Details for: FGF14

Gene ID: 2259

Symbol: FGF14

Ensembl ID: ENSG00000102466

Description: fibroblast growth factor 14

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 8.03
    Marker Score: 2,654
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.76
    Marker Score: 36,313
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.27
    Marker Score: 211,765
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 6.23
    Marker Score: 20,884
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.57
    Marker Score: 29,210
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.44
    Marker Score: 7,660
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.89
    Marker Score: 22,618
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.51
    Marker Score: 33,981
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.73
    Marker Score: 8,571
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.24
    Marker Score: 1,800
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.19
    Marker Score: 1,535
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.11
    Marker Score: 8,885
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.07
    Marker Score: 5,152
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.01
    Marker Score: 3,719
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.93
    Marker Score: 58,185
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.92
    Marker Score: 1,124
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22,101
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.87
    Marker Score: 42,857
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.76
    Marker Score: 5,239
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104,367
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.75
    Marker Score: 833
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.71
    Marker Score: 860
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10,874
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.58
    Marker Score: 1,500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90,692
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.39
    Marker Score: 1,000
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9,155
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,685
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 128,016
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8,264
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.02
    Marker Score: 2,327
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.01
    Marker Score: 1,127
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2
    Marker Score: 42,791
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20,596
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,344
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.91
    Marker Score: 986
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16,170
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.85
    Marker Score: 831
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.84
    Marker Score: 685
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.81
    Marker Score: 7,576
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.74
    Marker Score: 1,039
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7,182
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,557
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.65
    Marker Score: 451
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.63
    Marker Score: 3,321
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.61
    Marker Score: 1,609
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.61
    Marker Score: 35,989
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,167
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 453
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.49
    Marker Score: 982
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,296
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.44
    Marker Score: 1,790
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.43
    Marker Score: 5,095
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3,319
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.41
    Marker Score: 12,221
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.39
    Marker Score: 834
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20,354
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.22
    Marker Score: 2,470
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.18
    Marker Score: 482
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.15
    Marker Score: 599
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.14
    Marker Score: 3,928
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.11
    Marker Score: 4,769
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.09
    Marker Score: 1,178
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.06
    Marker Score: 5,717
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.05
    Marker Score: 910
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6,248
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.01
    Marker Score: 460
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,017
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.99
    Marker Score: 1,087
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 393
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.96
    Marker Score: 476
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,322
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.93
    Marker Score: 1,793
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 835
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,284
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.86
    Marker Score: 1,573
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.84
    Marker Score: 8,511
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.84
    Marker Score: 2,003
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.84
    Marker Score: 244
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.83
    Marker Score: 301
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.83
    Marker Score: 214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 389
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.8
    Marker Score: 416
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8
    Marker Score: 5,121
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FGF14 is a small, secreted protein that belongs to the fibroblast growth factor family. It is primarily expressed in the nervous system, particularly in sympathetic neurons, stellate neurons, and Purkinje cells. FGF14 is also found in other cell types, including macrophages, granule cells, and alveolar type 2 fibroblasts. Its expression is tightly regulated, with significant changes observed in various pathological conditions. **Pathways and Functions:** FGF14 is involved in multiple signaling pathways, including: 1. **Cardiac Conduction:** FGF14 is expressed in Purkinje cells, which are crucial for the transmission of electrical impulses in the heart. FGF14 plays a role in regulating the activity of voltage-gated sodium channels, affecting cardiac conduction and potentially contributing to arrhythmias. 2. **Cell-Cell Signaling:** FGF14 interacts with other growth factors and receptors, modulating cell proliferation, differentiation, and survival. Its signaling pathways are involved in the development and maintenance of the nervous system. 3. **Muscle Contraction:** FGF14 is expressed in skeletal muscle and regulates muscle contraction by interacting with muscle-specific factors. 4. **Nervous System Development:** FGF14 is essential for the development and maturation of neurons, particularly in the sympathetic nervous system. **Clinical Significance:** The dysregulation of FGF14 has been implicated in various diseases, including: 1. **Arrhythmias:** Abnormal FGF14 expression in Purkinje cells may contribute to arrhythmias, such as atrial fibrillation and ventricular tachycardia. 2. **Neurological Disorders:** Altered FGF14 expression in neurons has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer:** FGF14 has been implicated in the development and progression of various cancers, including breast, lung, and colon cancer. 4. **Respiratory Diseases:** Alveolar type 2 fibroblasts expressing FGF14 may contribute to the pathogenesis of respiratory diseases, such as acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD). In conclusion, FGF14 is a multifaceted protein with significant implications in the immune system, cardiac conduction, and nervous system development. Further research is necessary to fully understand the mechanisms by which FGF14 regulates these processes and to explore its therapeutic potential in various diseases.

Genular Protein ID: 142648585

Symbol: FGF14_HUMAN

Name: Fibroblast growth factor 14

UniProtKB Accession Codes:

Q92915 Q86YN7 Q96QX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 12364586

Title: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.

PubMed ID: 12364586

DOI: 10.1073/pnas.182412499

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26900580

Title: Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

PubMed ID: 26900580

DOI: 10.1002/acn3.276

PubMed ID: 12489043

Title: A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar (sic) ataxia.

PubMed ID: 12489043

DOI: 10.1086/345488

PubMed ID: 15470364

Title: Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias.

PubMed ID: 15470364

DOI: 10.1038/sj.ejhg.5201286

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 32162847

Title: FGF14-related episodic ataxia: delineating the phenotype of Episodic Ataxia type 9.

PubMed ID: 32162847

DOI: 10.1002/acn3.51005

PubMed ID: 36493768

Title: An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA50/ATX-FGF14.

PubMed ID: 36493768

DOI: 10.1016/j.ajhg.2022.11.015

PubMed ID: 36516086

Title: Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia.

PubMed ID: 36516086

DOI: 10.1056/nejmoa2207406

Sequence Information:

  • Length: 247
  • Mass: 27702
  • Checksum: 427C3373198B967E
  • Sequence:
    • MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR 
LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK 
TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ 
AMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK PGVTPSKSTS ASAIMNGGKP 
VNKSKTT

Genular Protein ID: 1569546216

Symbol: A0A9L9PX77_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PX77

Database IDs:

ARBA 1 CDD 1 EMBL 8 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 7 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 163
  • Mass: 17893
  • Checksum: D62196DB4B4A8C2B
  • Sequence:
    • MHPDGALDGT KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK 
FKESVFENYY VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA 
MYREPSLHDV GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Genular Protein ID: 2148946288

Symbol: A0A9L9PXK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PXK7

Database IDs:

ARBA 1 CDD 1 EMBL 8 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 213
  • Mass: 23827
  • Checksum: 4832F875BACCE3FC
  • Sequence:
    • MWFLWNIFSK GTHMLQCLCG KSLKKNKNPT DPQLKGIVTR LYCRQGYYLQ MHPDGALDGT 
KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK FKESVFENYY 
VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA MYREPSLHDV 
GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.