Details for: HLA A

Gene ID: 3105

Symbol: HLA A

Ensembl ID: ENSG00000206503

Description: major histocompatibility complex, class I, A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1005.6239
    Cell Significance Index: -156.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 477.7968
    Cell Significance Index: -121.1900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 442.3621
    Cell Significance Index: -182.2300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 381.9452
    Cell Significance Index: -180.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 379.8709
    Cell Significance Index: -195.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 269.8793
    Cell Significance Index: -181.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 127.5553
    Cell Significance Index: -157.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 51.2754
    Cell Significance Index: -157.4900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 46.7583
    Cell Significance Index: 125.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 43.2382
    Cell Significance Index: -170.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 31.4175
    Cell Significance Index: -68.7600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 13.0655
    Cell Significance Index: 241.4900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 11.6010
    Cell Significance Index: 205.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 11.3426
    Cell Significance Index: 333.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.2699
    Cell Significance Index: 105.3100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 8.8479
    Cell Significance Index: 63.5500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.6930
    Cell Significance Index: 166.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.1482
    Cell Significance Index: 241.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.0438
    Cell Significance Index: 646.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.9951
    Cell Significance Index: 685.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.9575
    Cell Significance Index: 255.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7070
    Cell Significance Index: 478.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.0739
    Cell Significance Index: 1359.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.9829
    Cell Significance Index: 295.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.9539
    Cell Significance Index: 363.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.8254
    Cell Significance Index: 210.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.6200
    Cell Significance Index: 1430.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4652
    Cell Significance Index: 444.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4158
    Cell Significance Index: 69.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2605
    Cell Significance Index: 159.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2139
    Cell Significance Index: 116.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6027
    Cell Significance Index: 189.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5056
    Cell Significance Index: 39.5900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1614
    Cell Significance Index: 126.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0438
    Cell Significance Index: 30.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0296
    Cell Significance Index: 204.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.7562
    Cell Significance Index: 86.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6486
    Cell Significance Index: 123.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4751
    Cell Significance Index: 24.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3468
    Cell Significance Index: 9.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3238
    Cell Significance Index: 52.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2980
    Cell Significance Index: 225.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2140
    Cell Significance Index: 193.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0647
    Cell Significance Index: 6.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0273
    Cell Significance Index: 20.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0065
    Cell Significance Index: 1.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0458
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0558
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0627
    Cell Significance Index: -46.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0933
    Cell Significance Index: -172.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1075
    Cell Significance Index: -165.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1264
    Cell Significance Index: -78.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1332
    Cell Significance Index: -181.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2190
    Cell Significance Index: -123.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2335
    Cell Significance Index: -148.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2462
    Cell Significance Index: -6.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2846
    Cell Significance Index: -14.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3285
    Cell Significance Index: -37.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3386
    Cell Significance Index: -121.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3404
    Cell Significance Index: -154.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3714
    Cell Significance Index: -78.2300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4681
    Cell Significance Index: -19.1800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5192
    Cell Significance Index: -8.9500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.5642
    Cell Significance Index: -9.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6972
    Cell Significance Index: -139.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8077
    Cell Significance Index: -117.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8845
    Cell Significance Index: -28.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.0111
    Cell Significance Index: -23.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.0597
    Cell Significance Index: -37.2400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.1056
    Cell Significance Index: -9.5000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1350
    Cell Significance Index: -132.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3548
    Cell Significance Index: -34.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.5746
    Cell Significance Index: -42.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.5989
    Cell Significance Index: -166.4800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.6677
    Cell Significance Index: -36.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.7256
    Cell Significance Index: -28.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.7439
    Cell Significance Index: -133.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.1846
    Cell Significance Index: -151.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.3405
    Cell Significance Index: -185.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.3712
    Cell Significance Index: -35.5300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -2.4519
    Cell Significance Index: -13.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.4759
    Cell Significance Index: -61.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.6889
    Cell Significance Index: -169.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.7945
    Cell Significance Index: -156.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.9351
    Cell Significance Index: -179.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.1480
    Cell Significance Index: -42.9500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -3.2062
    Cell Significance Index: -65.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -3.2893
    Cell Significance Index: -50.8900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -3.4641
    Cell Significance Index: -31.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: -3.4940
    Cell Significance Index: 9.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -3.6030
    Cell Significance Index: -70.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -3.6179
    Cell Significance Index: -77.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.6545
    Cell Significance Index: -22.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.7982
    Cell Significance Index: -131.9900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.8730
    Cell Significance Index: -171.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.1184
    Cell Significance Index: -151.1900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -4.1316
    Cell Significance Index: -42.7700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.2737
    Cell Significance Index: -125.8800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -4.5158
    Cell Significance Index: -47.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLA-A is a type I transmembrane protein, consisting of an alpha chain and a beta-2 microglobulin (β2M) non-covalently associated with the alpha chain. The alpha chain contains the peptide-binding groove, which is responsible for presenting peptides to CD8+ T cells. The HLA-A gene is highly polymorphic, with over 40 different alleles expressed in humans. These alleles differ in their amino acid sequences, resulting in variations in the peptide-binding groove and antigen-presenting capabilities. **Pathways and Functions** HLA-A plays a central role in the adaptive immune response, particularly in the recognition and elimination of infected cells or tumor cells. The HLA-A protein presents endogenously synthesized peptides to CD8+ T cells through the following pathways: 1. **Antigen processing and presentation**: HLA-A is responsible for processing and presenting endogenously synthesized peptides to CD8+ T cells. 2. **Antigen presentation: folding, assembly, and peptide loading of class I MHC**: HLA-A undergoes a series of post-translational modifications, including folding, assembly, and peptide loading, to form the peptide-binding groove. 3. **CD8 receptor binding**: HLA-A binds to CD8+ T cells, allowing the T cell receptor (TCR) to recognize and bind to the peptide-MHC complex. 4. **T cell activation**: The recognition of the peptide-MHC complex by the TCR triggers the activation of CD8+ T cells, leading to their proliferation, differentiation, and cytotoxic activity. **Clinical Significance** HLA-A is an important gene in the context of various diseases, including: 1. **Autoimmune diseases**: HLA-A allelic polymorphism can influence the risk of developing autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer**: HLA-A is involved in the recognition and elimination of tumor cells, making it an important target for cancer immunotherapy. 3. **Infectious diseases**: HLA-A plays a role in the recognition and elimination of infected cells, particularly in the context of viral infections such as HIV and SARS-CoV-2. 4. **Organ transplantation**: HLA-A is used as a marker for organ transplantation, as it is involved in the rejection of transplanted organs. In conclusion, the HLA-A gene is a critical component of the adaptive immune system, playing a central role in the recognition and elimination of infected cells or tumor cells. Its polymorphism allows for a more precise and efficient immune response, making it an important target for the development of immunotherapies and vaccines.

Genular Protein ID: 3039144565

Symbol: HLAA_HUMAN

Name: HLA class I histocompatibility antigen, A alpha chain

UniProtKB Accession Codes:

P04439 B1PKZ3 O02939 O02954 O02955 O02963 O19509 O19546 O19598 O19605 O19606 O19619 O19647 O19673 O19687 O19695 O19756 O19794 O19795 O43906 O43907 O46874 O62921 O62924 O77937 O77938 O77964 O78073 O78171 O98009 O98010 O98011 O98137 P01891 P01892 P05534 P06338 P10313 P10314 P10315 P10316 P13746 P16188 P16189 P16190 P18462 P30443 P30444 P30445 P30446 P30447 P30448 P30449 P30450 P30451 P30452 P30453 P30454 P30455 P30456 P30457 P30458 P30459 P30512 P30514 P79505 P79562 P79563 Q09160 Q29680 Q29747 Q29835 Q29837 Q29838 Q29899 Q29908 Q29909 Q29910 Q30208 Q31623 Q5S3G1 Q65A82 Q8MHM1 Q8MHN9 Q95352 Q95355 Q95362 Q95377 Q95380 Q95IZ5 Q9BCN0 Q9BD15 Q9BD19 Q9GJE6 Q9GJE7 Q9GJE8 Q9MW42 Q9MY89 Q9MYA3 Q9MYA5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 47 EMDB 10 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 49 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 15 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 22 Pumba 1 Reactome 9 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2431040

Title: The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.

PubMed ID: 2431040

PubMed ID: 3496393

Title: Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules.

PubMed ID: 3496393

PubMed ID: 2460344

Title: Nucleotide sequences of chimpanzee MHC class I alleles: evidence for trans-species mode of evolution.

PubMed ID: 2460344

DOI: 10.1002/j.1460-2075.1988.tb03131.x

PubMed ID: 2461903

Title: Molecular mapping of a new public HLA class I epitope shared by all HLA-B and HLA-C antigens and defined by a monoclonal antibody.

PubMed ID: 2461903

DOI: 10.1007/bf02341610

PubMed ID: 2478623

Title: Molecular analysis of the serologically defined HLA-Aw19 antigens. A genetically distinct family of HLA-A antigens comprising A29, A31, A32, and Aw33, but probably not A30.

PubMed ID: 2478623

PubMed ID: 2715640

Title: Diversity and diversification of HLA-A,B,C alleles.

PubMed ID: 2715640

PubMed ID: 2320591

Title: Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

PubMed ID: 2320591

DOI: 10.1073/pnas.87.7.2833

PubMed ID: 1782566

Title: HLA-A29 sub-types and 'Birdshot' choroido-retinopathy susceptibility: a possible 'resistance motif' in the HLA-A29.1 molecule.

PubMed ID: 1782566

PubMed ID: 1729171

Title: Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3.

PubMed ID: 1729171

DOI: 10.1007/bf00216625

PubMed ID: 1431115

Title: Distinctive HLA-A,B antigens of black populations formed by interallelic conversion.

PubMed ID: 1431115

PubMed ID: 1317015

Title: Unusual HLA-B alleles in two tribes of Brazilian Indians.

PubMed ID: 1317015

DOI: 10.1038/357326a0

PubMed ID: 8475492

Title: Structural diversity in the HLA-A10 family of alleles: correlations with serology.

PubMed ID: 8475492

DOI: 10.1111/j.1399-0039.1993.tb01982.x

PubMed ID: 8284791

Title: A sixth family of HLA-A alleles defined by HLA-A*8001.

PubMed ID: 8284791

DOI: 10.1111/j.1399-0039.1993.tb02186.x

PubMed ID: 8026990

Title: Sequences of four splits of HLA-A10 group. Implications for serologic cross-reactivities and their evolution.

PubMed ID: 8026990

DOI: 10.1016/0198-8859(94)90263-1

PubMed ID: 8188325

Title: Characterization of a new and highly distinguishable HLA-A allele in a Spanish family.

PubMed ID: 8188325

DOI: 10.1007/bf00176169

PubMed ID: 8016845

Title: Sequence analysis of serological HLA-A11 split antigens, A11.1 and A11.2.

PubMed ID: 8016845

DOI: 10.1111/j.1399-0039.1994.tb02304.x

PubMed ID: 7871528

Title: Correct sequence of the A*3001 allele obtained by PCR-SSP typing and automated nucleotide sequencing.

PubMed ID: 7871528

DOI: 10.1111/j.1399-0039.1994.tb02393.x

PubMed ID: 17092262

Title: Identification and frequency of a novel HLA-A allele, A*110104.

PubMed ID: 17092262

DOI: 10.1111/j.1399-0039.2006.00687.x

PubMed ID: 6609814

Title: Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.

PubMed ID: 6609814

DOI: 10.1002/j.1460-2075.1984.tb01901.x

PubMed ID: 3877632

Title: Exon shuffling in vivo can generate novel HLA class I molecules.

PubMed ID: 3877632

DOI: 10.1002/j.1460-2075.1985.tb04013.x

PubMed ID: 2982951

Title: Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

PubMed ID: 2982951

PubMed ID: 2437024

Title: DNA sequence of HLA-A11: remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells.

PubMed ID: 2437024

DOI: 10.1007/bf00404694

PubMed ID: 2251137

Title: Nucleotide sequence of an HLA-A1 gene.

PubMed ID: 2251137

DOI: 10.1093/nar/18.22.6701

PubMed ID: 7836067

Title: HLA class I allele (HLA-A2) expression defect associated with a mutation in its enhancer B inverted CAT box in two families.

PubMed ID: 7836067

DOI: 10.1016/0198-8859(94)90087-6

PubMed ID: 8795145

Title: On the sequence of A*3101.

PubMed ID: 8795145

DOI: 10.1111/j.1399-0039.1996.tb02580.x

PubMed ID: 9349616

Title: An intronic mutation responsible for a low level of expression of an HLA-A*24 allele.

PubMed ID: 9349616

DOI: 10.1111/j.1399-0039.1997.tb02884.x

PubMed ID: 9349617

Title: A nucleotide insertion in exon 4 is responsible for the absence of expression of an HLA-A*01 allele.

PubMed ID: 9349617

DOI: 10.1111/j.1399-0039.1997.tb02885.x

PubMed ID: 19735485

Title: Analysis of the complete genomic sequence of HLA-A alleles in the Chinese Han population.

PubMed ID: 19735485

DOI: 10.1111/j.1744-313x.2009.00874.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 92029

Title: Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

PubMed ID: 92029

DOI: 10.1073/pnas.76.9.4395

PubMed ID: 6179086

Title: Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.

PubMed ID: 6179086

DOI: 10.1073/pnas.79.12.3813

PubMed ID: 2456340

Title: Analysis of the molecular basis of HLA-A3 recognition by cytotoxic T cells using defined mutants of the HLA-A3 molecule.

PubMed ID: 2456340

PubMed ID: 2784196

Title: Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8.

PubMed ID: 2784196

DOI: 10.1038/338345a0

PubMed ID: 1402688

Title: A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

PubMed ID: 1402688

DOI: 10.1084/jem.176.5.1453

PubMed ID: 7504010

Title: HLA-A1 and HLA-A3 T cell epitopes derived from influenza virus proteins predicted from peptide binding motifs.

PubMed ID: 7504010

PubMed ID: 7679507

Title: Endogenous peptides bound to HLA-A3 possess a specific combination of anchor residues that permit identification of potential antigenic peptides.

PubMed ID: 7679507

DOI: 10.1073/pnas.90.4.1508

PubMed ID: 7506728

Title: Endogenous peptides with distinct amino acid anchor residue motifs bind to HLA-A1 and HLA-B8.

PubMed ID: 7506728

PubMed ID: 8805302

Title: Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP.

PubMed ID: 8805302

DOI: 10.1016/s0960-9822(02)00611-5

PubMed ID: 8630735

Title: A point mutation in HLA-A*0201 results in failure to bind the TAP complex and to present virus-derived peptides to CTL.

PubMed ID: 8630735

DOI: 10.1016/s1074-7613(00)80416-1

PubMed ID: 8622959

Title: Definition of the HLA-A29 peptide ligand motif allows prediction of potential T-cell epitopes from the retinal soluble antigen, a candidate autoantigen in birdshot retinopathy.

PubMed ID: 8622959

DOI: 10.1073/pnas.93.8.3466

PubMed ID: 9047241

Title: Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor.

PubMed ID: 9047241

DOI: 10.1016/s1074-7613(00)80426-4

PubMed ID: 9862734

Title: Identification of new melanoma epitopes on melanosomal proteins recognized by tumor infiltrating T lymphocytes restricted by HLA-A1, -A2, and -A3 alleles.

PubMed ID: 9862734

PubMed ID: 10449296

Title: HLA-A*1101-restricted cytotoxic T lymphocyte recognition of HIV-1 Pol protein.

PubMed ID: 10449296

DOI: 10.1097/00002030-199907300-00021

PubMed ID: 11390610

Title: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12(I) protein.

PubMed ID: 11390610

DOI: 10.1128/jvi.75.13.6086-6094.2001

PubMed ID: 12006494

Title: Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101-dependent degradation.

PubMed ID: 12006494

DOI: 10.1093/emboj/21.10.2418

PubMed ID: 12138174

Title: Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations.

PubMed ID: 12138174

DOI: 10.1073/pnas.112331099

PubMed ID: 12393434

Title: Tetramer-assisted identification and characterization of epitopes recognized by HLA A*2402-restricted Epstein-Barr virus-specific CD8+ T cells.

PubMed ID: 12393434

DOI: 10.1182/blood-2002-04-1240

PubMed ID: 15893615

Title: Identification and characterization of HIV-1-specific CD8+ T cell epitopes presented by HLA-A*2601.

PubMed ID: 15893615

DOI: 10.1016/j.vaccine.2005.02.022

PubMed ID: 17189421

Title: Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1.

PubMed ID: 17189421

DOI: 10.1158/1078-0432.ccr-06-1337

PubMed ID: 17182537

Title: Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.

PubMed ID: 17182537

DOI: 10.4049/jimmunol.178.1.33

PubMed ID: 17079320

Title: Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus.

PubMed ID: 17079320

DOI: 10.1128/jvi.01779-06

PubMed ID: 18502829

Title: Human leukocyte antigens A23, A24, and A32 but not A25 are ligands for KIR3DL1.

PubMed ID: 18502829

DOI: 10.1182/blood-2008-02-137521

PubMed ID: 18779413

Title: A mechanism for the HLA-A*01-associated risk for EBV+ Hodgkin lymphoma and infectious mononucleosis.

PubMed ID: 18779413

DOI: 10.1182/blood-2008-06-162883

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19543285

Title: Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.

PubMed ID: 19543285

DOI: 10.1038/nmeth.1345

PubMed ID: 20364150

Title: Production of an antigenic peptide by insulin-degrading enzyme.

PubMed ID: 20364150

DOI: 10.1038/ni.1862

PubMed ID: 20356336

Title: Nomenclature for factors of the HLA system, 2010.

PubMed ID: 20356336

DOI: 10.1111/j.1399-0039.2010.01466.x

PubMed ID: 21263072

Title: Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.

PubMed ID: 21263072

DOI: 10.4049/jimmunol.1002959

PubMed ID: 21498667

Title: HLA-A*7401-mediated control of HIV viremia is independent of its linkage disequilibrium with HLA-B*5703.

PubMed ID: 21498667

DOI: 10.4049/jimmunol.1003711

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24192765

Title: Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.

PubMed ID: 24192765

DOI: 10.1038/srep03097

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25880248

Title: A comprehensive analysis of peptides presented by HLA-A1.

PubMed ID: 25880248

DOI: 10.1111/tan.12565

PubMed ID: 26869717

Title: Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing.

PubMed ID: 26869717

DOI: 10.1073/pnas.1519894113

PubMed ID: 26929325

Title: Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome.

PubMed ID: 26929325

DOI: 10.1073/pnas.1521812113

PubMed ID: 27049119

Title: Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

PubMed ID: 27049119

DOI: 10.1038/srep24032

PubMed ID: 30530481

Title: Measuring Antiviral Capacity of T Cell Responses to Adenovirus.

PubMed ID: 30530481

DOI: 10.4049/jimmunol.1801003

PubMed ID: 32887977

Title: Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19.

PubMed ID: 32887977

DOI: 10.1038/s41590-020-0782-6

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 1448153

Title: Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle.

PubMed ID: 1448153

DOI: 10.1038/360364a0

PubMed ID: 1448154

Title: Atomic structure of a human MHC molecule presenting an influenza virus peptide.

PubMed ID: 1448154

DOI: 10.1038/360367a0

PubMed ID: 7694806

Title: The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2.

PubMed ID: 7694806

DOI: 10.1016/0092-8674(93)90490-h

PubMed ID: 7935798

Title: Three-dimensional structure of a peptide extending from one end of a class I MHC binding site.

PubMed ID: 7935798

DOI: 10.1038/371626a0

PubMed ID: 8906788

Title: Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.

PubMed ID: 8906788

DOI: 10.1038/384134a0

PubMed ID: 9177355

Title: Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2.

PubMed ID: 9177355

DOI: 10.1038/42523

PubMed ID: 11502003

Title: High-resolution structure of HLA-A*0201 in complex with a tumour-specific antigenic peptide encoded by the MAGE-A4 gene.

PubMed ID: 11502003

DOI: 10.1006/jmbi.2001.4816

PubMed ID: 12796775

Title: A structural basis for immunodominant human T cell receptor recognition.

PubMed ID: 12796775

DOI: 10.1038/ni942

PubMed ID: 16041067

Title: High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide.

PubMed ID: 16041067

DOI: 10.1107/s0907444905013090

PubMed ID: 18275829

Title: The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.

PubMed ID: 18275829

DOI: 10.1016/j.immuni.2007.12.018

PubMed ID: 19542454

Title: Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.

PubMed ID: 19542454

DOI: 10.4049/jimmunol.0900556

PubMed ID: 19177349

Title: Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.

PubMed ID: 19177349

DOI: 10.1002/pro.4

PubMed ID: 20844028

Title: Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.

PubMed ID: 20844028

DOI: 10.1128/jvi.01464-10

PubMed ID: 20619457

Title: Structures of native and affinity-enhanced WT1 epitopes bound to HLA-A*0201: implications for WT1-based cancer therapeutics.

PubMed ID: 20619457

DOI: 10.1016/j.molimm.2010.06.005

PubMed ID: 21543847

Title: Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

PubMed ID: 21543847

DOI: 10.1107/s0907444911007888

PubMed ID: 21943705

Title: Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes.

PubMed ID: 21943705

DOI: 10.1016/j.molimm.2011.08.015

PubMed ID: 22245737

Title: Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

PubMed ID: 22245737

DOI: 10.1038/ni.2206

PubMed ID: 24395804

Title: Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities.

PubMed ID: 24395804

DOI: 10.1073/pnas.1322229111

PubMed ID: 26758806

Title: Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.

PubMed ID: 26758806

DOI: 10.1038/srep18851

PubMed ID: 28250417

Title: Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope.

PubMed ID: 28250417

DOI: 10.1038/nsmb.3383

PubMed ID: 1728143

Title: HLA-A29.2 subtype associated with birdshot retinochoroidopathy.

PubMed ID: 1728143

DOI: 10.1016/s0002-9394(14)75749-6

PubMed ID: 10746785

Title: Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease.

PubMed ID: 10746785

DOI: 10.1034/j.1399-0039.2000.550205.x

PubMed ID: 16731854

Title: Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function.

PubMed ID: 16731854

DOI: 10.2337/db05-1049

PubMed ID: 18802479

Title: CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.

PubMed ID: 18802479

DOI: 10.1172/jci35449

PubMed ID: 18953350

Title: Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

PubMed ID: 18953350

DOI: 10.1038/nm.1881

PubMed ID: 22522618

Title: Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells.

PubMed ID: 22522618

DOI: 10.2337/db11-1520

PubMed ID: 21428769

Title: HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

PubMed ID: 21428769

DOI: 10.1056/nejmoa1013297

PubMed ID: 30872678

Title: The association analysis between HLA-A*26 and Behcet's disease.

PubMed ID: 30872678

DOI: 10.1038/s41598-019-40824-y

PubMed ID: 28650991

Title: Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.

PubMed ID: 28650991

DOI: 10.1371/journal.pgen.1006862

Sequence Information:

  • Length: 365
  • Mass: 40841
  • Checksum: DEDFCEC4450E0580
  • Sequence:
    • MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 
DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ 
IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL 
RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL 
TACKV

Genular Protein ID: 1905827453

Symbol: Q5SUL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SUL5

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 16 Ensembl 5 GO 8 Gene3D 2 HGNC 1 IntAct 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 19735485

Title: Analysis of the complete genomic sequence of HLA-A alleles in the Chinese Han population.

PubMed ID: 19735485

DOI: 10.1111/j.1744-313X.2009.00874.x

PubMed ID: 23714642

Title: Phase-defined complete sequencing of the HLA genes by next-generation sequencing.

PubMed ID: 23714642

DOI: 10.1186/1471-2164-14-355

PubMed ID: 28547825

Title: Dual redundant sequencing strategy: Full-length gene characterisation of 1056 novel and confirmatory HLA alleles.

PubMed ID: 28547825

DOI: 10.1111/tan.13057

PubMed ID: 30337930

Title: Reference Grade Characterization of Polymorphisms in Full-Length HLA Class I and II Genes With Short-Read Sequencing on the ION PGM System and Long-Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio Platform.

PubMed ID: 30337930

DOI: .3389/fimmu.2018.02294

PubMed ID: 29327506

Title: Next generation sequencing characterizes the extent of HLA diversity in an Argentinian registry population.

PubMed ID: 29327506

DOI: .1111/tan.13210

Sequence Information:

  • Length: 365
  • Mass: 40846
  • Checksum: 8667AFF3F06C4932
  • Sequence:
    • MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 
DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA NLGTLRGYYN QSEDGSHTIQ 
IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAVHAAEQR 
RVYLEGRCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL 
TACKV

Genular Protein ID: 3723161141

Symbol: B2R7U3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R7U3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 13 Gene3D 2 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 365
  • Mass: 40827
  • Checksum: 8EC0D1C4450E128B
  • Sequence:
    • MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF 
DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ 
IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL 
RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL 
SSQPTIPIVG VIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL 
TACKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.