Details for: IGF1

Gene ID: 3479

Symbol: IGF1

Ensembl ID: ENSG00000017427

Description: insulin like growth factor 1

Associated with

  • Hemostasis
    (R-HSA-109582)
  • Igf1r signaling cascade
    (R-HSA-2428924)
  • Irs-related events triggered by igf1r
    (R-HSA-2428928)
  • Metabolism of proteins
    (R-HSA-392499)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-HSA-381426)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Shc-related events triggered by igf1r
    (R-HSA-2428933)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
    (R-HSA-2404192)
  • Synthesis, secretion, and deacylation of ghrelin
    (R-HSA-422085)
  • Activation of protein kinase b activity
    (GO:0032148)
  • Bone mineralization involved in bone maturation
    (GO:0035630)
  • Cell activation
    (GO:0001775)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Glycolate metabolic process
    (GO:0009441)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin receptor binding
    (GO:0005158)
  • Integrin binding
    (GO:0005178)
  • Muscle hypertrophy
    (GO:0014896)
  • Muscle organ development
    (GO:0007517)
  • Myoblast differentiation
    (GO:0045445)
  • Myoblast proliferation
    (GO:0051450)
  • Myotube cell development
    (GO:0014904)
  • Negative regulation of amyloid-beta formation
    (GO:1902430)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of extrinsic apoptotic signaling pathway
    (GO:2001237)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-1 beta production
    (GO:0032691)
  • Negative regulation of neuroinflammatory response
    (GO:0150079)
  • Negative regulation of oocyte development
    (GO:0060283)
  • Negative regulation of release of cytochrome c from mitochondria
    (GO:0090201)
  • Negative regulation of smooth muscle cell apoptotic process
    (GO:0034392)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of vascular associated smooth muscle cell apoptotic process
    (GO:1905460)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of calcineurin-nfat signaling cascade
    (GO:0070886)
  • Positive regulation of cardiac muscle hypertrophy
    (GO:0010613)
  • Positive regulation of cell growth involved in cardiac muscle cell development
    (GO:0061051)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna binding
    (GO:0043388)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of glycoprotein biosynthetic process
    (GO:0010560)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein secretion
    (GO:0050714)
  • Positive regulation of ras protein signal transduction
    (GO:0046579)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription regulatory region dna binding
    (GO:2000679)
  • Positive regulation of trophectodermal cell proliferation
    (GO:1904075)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein stabilization
    (GO:0050821)
  • Proteoglycan biosynthetic process
    (GO:0030166)
  • Ras protein signal transduction
    (GO:0007265)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Response to heat
    (GO:0009408)
  • Signal transduction
    (GO:0007165)
  • Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
    (GO:0014834)
  • Skeletal system development
    (GO:0001501)
  • Wound healing
    (GO:0042060)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.11
    Marker Score: 1502
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.71
    Marker Score: 3162
  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.57
    Marker Score: 1632
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.07
    Marker Score: 34567.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.71
    Marker Score: 1783
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.63
    Marker Score: 1469
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.19
    Marker Score: 9465
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.99
    Marker Score: 811
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.98
    Marker Score: 1036.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.89
    Marker Score: 1042
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.86
    Marker Score: 774
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.83
    Marker Score: 13991
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.79
    Marker Score: 60773
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.77
    Marker Score: 26500.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.69
    Marker Score: 4433
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.69
    Marker Score: 7030
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.6
    Marker Score: 60601
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.58
    Marker Score: 2064
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.58
    Marker Score: 2985
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.47
    Marker Score: 2998
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168704
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.45
    Marker Score: 7793
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.44
    Marker Score: 6216
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.44
    Marker Score: 52943
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.43
    Marker Score: 736
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.41
    Marker Score: 349
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.36
    Marker Score: 26965
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.35
    Marker Score: 5212
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.32
    Marker Score: 8586
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.29
    Marker Score: 384
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.28
    Marker Score: 3153
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.22
    Marker Score: 316
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.22
    Marker Score: 7818
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.18
    Marker Score: 3342
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.17
    Marker Score: 837
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.08
    Marker Score: 269
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.07
    Marker Score: 269
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.06
    Marker Score: 1308
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.03
    Marker Score: 271
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.01
    Marker Score: 1007
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.96
    Marker Score: 479
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2415
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5291
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.93
    Marker Score: 569
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.91
    Marker Score: 5495
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.91
    Marker Score: 1100
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.87
    Marker Score: 486
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13415
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.84
    Marker Score: 194
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.84
    Marker Score: 521
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 636.5
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.83
    Marker Score: 496
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.74
    Marker Score: 634
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.68
    Marker Score: 652
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.61
    Marker Score: 294
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.6
    Marker Score: 831
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.6
    Marker Score: 648
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.6
    Marker Score: 920
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.59
    Marker Score: 1107
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.56
    Marker Score: 748
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.56
    Marker Score: 252
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 141
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.53
    Marker Score: 364
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 252
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.51
    Marker Score: 547
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.51
    Marker Score: 177
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.51
    Marker Score: 920
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.5
    Marker Score: 333
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 183
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.49
    Marker Score: 947
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.48
    Marker Score: 536
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.47
    Marker Score: 178
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.47
    Marker Score: 202.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.47
    Marker Score: 268
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.47
    Marker Score: 132
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.46
    Marker Score: 263
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.46
    Marker Score: 158.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.46
    Marker Score: 534
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.45
    Marker Score: 1069
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.45
    Marker Score: 15202
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.45
    Marker Score: 222
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.41
    Marker Score: 966.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.39
    Marker Score: 487
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.39
    Marker Score: 1132
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 3985
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.38
    Marker Score: 166

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** * IGF1 is a protein that is produced by cells throughout the body. * It is a glycoprotein with a molecular weight of approximately 70,000 Da. * IGF1 is a potent activator of the IGF1 receptor (IGF1R). * It plays a role in promoting cell growth, differentiation, and proliferation. * It also plays a role in metabolism and energy production. **Pathways and functions** * IGF1 binds to the IGF1 receptor (IGF1R) on the surface of target cells. * This binding triggers a cascade of intracellular events that lead to the activation of downstream signaling pathways. * These pathways include the MAPK pathway, the PI3K/AKT pathway, and the mTOR pathway. * Activation of these pathways leads to a variety of cellular responses, including cell growth, proliferation, and differentiation. * IGF1 also plays a role in metabolism and energy production. * It stimulates the production of glucose and fatty acids, and it inhibits the production of proteins and cholesterol. **Clinical significance** * IGF1 is a key hormone involved in growth, development, and metabolism. * It is often elevated in people with cancer and other diseases. * High levels of IGF1 are associated with increased risk of cancer, heart disease, and diabetes. * Targeting IGF1 signaling is a promising strategy for treating these diseases. **Additional information** * IGF1 is produced by a variety of cell types, including: * Fat cells * Muscle cells * Cells of the immune system * It is a potent activator of the IGF1 receptor (IGF1R). * It plays a role in promoting cell growth, differentiation, and proliferation. * It also plays a role in metabolism and energy production.

Genular Protein ID: 4077850127

Symbol: IGF1_HUMAN

Name: Insulin-like growth factor I

UniProtKB Accession Codes:

P05019 B2RWM7 E9PD02 P01343 Q14620

Database IDs:

ABCD 1 AGR 1 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 25 EMDB 5 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 77 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 26 PIR 2 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6358902

Title: Sequence of cDNA encoding human insulin-like growth factor I precursor.

PubMed ID: 6358902

DOI: 10.1038/306609a0

PubMed ID: 3002851

Title: Organization of the human genes for insulin-like growth factors I and II.

PubMed ID: 3002851

DOI: 10.1016/0014-5793(86)80156-9

PubMed ID: 2935423

Title: Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library.

PubMed ID: 2935423

DOI: 10.1016/0014-5793(86)80223-x

PubMed ID: 2937782

Title: Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides.

PubMed ID: 2937782

DOI: 10.1016/s0021-9258(19)89179-2

PubMed ID: 3455760

Title: Two insulin-like growth factor I messenger RNAs are expressed in human liver.

PubMed ID: 3455760

DOI: 10.1073/pnas.83.1.77

PubMed ID: 2082190

Title: A novel human insulin-like growth factor I messenger RNA is expressed in normal and tumor cells.

PubMed ID: 2082190

DOI: 10.1210/mend-4-12-1914

PubMed ID: 2018498

Title: Complete nucleotide sequence of the high molecular weight human IGF-I mRNA.

PubMed ID: 2018498

DOI: 10.1016/0006-291x(91)91593-2

PubMed ID: 1372070

Title: Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain.

PubMed ID: 1372070

DOI: 10.1016/0169-328x(92)90094-r

PubMed ID: 8495408

Title: Characterization of insulin-like growth factor 1 in human primary brain tumors.

PubMed ID: 8495408

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6382022

Title: Insulin-like growth factor II precursor gene organization in relation to insulin gene family.

PubMed ID: 6382022

DOI: 10.1038/310777a0

PubMed ID: 632300

Title: The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.

PubMed ID: 632300

DOI: 10.1016/s0021-9258(17)40889-1

PubMed ID: 3242681

Title: Location of disulphide bonds in human insulin-like growth factors (IGFs) synthesized by recombinant DNA technology.

PubMed ID: 3242681

DOI: 10.1002/bms.1200160102

PubMed ID: 19578119

Title: The direct binding of insulin-like growth factor-1 (IGF-1) to integrin alphavbeta3 is involved in IGF-1 signaling.

PubMed ID: 19578119

DOI: 10.1074/jbc.m109.013201

PubMed ID: 20881139

Title: The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.

PubMed ID: 20881139

DOI: 10.1523/jneurosci.3289-10.2010

PubMed ID: 21076856

Title: Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.

PubMed ID: 21076856

DOI: 10.1007/s11010-010-0634-z

PubMed ID: 22351760

Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.

PubMed ID: 22351760

DOI: 10.1074/jbc.m111.304170

PubMed ID: 23243309

Title: Insulin-like growth factor (IGF) signaling requires alphavbeta3-IGF1-IGF type 1 receptor (IGF1R) ternary complex formation in anchorage independence, and the complex formation does not require IGF1R and Src activation.

PubMed ID: 23243309

DOI: 10.1074/jbc.m112.412536

PubMed ID: 23696648

Title: An integrin binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of the IGF1 receptor (IGF1R) and suppresses tumorigenesis but still binds to IGF1R.

PubMed ID: 23696648

DOI: 10.1074/jbc.m113.470872

PubMed ID: 24132240

Title: SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.

PubMed ID: 24132240

DOI: 10.1038/nature12618

PubMed ID: 6189745

Title: Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors.

PubMed ID: 6189745

PubMed ID: 2036417

Title: Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.

PubMed ID: 2036417

DOI: 10.1021/bi00236a022

PubMed ID: 1319992

Title: 1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution.

PubMed ID: 1319992

DOI: 10.1093/oxfordjournals.jbchem.a123791

PubMed ID: 8857020

Title: Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene.

PubMed ID: 8857020

DOI: 10.1056/nejm199610313351805

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 24389050

Title: Genomic analysis of primordial dwarfism reveals novel disease genes.

PubMed ID: 24389050

DOI: 10.1101/gr.160572.113

Sequence Information:

  • Length: 195
  • Mass: 21841
  • Checksum: E88A8CFBD1CD1873
  • Sequence:
    • MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS 
VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR 
EIGSRNAECR GKKGK

Genular Protein ID: 569942152

Symbol: Q59GC5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GC5

Database IDs:

ARBA 5 Allergome 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 184
  • Mass: 20618
  • Checksum: 3B94B8DA4033D63A
  • Sequence:
    • HCSQHLPSLW ISFCFIIPAN QFIFRLCTSE AMGKISSLPT QLFKCCFCDF LKVKMHTMSS 
SHLFYLALCL LTFTSSATAG PETLCGAELV DALQFVCGDR GFYFNKPTGY GSSSRRAPQT 
GIVDECCFRS CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKTQKEVHLK NASRGSAGNK 
NYRM

Genular Protein ID: 3417222958

Symbol: Q5U743_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5U743

Database IDs:

ARBA 5 Allergome 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 7 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 153
  • Mass: 17026
  • Checksum: C6ECD92DCA9B37BC
  • Sequence:
    • MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS 
VRAQRHTDMP KTQKEVHLKN ASRGSAGNKN YRM

Genular Protein ID: 138221189

Symbol: Q13429_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13429

Database IDs:

ARBA 5 Allergome 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 7720641

Title: An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide.

PubMed ID: 7720641

DOI: 10.1210/en.136.5.1939

Sequence Information:

  • Length: 139
  • Mass: 15611
  • Checksum: A62271872CA29DE4
  • Sequence:
    • LKVKMHTMSS SHLFYLALCL LTFTSSATAG PETLCGAELV DALQFVCGDR GFYFNKPTGY 
GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPAKSAR SVRAQRHTDM PKTQKYQPPS 
TNKNTKSQRR KGSTFEERK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.