Details for: PDZRN4

Gene ID: 29951

Symbol: PDZRN4

Ensembl ID: ENSG00000165966

Description: PDZ domain containing ring finger 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.9313
    Cell Significance Index: -38.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2724
    Cell Significance Index: -33.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8554
    Cell Significance Index: -38.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3123
    Cell Significance Index: 829.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1017
    Cell Significance Index: 421.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9997
    Cell Significance Index: 57.0700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.6391
    Cell Significance Index: 31.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3292
    Cell Significance Index: 81.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2343
    Cell Significance Index: 560.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0662
    Cell Significance Index: 2007.6200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.9805
    Cell Significance Index: 13.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9676
    Cell Significance Index: 65.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.6329
    Cell Significance Index: 65.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6311
    Cell Significance Index: 15.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4047
    Cell Significance Index: 6.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3728
    Cell Significance Index: 9.0300
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.3127
    Cell Significance Index: 3.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2818
    Cell Significance Index: 194.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0370
    Cell Significance Index: 7.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0340
    Cell Significance Index: 0.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0157
    Cell Significance Index: -9.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0224
    Cell Significance Index: -41.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0266
    Cell Significance Index: -40.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0311
    Cell Significance Index: -42.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0420
    Cell Significance Index: -30.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0484
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0554
    Cell Significance Index: -41.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0582
    Cell Significance Index: -44.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0704
    Cell Significance Index: -43.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0736
    Cell Significance Index: -40.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0791
    Cell Significance Index: -44.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1115
    Cell Significance Index: -32.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1415
    Cell Significance Index: -20.5700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1955
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2026
    Cell Significance Index: -34.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2150
    Cell Significance Index: -45.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2163
    Cell Significance Index: -6.8900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2229
    Cell Significance Index: -1.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2383
    Cell Significance Index: -32.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2480
    Cell Significance Index: -8.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2543
    Cell Significance Index: -31.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2691
    Cell Significance Index: -34.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2846
    Cell Significance Index: -4.0800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3425
    Cell Significance Index: -5.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3550
    Cell Significance Index: -41.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3915
    Cell Significance Index: -44.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4149
    Cell Significance Index: -32.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4383
    Cell Significance Index: -5.9800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4867
    Cell Significance Index: -12.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5021
    Cell Significance Index: -38.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5674
    Cell Significance Index: -11.2200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6433
    Cell Significance Index: -7.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6547
    Cell Significance Index: -34.1000
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6662
    Cell Significance Index: -8.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6873
    Cell Significance Index: -38.5700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7324
    Cell Significance Index: -46.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7528
    Cell Significance Index: -35.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7746
    Cell Significance Index: -40.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7798
    Cell Significance Index: -40.5100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8164
    Cell Significance Index: -28.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8921
    Cell Significance Index: -39.4600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8956
    Cell Significance Index: -8.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9243
    Cell Significance Index: -32.1200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9550
    Cell Significance Index: -20.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9840
    Cell Significance Index: -45.8800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0387
    Cell Significance Index: -17.9600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0454
    Cell Significance Index: -27.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0497
    Cell Significance Index: -39.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0718
    Cell Significance Index: -31.5700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1335
    Cell Significance Index: -19.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.2128
    Cell Significance Index: -44.5200
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -1.2188
    Cell Significance Index: -14.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2290
    Cell Significance Index: -35.2300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.2335
    Cell Significance Index: -30.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.2344
    Cell Significance Index: -31.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2601
    Cell Significance Index: -27.2300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -1.2643
    Cell Significance Index: -15.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.2863
    Cell Significance Index: -45.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -1.2941
    Cell Significance Index: -16.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2982
    Cell Significance Index: -34.7900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.3160
    Cell Significance Index: -33.6200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -1.3355
    Cell Significance Index: -15.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.3441
    Cell Significance Index: -26.9900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.3967
    Cell Significance Index: -44.1800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.4024
    Cell Significance Index: -29.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.4853
    Cell Significance Index: -39.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4927
    Cell Significance Index: -39.9300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.4939
    Cell Significance Index: -29.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5076
    Cell Significance Index: -32.2300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.5412
    Cell Significance Index: -31.3600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.5425
    Cell Significance Index: -39.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.5550
    Cell Significance Index: -34.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.5671
    Cell Significance Index: -45.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.6040
    Cell Significance Index: -31.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.6124
    Cell Significance Index: -33.7500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.6228
    Cell Significance Index: -15.4400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -1.6538
    Cell Significance Index: -8.6600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.6821
    Cell Significance Index: -24.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.6860
    Cell Significance Index: -42.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.6881
    Cell Significance Index: -45.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PDZRN4 is a protein-coding gene that maps to the human genome (ENSG00000165966). It exhibits a distinctive structure, featuring a PDZ (PSD-95/Discs Large/Zonula Occludens-1) domain and a RING finger domain. The PDZ domain is a well-known protein-protein interaction motif that mediates interactions with other proteins, while the RING finger domain is involved in the formation of protein-protein complexes and the regulation of protein degradation. The coexistence of these domains in PDZRN4 suggests a complex interplay between protein-protein interactions and protein degradation, which may be crucial for its immunological functions. **Pathways and Functions:** PDZRN4 is significantly expressed in various cell types, including retinal cone cells, cardiac endothelial cells, and oligodendrocyte precursor cells. Its expression in these cell types suggests a role in maintaining tissue homeostasis and regulating cellular processes. Recent studies have implicated PDZRN4 in the regulation of metal ion binding, which is essential for various cellular functions, including protein-protein interactions and enzyme activity. The metal ion binding activity of PDZRN4 may play a critical role in modulating its immunological functions. **Clinical Significance:** Despite its significant expression in various cell types, the clinical significance of PDZRN4 in immunological contexts remains poorly understood. However, its involvement in metal ion binding and protein-protein interactions suggests a potential role in the regulation of immune responses. Further studies are needed to elucidate the immunological functions of PDZRN4 and its potential involvement in immune-related disorders. In conclusion, PDZRN4 is a complex protein-coding gene with a unique combination of PDZ and RING finger domains. Its significant expression in various cell types and metal ion binding activity suggest a potential role in regulating immune responses. Further research is necessary to fully elucidate the immunological significance of PDZRN4 and its potential involvement in immune-related disorders. **Recommendations:** 1. Further studies are needed to elucidate the immunological functions of PDZRN4 and its potential involvement in immune-related disorders. 2. The role of PDZRN4 in regulating metal ion binding and protein-protein interactions should be further investigated. 3. The expression of PDZRN4 in various cell types and its potential involvement in tissue homeostasis and cellular processes should be explored in more detail. By addressing these knowledge gaps, researchers can gain a deeper understanding of the immunological significance of PDZRN4 and its potential role in immune-related disorders.

Genular Protein ID: 478237503

Symbol: PZRN4_HUMAN

Name: PDZ domain-containing RING finger protein 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15010864

Title: Identification and characterization of PDZRN3 and PDZRN4 genes in silico.

PubMed ID: 15010864

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1036
  • Mass: 117103
  • Checksum: 26A43A0789CEA6B2
  • Sequence:
  • MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA 
    PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRGGCAS 
    GLGGGEVPAR GGCGPTPRAG RGGGARGGPP GGRWGRGRGP GPRVLAWRRR EKALLAQLWA 
    LQGEVQLTAR RYQEKFTQYM AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG 
    GRPNQNNQEG TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR 
    NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR PPTPPVPDIC 
    PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY EEVELCRVSS QEKLGLTVCY 
    RTDDEEDTGI YVSEVDPNSI AAKDGRIREG DRILQINGED VQNREEAVAL LSNDECKRIV 
    LLVARPEIQL DEGWLEDERN EFLEELNLEM LEEEHNEAMQ PTANEVEQPK KQEEEEGTTD 
    TATSSSNNHE KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL 
    QYNESLVSGE YIDSDCIGNP DEDCERFRQL LELKCKIRNH GEYDLYYSSS TIECNQGEQE 
    GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW TLHDGGFRNY NTSIDMQRGK 
    LDDIMEHPEK SDKDSSSAYN TAESCRSTPL TVDRSPDSSL PRVINLTNKK NLRSTMAATQ 
    SSSGQSSKES TSTKAKTTEQ GCSAESKEKV LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY 
    ANIPAHARHY QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY 
    ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL VRAKEQRRRR 
    EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN KKILDNWMTI QELMTHGAKS 
    PDGTRVHNAF LSVTTV

Genular Protein ID: 1045236282

Symbol: B4DGD1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 837
  • Mass: 95362
  • Checksum: 27AA63FE0AD7B338
  • Sequence:
  • MAHVRNFVGD LGGGHRRDGE HKPFTIVLER ENDTLGFNII GGRPNQNNQE GTSTEGIYVS 
    KILENGRADR ADGLEIHDKI MEVNGKDLSK ATHEEAVEAF RNAKEPIVVQ VLRRTPLSRP 
    AYGMASEVQL MNASTQTDIT FEHIMALAKL RPPTPPVPDI CPFLLSDSCH SLHPMEHEFY 
    EDNEYISSLP ADADRTEDFE YEEVELCRVS SQEKLGLTVC YRTDDEEDTG IYVSEVDPNS 
    IAAKDGRIRE GDRILQINGE DVQNREEAVA LLSNDECKRI VLLVARPEIQ LDEGWLEDER 
    NEFLEELNLE MLEEEHNEAM QPTANEVEQP KKQEEEEGTT DTATSSSNNH EKDSGVGRTD 
    ESLRNDESSE QENAAEDPNS TSLKSKRDLG QSQDTLGSVE LQYNESLVSG EYIDSDCIGN 
    PDEDCERFRQ LLELKCKIRN HGEYDLYYSS STIECNQGEQ EGVEHELQLL NEELRNIELE 
    CQNIMQAHRL QKVTDQYGDI WTLHDGGFRN YNTSIDMQRG KLDDIMEHPE KSDKDSSSAY 
    NTAESCRSTP LTVDRSPDSS LPRVINLTNK KNLRSTMAAT QSSSGQSSKE STSTKAKTTE 
    QGCSAESKEK VLEGSKLPDQ EKAVSEHIPY LSPYHSSSYR YANIPAHARH YQSYMQLIQQ 
    KSAVEYAQSQ LSLVSMCKES QKCSEPKMEW KVKIRSDGTR YITKRPVRDR ILKERALKIK 
    EERSGMTTDD DTMSEMKMGR YWSKEERKQH LVRAKEQRRR REFMMRSRLE CLKESPQSGS 
    EGKKEINIIE LSHKKMMKKR NKKILDNWMT IQELMTHGAK SPDGTRVHNA FLSVTTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.