Details for: HIF1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 498.7617
Cell Significance Index: -77.5800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 298.4111
Cell Significance Index: -75.6900 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 184.3438
Cell Significance Index: -75.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 175.2723
Cell Significance Index: -82.7500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 170.6801
Cell Significance Index: -69.3400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 150.2473
Cell Significance Index: -77.2900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 123.6621
Cell Significance Index: -82.9800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 73.7057
Cell Significance Index: -70.3700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.7590
Cell Significance Index: -79.8500 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 27.6498
Cell Significance Index: -74.0700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.3877
Cell Significance Index: -62.6200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 20.3368
Cell Significance Index: -80.2500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.5896
Cell Significance Index: -40.6900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.1111
Cell Significance Index: 174.5800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.9363
Cell Significance Index: 77.2100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.5170
Cell Significance Index: 46.5200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.4372
Cell Significance Index: 299.6700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.3336
Cell Significance Index: 420.6800 - Cell Name: peg cell (CL4033014)
Fold Change: 2.0629
Cell Significance Index: 47.6600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.0625
Cell Significance Index: 56.1400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.9928
Cell Significance Index: 103.8000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.9796
Cell Significance Index: 53.0500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.7446
Cell Significance Index: 133.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.5397
Cell Significance Index: 840.8400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.5211
Cell Significance Index: 179.3900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.4850
Cell Significance Index: 2019.1500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.4735
Cell Significance Index: 41.1800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.3909
Cell Significance Index: 151.2900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.3301
Cell Significance Index: 263.9700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3026
Cell Significance Index: 261.3000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0139
Cell Significance Index: 60.8700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9578
Cell Significance Index: 864.7900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9091
Cell Significance Index: 124.8400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.8192
Cell Significance Index: 105.0200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.7146
Cell Significance Index: 1100.0800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6532
Cell Significance Index: 234.2900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5575
Cell Significance Index: 28.9600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.5214
Cell Significance Index: 3.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.4855
Cell Significance Index: 895.3200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4811
Cell Significance Index: 33.2700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.4422
Cell Significance Index: 7.8200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4348
Cell Significance Index: 192.2500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4292
Cell Significance Index: 42.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.3984
Cell Significance Index: 180.8400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3481
Cell Significance Index: 240.7600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3144
Cell Significance Index: 59.8300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.2979
Cell Significance Index: 22.2000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2734
Cell Significance Index: 12.8500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2714
Cell Significance Index: 12.3000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2334
Cell Significance Index: 10.8800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2218
Cell Significance Index: 6.3900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2123
Cell Significance Index: 5.6700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1977
Cell Significance Index: 372.1900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1095
Cell Significance Index: 5.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0670
Cell Significance Index: 8.6600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0318
Cell Significance Index: 20.1800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0156
Cell Significance Index: 2.6700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0112
Cell Significance Index: 0.6900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0087
Cell Significance Index: 0.0800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0031
Cell Significance Index: 0.1100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0191
Cell Significance Index: -14.0200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0274
Cell Significance Index: -20.2800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0402
Cell Significance Index: -30.4300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0475
Cell Significance Index: -1.0300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0504
Cell Significance Index: -7.3200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0838
Cell Significance Index: -8.5600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0957
Cell Significance Index: -53.9500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0999
Cell Significance Index: -62.3900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1200
Cell Significance Index: -1.4300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1720
Cell Significance Index: -4.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2168
Cell Significance Index: -13.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2424
Cell Significance Index: -69.7500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2816
Cell Significance Index: -59.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2957
Cell Significance Index: -30.7900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3196
Cell Significance Index: -36.6200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3408
Cell Significance Index: -7.2900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3545
Cell Significance Index: -22.3400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.4058
Cell Significance Index: -66.0100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4171
Cell Significance Index: -29.5000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4199
Cell Significance Index: -48.9400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.4288
Cell Significance Index: -28.8300 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5046
Cell Significance Index: -7.4500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.5673
Cell Significance Index: -25.1000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6101
Cell Significance Index: -69.6400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.6271
Cell Significance Index: -10.5000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6733
Cell Significance Index: -14.3400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7809
Cell Significance Index: -61.8500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8007
Cell Significance Index: -30.3200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8553
Cell Significance Index: -29.7200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8587
Cell Significance Index: -43.4000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.9588
Cell Significance Index: -28.1600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0396
Cell Significance Index: -27.8100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.0464
Cell Significance Index: -33.5200 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.0738
Cell Significance Index: -9.0200 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -1.1323
Cell Significance Index: -14.1200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.1391
Cell Significance Index: -8.7800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.2456
Cell Significance Index: -18.3900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3122
Cell Significance Index: -80.4500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -1.3498
Cell Significance Index: -20.5000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.3526
Cell Significance Index: -23.1800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 373320539
Symbol: HIF1A_HUMAN
Name: ARNT-interacting protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7539918
Title: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
PubMed ID: 7539918
PubMed ID: 9079689
Title: Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.
PubMed ID: 9079689
PubMed ID: 9782081
Title: The human hypoxia-inducible factor 1alpha gene: HIF1A structure and evolutionary conservation.
PubMed ID: 9782081
PubMed ID: 18638657
Title: Preferential expression of the novel alternative isoform I.3 of hypoxia-inducible factor 1alpha in activated human T lymphocytes.
PubMed ID: 18638657
PubMed ID: 12508121
Title: The DNA sequence and analysis of human chromosome 14.
PubMed ID: 12508121
DOI: 10.1038/nature01348
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8917528
Title: An essential role for p300/CBP in the cellular response to hypoxia.
PubMed ID: 8917528
PubMed ID: 9235919
Title: Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension.
PubMed ID: 9235919
PubMed ID: 9822602
Title: Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha.
PubMed ID: 9822602
PubMed ID: 9653127
Title: Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
PubMed ID: 9653127
PubMed ID: 10202154
Title: Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.
PubMed ID: 10202154
PubMed ID: 9887100
Title: Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1.
PubMed ID: 9887100
DOI: 10.1101/gad.13.1.64
PubMed ID: 11006129
Title: Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.
PubMed ID: 11006129
PubMed ID: 10944113
Title: Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
PubMed ID: 10944113
PubMed ID: 10594042
Title: Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha.
PubMed ID: 10594042
PubMed ID: 10758161
Title: Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations.
PubMed ID: 10758161
PubMed ID: 11566883
Title: Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.
PubMed ID: 11566883
PubMed ID: 11389899
Title: Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7.
PubMed ID: 11389899
PubMed ID: 11292861
Title: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
PubMed ID: 11292861
PubMed ID: 12464182
Title: Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation.
PubMed ID: 12464182
PubMed ID: 12080085
Title: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.
PubMed ID: 12080085
DOI: 10.1101/gad.991402
PubMed ID: 12351678
Title: Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor.
PubMed ID: 12351678
PubMed ID: 12914934
Title: S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity.
PubMed ID: 12914934
PubMed ID: 12560087
Title: HIF-1 alpha protein as a target for S-nitrosation.
PubMed ID: 12560087
PubMed ID: 12778114
Title: Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.
PubMed ID: 12778114
DOI: 10.1038/nsb936
PubMed ID: 15465032
Title: Sumoylation increases HIF-1alpha stability and its transcriptional activity.
PubMed ID: 15465032
PubMed ID: 14757845
Title: Molecular cloning and characterization of the von Hippel-Lindau-like protein.
PubMed ID: 14757845
PubMed ID: 15776016
Title: VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha.
PubMed ID: 15776016
PubMed ID: 16288748
Title: Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha.
PubMed ID: 16288748
PubMed ID: 16543236
Title: Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha.
PubMed ID: 16543236
PubMed ID: 16973622
Title: Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
PubMed ID: 16973622
PubMed ID: 17610843
Title: SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.
PubMed ID: 17610843
PubMed ID: 17956732
Title: RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia.
PubMed ID: 17956732
PubMed ID: 17244529
Title: RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.
PubMed ID: 17244529
PubMed ID: 16862177
Title: HIF-1alpha and EPAS ubiquitination mediated by the VHL tumour suppressor involves flexibility in the ubiquitination mechanism, similar to other RING E3 ligases.
PubMed ID: 16862177
PubMed ID: 18658046
Title: Transcriptional activation of HIF-1 by RORalpha and its role in hypoxia signaling.
PubMed ID: 18658046
PubMed ID: 18809331
Title: HIF-1 regulation: not so easy come, easy go.
PubMed ID: 18809331
PubMed ID: 19046997
Title: Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth.
PubMed ID: 19046997
PubMed ID: 19528298
Title: HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport.
PubMed ID: 19528298
PubMed ID: 20624928
Title: Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.
PubMed ID: 20624928
DOI: 10.1096/fj.10-159806
PubMed ID: 20889502
Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
PubMed ID: 20889502
PubMed ID: 20699359
Title: Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
PubMed ID: 20699359
DOI: 10.1242/jcs.068122
PubMed ID: 22537386
Title: UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1alpha accumulation.
PubMed ID: 22537386
PubMed ID: 22009797
Title: RSUME is implicated in HIF-1-induced VEGF-A production in pituitary tumour cells.
PubMed ID: 22009797
DOI: 10.1530/erc-11-0211
PubMed ID: 22128162
Title: Ubiquitin-specific protease 19 (USP19) regulates hypoxia-inducible factor 1alpha (HIF-1alpha) during hypoxia.
PubMed ID: 22128162
PubMed ID: 22286099
Title: The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
PubMed ID: 22286099
DOI: 10.1038/ncb2424
PubMed ID: 23401859
Title: DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase.
PubMed ID: 23401859
DOI: 10.1128/mcb.01342-12
PubMed ID: 23469069
Title: In silico structural and functional characterization of the RSUME splice variants.
PubMed ID: 23469069
PubMed ID: 24681946
Title: SIRT2 regulates tumour hypoxia response by promoting HIF-1alpha hydroxylation.
PubMed ID: 24681946
DOI: 10.1038/onc.2014.76
PubMed ID: 26517842
Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.
PubMed ID: 26517842
PubMed ID: 25974097
Title: Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
PubMed ID: 25974097
PubMed ID: 25615526
Title: UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1alpha.
PubMed ID: 25615526
DOI: 10.1038/ncomms7153
PubMed ID: 28296633
Title: The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.
PubMed ID: 28296633
DOI: 10.7554/elife.22693
PubMed ID: 30125331
Title: A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1alpha protein.
PubMed ID: 30125331
PubMed ID: 32697943
Title: Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1alpha/Glycolysis-Dependent Axis.
PubMed ID: 32697943
PubMed ID: 11089639
Title: A model for the complex between the hypoxia-inducible factor-1 (HIF-1) and its consensus DNA sequence.
PubMed ID: 11089639
PubMed ID: 12446723
Title: Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
PubMed ID: 12446723
PubMed ID: 11959990
Title: Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha.
PubMed ID: 11959990
PubMed ID: 11959977
Title: Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response.
PubMed ID: 11959977
PubMed ID: 12004076
Title: Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling.
PubMed ID: 12004076
PubMed ID: 12050673
Title: Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
PubMed ID: 12050673
DOI: 10.1038/nature00767
Sequence Information:
- Length: 826
- Mass: 92670
- Checksum: ABD4F7DAA135BE2D
- Sequence:
MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDDMKAQMNC FYLKALDGFV MVLTDDGDMI YISDNVNKYM GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGLVKKGKE QNTQRSFFLR MKCTLTSRGR TMNIKSATWK VLHCTGHIHV YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL IFSLQQTECV LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL APAAGDTIIS LDFGSNDTET DDQQLEEVPL YNDVMLPSPN EKLQNINLAM SPLPTAETPK PLRSSADPAL NQEVALKLEP NPESLELSFT MPQIQDQTPS PSDGSTRQSS PEPNSPSEYC FYVDSDMVNE FKLELVEKLF AEDTEAKNPF STQDTDLDLE MLAPYIPMDD DFQLRSFDQL SPLESSSASP ESASPQSTVT VFQQTQIQEP TANATTTTAT TDELKTVTKD RMEDIKILIA SPSPTHIHKE TTSATSSPYR DTQSRTASPN RAGKGVIEQT EKSHPRSPNV LSVALSQRTT VPEEELNPKI LALQNAQRKR KMEHDGSLFQ AVGIGTLLQQ PDDHAATTSL SWKRVKGCKS SEQNGMEQKT IILIPSDLAC RLLGQSMDES GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.