Details for: MAGI2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: neuronal brush cell (CL0000555)
Fold Change: 8.57
Marker Score: 28,744 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 8.23
Marker Score: 146,180 - Cell Name: granule cell (CL0000120)
Fold Change: 6.65
Marker Score: 50,165 - Cell Name: stellate neuron (CL0000122)
Fold Change: 6.56
Marker Score: 35,259 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 6.38
Marker Score: 4,197 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 6.12
Marker Score: 8,606 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 5.96
Marker Score: 1,970 - Cell Name: macroglial cell (CL0000126)
Fold Change: 5.89
Marker Score: 13,540 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.76
Marker Score: 194,646 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.98
Marker Score: 26,138 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 4.84
Marker Score: 11,580 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 4.81
Marker Score: 22,269 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 4.2
Marker Score: 2,338 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 4.12
Marker Score: 1,981 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.03
Marker Score: 5,424 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 4.01
Marker Score: 4,851 - Cell Name: endocrine cell (CL0000163)
Fold Change: 3.9
Marker Score: 2,016 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.74
Marker Score: 2,173 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.63
Marker Score: 15,196 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.55
Marker Score: 7,789 - Cell Name: fat cell (CL0000136)
Fold Change: 3.39
Marker Score: 1,892 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 3.37
Marker Score: 3,881 - Cell Name: renal principal cell (CL0005009)
Fold Change: 3.37
Marker Score: 2,596 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 3.32
Marker Score: 2,501 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.31
Marker Score: 2,861 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 3.27
Marker Score: 1,039 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 3.27
Marker Score: 955 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.27
Marker Score: 69,707 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 3.26
Marker Score: 11,599 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.25
Marker Score: 72,692 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 3.22
Marker Score: 4,010 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.2
Marker Score: 6,159 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 3.19
Marker Score: 827 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 3.08
Marker Score: 8,796 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.06
Marker Score: 1,784 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 3.06
Marker Score: 5,135 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.92
Marker Score: 58,151 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.88
Marker Score: 22,076 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.87
Marker Score: 1,888 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.86
Marker Score: 42,778 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.84
Marker Score: 1,594 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.79
Marker Score: 1,633 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.79
Marker Score: 1,071 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.74
Marker Score: 104,220 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.71
Marker Score: 2,351 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.71
Marker Score: 1,337 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.7
Marker Score: 853 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.66
Marker Score: 1,444 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.66
Marker Score: 3,318 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.63
Marker Score: 960 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.62
Marker Score: 10,850 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.58
Marker Score: 1,081 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 2.52
Marker Score: 916 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.46
Marker Score: 90,709 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 2.44
Marker Score: 740 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.42
Marker Score: 8,594 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.36
Marker Score: 2,251 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.36
Marker Score: 9,121 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.35
Marker Score: 2,902 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.24
Marker Score: 1,335 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.2
Marker Score: 20,657 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.09
Marker Score: 21,591 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.08
Marker Score: 127,967 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.08
Marker Score: 1,844 - Cell Name: neuron (CL0000540)
Fold Change: 2.05
Marker Score: 8,333 - Cell Name: hepatoblast (CL0005026)
Fold Change: 2
Marker Score: 6,539 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,312 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.92
Marker Score: 526 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.92
Marker Score: 1,011 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,139 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.86
Marker Score: 2,001 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.85
Marker Score: 3,759 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.79
Marker Score: 455 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.68
Marker Score: 540 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.67
Marker Score: 529 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.66
Marker Score: 6,934 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.66
Marker Score: 999 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.65
Marker Score: 3,897 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.64
Marker Score: 2,539 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.64
Marker Score: 26,374 - Cell Name: podocyte (CL0000653)
Fold Change: 1.61
Marker Score: 596 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.56
Marker Score: 410 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.51
Marker Score: 473 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.48
Marker Score: 1,586 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,533 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.45
Marker Score: 523 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.35
Marker Score: 8,678 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.35
Marker Score: 21,111 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.33
Marker Score: 502 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.33
Marker Score: 1,883 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.3
Marker Score: 376 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.3
Marker Score: 442 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.24
Marker Score: 604 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.23
Marker Score: 313 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.22
Marker Score: 1,775 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.2
Marker Score: 1,099 - Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.15
Marker Score: 1,103 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.14
Marker Score: 721 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.12
Marker Score: 4,684 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.12
Marker Score: 4,815
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2401122005
Symbol: MAGI2_HUMAN
Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9647693
Title: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
PubMed ID: 9647693
PubMed ID: 9734811
Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
PubMed ID: 9734811
PubMed ID: 12853948
PubMed ID: 12690205
Title: Human chromosome 7: DNA sequence and biology.
PubMed ID: 12690205
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10760291
Title: Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2.
PubMed ID: 10760291
PubMed ID: 11707428
Title: Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.
PubMed ID: 11707428
PubMed ID: 16464232
Title: Postsynaptic recruitment of Dendrin depends on both dendritic mRNA transport and synaptic anchoring.
PubMed ID: 16464232
PubMed ID: 23751499
Title: The adhesion protein IgSF9b is coupled to neuroligin 2 via S-SCAM to promote inhibitory synapse development.
PubMed ID: 23751499
PubMed ID: 24608321
Title: Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis.
PubMed ID: 24608321
DOI: 10.1093/hmg/ddu104
PubMed ID: 27932480
Title: MAGI2 mutations cause congenital nephrotic syndrome.
PubMed ID: 27932480
Sequence Information:
- Length: 1455
- Mass: 158754
- Checksum: 93E170D070A70A9C
- Sequence:
MSKSLKKKSH WTSKVHESVI GRNPEGQLGF ELKGGAENGQ FPYLGEVKPG KVAYESGSKL VSEELLLEVN ETPVAGLTIR DVLAVIKHCK DPLRLKCVKQ GGIVDKDLRH YLNLRFQKGS VDHELQQIIR DNLYLRTVPC TTRPHKEGEV PGVDYIFITV EDFMELEKSG ALLESGTYED NYYGTPKPPA EPAPLLLNVT DQILPGATPS AEGKRKRNKS VSNMEKASIE PPEEEEEERP VVNGNGVVVT PESSEHEDKS AGASGEMPSQ PYPAPVYSQP EELKEQMDDT KPTKPEDNEE PDPLPDNWEM AYTEKGEVYF IDHNTKTTSW LDPRLAKKAK PPEECKENEL PYGWEKIDDP IYGTYYVDHI NRRTQFENPV LEAKRKLQQH NMPHTELGTK PLQAPGFREK PLFTRDASQL KGTFLSTTLK KSNMGFGFTI IGGDEPDEFL QVKSVIPDGP AAQDGKMETG DVIVYINEVC VLGHTHADVV KLFQSVPIGQ SVNLVLCRGY PLPFDPEDPA NSMVPPLAIM ERPPPVMVNG RHNYETYLEY ISRTSQSVPD ITDRPPHSLH SMPTDGQLDG TYPPPVHDDN VSMASSGATQ AELMTLTIVK GAQGFGFTIA DSPTGQRVKQ ILDIQGCPGL CEGDLIVEIN QQNVQNLSHT EVVDILKDCP IGSETSLIIH RGGFFSPWKT PKPIMDRWEN QGSPQTSLSA PAIPQNLPFP PALHRSSFPD STEAFDPRKP DPYELYEKSR AIYESRQQVP PRTSFRMDSS GPDYKELDVH LRRMESGFGF RILGGDEPGQ PILIGAVIAM GSADRDGRLH PGDELVYVDG IPVAGKTHRY VIDLMHHAAR NGQVNLTVRR KVLCGGEPCP ENGRSPGSVS THHSSPRSDY ATYTNSNHAA PSSNASPPEG FASHSLQTSD VVIHRKENEG FGFVIISSLN RPESGSTITV PHKIGRIIDG SPADRCAKLK VGDRILAVNG QSIINMPHAD IVKLIKDAGL SVTLRIIPQE ELNSPTSAPS SEKQSPMAQQ SPLAQQSPLA QPSPATPNSP IAQPAPPQPL QLQGHENSYR SEVKARQDVK PDIRQPPFTD YRQPPLDYRQ PPGGDYQQPP PLDYRQPPLL DYRQHSPDTR QYPLSDYRQP QDFDYFTVDM EKGAKGFGFS IRGGREYKMD LYVLRLAEDG PAIRNGRMRV GDQIIEINGE STRDMTHARA IELIKSGGRR VRLLLKRGTG QVPEYDEPAP WSSPAAAAPG LPEVGVSLDD GLAPFSPSHP APPSDPSHQI SPGPTWDIKR EHDVRKPKEL SACGQKKQRL GEQRERSASP QRAARPRLEE APGGQGRPEA GRPASEARAP GLAAADAADA ARAGGKEAPR AAAGSELCRR EGPGAAPAFA GPGGGGSGAL EAEGRAGARA GPRPGPRPPG GAPARKAAVA PGPWKVPGSD KLPSVLKPGA SAASR
Genular Protein ID: 3026157830
Symbol: B7Z4H4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1253
- Mass: 138877
- Checksum: 9DB5F5EF602919C5
- Sequence:
MSKSLKKKSH WTSKVHESVI GRNPEGQLGF ELKGGAENGQ FPYLGEVKPG KVAYESGSKL VSEELLLEVN ETPVAGLTIR DVLAVIKHCK DPLRLKCVKQ GGIVDKDLRH YLNLRFQKGS VDHELQQIIR DNLYLRTVPC TTRPHKEGEV PGVDYIFITV EDFMELEKSG ALLESGTYED NYYGTPKPPA EPAPLLLNVT DQILPGATPS AEGKRKRNKS VSNMEKASIE PPEEEEEERP VVNGNGVVVT PESSEHEDKS AGASGEMPSQ PYPAPVYSQP EELKEQMDDT KPTKPEDNEE PDPLPDNWEM AYTEKGEVYF IDHNTKTTSW LDPRLAKKAK PPEECKENEL PYGWEKIDDP IYGTYYVDHI NRRTQFENPV LEAKRKLQQH NMPHTELGTK PLQAPGFREK PLFTRDASQL KGTFLSTTLK KSNMGFGFTI IGGDEPDEFL QVKSVIPDGP AAQDGKMETG DVIVYINEVC VLGHTHADVV KLFQSVPIGQ SVNLVLCRGY PLPFDPEDPA NSMVPPLAIM ERPPPVMVNG RHNYETYLEY ISRTSQSVPD ITDRPPHSLH SMPTDGQLDG TYPPPVHDDN VSMASSGATQ AELMTLTIVK GAQGFGFTIA DSPTGQRVKQ ILDIQGCPGL CEGDLIVEIN QQNVQNLSHT EVVDILKDCP IGSETSLIIH RGGFFSPWKT PKPIMDRWEN QGSPQTSLSA PAIPQNLPFP PALHRSSFPD STEAFDPRKP DPYELYEKSR AIYESRQQVP PRTSFRMDSS GPDYKELDVH LRRMESGFGF RILGGDEPGQ PILIGAVIAM GSADRDGRLH PGDELVYVDG IPVAGKTHRY VIDLMHHAAR NGQVNLTVRR KVLCGGEPCP ENGRSPGSVS THHSSPRSDY ATYTNSNHAA PSSNASPPEG FASHSLQTSD VVIHRKENEG FGFVIISSLN RPESGSTITV PHKIGRIIDG SPADRCAKLK VGDRILAVNG QSIINMPHAD IVKLIKDAGL SVTLRIIPQE ELNSPTSAPS SEKQSPMAQQ SPLAQQSPLA QPSPATPNSP IAQPAPPQPL QLQGHENSYR SEVKARQDVK PDIRQPPFTD YRQPPLDYRQ PPGGDYQQPP PLDYRQPPLL DYRQHSPDTR QYPLSDYRQP QDFDYFTVDM EKGAKGFGFS IRGGREYKMD LYVLRLAEDG PAIRNGRMRV GDQIIEINGE STRDMTHARA IELIKSGGRR VRLLLKRGTG QVPEYDEPAP AQAVLLRFRL TAF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.