ENO1 | ENSG00000074800 | NCBI 2023

Details for: ENO1

Gene ID: 2023

Symbol: ENO1

Ensembl ID: ENSG00000074800

Description: enolase 1

Associated with

Bacterial infection pathways
(R-HSA-9824439)
Disease
(R-HSA-1643685)
Glucose metabolism
(R-HSA-70326)
Glycolysis
(R-HSA-70171)
Infection with mycobacterium tuberculosis
(R-HSA-9635486)
Infectious disease
(R-HSA-5663205)
Manipulation of host energy metabolism
(R-HSA-9636667)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Response of mtb to phagocytosis
(R-HSA-9637690)
Cadherin binding
(GO:0045296)
Canonical glycolysis
(GO:0061621)
Cell cortex
(GO:0005938)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Gluconeogenesis
(GO:0006094)
Glycolytic process
(GO:0006096)
Gtpase binding
(GO:0051020)
Magnesium ion binding
(GO:0000287)
M band
(GO:0031430)
Membrane
(GO:0016020)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
(GO:1903298)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear outer membrane
(GO:0005640)
Nucleus
(GO:0005634)
Phosphopyruvate hydratase activity
(GO:0004634)
Phosphopyruvate hydratase complex
(GO:0000015)
Plasma membrane
(GO:0005886)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of muscle contraction
(GO:0045933)
Positive regulation of plasminogen activation
(GO:0010756)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to virus
(GO:0009615)
Rna binding
(GO:0003723)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription corepressor activity
(GO:0003714)
Transcription corepressor binding
(GO:0001222)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: cell in vitro (CL0001034)
Fold Change: 2.68
Cell Significance Index: 5
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.75
Cell Significance Index: 2
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.7
Cell Significance Index: 2
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.44
Cell Significance Index: 2
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.36
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.26
Cell Significance Index: 1
Cell Name: lactocyte (CL0002325)
Fold Change: 1.22
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.19
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.15
Cell Significance Index: 1
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.13
Cell Significance Index: 1
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.09
Cell Significance Index: 1
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: kidney cell (CL1000497)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1
Cell Significance Index: 1
Cell Name: granulosa cell (CL0000501)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1
Cell Significance Index: 1
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: colon endothelial cell (CL1001572)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pro-T cell (CL0000827)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: germ cell (CL0000586)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.98
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Glycolytic enzyme:** ENO1 catalyzes the conversion of 2-phosphoglycerate to enolpyruvate, a key step in the glycolytic pathway. 2. **Cellular localization:** ENO1 is predominantly found in the cytosol, but also localizes to the plasma membrane and nucleus. 3. **Expression patterns:** ENO1 is highly expressed in hematopoietic stem cells, T cells, neurons, and various epithelial cells. 4. **Enzyme activity:** ENO1 exhibits phosphopyruvate hydratase activity, which is essential for glycolytic regulation. **Pathways and Functions:** 1. **Glycolysis:** ENO1 is a key enzyme in the glycolytic pathway, regulating glucose metabolism and energy production. 2. **Bacterial infections:** ENO1 is involved in the response to bacterial infections, including Mycobacterium tuberculosis, by modulating host energy metabolism. 3. **Cell adhesion:** ENO1 interacts with cadherins, a family of cell adhesion molecules, facilitating cell-cell interactions and tissue development. 4. **Transcriptional regulation:** ENO1 acts as a transcriptional corepressor, regulating gene expression in response to various stimuli. 5. **Signaling pathways:** ENO1 is involved in GTPase binding, protein binding, and RNA binding, modulating signaling pathways and cellular processes. **Clinical Significance:** 1. **Cancer:** ENO1 is overexpressed in various types of cancer, including leukemia, breast cancer, and glioblastoma, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Infectious diseases:** ENO1 plays a critical role in the response to bacterial infections, such as M. tuberculosis, highlighting its potential as a therapeutic target. 3. **Neurological disorders:** ENO1 is implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may contribute to disease pathogenesis. 4. **Metabolic disorders:** ENO1 is involved in glucose metabolism and energy production, making it a potential target for the treatment of metabolic disorders, such as diabetes and obesity. In conclusion, ENO1 is a multifunctional enzyme with far-reaching implications in immunological processes, metabolic regulation, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms underlying ENO1's role in these complex biological systems and to explore its potential as a therapeutic target for various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.