Details for: FGF14

Gene ID: 2259

Symbol: FGF14

Ensembl ID: ENSG00000102466

Description: fibroblast growth factor 14

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 8.03
    Marker Score: 2654
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.76
    Marker Score: 36313
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 6.27
    Marker Score: 211765
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 6.23
    Marker Score: 20884
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.57
    Marker Score: 29210
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 5.44
    Marker Score: 7659.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.89
    Marker Score: 22618
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.51
    Marker Score: 33981
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 3.73
    Marker Score: 8571
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.24
    Marker Score: 1800
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.19
    Marker Score: 1535
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.11
    Marker Score: 8885
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.07
    Marker Score: 5152
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.01
    Marker Score: 3719
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.93
    Marker Score: 58185
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.92
    Marker Score: 1124
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.88
    Marker Score: 22101
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.87
    Marker Score: 42857
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.76
    Marker Score: 5239
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.75
    Marker Score: 104367
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 2.75
    Marker Score: 833
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.71
    Marker Score: 860
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10874
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 2.58
    Marker Score: 1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90692
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.39
    Marker Score: 1000
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.37
    Marker Score: 9155
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20685
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 128016
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8264
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.02
    Marker Score: 2327
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.01
    Marker Score: 1127
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2
    Marker Score: 42791
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.99
    Marker Score: 20596
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18344
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.91
    Marker Score: 986
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16170
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.85
    Marker Score: 831
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.84
    Marker Score: 685
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.81
    Marker Score: 7576
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.74
    Marker Score: 1039
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.72
    Marker Score: 7182
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2557
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.65
    Marker Score: 451
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.63
    Marker Score: 3321
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.61
    Marker Score: 1609
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.61
    Marker Score: 35989
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.55
    Marker Score: 453
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.49
    Marker Score: 982
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167296
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.44
    Marker Score: 1790
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.43
    Marker Score: 5095
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3319
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.41
    Marker Score: 12221
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.39
    Marker Score: 833.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3
    Marker Score: 20354
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.22
    Marker Score: 2470
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.18
    Marker Score: 482
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.15
    Marker Score: 599
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.14
    Marker Score: 3928
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.11
    Marker Score: 4769
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.09
    Marker Score: 1178
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.06
    Marker Score: 5717
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.05
    Marker Score: 910
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.04
    Marker Score: 326
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.04
    Marker Score: 6248
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.01
    Marker Score: 460
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71791
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48017
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.99
    Marker Score: 1087
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 393
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.96
    Marker Score: 476
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.93
    Marker Score: 1793
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.91
    Marker Score: 835
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.86
    Marker Score: 1573
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.84
    Marker Score: 8511
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.84
    Marker Score: 2003
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.84
    Marker Score: 244
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.83
    Marker Score: 301
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.83
    Marker Score: 214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.82
    Marker Score: 389
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.8
    Marker Score: 416
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.8
    Marker Score: 5121
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262

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Other Information

**Key characteristics** - FGF14 is a transmembrane protein belonging to the fibroblast growth factor 14 (FGF14) family. - It is a secreted protein that acts as a signaling molecule. - It is highly expressed in the heart, where it is primarily produced by cardiac myocytes. - It is also expressed in other tissues, including the brain, skeletal muscle, and vascular smooth muscle. **Pathways and functions** - FGF14 is a key factor in cardiac conduction. It is expressed in the sinoatrial node (SA node), where it promotes the depolarization of cardiac cells and initiates the cardiac conduction cycle. - It also regulates the contraction of cardiac myocytes. - In addition to its roles in cardiac conduction and contraction, FGF14 has been shown to play a role in cell-cell signaling, epithelial-mesenchymal transition, and angiogenesis. - It is also involved in the development and maintenance of the nervous system, where it promotes the survival and differentiation of neural cells. **Clinical significance** Mutations in FGF14 genes have been linked to several human diseases, including hypertension, heart failure, and stroke. These diseases are characterized by abnormal heart function and remodeling. FGF14 is therefore a potential therapeutic target for these conditions. FGF14 is a versatile protein that plays a critical role in the heart and other tissues. Its involvement in cardiac conduction, cell-cell signaling, and muscle contraction makes it an important target for understanding and treating heart disease.

Genular Protein ID: 142648585

Symbol: FGF14_HUMAN

Name: Fibroblast growth factor 14

UniProtKB Accession Codes:

Q92915 Q86YN7 Q96QX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8790420

Title: Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.

PubMed ID: 8790420

DOI: 10.1073/pnas.93.18.9850

PubMed ID: 12364586

Title: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.

PubMed ID: 12364586

DOI: 10.1073/pnas.182412499

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26900580

Title: Pathogenic mechanism of recurrent mutations of SCN8A in epileptic encephalopathy.

PubMed ID: 26900580

DOI: 10.1002/acn3.276

PubMed ID: 12489043

Title: A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar (sic) ataxia.

PubMed ID: 12489043

DOI: 10.1086/345488

PubMed ID: 15470364

Title: Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias.

PubMed ID: 15470364

DOI: 10.1038/sj.ejhg.5201286

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 32162847

Title: FGF14-related episodic ataxia: delineating the phenotype of Episodic Ataxia type 9.

PubMed ID: 32162847

DOI: 10.1002/acn3.51005

PubMed ID: 36493768

Title: An intronic GAA repeat expansion in FGF14 causes the autosomal-dominant adult-onset ataxia SCA50/ATX-FGF14.

PubMed ID: 36493768

DOI: 10.1016/j.ajhg.2022.11.015

PubMed ID: 36516086

Title: Deep intronic FGF14 GAA repeat expansion in late-onset cerebellar ataxia.

PubMed ID: 36516086

DOI: 10.1056/nejmoa2207406

Sequence Information:

  • Length: 247
  • Mass: 27702
  • Checksum: 427C3373198B967E
  • Sequence:
    • MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR 
LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK 
TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ 
AMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK PGVTPSKSTS ASAIMNGGKP 
VNKSKTT

Genular Protein ID: 1569546216

Symbol: A0A9L9PX77_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PX77

Database IDs:

ARBA 1 CDD 1 EMBL 8 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 7 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 163
  • Mass: 17893
  • Checksum: D62196DB4B4A8C2B
  • Sequence:
    • MHPDGALDGT KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK 
FKESVFENYY VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA 
MYREPSLHDV GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Genular Protein ID: 2148946288

Symbol: A0A9L9PXK7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A9L9PXK7

Database IDs:

ARBA 1 CDD 1 EMBL 8 Ensembl 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 2 PROSITE 1 Pfam 1 Proteomes 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

Sequence Information:

  • Length: 213
  • Mass: 23827
  • Checksum: 4832F875BACCE3FC
  • Sequence:
    • MWFLWNIFSK GTHMLQCLCG KSLKKNKNPT DPQLKGIVTR LYCRQGYYLQ MHPDGALDGT 
KDDSTNSTLF NLIPVGLRVV AIQGVKTGLY IAMNGEGYLY PSELFTPECK FKESVFENYY 
VIYSSMLYRQ QESGRAWFLG LNKEGQAMKG NRVKKTKPAA HFLPKPLEVA MYREPSLHDV 
GETVPKPGVT PSKSTSASAI MNGGKPVNKS KTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.