Details for: FGF14

Gene ID: 2259

Symbol: FGF14

Ensembl ID: ENSG00000102466

Description: fibroblast growth factor 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 382.9786
    Cell Significance Index: -97.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 244.6670
    Cell Significance Index: -100.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.8281
    Cell Significance Index: -52.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 13.1895
    Cell Significance Index: 226.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 8.4938
    Cell Significance Index: 3046.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 8.3023
    Cell Significance Index: 367.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 7.8614
    Cell Significance Index: 297.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 7.6058
    Cell Significance Index: 217.0500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 7.4336
    Cell Significance Index: 96.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 7.4307
    Cell Significance Index: 456.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 7.1746
    Cell Significance Index: 482.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.1122
    Cell Significance Index: 111.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 5.0391
    Cell Significance Index: 120.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 4.6561
    Cell Significance Index: 3220.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.8601
    Cell Significance Index: 774.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.1603
    Cell Significance Index: 61.6800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 2.8794
    Cell Significance Index: 38.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8623
    Cell Significance Index: 175.4900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.3909
    Cell Significance Index: 35.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.4065
    Cell Significance Index: 893.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0495
    Cell Significance Index: 80.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6244
    Cell Significance Index: 28.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6058
    Cell Significance Index: 1140.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4412
    Cell Significance Index: 398.4100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.2159
    Cell Significance Index: 4.2700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0854
    Cell Significance Index: 0.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.6900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0357
    Cell Significance Index: -54.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0437
    Cell Significance Index: -59.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0437
    Cell Significance Index: -19.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0557
    Cell Significance Index: -5.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0714
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0783
    Cell Significance Index: -58.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1231
    Cell Significance Index: -23.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1249
    Cell Significance Index: -20.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1266
    Cell Significance Index: -92.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1401
    Cell Significance Index: -76.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1483
    Cell Significance Index: -112.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1524
    Cell Significance Index: -69.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1533
    Cell Significance Index: -86.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1615
    Cell Significance Index: -100.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1639
    Cell Significance Index: -3.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2193
    Cell Significance Index: -3.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2829
    Cell Significance Index: -81.4100
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.3100
    Cell Significance Index: -2.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3573
    Cell Significance Index: -20.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.4258
    Cell Significance Index: -76.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4393
    Cell Significance Index: -92.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4477
    Cell Significance Index: -12.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4488
    Cell Significance Index: -89.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4910
    Cell Significance Index: -53.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5035
    Cell Significance Index: -73.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5640
    Cell Significance Index: -96.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6634
    Cell Significance Index: -14.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.6669
    Cell Significance Index: -91.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7025
    Cell Significance Index: -8.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.7104
    Cell Significance Index: -87.3500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.7140
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7370
    Cell Significance Index: -24.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7486
    Cell Significance Index: -20.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.7504
    Cell Significance Index: -96.9400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7567
    Cell Significance Index: -24.1000
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.8370
    Cell Significance Index: -6.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8466
    Cell Significance Index: -99.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8645
    Cell Significance Index: -100.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8775
    Cell Significance Index: -100.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8880
    Cell Significance Index: -92.4600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9205
    Cell Significance Index: -19.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9217
    Cell Significance Index: -63.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9655
    Cell Significance Index: -98.6300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -1.0060
    Cell Significance Index: -12.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -1.0197
    Cell Significance Index: -11.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -1.0305
    Cell Significance Index: -132.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0493
    Cell Significance Index: -45.6300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0682
    Cell Significance Index: -15.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1252
    Cell Significance Index: -24.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2296
    Cell Significance Index: -64.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2428
    Cell Significance Index: -74.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2458
    Cell Significance Index: -98.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.2998
    Cell Significance Index: -96.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.3523
    Cell Significance Index: -95.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5088
    Cell Significance Index: -48.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.5760
    Cell Significance Index: -81.8700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.6068
    Cell Significance Index: -19.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.6458
    Cell Significance Index: -106.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.6583
    Cell Significance Index: -104.5200
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.6679
    Cell Significance Index: -15.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6830
    Cell Significance Index: -58.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.7082
    Cell Significance Index: -42.6100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.7932
    Cell Significance Index: -20.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8946
    Cell Significance Index: -41.0500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.9245
    Cell Significance Index: -24.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.9505
    Cell Significance Index: -91.6700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -2.1384
    Cell Significance Index: -44.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.2036
    Cell Significance Index: -102.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2516
    Cell Significance Index: -56.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.2887
    Cell Significance Index: -58.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.3155
    Cell Significance Index: -117.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -2.3184
    Cell Significance Index: -45.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.3286
    Cell Significance Index: -85.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF14 is a small, secreted protein that belongs to the fibroblast growth factor family. It is primarily expressed in the nervous system, particularly in sympathetic neurons, stellate neurons, and Purkinje cells. FGF14 is also found in other cell types, including macrophages, granule cells, and alveolar type 2 fibroblasts. Its expression is tightly regulated, with significant changes observed in various pathological conditions. **Pathways and Functions:** FGF14 is involved in multiple signaling pathways, including: 1. **Cardiac Conduction:** FGF14 is expressed in Purkinje cells, which are crucial for the transmission of electrical impulses in the heart. FGF14 plays a role in regulating the activity of voltage-gated sodium channels, affecting cardiac conduction and potentially contributing to arrhythmias. 2. **Cell-Cell Signaling:** FGF14 interacts with other growth factors and receptors, modulating cell proliferation, differentiation, and survival. Its signaling pathways are involved in the development and maintenance of the nervous system. 3. **Muscle Contraction:** FGF14 is expressed in skeletal muscle and regulates muscle contraction by interacting with muscle-specific factors. 4. **Nervous System Development:** FGF14 is essential for the development and maturation of neurons, particularly in the sympathetic nervous system. **Clinical Significance:** The dysregulation of FGF14 has been implicated in various diseases, including: 1. **Arrhythmias:** Abnormal FGF14 expression in Purkinje cells may contribute to arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Neurological Disorders:** Altered FGF14 expression in neurons has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** FGF14 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 4. **Respiratory Diseases:** Alveolar type 2 fibroblasts expressing FGF14 may contribute to the pathogenesis of respiratory diseases, such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). In conclusion, FGF14 is a multifaceted protein with significant implications in the immune system, cardiac conduction, and nervous system development. Further research is necessary to fully understand the mechanisms by which FGF14 regulates these processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 142648585

Symbol: FGF14_HUMAN

Name: Fibroblast growth factor 14

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 12364586

Title: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.

PubMed ID: 12364586

DOI: 10.1073/pnas.182412499

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26900580

Title: Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

PubMed ID: 26900580

DOI: 10.1002/acn3.276

PubMed ID: 12489043

Title: A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar (sic) ataxia.

PubMed ID: 12489043

DOI: 10.1086/345488

PubMed ID: 15470364

Title: Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias.

PubMed ID: 15470364

DOI: 10.1038/sj.ejhg.5201286

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 32162847

Title: FGF14-related episodic ataxia: delineating the phenotype of Episodic Ataxia type 9.

PubMed ID: 32162847

DOI: 10.1002/acn3.51005

PubMed ID: 36493768

Title: An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA50/ATX-FGF14.

PubMed ID: 36493768

DOI: 10.1016/j.ajhg.2022.11.015

PubMed ID: 36516086

Title: Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia.

PubMed ID: 36516086

DOI: 10.1056/nejmoa2207406

Sequence Information:

  • Length: 247
  • Mass: 27702
  • Checksum: 427C3373198B967E
  • Sequence:
  • MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR 
    LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK 
    TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ 
    AMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK PGVTPSKSTS ASAIMNGGKP 
    VNKSKTT

Genular Protein ID: 1569546216

Symbol: A0A9L9PX77_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 163
  • Mass: 17893
  • Checksum: D62196DB4B4A8C2B
  • Sequence:
  • MHPDGALDGT KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK 
    FKESVFENYY VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA 
    MYREPSLHDV GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Genular Protein ID: 2148946288

Symbol: A0A9L9PXK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 213
  • Mass: 23827
  • Checksum: 4832F875BACCE3FC
  • Sequence:
  • MWFLWNIFSK GTHMLQCLCG KSLKKNKNPT DPQLKGIVTR LYCRQGYYLQ MHPDGALDGT 
    KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK FKESVFENYY 
    VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA MYREPSLHDV 
    GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.