Details for: AKR1C1

Gene ID: 1645

Symbol: AKR1C1

Ensembl ID: ENSG00000187134

Description: aldo-keto reductase family 1 member C1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.62
    Marker Score: 89030
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.38
    Marker Score: 1176
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.32
    Marker Score: 14796
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.21
    Marker Score: 921
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2
    Marker Score: 498
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2
    Marker Score: 1163
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.98
    Marker Score: 498
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.97
    Marker Score: 6438
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.96
    Marker Score: 1671
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.89
    Marker Score: 546
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.89
    Marker Score: 1986
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.86
    Marker Score: 1551
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.83
    Marker Score: 1043
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.75
    Marker Score: 1172
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.69
    Marker Score: 2482
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168569
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.46
    Marker Score: 427
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.39
    Marker Score: 10355
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.39
    Marker Score: 1411
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.38
    Marker Score: 646
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.35
    Marker Score: 310
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.3
    Marker Score: 1523
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.3
    Marker Score: 322
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.3
    Marker Score: 412
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.28
    Marker Score: 8216
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.26
    Marker Score: 312
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.24
    Marker Score: 975
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.18
    Marker Score: 4193
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.15
    Marker Score: 387
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.14
    Marker Score: 4904
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.13
    Marker Score: 403
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.13
    Marker Score: 632
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.06
    Marker Score: 5701
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.06
    Marker Score: 2763
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6321
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.02
    Marker Score: 10306.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48011
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.96
    Marker Score: 1106
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.95
    Marker Score: 8239
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.93
    Marker Score: 256
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.91
    Marker Score: 3810
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.91
    Marker Score: 1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5161
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.87
    Marker Score: 212
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 789
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 615
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.8
    Marker Score: 1823
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8
    Marker Score: 4738.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4742
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 314.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.78
    Marker Score: 220
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.78
    Marker Score: 4074
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.76
    Marker Score: 522
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.76
    Marker Score: 674
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.74
    Marker Score: 360
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 831.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11560
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.73
    Marker Score: 1477
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.72
    Marker Score: 262
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.72
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 654
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.72
    Marker Score: 5586
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.71
    Marker Score: 4626
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2976
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.7
    Marker Score: 255
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.7
    Marker Score: 751
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.69
    Marker Score: 259
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.68
    Marker Score: 292.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.68
    Marker Score: 5854
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.66
    Marker Score: 173
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.65
    Marker Score: 631
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.65
    Marker Score: 250
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.65
    Marker Score: 731
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.64
    Marker Score: 241
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.64
    Marker Score: 21458
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.62
    Marker Score: 126
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.62
    Marker Score: 619
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.61
    Marker Score: 177
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.61
    Marker Score: 414
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.61
    Marker Score: 1153
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.59
    Marker Score: 228
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.59
    Marker Score: 141
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.58
    Marker Score: 177
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 345
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.57
    Marker Score: 149
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.57
    Marker Score: 883
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.57
    Marker Score: 356
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.55
    Marker Score: 3603
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.55
    Marker Score: 594

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Other Information

**Key characteristics:** * AKR1C1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is expressed in a variety of cell types, including fibroblasts, bronchial goblet cells, and corneal endothelial cells. * AKR1C1 is a key enzyme in the metabolism of bile acids and bile salts. * It is also involved in the metabolism of steroids, vitamin A, and other molecules. **Pathways and functions:** * AKR1C1 is involved in the following pathways: * Alditol:nadp+ 1-oxidoreductase activity * Aldo-keto reductase (nadp) activity * Bile acid and bile salt metabolism * Drug adme * Estradiol 17-beta-dehydrogenase [nad(p)] activity * Metabolism * Metabolism of fat-soluble vitamins * Metabolism of lipids * Metabolism of steroids * Metabolism of vitamins and cofactors * Prednisone adme * It is also involved in visual phototransduction. **Clinical significance:** * Mutations in the AKR1C1 gene have been linked to various diseases, including liver disease, gallbladder disease, and bile duct disease. * AKR1C1 inhibitors are being investigated as potential treatments for these diseases. * By understanding the role of AKR1C1 in bile acid and bile salt metabolism, researchers may be able to develop new therapies for liver diseases.

Genular Protein ID: 1057798921

Symbol: AK1C1_HUMAN

Name: Chlordecone reductase homolog HAKRC

UniProtKB Accession Codes:

Q04828 P52896 Q5SR15 Q7M4N2 Q9UCX2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 5 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 14 DrugCentral 1 EC 13 EMBL 20 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PIR 4 PIRSF 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 Rhea 46 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486699

Title: cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family.

PubMed ID: 8486699

DOI: 10.1016/s0021-9258(18)82220-7

PubMed ID: 8132567

Title: Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding.

PubMed ID: 8132567

DOI: 10.1016/s0021-9258(17)37210-1

PubMed ID: 7515059

Title: Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.

PubMed ID: 7515059

DOI: 10.1016/s0021-9258(17)40716-2

PubMed ID: 7626489

Title: Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

PubMed ID: 7626489

DOI: 10.1016/0960-0760(95)00019-v

PubMed ID: 10672042

Title: Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

PubMed ID: 10672042

DOI: 10.1046/j.1365-2443.2000.00310.x

PubMed ID: 11013348

Title: Characterization of a human 20alpha-hydroxysteroid dehydrogenase.

PubMed ID: 11013348

DOI: 10.1677/jme.0.0250221

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8274401

Title: Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

PubMed ID: 8274401

DOI: 10.1016/0960-0760(93)90308-j

PubMed ID: 8573067

Title: Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

PubMed ID: 8573067

DOI: 10.1042/bj3130373

PubMed ID: 8172617

Title: Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

PubMed ID: 8172617

DOI: 10.1042/bj2990545

PubMed ID: 10998348

Title: Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

PubMed ID: 10998348

DOI: 10.1042/0264-6021:3510067

PubMed ID: 14672942

Title: Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

PubMed ID: 14672942

DOI: 10.1074/jbc.m313308200

PubMed ID: 19218247

Title: Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

PubMed ID: 19218247

DOI: 10.1074/jbc.m809465200

PubMed ID: 12899831

Title: Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids.

PubMed ID: 12899831

DOI: 10.1016/s0022-2836(03)00762-9

PubMed ID: 21414777

Title: Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.

PubMed ID: 21414777

DOI: 10.1016/j.bmcl.2011.01.076

Sequence Information:

  • Length: 323
  • Mass: 36788
  • Checksum: 9CB215478FBD29D5
  • Sequence:
    • MDSKYQCVKL NDGHFMPVLG FGTYAPAEVP KSKALEATKL AIEAGFRHID SAHLYNNEEQ 
VGLAIRSKIA DGSVKREDIF YTSKLWCNSH RPELVRPALE RSLKNLQLDY VDLYLIHFPV 
SVKPGEEVIP KDENGKILFD TVDLCATWEA VEKCKDAGLA KSIGVSNFNR RQLEMILNKP 
GLKYKPVCNQ VECHPYFNQR KLLDFCKSKD IVLVAYSALG SHREEPWVDP NSPVLLEDPV 
LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTS EEMKAIDGLN 
RNVRYLTLDI FAGPPNYPFS DEY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.