Details for: ENO1

Gene ID: 2023

Symbol: ENO1

Ensembl ID: ENSG00000074800

Description: enolase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 835.7376
    Cell Significance Index: -130.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 333.0642
    Cell Significance Index: -137.2100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 322.8943
    Cell Significance Index: -81.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 300.4009
    Cell Significance Index: -122.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 285.0530
    Cell Significance Index: -134.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 259.2998
    Cell Significance Index: -133.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 201.5731
    Cell Significance Index: -135.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 128.6734
    Cell Significance Index: -122.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 107.9236
    Cell Significance Index: -133.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.7183
    Cell Significance Index: -137.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.3067
    Cell Significance Index: -102.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4019
    Cell Significance Index: -51.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.1905
    Cell Significance Index: -42.0000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 13.5273
    Cell Significance Index: 116.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 8.4256
    Cell Significance Index: 225.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 7.5073
    Cell Significance Index: 220.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.9102
    Cell Significance Index: 310.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 5.0086
    Cell Significance Index: 39.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 4.7255
    Cell Significance Index: 610.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.6375
    Cell Significance Index: 217.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.3738
    Cell Significance Index: 2388.6300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.8625
    Cell Significance Index: 41.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.6872
    Cell Significance Index: 96.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.3673
    Cell Significance Index: 414.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.3211
    Cell Significance Index: 234.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2187
    Cell Significance Index: 59.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.0609
    Cell Significance Index: 197.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.9874
    Cell Significance Index: 538.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8139
    Cell Significance Index: 1244.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7365
    Cell Significance Index: 203.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.7275
    Cell Significance Index: 321.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6147
    Cell Significance Index: 90.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.4320
    Cell Significance Index: 113.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3877
    Cell Significance Index: 687.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3799
    Cell Significance Index: 326.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2811
    Cell Significance Index: 60.9100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2036
    Cell Significance Index: 59.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1469
    Cell Significance Index: 24.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0573
    Cell Significance Index: 408.2700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5938
    Cell Significance Index: 33.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4859
    Cell Significance Index: 190.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3937
    Cell Significance Index: 38.9500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2195
    Cell Significance Index: 21.5500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1802
    Cell Significance Index: 33.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.1349
    Cell Significance Index: 1747.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1250
    Cell Significance Index: 10.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.9130
    Cell Significance Index: 1683.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8799
    Cell Significance Index: 794.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.8669
    Cell Significance Index: 656.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8018
    Cell Significance Index: 17.3700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7877
    Cell Significance Index: 128.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7534
    Cell Significance Index: 151.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6922
    Cell Significance Index: 131.7300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5367
    Cell Significance Index: 3.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4966
    Cell Significance Index: 25.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4463
    Cell Significance Index: 10.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4134
    Cell Significance Index: 303.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4042
    Cell Significance Index: 549.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3138
    Cell Significance Index: 17.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2863
    Cell Significance Index: 28.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2459
    Cell Significance Index: 88.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1525
    Cell Significance Index: 287.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1521
    Cell Significance Index: 25.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0706
    Cell Significance Index: 2.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0512
    Cell Significance Index: 32.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0329
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0340
    Cell Significance Index: -21.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0472
    Cell Significance Index: -34.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0499
    Cell Significance Index: -5.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0731
    Cell Significance Index: -33.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1670
    Cell Significance Index: -94.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2701
    Cell Significance Index: -56.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3415
    Cell Significance Index: -27.0500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3431
    Cell Significance Index: -39.1600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3549
    Cell Significance Index: -4.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3817
    Cell Significance Index: -41.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4204
    Cell Significance Index: -2.5400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5187
    Cell Significance Index: -13.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5732
    Cell Significance Index: -7.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5783
    Cell Significance Index: -84.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6371
    Cell Significance Index: -74.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6725
    Cell Significance Index: -77.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7291
    Cell Significance Index: -45.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7434
    Cell Significance Index: -19.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7582
    Cell Significance Index: -58.1800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7904
    Cell Significance Index: -12.0300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.0720
    Cell Significance Index: -15.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1117
    Cell Significance Index: -115.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.1880
    Cell Significance Index: -73.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2036
    Cell Significance Index: -38.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2961
    Cell Significance Index: -87.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4869
    Cell Significance Index: -22.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.5349
    Cell Significance Index: -26.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6842
    Cell Significance Index: -87.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.7033
    Cell Significance Index: -77.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.8106
    Cell Significance Index: -108.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9082
    Cell Significance Index: -116.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.3205
    Cell Significance Index: -68.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.3573
    Cell Significance Index: -28.1000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.3600
    Cell Significance Index: -104.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Glycolytic enzyme:** ENO1 catalyzes the conversion of 2-phosphoglycerate to enolpyruvate, a key step in the glycolytic pathway. 2. **Cellular localization:** ENO1 is predominantly found in the cytosol, but also localizes to the plasma membrane and nucleus. 3. **Expression patterns:** ENO1 is highly expressed in hematopoietic stem cells, T cells, neurons, and various epithelial cells. 4. **Enzyme activity:** ENO1 exhibits phosphopyruvate hydratase activity, which is essential for glycolytic regulation. **Pathways and Functions:** 1. **Glycolysis:** ENO1 is a key enzyme in the glycolytic pathway, regulating glucose metabolism and energy production. 2. **Bacterial infections:** ENO1 is involved in the response to bacterial infections, including Mycobacterium tuberculosis, by modulating host energy metabolism. 3. **Cell adhesion:** ENO1 interacts with cadherins, a family of cell adhesion molecules, facilitating cell-cell interactions and tissue development. 4. **Transcriptional regulation:** ENO1 acts as a transcriptional corepressor, regulating gene expression in response to various stimuli. 5. **Signaling pathways:** ENO1 is involved in GTPase binding, protein binding, and RNA binding, modulating signaling pathways and cellular processes. **Clinical Significance:** 1. **Cancer:** ENO1 is overexpressed in various types of cancer, including leukemia, breast cancer, and glioblastoma, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Infectious diseases:** ENO1 plays a critical role in the response to bacterial infections, such as M. tuberculosis, highlighting its potential as a therapeutic target. 3. **Neurological disorders:** ENO1 is implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may contribute to disease pathogenesis. 4. **Metabolic disorders:** ENO1 is involved in glucose metabolism and energy production, making it a potential target for the treatment of metabolic disorders, such as diabetes and obesity. In conclusion, ENO1 is a multifunctional enzyme with far-reaching implications in immunological processes, metabolic regulation, and disease pathogenesis. Further research is needed to fully elucidate the mechanisms underlying ENO1's role in these complex biological systems and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2372595488

Symbol: ENOA_HUMAN

Name: Alpha-enolase

UniProtKB Accession Codes:

P06733 B2RD59 P22712 Q16704 Q4TUS4 Q53FT9 Q53HR3 Q658M5 Q6GMP2 Q71V37 Q7Z3V6 Q8WU71 Q96GV1 Q9BT62 Q9UCH6 Q9UM55

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 1 EMBL 28 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 33 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 2 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 1 SABIO-RK 1 SFLD 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3529090

Title: Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.

PubMed ID: 3529090

DOI: 10.1073/pnas.83.18.6741

PubMed ID: 2373081

Title: Structure of the human gene for alpha-enolase.

PubMed ID: 2373081

DOI: 10.1111/j.1432-1033.1990.tb15611.x

PubMed ID: 2005901

Title: Cloning and characterization of a human c-myc promoter-binding protein.

PubMed ID: 2005901

DOI: 10.1128/mcb.11.4.2154-2161.1991

PubMed ID: 8824716

Title: Autoreactive epitopes within the human alpha-enolase and their recognition by sera from patients with endometriosis.

PubMed ID: 8824716

DOI: 10.1016/s0896-8411(95)80027-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150948

Title: A two-dimensional gel database of human colon carcinoma proteins.

PubMed ID: 9150948

DOI: 10.1002/elps.1150180344

PubMed ID: 9653645

Title: Molecular cloning and expression analysis of five novel genes in chromosome 1p36.

PubMed ID: 9653645

DOI: 10.1006/geno.1997.5186

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 1369209

Title: Purification and characterization of immunoglobulin production stimulating factor-II beta derived from Namalwa cells.

PubMed ID: 1369209

DOI: 10.1007/bf00570890

PubMed ID: 7787969

Title: Induced expression of alpha-enolase in differentiated diffuse large cell lymphoma.

PubMed ID: 7787969

DOI: 10.1159/000474967

PubMed ID: 10082554

Title: Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation.

PubMed ID: 10082554

DOI: 10.1128/mcb.19.4.2880

PubMed ID: 10802057

Title: ENO1 gene product binds to the c-myc promoter and acts as a transcriptional repressor: relationship with Myc promoter-binding protein 1 (MBP-1).

PubMed ID: 10802057

DOI: 10.1016/s0014-5793(00)01494-0

PubMed ID: 12666133

Title: Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-enolase.

PubMed ID: 12666133

DOI: 10.1002/ajh.10299

PubMed ID: 9308760

Title: Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display.

PubMed ID: 9308760

PubMed ID: 9878089

Title: Anti-enolase-alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cells.

PubMed ID: 9878089

DOI: 10.1006/jaut.1998.0239

PubMed ID: 10681589

Title: Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene.

PubMed ID: 10681589

DOI: 10.1074/jbc.275.8.5958

PubMed ID: 11497239

Title: Multifunctional alpha-enolase: its role in diseases.

PubMed ID: 11497239

DOI: 10.1007/pl00000910

PubMed ID: 11134351

Title: A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.

PubMed ID: 11134351

DOI: 10.1128/mcb.21.2.655-662.2001

PubMed ID: 12297304

Title: Proteomic analysis of human brain identifies alpha-enolase as a novel autoantigen in Hashimoto's encephalopathy.

PubMed ID: 12297304

DOI: 10.1016/s0014-5793(02)03307-0

PubMed ID: 16139798

Title: Proteomic identification of proteins conjugated to ISG15 in mouse and human cells.

PubMed ID: 16139798

DOI: 10.1016/j.bbrc.2005.08.132

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 16815975

Title: HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.

PubMed ID: 16815975

DOI: 10.1073/pnas.0600397103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 18560153

Title: Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme.

PubMed ID: 18560153

DOI: 10.1107/s0907444908008561

Sequence Information:

  • Length: 434
  • Mass: 47169
  • Checksum: A0ED663FCC15ADA5
  • Sequence:
    • MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR DNDKTRYMGK 
GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT ENKSKFGANA ILGVSLAVCK 
AGAVEKGVPL YRHIADLAGN SEVILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAANFRE 
AMRIGAEVYH NLKNVIKEKY GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV 
VIGMDVAASE FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD 
WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV TESLQACKLA 
QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL LRIEEELGSK 
AKFAGRNFRN PLAK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.