Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 4.92
Marker Score: 16,111 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 3.89
Marker Score: 4,122 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.86
Marker Score: 10,334 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.16
Marker Score: 4,354 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.74
Marker Score: 14,734 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.07
Marker Score: 13,320 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.01
Marker Score: 8,684 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,172 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.55
Marker Score: 1,656 - Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170,223 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 1.42
Marker Score: 5,497 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.39
Marker Score: 581 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.28
Marker Score: 1,813 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 1.16
Marker Score: 361 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 1.16
Marker Score: 3,380 - Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7,656 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.12
Marker Score: 6,808 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.12
Marker Score: 762 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.09
Marker Score: 1,180 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.07
Marker Score: 402 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 707 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.04
Marker Score: 431 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,829 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,054 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.95
Marker Score: 630 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,351 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 375 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.93
Marker Score: 517 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.86
Marker Score: 13,473 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.85
Marker Score: 1,722 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.83
Marker Score: 831 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.81
Marker Score: 191 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.81
Marker Score: 2,051 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.81
Marker Score: 1,540 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.8
Marker Score: 219 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3,122 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.72
Marker Score: 451 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.65
Marker Score: 661 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.65
Marker Score: 618 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.64
Marker Score: 410 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.61
Marker Score: 1,005 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 482 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 0.57
Marker Score: 306 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.57
Marker Score: 275 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174 - Cell Name: leukocyte (CL0000738)
Fold Change: 0.53
Marker Score: 304 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.52
Marker Score: 312 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.46
Marker Score: 894 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.45
Marker Score: 88 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.43
Marker Score: 307 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.41
Marker Score: 184 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.4
Marker Score: 398 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.37
Marker Score: 138 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.35
Marker Score: 2,927 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.31
Marker Score: 63 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.31
Marker Score: 68 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.3
Marker Score: 137 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.29
Marker Score: 1,761 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.28
Marker Score: 998 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.26
Marker Score: 70 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.26
Marker Score: 124 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.24
Marker Score: 185 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.23
Marker Score: 485 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.22
Marker Score: 93 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.22
Marker Score: 52 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.22
Marker Score: 132 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.22
Marker Score: 165 - Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.21
Marker Score: 55 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.21
Marker Score: 4,618 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.2
Marker Score: 308 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.19
Marker Score: 77 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.18
Marker Score: 161 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.17
Marker Score: 61 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.17
Marker Score: 596 - Cell Name: kidney loop of Henle epithelial cell (CL1000909)
Fold Change: 0.16
Marker Score: 101 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.16
Marker Score: 122 - Cell Name: fat cell (CL0000136)
Fold Change: 0.16
Marker Score: 88 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.15
Marker Score: 81 - Cell Name: glial cell (CL0000125)
Fold Change: 0.15
Marker Score: 169 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.15
Marker Score: 47 - Cell Name: podocyte (CL0000653)
Fold Change: 0.15
Marker Score: 55 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.14
Marker Score: 63 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.14
Marker Score: 324 - Cell Name: pericyte (CL0000669)
Fold Change: 0.13
Marker Score: 77 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.13
Marker Score: 87 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.13
Marker Score: 33 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.11
Marker Score: 74 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.11
Marker Score: 71
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 203554976
Symbol: KNG1_HUMAN
Name: Kininogen-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6441591
Title: Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen.
PubMed ID: 6441591
DOI: 10.1021/bi00319a005
PubMed ID: 2989293
Title: Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.
PubMed ID: 2989293
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3484703
Title: Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication.
PubMed ID: 3484703
PubMed ID: 3828072
Title: Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites.
PubMed ID: 3828072
PubMed ID: 2076202
Title: Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions.
PubMed ID: 2076202
PubMed ID: 4054110
Title: The amino acid sequence of the light chain of human high-molecular-mass kininogen.
PubMed ID: 4054110
PubMed ID: 3366244
Title: Isolation and identification of hydroxyproline analogues of bradykinin in human urine.
PubMed ID: 3366244
PubMed ID: 4952632
Title: Structural features of plasma kinins and kininogens.
PubMed ID: 4952632
PubMed ID: 7589467
Title: Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage.
PubMed ID: 7589467
PubMed ID: 6055465
PubMed ID: 4322742
Title: A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.
PubMed ID: 4322742
PubMed ID: 2989294
Title: Structural organization of the human kininogen gene and a model for its evolution.
PubMed ID: 2989294
PubMed ID: 3182782
Title: Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.
PubMed ID: 3182782
PubMed ID: 8760820
Title: Streptococcal cysteine proteinase releases kinins: a virulence mechanism.
PubMed ID: 8760820
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19824718
Title: An initial characterization of the serum phosphoproteome.
PubMed ID: 19824718
DOI: 10.1021/pr900603n
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 31087670
Title: Hereditary angioedema cosegregating with a novel kininogen 1 gene mutation changing the N-terminal cleavage site of bradykinin.
PubMed ID: 31087670
DOI: 10.1111/all.13869
PubMed ID: 33114181
Title: Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor.
PubMed ID: 33114181
DOI: 10.3390/jcm9113402
Sequence Information:
- Length: 644
- Mass: 71957
- Checksum: 3132B4DF2954C24E
- Sequence:
MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.