Details for: KNG1

Gene ID: 3827

Symbol: KNG1

Ensembl ID: ENSG00000113889

Description: kininogen 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.92
    Marker Score: 16,111
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.89
    Marker Score: 4,122
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.86
    Marker Score: 10,334
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.16
    Marker Score: 4,354
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.74
    Marker Score: 14,734
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.07
    Marker Score: 13,320
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.01
    Marker Score: 8,684
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.55
    Marker Score: 1,656
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170,223
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.42
    Marker Score: 5,497
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.39
    Marker Score: 581
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.28
    Marker Score: 1,813
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.16
    Marker Score: 361
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.16
    Marker Score: 3,380
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7,656
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.12
    Marker Score: 6,808
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.12
    Marker Score: 762
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.09
    Marker Score: 1,180
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.07
    Marker Score: 402
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 707
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.04
    Marker Score: 431
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.95
    Marker Score: 630
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,351
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.93
    Marker Score: 517
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13,473
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.85
    Marker Score: 1,722
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.83
    Marker Score: 831
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.81
    Marker Score: 191
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.81
    Marker Score: 2,051
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1,540
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.8
    Marker Score: 219
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.74
    Marker Score: 3,122
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.72
    Marker Score: 451
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.65
    Marker Score: 661
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.65
    Marker Score: 618
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 410
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.61
    Marker Score: 1,005
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.57
    Marker Score: 306
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.57
    Marker Score: 275
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.53
    Marker Score: 304
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 312
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.46
    Marker Score: 894
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.45
    Marker Score: 88
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.43
    Marker Score: 307
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 184
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.4
    Marker Score: 398
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.37
    Marker Score: 138
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.35
    Marker Score: 2,927
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.31
    Marker Score: 63
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.31
    Marker Score: 68
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3
    Marker Score: 137
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.29
    Marker Score: 1,761
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.28
    Marker Score: 998
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.26
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.24
    Marker Score: 185
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 485
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.22
    Marker Score: 52
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.22
    Marker Score: 165
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.21
    Marker Score: 4,618
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.2
    Marker Score: 308
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 77
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 161
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.17
    Marker Score: 596
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.16
    Marker Score: 101
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.16
    Marker Score: 122
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.15
    Marker Score: 169
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 55
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 63
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 324
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 77
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.11
    Marker Score: 71

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** KNG1 is a large protein with a molecular weight of approximately 70 kDa. It is a member of the serine protease inhibitor family and is characterized by its ability to bind to heparin, a potent anticoagulant. The KNG1 protein is expressed in various tissues, including the liver, kidney, and colon, and is also found in platelets and endothelial cells. **Pathways and Functions** The KNG1 gene is involved in several key pathways, including: 1. **Blood Coagulation**: KNG1 plays a crucial role in the intrinsic pathway of fibrin clot formation, where it acts as a cofactor for the activation of factor XII. 2. **Inflammation**: KNG1 is involved in the regulation of inflammatory responses, particularly in the context of platelet activation and thrombosis. 3. **Cell Signaling**: KNG1 interacts with G-protein coupled receptors (GPCRs) and modulates signaling pathways, including those involved in vasodilation and platelet aggregation. 4. **Protein Modification**: KNG1 is involved in post-translational protein modification, including phosphorylation and proteolysis. **Clinical Significance** Dysregulation of the KNG1 gene has been implicated in various diseases, including: 1. **Thrombosis**: Mutations in the KNG1 gene have been associated with an increased risk of thrombosis and cardiovascular disease. 2. **Inflammatory Disorders**: KNG1 expression has been linked to inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 3. **Cancer**: KNG1 has been identified as a potential biomarker for cancer, particularly in the context of pancreatic and colorectal cancer. 4. **Neurological Disorders**: KNG1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Significantly Expressed Cells** The KNG1 gene is expressed in various cell types, including: 1. Hepatoblasts 2. Kidney distal convoluted tubule epithelial cells 3. Kidney loop of Henle thick ascending limb epithelial cells 4. Double negative thymocytes 5. Periportal region hepatocytes 6. Centrilobular region hepatocytes 7. Midzonal region hepatocytes 8. Colon goblet cells 9. Endothelial cells of pericentral hepatic sinusoids 10. Mural cells **Conclusion** In conclusion, the KNG1 gene plays a critical role in various physiological processes, including blood coagulation, inflammation, and cell signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the immunological significance of this gene.

Genular Protein ID: 203554976

Symbol: KNG1_HUMAN

Name: Kininogen-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6441591

Title: Isolation of a human cDNA for alpha 2-thiol proteinase inhibitor and its identity with low molecular weight kininogen.

PubMed ID: 6441591

DOI: 10.1021/bi00319a005

PubMed ID: 2989293

Title: Cloning and sequence analysis of cDNAs for human high molecular weight and low molecular weight prekininogens. Primary structures of two human prekininogens.

PubMed ID: 2989293

DOI: 10.1016/s0021-9258(17)39515-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3484703

Title: Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication.

PubMed ID: 3484703

DOI: 10.1111/j.1432-1033.1986.tb09421.x

PubMed ID: 3828072

Title: Human Ile-Ser-bradykinin, identical with rat T-kinin, is a major permeability factor in ovarian carcinoma ascites.

PubMed ID: 3828072

DOI: 10.1515/bchm3.1986.367.2.1231

PubMed ID: 2076202

Title: Ile-Ser-bradykinin is an aberrant permeability factor in various human malignant effusions.

PubMed ID: 2076202

DOI: 10.1515/bchm3.1990.371.2.977

PubMed ID: 4054110

Title: The amino acid sequence of the light chain of human high-molecular-mass kininogen.

PubMed ID: 4054110

DOI: 10.1111/j.1432-1033.1985.tb09199.x

PubMed ID: 3366244

Title: Isolation and identification of hydroxyproline analogues of bradykinin in human urine.

PubMed ID: 3366244

DOI: 10.1016/0014-5793(88)80427-7

PubMed ID: 4952632

Title: Structural features of plasma kinins and kininogens.

PubMed ID: 4952632

PubMed ID: 7589467

Title: Purification from human plasma of a tetrapeptide that potentiates insulin-like growth factor-I activity in chick embryo cartilage.

PubMed ID: 7589467

DOI: 10.1016/0014-5793(95)01037-f

PubMed ID: 6055465

Title: Second kininase in human blood plasma.

PubMed ID: 6055465

DOI: 10.1038/2151402a0

PubMed ID: 4322742

Title: A dipeptidyl carboxypeptidase that converts angiotensin I and inactivates bradykinin.

PubMed ID: 4322742

DOI: 10.1016/0005-2795(70)90017-6

PubMed ID: 2989294

Title: Structural organization of the human kininogen gene and a model for its evolution.

PubMed ID: 2989294

DOI: 10.1016/s0021-9258(17)39516-9

PubMed ID: 3182782

Title: Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

PubMed ID: 3182782

DOI: 10.1016/s0021-9258(18)37555-0

PubMed ID: 8760820

Title: Streptococcal cysteine proteinase releases kinins: a virulence mechanism.

PubMed ID: 8760820

DOI: 10.1084/jem.184.2.665

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19824718

Title: An initial characterization of the serum phosphoproteome.

PubMed ID: 19824718

DOI: 10.1021/pr900603n

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 31087670

Title: Hereditary angioedema cosegregating with a novel kininogen 1 gene mutation changing the N-terminal cleavage site of bradykinin.

PubMed ID: 31087670

DOI: 10.1111/all.13869

PubMed ID: 33114181

Title: Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor.

PubMed ID: 33114181

DOI: 10.3390/jcm9113402

Sequence Information:

  • Length: 644
  • Mass: 71957
  • Checksum: 3132B4DF2954C24E
  • Sequence:
  • MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT 
    EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS 
    VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN 
    EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR 
    IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK 
    IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW 
    EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TVSPPHTSMA PAQDEERDSG 
    KEQGHTRRHD WGHEKQRKHN LGHGHKHERD QGHGHQRGHG LGHGHEQQHG LGHGHKFKLD 
    DDLEHQGGHV LDHGHKHKHG HGHGKHKNKG KKNGKHNGWK TEHLASSSED STTPSAQTQE 
    KTEGPTPIPS LAKPGVTVTF SDFQDSDLIA TMMPPISPAP IQSDDDWIPD IQIDPNGLSF 
    NPISDFPDTT SPKCPGRPWK SVSEINPTTQ MKESYYFDLT DGLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.