EGR1 | ENSG00000120738 | NCBI 1958

Details for: EGR1

Gene ID: 1958

Symbol: EGR1

Ensembl ID: ENSG00000120738

Description: early growth response 1

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Intracellular signaling by second messengers
(R-HSA-9006925)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Bmp signaling pathway
(GO:0030509)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to heparin
(GO:0071504)
Cellular response to interleukin-8
(GO:0098759)
Cellular response to mycophenolic acid
(GO:0071506)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Circadian temperature homeostasis
(GO:0060086)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded methylated dna binding
(GO:0010385)
Estrous cycle
(GO:0044849)
Glomerular mesangial cell proliferation
(GO:0072110)
Hemi-methylated dna-binding
(GO:0044729)
Histone acetyltransferase binding
(GO:0035035)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Locomotor rhythm
(GO:0045475)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gene expression via chromosomal cpg island demethylation
(GO:0044029)
Positive regulation of glomerular metanephric mesangial cell proliferation
(GO:0072303)
Positive regulation of hormone biosynthetic process
(GO:0046886)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of post-translational protein modification
(GO:1901875)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Regulation of neuron apoptotic process
(GO:0043523)
Regulation of progesterone biosynthetic process
(GO:2000182)
Regulation of protein sumoylation
(GO:0033233)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to glucose
(GO:0009749)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to ischemia
(GO:0002931)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
T cell differentiation
(GO:0030217)
Transcription cis-regulatory region binding
(GO:0000976)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 488.6682
Cell Significance Index: -76.0100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 286.7806
Cell Significance Index: -72.7400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 170.9441
Cell Significance Index: -70.4200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 162.7755
Cell Significance Index: -76.8500
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 142.6606
Cell Significance Index: -73.3800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 114.1989
Cell Significance Index: -76.6300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 61.8676
Cell Significance Index: -76.2800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.3877
Cell Significance Index: -68.0100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 22.4096
Cell Significance Index: -68.8300
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 19.0798
Cell Significance Index: -75.2900
Cell Name: theca cell (CL0000503)
Fold Change: 14.9276
Cell Significance Index: 87.7000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 10.1490
Cell Significance Index: 129.9800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 9.7346
Cell Significance Index: 279.0500
Cell Name: odontoblast (CL0000060)
Fold Change: 7.0908
Cell Significance Index: 909.0000
Cell Name: peg cell (CL4033014)
Fold Change: 6.7147
Cell Significance Index: 155.1300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 6.1780
Cell Significance Index: 168.1600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 6.0559
Cell Significance Index: 107.0200
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 4.7401
Cell Significance Index: 18.1500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 4.3578
Cell Significance Index: 497.4400
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 4.3351
Cell Significance Index: 26.8200
Cell Name: kidney cell (CL1000497)
Fold Change: 4.2834
Cell Significance Index: 34.2000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 3.7383
Cell Significance Index: 264.3900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.6539
Cell Significance Index: 1615.4700
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.5205
Cell Significance Index: 73.6900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 3.4309
Cell Significance Index: 46.8100
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.8089
Cell Significance Index: 130.9700
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.8034
Cell Significance Index: 73.7200
Cell Name: supporting cell (CL0000630)
Fold Change: 2.5937
Cell Significance Index: 11.9800
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.3858
Cell Significance Index: 15.2300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2460
Cell Significance Index: 404.8900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 1.9060
Cell Significance Index: 11.7300
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.7696
Cell Significance Index: 11.7400
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7400
Cell Significance Index: 950.2500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.5844
Cell Significance Index: 194.8200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.5818
Cell Significance Index: 74.3500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.5701
Cell Significance Index: 54.5600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4966
Cell Significance Index: 111.5400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.4561
Cell Significance Index: 15.8300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.4550
Cell Significance Index: 199.8100
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3458
Cell Significance Index: 61.0000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0753
Cell Significance Index: 204.6300
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.9612
Cell Significance Index: 4.6800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8880
Cell Significance Index: 25.5900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8606
Cell Significance Index: 24.0500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8563
Cell Significance Index: 84.7000
Cell Name: lactocyte (CL0002325)
Fold Change: 0.8396
Cell Significance Index: 108.4800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5600
Cell Significance Index: 505.6400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4402
Cell Significance Index: 22.8700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3241
Cell Significance Index: 55.3400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2538
Cell Significance Index: 41.2800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2435
Cell Significance Index: 12.7900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1511
Cell Significance Index: 30.3200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0911
Cell Significance Index: 1.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0900
Cell Significance Index: 9.7900
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0807
Cell Significance Index: 5.2100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0548
Cell Significance Index: 41.4800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0367
Cell Significance Index: 0.9800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0317
Cell Significance Index: 23.2600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0240
Cell Significance Index: -45.1000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0263
Cell Significance Index: -2.6900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0301
Cell Significance Index: -46.3500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0336
Cell Significance Index: -20.9700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0356
Cell Significance Index: -26.4000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0483
Cell Significance Index: -89.0100
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0690
Cell Significance Index: -93.8300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0808
Cell Significance Index: -51.2900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0907
Cell Significance Index: -51.1500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0932
Cell Significance Index: -64.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1360
Cell Significance Index: -28.6500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1446
Cell Significance Index: -65.6500
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1758
Cell Significance Index: -2.6700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1787
Cell Significance Index: -2.0300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1898
Cell Significance Index: -68.0700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2023
Cell Significance Index: -23.1800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2075
Cell Significance Index: -24.4700
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2377
Cell Significance Index: -47.1800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2525
Cell Significance Index: -72.6600
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2651
Cell Significance Index: -18.3300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2724
Cell Significance Index: -39.6000
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.3110
Cell Significance Index: -18.6700
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3351
Cell Significance Index: -6.5400
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.4066
Cell Significance Index: -4.2500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4227
Cell Significance Index: -49.2600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4926
Cell Significance Index: -20.1800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.5050
Cell Significance Index: -4.6500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.6358
Cell Significance Index: -32.1300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.6816
Cell Significance Index: -38.2500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7033
Cell Significance Index: -73.2400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.7368
Cell Significance Index: -19.7100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8220
Cell Significance Index: -65.1000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8465
Cell Significance Index: -56.9200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8770
Cell Significance Index: -19.0000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.8936
Cell Significance Index: -68.5700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9284
Cell Significance Index: -17.1600
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9879
Cell Significance Index: -60.5700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0360
Cell Significance Index: -33.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0661
Cell Significance Index: -67.1900
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.0943
Cell Significance Index: -26.7000
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: -1.1281
Cell Significance Index: -6.7600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.2575
Cell Significance Index: -31.4400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** EGR1 is a member of the EGR family of transcription factors, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. EGR1 is a zinc finger protein that contains a highly conserved DNA-binding domain. It is highly expressed in various cell types, including immune cells, and its expression is tightly regulated by post-transcriptional modifications. EGR1 has been shown to interact with a wide range of transcriptional regulators, including histone acetyltransferases, histone deacetylases, and other transcription factors. **Pathways and Functions:** EGR1 plays a central role in various signaling pathways, including: 1. **Cytokine Signaling:** EGR1 is a key regulator of cytokine signaling, particularly in the context of immune responses. It has been shown to interact with cytokine receptors, including IL-1R and TNF-R, and modulate their signaling pathways. 2. **Growth Factor Signaling:** EGR1 is also involved in growth factor signaling, particularly in the context of cell proliferation and differentiation. 3. **Stress Response:** EGR1 has been shown to play a role in the cellular response to stress signals, including heat shock, oxidative stress, and DNA damage. 4. **Cellular Response to Gamma Radiation:** EGR1 has been implicated in the cellular response to gamma radiation, which is a key component of the DNA damage response. EGR1 has been shown to regulate a wide range of cellular processes, including: 1. **Cell Growth and Proliferation:** EGR1 has been shown to regulate cell growth and proliferation in various cell types, including immune cells and cancer cells. 2. **Differentiation:** EGR1 has been implicated in the regulation of differentiation processes, particularly in the context of immune cell development. 3. **Apoptosis:** EGR1 has been shown to regulate apoptosis in various cell types, including immune cells and cancer cells. 4. **Transcriptional Regulation:** EGR1 has been shown to regulate transcriptional processes, including the regulation of gene expression and chromatin structure. **Clinical Significance:** EGR1 has been implicated in several diseases, including: 1. **Cancer:** EGR1 has been shown to play a role in the regulation of cancer cell growth, proliferation, and differentiation. 2. **Autoimmune Disorders:** EGR1 has been implicated in the regulation of immune responses, particularly in the context of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. 3. **Cardiovascular Diseases:** EGR1 has been shown to play a role in the regulation of cardiovascular disease, particularly in the context of atherosclerosis and cardiac hypertrophy. 4. **Neurological Disorders:** EGR1 has been implicated in the regulation of neurological disorders, particularly in the context of Alzheimer's disease and Parkinson's disease. In conclusion, EGR1 is a multifaceted transcription factor that plays a crucial role in various cellular processes, including cell growth, differentiation, and immune response. Its expression is significantly elevated in various cell types, and it has been implicated in several diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Further research is needed to fully understand the role of EGR1 in human disease and to develop therapeutic strategies to target this transcription factor.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AT225

Genular Protein ID: 481652585

Symbol: EGR1_HUMAN

Name: AT225

UniProtKB Accession Codes:

P18146

Database IDs:

Citations:

PubMed ID: 2377485

Title: cDNA sequence of the human cellular early growth response gene Egr-1.

PubMed ID: 2377485

DOI: 10.1093/nar/18.14.4283

PubMed ID: 1569051

Title: A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation.

PubMed ID: 1569051

DOI: 10.1093/oxfordjournals.jbchem.a123748

PubMed ID: 2110381

Title: Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells.

PubMed ID: 2110381

DOI: 10.1126/science.2110381

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20121949

Title: Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.

PubMed ID: 20121949

DOI: 10.1111/j.1742-4658.2009.07553.x

PubMed ID: 20363028

Title: Mature human neutrophils constitutively express the transcription factor EGR-1.

PubMed ID: 20363028

DOI: 10.1016/j.molimm.2010.03.003

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 25258363

Title: Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.

PubMed ID: 25258363

DOI: 10.1101/gad.250746.114

PubMed ID: 25999311

Title: Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1.

PubMed ID: 25999311

DOI: 10.1016/j.febslet.2015.05.022

Sequence Information:

Length: 543
Mass: 57507
Checksum: 768CE670D9743E4E
Sequence:

MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGAPEGSGS 
NSSSSSSGGG GGGGGGSNSS SSSSTFNPQA DTGEQPYEHL TAESFPDISL NNEKVLVETS 
YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAS SSSAPSPAAS 
SASASQSPPL SCAVPSNDSS PIYSAAPTFP TPNTDIFPEP QSQAFPGSAG TALQYPPPAY 
PAAKGGFQVP MIPDYLFPQQ QGDLGLGTPD QKPFQGLESR TQQPSLTPLS TIKAFATQSG 
SQDLKALNTS YQSQLIKPSR MRKYPNRPSK TPPHERPYAC PVESCDRRFS RSDELTRHIR 
IHTGQKPFQC RICMRNFSRS DHLTTHIRTH TGEKPFACDI CGRKFARSDE RKRHTKIHLR 
QKDKKADKSV VASSATSSLS SYPSPVATSY PSPVTTSYPS PATTSYPSPV PTSFSSPGSS 
TYPSPVHSGF PSPSVATTYS SVPPAFPAQV SSFPSSAVTN SFSASTGLSD MTATFSPRTI 
EIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: EGR1

Associated with

Cells (max top 100)

Other Information

cDNA sequence of the human cellular early growth response gene Egr-1. PubMed ID: 2377485

A gene coding for a zinc finger protein is induced during 12-O-tetradecanoylphorbol-13-acetate-stimulated HL-60 cell differentiation. PubMed ID: 1569051

Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells. PubMed ID: 2110381

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. PubMed ID: 20121949

Mature human neutrophils constitutively express the transcription factor EGR-1. PubMed ID: 20363028

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence. PubMed ID: 25258363

Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. PubMed ID: 25999311