Details for: KNG1

Gene ID: 3827

Symbol: KNG1

Ensembl ID: ENSG00000113889

Description: kininogen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 23.6312
    Cell Significance Index: 397.4600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 15.5689
    Cell Significance Index: 41.0700
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 8.9788
    Cell Significance Index: 30.8300
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 6.0016
    Cell Significance Index: 22.9800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.3096
    Cell Significance Index: 55.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.8688
    Cell Significance Index: 2103.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8158
    Cell Significance Index: 360.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.5888
    Cell Significance Index: 23.4500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.1497
    Cell Significance Index: 4.3300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.0671
    Cell Significance Index: 6.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0319
    Cell Significance Index: 81.7300
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.9982
    Cell Significance Index: 8.4200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.9838
    Cell Significance Index: 12.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9415
    Cell Significance Index: 22.8100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4146
    Cell Significance Index: 4.0900
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3882
    Cell Significance Index: 1.0400
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.3312
    Cell Significance Index: 2.5500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.3281
    Cell Significance Index: 2.5900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.2846
    Cell Significance Index: 0.9900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.1576
    Cell Significance Index: 1.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1460
    Cell Significance Index: 3.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0847
    Cell Significance Index: 1.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0783
    Cell Significance Index: 1.3400
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.0757
    Cell Significance Index: 0.6900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0757
    Cell Significance Index: 0.7200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0513
    Cell Significance Index: 0.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0509
    Cell Significance Index: 35.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0397
    Cell Significance Index: 1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0243
    Cell Significance Index: 4.8700
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.0241
    Cell Significance Index: 0.2600
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.0122
    Cell Significance Index: 0.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0058
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0029
    Cell Significance Index: 5.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0026
    Cell Significance Index: 4.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.6200
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: -0.0005
    Cell Significance Index: 0.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0026
    Cell Significance Index: -0.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0030
    Cell Significance Index: -1.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0049
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0052
    Cell Significance Index: -2.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0061
    Cell Significance Index: -4.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0073
    Cell Significance Index: -0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0083
    Cell Significance Index: -5.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1500
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0097
    Cell Significance Index: -0.0900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0111
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0135
    Cell Significance Index: -2.3100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0144
    Cell Significance Index: -0.2000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0164
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0179
    Cell Significance Index: -3.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0229
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0255
    Cell Significance Index: -2.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0258
    Cell Significance Index: -1.9800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0279
    Cell Significance Index: -0.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0289
    Cell Significance Index: -0.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0304
    Cell Significance Index: -0.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0320
    Cell Significance Index: -5.7700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0335
    Cell Significance Index: -0.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0347
    Cell Significance Index: -3.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0360
    Cell Significance Index: -1.8900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0370
    Cell Significance Index: -0.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0376
    Cell Significance Index: -1.2300
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0382
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0405
    Cell Significance Index: -1.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0405
    Cell Significance Index: -1.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0425
    Cell Significance Index: -0.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0430
    Cell Significance Index: -1.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0437
    Cell Significance Index: -2.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0465
    Cell Significance Index: -0.6200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0465
    Cell Significance Index: -0.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0469
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0472
    Cell Significance Index: -1.2900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0480
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0492
    Cell Significance Index: -6.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0501
    Cell Significance Index: -0.7400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0531
    Cell Significance Index: -1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0544
    Cell Significance Index: -1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0571
    Cell Significance Index: -3.5100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0577
    Cell Significance Index: -0.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0586
    Cell Significance Index: -3.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0587
    Cell Significance Index: -6.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0594
    Cell Significance Index: -1.7100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0601
    Cell Significance Index: -0.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0609
    Cell Significance Index: -2.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0622
    Cell Significance Index: -2.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0629
    Cell Significance Index: -0.7800
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0662
    Cell Significance Index: -0.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0693
    Cell Significance Index: -1.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0734
    Cell Significance Index: -2.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0736
    Cell Significance Index: -1.1800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.0771
    Cell Significance Index: -1.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0790
    Cell Significance Index: -1.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0795
    Cell Significance Index: -1.3700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0818
    Cell Significance Index: -1.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0822
    Cell Significance Index: -1.7800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0823
    Cell Significance Index: -1.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KNG1 is a large protein with a molecular weight of approximately 70 kDa. It is a member of the serine protease inhibitor family and is characterized by its ability to bind to heparin, a potent anticoagulant. The KNG1 protein is expressed in various tissues, including the liver, kidney, and colon, and is also found in platelets and endothelial cells. **Pathways and Functions** The KNG1 gene is involved in several key pathways, including: 1. **Blood Coagulation**: KNG1 plays a crucial role in the intrinsic pathway of fibrin clot formation, where it acts as a cofactor for the activation of factor XII. 2. **Inflammation**: KNG1 is involved in the regulation of inflammatory responses, particularly in the context of platelet activation and thrombosis. 3. **Cell Signaling**: KNG1 interacts with G-protein coupled receptors (GPCRs) and modulates signaling pathways, including those involved in vasodilation and platelet aggregation. 4. **Protein Modification**: KNG1 is involved in post-translational protein modification, including phosphorylation and proteolysis. **Clinical Significance** Dysregulation of the KNG1 gene has been implicated in various diseases, including: 1. **Thrombosis**: Mutations in the KNG1 gene have been associated with an increased risk of thrombosis and cardiovascular disease. 2. **Inflammatory Disorders**: KNG1 expression has been linked to inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 3. **Cancer**: KNG1 has been identified as a potential biomarker for cancer, particularly in the context of pancreatic and colorectal cancer. 4. **Neurological Disorders**: KNG1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells** The KNG1 gene is expressed in various cell types, including: 1. Hepatoblasts 2. Kidney distal convoluted tubule epithelial cells 3. Kidney loop of Henle thick ascending limb epithelial cells 4. Double negative thymocytes 5. Periportal region hepatocytes 6. Centrilobular region hepatocytes 7. Midzonal region hepatocytes 8. Colon goblet cells 9. Endothelial cells of pericentral hepatic sinusoids 10. Mural cells **Conclusion** In conclusion, the KNG1 gene plays a critical role in various physiological processes, including blood coagulation, inflammation, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the immunological significance of this gene.

Genular Protein ID: 203554976

Symbol: KNG1_HUMAN

Name: Kininogen-1

UniProtKB Accession Codes:

P01042 A8K474 B2RCR2 C9JEX1 P01043 Q53EQ0 Q6PAU9 Q7M4P1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 2 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 EMBL 29 EMDB 3 Ensembl 3 EvolutionaryTrace 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 3 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 3 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 7 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6441591

Title: Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen.

PubMed ID: 6441591

DOI: 10.1021/bi00319a005

PubMed ID: 2989293

Title: Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.

PubMed ID: 2989293

DOI: 10.1016/s0021-9258(17)39515-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3484703

Title: Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication.

PubMed ID: 3484703

DOI: 10.1111/j.1432-1033.1986.tb09421.x

PubMed ID: 3828072

Title: Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites.

PubMed ID: 3828072

DOI: 10.1515/bchm3.1986.367.2.1231

PubMed ID: 2076202

Title: Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions.

PubMed ID: 2076202

DOI: 10.1515/bchm3.1990.371.2.977

PubMed ID: 4054110

Title: The amino acid sequence of the light chain of human high-molecular-mass kininogen.

PubMed ID: 4054110

DOI: 10.1111/j.1432-1033.1985.tb09199.x

PubMed ID: 3366244

Title: Isolation and identification of hydroxyproline analogues of bradykinin in human urine.

PubMed ID: 3366244

DOI: 10.1016/0014-5793(88)80427-7

PubMed ID: 4952632

Title: Structural features of plasma kinins and kininogens.

PubMed ID: 4952632

PubMed ID: 7589467

Title: Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage.

PubMed ID: 7589467

DOI: 10.1016/0014-5793(95)01037-f

PubMed ID: 6055465

Title: Second kininase in human blood plasma.

PubMed ID: 6055465

DOI: 10.1038/2151402a0

PubMed ID: 4322742

Title: A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

PubMed ID: 4322742

DOI: 10.1016/0005-2795(70)90017-6

PubMed ID: 2989294

Title: Structural organization of the human kininogen gene and a model for its evolution.

PubMed ID: 2989294

DOI: 10.1016/s0021-9258(17)39516-9

PubMed ID: 3182782

Title: Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

PubMed ID: 3182782

DOI: 10.1016/s0021-9258(18)37555-0

PubMed ID: 8760820

Title: Streptococcal cysteine proteinase releases kinins: a virulence mechanism.

PubMed ID: 8760820

DOI: 10.1084/jem.184.2.665

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19824718

Title: An initial characterization of the serum phosphoproteome.

PubMed ID: 19824718

DOI: 10.1021/pr900603n

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 31087670

Title: Hereditary angioedema cosegregating with a novel kininogen 1 gene mutation changing the N-terminal cleavage site of bradykinin.

PubMed ID: 31087670

DOI: 10.1111/all.13869

PubMed ID: 33114181

Title: Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor.

PubMed ID: 33114181

DOI: 10.3390/jcm9113402

Sequence Information:

  • Length: 644
  • Mass: 71957
  • Checksum: 3132B4DF2954C24E
  • Sequence:
    • MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT 
EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS 
VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN 
EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR 
IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK 
IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW 
EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG 
KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD 
DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE 
KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF 
NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.