Details for: EFNA5

Gene ID: 1946

Symbol: EFNA5

Ensembl ID: ENSG00000184349

Description: ephrin A5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 161.7924
    Cell Significance Index: -66.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8340
    Cell Significance Index: -74.3200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.2525
    Cell Significance Index: -35.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 6.5689
    Cell Significance Index: 504.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.1819
    Cell Significance Index: 116.8700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.8708
    Cell Significance Index: 34.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7896
    Cell Significance Index: 212.6500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.4201
    Cell Significance Index: 42.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3295
    Cell Significance Index: 126.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.0970
    Cell Significance Index: 1110.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.9426
    Cell Significance Index: 130.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9109
    Cell Significance Index: 583.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.8594
    Cell Significance Index: 1816.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0652
    Cell Significance Index: 1428.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.7297
    Cell Significance Index: 23.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.4034
    Cell Significance Index: 2160.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.3961
    Cell Significance Index: 30.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.2543
    Cell Significance Index: 24.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2260
    Cell Significance Index: 32.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0448
    Cell Significance Index: 1967.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.0254
    Cell Significance Index: 465.3800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.6648
    Cell Significance Index: 14.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6084
    Cell Significance Index: 15.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5733
    Cell Significance Index: 517.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5620
    Cell Significance Index: 101.3100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5476
    Cell Significance Index: 54.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.5290
    Cell Significance Index: 7.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4986
    Cell Significance Index: 61.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4943
    Cell Significance Index: 57.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4892
    Cell Significance Index: 25.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4766
    Cell Significance Index: 648.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4376
    Cell Significance Index: 7.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3878
    Cell Significance Index: 49.7200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.3339
    Cell Significance Index: 5.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2796
    Cell Significance Index: 45.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2094
    Cell Significance Index: 386.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1332
    Cell Significance Index: 58.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1176
    Cell Significance Index: 12.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1128
    Cell Significance Index: 5.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0278
    Cell Significance Index: 15.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0094
    Cell Significance Index: -0.5800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0104
    Cell Significance Index: -0.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0267
    Cell Significance Index: -2.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0319
    Cell Significance Index: -1.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0384
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0455
    Cell Significance Index: -28.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0501
    Cell Significance Index: -37.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0535
    Cell Significance Index: -39.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0701
    Cell Significance Index: -2.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0894
    Cell Significance Index: -67.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1313
    Cell Significance Index: -19.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1342
    Cell Significance Index: -28.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2027
    Cell Significance Index: -12.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2049
    Cell Significance Index: -58.9700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2208
    Cell Significance Index: -2.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2546
    Cell Significance Index: -5.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2635
    Cell Significance Index: -36.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2864
    Cell Significance Index: -56.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2937
    Cell Significance Index: -50.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3000
    Cell Significance Index: -6.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3303
    Cell Significance Index: -42.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3363
    Cell Significance Index: -15.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3607
    Cell Significance Index: -24.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3680
    Cell Significance Index: -11.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3917
    Cell Significance Index: -40.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4487
    Cell Significance Index: -14.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4537
    Cell Significance Index: -27.2400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.4700
    Cell Significance Index: -2.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4927
    Cell Significance Index: -33.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5158
    Cell Significance Index: -12.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5415
    Cell Significance Index: -14.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5722
    Cell Significance Index: -65.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6011
    Cell Significance Index: -42.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.6133
    Cell Significance Index: -72.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6182
    Cell Significance Index: -26.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6368
    Cell Significance Index: -72.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6462
    Cell Significance Index: -7.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6681
    Cell Significance Index: -13.8600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.6892
    Cell Significance Index: -3.0000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7216
    Cell Significance Index: -6.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7360
    Cell Significance Index: -38.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8145
    Cell Significance Index: -64.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8147
    Cell Significance Index: -5.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.8390
    Cell Significance Index: -16.5900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.8695
    Cell Significance Index: -11.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8829
    Cell Significance Index: -65.8100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9004
    Cell Significance Index: -31.2900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9287
    Cell Significance Index: -19.7100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.9519
    Cell Significance Index: -13.5500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.9612
    Cell Significance Index: -16.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9985
    Cell Significance Index: -16.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0711
    Cell Significance Index: -55.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.0904
    Cell Significance Index: -70.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2583
    Cell Significance Index: -44.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2671
    Cell Significance Index: -36.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.3149
    Cell Significance Index: -32.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3397
    Cell Significance Index: -84.4400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.3473
    Cell Significance Index: -14.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Receptor Tyrosine Kinase**: EFNA5 is a member of the Ephrin family, which are transmembrane receptor tyrosine kinases that mediate cell-cell interactions through ligand-dependent receptor activation. 2. **Highly Conserved**: EFNA5 exhibits high sequence conservation across species, suggesting its essential role in fundamental biological processes. 3. **Widespread Expression**: EFNA5 is expressed in various cell types, including neurons, epithelial cells, cardiac myocytes, and taste receptor cells. 4. **Regulatory Functions**: EFNA5 modulates cell-cell interactions, axon guidance, and synaptic plasticity, highlighting its importance in neural development and organization. **Pathways and Functions** 1. **Eph-ephrin Mediated Repulsion of Cells**: EFNA5 interacts with Eph receptors to mediate repulsive signals, guiding axons and regulating cell migration during neural development. 2. **Axon Guidance**: EFNA5 plays a critical role in retinal ganglion cell axon guidance, ensuring proper neural circuit formation. 3. **Neurotrophin Trka/Trkb/Trkc Receptor Binding**: EFNA5 interacts with neurotrophin receptors, regulating the growth and survival of neurons. 4. **Cell-Cell Adhesion**: EFNA5 modulates cell-cell adhesion, influencing the organization and function of epithelial tissues. 5. **Regulation of Actin Cytoskeleton Organization**: EFNA5 regulates the organization of the actin cytoskeleton, impacting cell shape, migration, and adhesion. **Clinical Significance** 1. **Neurological Disorders**: Alterations in EFNA5 expression or function have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and autism spectrum disorder. 2. **Cardiovascular Disease**: EFNA5 has been linked to cardiovascular disease, with studies suggesting its role in cardiac development and function. 3. **Cancer**: EFNA5 has been identified as a potential oncogene, with its overexpression associated with tumor progression and metastasis. 4. **Neuropsychiatric Disorders**: EFNA5 has been implicated in neuropsychiatric disorders, including schizophrenia and bipolar disorder. In conclusion, EFNA5 is a multifunctional receptor tyrosine kinase that plays a critical role in various cellular processes, including cell-cell interactions, axon guidance, and synaptic plasticity. Its widespread expression and regulatory functions highlight its importance in neural development and organization, as well as its potential involvement in various diseases. Further research is needed to fully elucidate the role of EFNA5 in human health and disease.

Genular Protein ID: 1923765930

Symbol: EFNA5_HUMAN

Name: Ephrin-A5

UniProtKB Accession Codes:

P52803

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7748564

Title: Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation.

PubMed ID: 7748564

DOI: 10.1016/0896-6273(95)90335-6

PubMed ID: 9245480

Title: LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.

PubMed ID: 9245480

DOI: 10.1006/cyto.1997.0199

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10601038

Title: Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion.

PubMed ID: 10601038

DOI: 10.1101/gad.13.23.3125

PubMed ID: 11870224

Title: Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

PubMed ID: 11870224

DOI: 10.1242/jcs.115.5.1059

PubMed ID: 16239146

Title: Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

PubMed ID: 16239146

DOI: 10.1016/j.cell.2005.08.014

PubMed ID: 17400922

Title: Crystal structure of the human ephrin-A5 ectodomain.

PubMed ID: 17400922

DOI: 10.1110/ps.062665807

Sequence Information:

  • Length: 228
  • Mass: 26297
  • Checksum: 6893B1CCACFF3F57
  • Sequence:
    • MLHVEMLTLV FLVLWMCVFS QDPGSKAVAD RYAVYWNSSN PRFQRGDYHI DVCINDYLDV 
FCPHYEDSVP EDKTERYVLY MVNFDGYSAC DHTSKGFKRW ECNRPHSPNG PLKFSEKFQL 
FTPFSLGFEF RPGREYFYIS SAIPDNGRRS CLKLKVFVRP TNSCMKTIGV HDRVFDVNDK 
VENSLEPADD TVHESAEPSR GENAAQTPRI PSRLLAILLF LLAMLLTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.