2116
    Cell Significance Index: -16.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2144
    Cell Significance Index: -22.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2164
    Cell Significance Index: -4.6300
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.2253
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2278
    Cell Significance Index: -26.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2286
    Cell Significance Index: -15.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2333
    Cell Significance Index: -2.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2528
    Cell Significance Index: -11.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2699
    Cell Significance Index: -3.8700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2732
    Cell Significance Index: -1.7100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2941
    Cell Significance Index: -23.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3023
    Cell Significance Index: -22.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3046
    Cell Significance Index: -18.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3195
    Cell Significance Index: -8.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3209
    Cell Significance Index: -5.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3279
    Cell Significance Index: -17.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3894
    Cell Significance Index: -23.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4045
    Cell Significance Index: -17.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4256
    Cell Significance Index: -10.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4468
    Cell Significance Index: -25.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4735
    Cell Significance Index: -17.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4768
    Cell Significance Index: -22.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4849
    Cell Significance Index: -25.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5217
    Cell Significance Index: -27.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5384
    Cell Significance Index: -23.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5855
    Cell Significance Index: -20.5100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5921
    Cell Significance Index: -20.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5999
    Cell Significance Index: -14.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6332
    Cell Significance Index: -20.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6347
    Cell Significance Index: -23.3000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6381
    Cell Significance Index: -6.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6383
    Cell Significance Index: -18.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6526
    Cell Significance Index: -20.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6762
    Cell Significance Index: -23.7600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.6871
    Cell Significance Index: -5.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7193
    Cell Significance Index: -7.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7225
    Cell Significance Index: -21.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.7230
    Cell Significance Index: -15.6200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7272
    Cell Significance Index: -11.0500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7303
    Cell Significance Index: -15.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7351
    Cell Significance Index: -23.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Collagen type XIV**: COL14A1 is a member of the collagen family, specifically type XIV, which is characterized by its unique structure and function. 2. **Alpha 1 chain**: The COL14A1 gene encodes for the alpha 1 chain of collagen type XIV, which is a crucial subunit for the assembly of collagen fibrils. 3. **Expression in various cell types**: COL14A1 is expressed in a wide range of cell types, including fibroblasts, muscle fibers, neurons, and endothelial cells, highlighting its broad involvement in tissue development and homeostasis. 4. **Significant pathway involvement**: The COL14A1 protein is involved in various pathways, including assembly of collagen fibrils, cell-cell adhesion, and regulation of cell growth. **Pathways and Functions:** 1. **Assembly of collagen fibrils**: COL14A1 plays a critical role in the assembly of collagen fibrils, which are essential for maintaining tissue structure and function. 2. **Cell-cell adhesion**: The COL14A1 protein is involved in cell-cell adhesion, which is critical for tissue development and homeostasis. 3. **Collagen biosynthesis and modifying enzymes**: COL14A1 interacts with collagen biosynthesis and modifying enzymes, which are essential for the production and modification of collagen fibrils. 4. **Regulation of cell growth**: The COL14A1 protein is involved in the regulation of cell growth, which is critical for tissue development and homeostasis. **Clinical Significance:** Dysregulation of COL14A1 has been implicated in various diseases, including: 1. **Musculoskeletal disorders**: Mutations in COL14A1 have been associated with musculoskeletal disorders, such as osteogenesis imperfecta and Ehlers-Danlos syndrome. 2. **Cardiac disorders**: COL14A1 has been implicated in cardiac disorders, such as hypertrophic cardiomyopathy and cardiac fibrosis. 3. **Neurological disorders**: The COL14A1 protein has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, COL14A1 is a critical gene that plays a vital role in maintaining tissue structure and function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its function and regulation in maintaining tissue homeostasis.

Genular Protein ID: 2911924718

Symbol: COEA1_HUMAN

Name: Collagen alpha-1(XIV) chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427527

Title: Complete primary structure of human collagen type XIV (undulin).

PubMed ID: 9427527

DOI: 10.1016/s0167-4781(97)00131-0

PubMed ID: 1716629

Title: Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins.

PubMed ID: 1716629

DOI: 10.1016/s0021-9258(19)47377-8

PubMed ID: 7827751

Title: Structure and stability of the triple-helical domains of human collagen XIV.

PubMed ID: 7827751

DOI: 10.1016/0945-053x(94)90194-5

PubMed ID: 2187872

Title: Undulin, an extracellular matrix glycoprotein associated with collagen fibrils.

PubMed ID: 2187872

DOI: 10.1016/s0021-9258(19)38962-8

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 1796
  • Mass: 193515
  • Checksum: 30A72F6E2CC07F70
  • Sequence:
  • MKIFQRKMRY WLLPPFLAIV YFCTIVQGQV APPTRLRYNV ISHDSIQISW KAPRGKFGGY 
    KLLVTPTSGG KTNQLNLQNT ATKAIIQGLM PDQNYTVQII AYNKDKESKP AQGQFRIKDL 
    EKRKDPKPRV KVVDRGNGSR PSSPEEVKFV CQTPAIADIV ILVDGSWSIG RFNFRLVRHF 
    LENLVTAFDV GSEKTRIGLA QYSGDPRIEW HLNAFSTKDE VIEAVRNLPY KGGNTLTGLA 
    LNYIFENSFK PEAGSRTGVS KIGILITDGK SQDDIIPPSR NLRESGVELF AIGVKNADVN 
    ELQEIASEPD STHVYNVAEF DLMHTVVESL TRTLCSRVEE QDREIKASAH AITGPPTELI 
    TSEVTARSFM VNWTHAPGNV EKYRVVYYPT RGGKPDEVVV DGTVSSTVLK NLMSLTEYQI 
    AVFAIYAHTA SEGLRGTETT LALPMASDLL LYDVTENSMR VKWDAVPGAS GYLILYAPLT 
    EGLAGDEKEM KIGETHTDIE LSGLLPNTEY TVTVYAMFGE EASDPVTGQE TTLALSPPRN 
    LRISNVGSNS ARLTWDPTSR QINGYRIVYN NADGTEINEV EVDPITTFPL KGLTPLTEYT 
    IAIFSIYDEG QSEPLTGVFT TEEVPAQQYL EIDEVTTDSF RVTWHPLSAD EGLHKLMWIP 
    VYGGKTEEVV LKEEQDSHVI EGLEPGTEYE VSLLAVLDDG SESEVVTAVG TTLDSFWTEP 
    ATTIVPTTSV TSVFQTGIRN LVVGDETTSS LRVKWDISDS DVQQFRVTYM TAQGDPEEEV 
    IGTVMVPGSQ NNLLLKPLLP DTEYKVTVTP IYTDGEGVSV SAPGKTLPSS GPQNLRVSEE 
    WYNRLRITWD PPSSPVKGYR IVYKPVSVPG PTLETFVGAD INTILITNLL SGMDYNVKIF 
    ASQASGFSDA LTGMVKTLFL GVTNLQAKHV EMTSLCAHWQ VHRHATAYRV VIESLQDRQK 
    QESTVGGGTT RHCFYGLQPD SEYKISVYTK LQEIEGPSVS IMEKTQSLPT RPPTFPPTIP 
    PAKEVCKAAK ADLVFMVDGS WSIGDENFNK IISFLYSTVG ALNKIGTDGT QVAMVQFTDD 
    PRTEFKLNAY KTKETLLDAI KHISYKGGNT KTGKAIKYVR DTLFTAESGT RRGIPKVIVV 
    ITDGRSQDDV NKISREMQLD GYSIFAIGVA DADYSELVSI GSKPSARHVF FVDDFDAFKK 
    IEDELITFVC ETASATCPVV HKDGIDLAGF KMMEMFGLVE KDFSSVEGVS MEPGTFNVFP 
    CYQLHKDALV SQPTRYLHPE GLPSDYTISF LFRILPDTPQ EPFALWEILN KNSDPLVGVI 
    LDNGGKTLTY FNYDQSGDFQ TVTFEGPEIR KIFYGSFHKL HIVVSETLVK VVIDCKQVGE 
    KAMNASANIT SDGVEVLGKM VRSRGPGGNS APFQLQMFDI VCSTSWANTD KCCELPGLRD 
    DESCPDLPHS CSCSETNEVA LGPAGPPGGP GLRGPKGQQG EPGPKGPDGP RGEIGLPGPQ 
    GPPGPQGPSG LSIQGMPGMP GEKGEKGDTG LPGPQGIPGG VGSPGRDGSP GQRGLPGKDG 
    SSGPPGPPGP IGIPGTPGVP GITGSMGPQG ALGPPGVPGA KGERGERGDL QSQAMVRSVA 
    RQVCEQLIQS HMARYTAILN QIPSHSSSIR TVQGPPGEPG RPGSPGAPGE QGPPGTPGFP 
    GNAGVPGTPG ERGLTGIKGE KGNPGVGTQG PRGPPGPAGP SGESRPGSPG PPGSPGPRGP 
    PGHLGVPGPQ GPSGQPGYCD PSSCSAYGVR APHPDQPEFT PVQDELEAME LWGPGV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.