Details for: PAEP

Gene ID: 5047

Symbol: PAEP

Ensembl ID: ENSG00000122133

Description: progestagen associated endometrial protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 76.3113
    Cell Significance Index: 607.1700
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 54.9425
    Cell Significance Index: 170.4300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.4170
    Cell Significance Index: 58.4100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 3.0735
    Cell Significance Index: 39.7700
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.9514
    Cell Significance Index: 18.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2165
    Cell Significance Index: 1210.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1544
    Cell Significance Index: 295.8600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.6974
    Cell Significance Index: 8.1200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.2857
    Cell Significance Index: 13.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9271
    Cell Significance Index: 21.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3161
    Cell Significance Index: 4.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0536
    Cell Significance Index: 33.4600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0490
    Cell Significance Index: 0.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0048
    Cell Significance Index: 0.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0041
    Cell Significance Index: -0.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0050
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0079
    Cell Significance Index: -1.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0107
    Cell Significance Index: -0.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0108
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0143
    Cell Significance Index: -0.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0155
    Cell Significance Index: -9.8200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0253
    Cell Significance Index: -0.2800
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0258
    Cell Significance Index: -0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0360
    Cell Significance Index: -12.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0364
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0382
    Cell Significance Index: -4.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0415
    Cell Significance Index: -18.8400
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0425
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0436
    Cell Significance Index: -0.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0488
    Cell Significance Index: -14.0300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0599
    Cell Significance Index: -0.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0653
    Cell Significance Index: -12.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0664
    Cell Significance Index: -9.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0682
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0778
    Cell Significance Index: -8.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0872
    Cell Significance Index: -8.9100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0961
    Cell Significance Index: -0.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1447
    Cell Significance Index: -18.7000
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.1957
    Cell Significance Index: -0.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2325
    Cell Significance Index: -17.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2495
    Cell Significance Index: -2.3700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2520
    Cell Significance Index: -4.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2851
    Cell Significance Index: -17.4800
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3424
    Cell Significance Index: -3.9400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3561
    Cell Significance Index: -5.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3664
    Cell Significance Index: -13.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3865
    Cell Significance Index: -17.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3869
    Cell Significance Index: -10.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3972
    Cell Significance Index: -13.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4239
    Cell Significance Index: -13.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4358
    Cell Significance Index: -13.8800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.4402
    Cell Significance Index: -4.4900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4474
    Cell Significance Index: -11.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4493
    Cell Significance Index: -12.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4680
    Cell Significance Index: -20.7000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4762
    Cell Significance Index: -13.5900
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.4779
    Cell Significance Index: -6.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4862
    Cell Significance Index: -22.8500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.5169
    Cell Significance Index: -12.8900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.5311
    Cell Significance Index: -6.4600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.5425
    Cell Significance Index: -7.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5466
    Cell Significance Index: -20.7000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5500
    Cell Significance Index: -13.7200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5516
    Cell Significance Index: -13.3600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.5600
    Cell Significance Index: -9.0700
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.5808
    Cell Significance Index: -7.3600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5898
    Cell Significance Index: -9.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6060
    Cell Significance Index: -13.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6157
    Cell Significance Index: -11.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6251
    Cell Significance Index: -17.9200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6404
    Cell Significance Index: -13.8400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6592
    Cell Significance Index: -13.9900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6639
    Cell Significance Index: -12.9800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.6652
    Cell Significance Index: -9.0500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.6670
    Cell Significance Index: -13.9200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6840
    Cell Significance Index: -13.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6885
    Cell Significance Index: -9.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6899
    Cell Significance Index: -13.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7032
    Cell Significance Index: -13.8400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7095
    Cell Significance Index: -14.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7098
    Cell Significance Index: -30.8600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.7203
    Cell Significance Index: -11.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7440
    Cell Significance Index: -14.5200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.7515
    Cell Significance Index: -12.6400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.7538
    Cell Significance Index: -8.9000
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.7803
    Cell Significance Index: -8.9800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8114
    Cell Significance Index: -14.0300
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.8208
    Cell Significance Index: -7.6900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.8531
    Cell Significance Index: -10.9600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.8696
    Cell Significance Index: -9.4200
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.8754
    Cell Significance Index: -10.5600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: -0.8967
    Cell Significance Index: -9.1600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.9278
    Cell Significance Index: -13.8800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.9309
    Cell Significance Index: -12.3700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.9365
    Cell Significance Index: -9.6600
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.9387
    Cell Significance Index: -11.2800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9437
    Cell Significance Index: -12.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PAEP is a progestagen-associated protein, meaning its expression is modulated by progesterone, a hormone involved in the menstrual cycle and pregnancy. The protein is also known as Glycodelin, and its sequence is highly conserved across species. PAEP has been implicated in various cellular processes, including apoptosis, regulation of sperm capacitation, and modulation of granulocyte macrophage colony-stimulating factor (GM-CSF) production. **Pathways and Functions:** PAEP is involved in several key pathways, including: 1. **Apoptotic process**: PAEP has been shown to regulate apoptosis in various cell types, including erythrocytes and leukocytes. Its expression is downregulated in apoptotic cells, suggesting a role in promoting cell survival. 2. **Negative regulation of sperm capacitation**: PAEP has been shown to inhibit sperm capacitation, a critical step in fertilization. This suggests that PAEP plays a role in regulating reproductive processes. 3. **Positive regulation of GM-CSF production**: PAEP has been shown to increase GM-CSF production in hematopoietic stem cells, which is essential for the development and function of the immune system. 4. **Protein binding**: PAEP has been shown to bind to various proteins, including sperm and zona pellucida, suggesting a role in regulating sperm-egg interactions. 5. **Small molecule binding**: PAEP has been shown to bind to small molecules, including steroids, which may regulate its expression and function. **Clinical Significance:** The PAEP gene has been implicated in various diseases, including: 1. **Endometriosis**: PAEP has been shown to be overexpressed in endometriotic lesions, suggesting a role in the development and progression of this disease. 2. **Reproductive disorders**: PAEP has been implicated in reproductive disorders, including infertility and recurrent miscarriage. 3. **Immune system disorders**: PAEP has been shown to be involved in immune system disorders, including autoimmune diseases and cancer. In conclusion, PAEP is a multifaceted gene involved in regulating various cellular processes, including apoptosis, sperm capacitation, and immune system function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the role of PAEP in human health and disease.

Genular Protein ID: 1041656930

Symbol: PAEP_HUMAN

Name: Glycodelin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3194393

Title: Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins.

PubMed ID: 3194393

DOI: 10.1073/pnas.85.23.8845

PubMed ID: 2206398

Title: Human placental protein 14 gene: sequence and characterization of a short duplication.

PubMed ID: 2206398

DOI: 10.1089/dna.1990.9.401

PubMed ID: 2006183

Title: Multiple forms of mRNA encoding human pregnancy-associated endometrial alpha 2-globulin, a beta-lactoglobulin homologue.

PubMed ID: 2006183

DOI: 10.1073/pnas.88.6.2456

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3667877

Title: Pregnancy-associated endometrial alpha 2-globulin, the major secretory protein of the luteal phase and first trimester pregnancy endometrium, is not glycosylated prolactin but related to beta-lactoglobulins.

PubMed ID: 3667877

DOI: 10.1210/jcem-65-5-1067

PubMed ID: 3569148

Title: Amino acid sequence homology between human placental protein 14 and beta-lactoglobulins from various species.

PubMed ID: 3569148

DOI: 10.1210/endo-120-6-2620

PubMed ID: 11278680

Title: Purification and characterization of an immunomodulatory endometrial protein, glycodelin.

PubMed ID: 11278680

DOI: 10.1074/jbc.m010451200

PubMed ID: 12672671

Title: Zona-binding inhibitory factor-1 from human follicular fluid is an isoform of glycodelin.

PubMed ID: 12672671

DOI: 10.1095/biolreprod.102.012658

PubMed ID: 7531163

Title: Factors affecting fertilization: endometrial placental protein 14 reduces the capacity of human spermatozoa to bind to the human zona pellucida.

PubMed ID: 7531163

DOI: 10.1016/s0015-0282(16)57372-5

PubMed ID: 7592613

Title: Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.

PubMed ID: 7592613

DOI: 10.1074/jbc.270.41.24116

PubMed ID: 8943270

Title: Gender-specific glycosylation of human glycodelin affects its contraceptive activity.

PubMed ID: 8943270

DOI: 10.1074/jbc.271.50.32159

PubMed ID: 9239694

Title: Glycodelin from seminal plasma is a differentially glycosylated form of contraceptive glycodelin-A.

PubMed ID: 9239694

DOI: 10.1093/molehr/2.10.759

PubMed ID: 9918684

Title: Placental protein 14 functions as a direct T-cell inhibitor.

PubMed ID: 9918684

DOI: 10.1006/cimm.1998.1408

PubMed ID: 15883155

Title: Glycodelin-S in human seminal plasma reduces cholesterol efflux and inhibits capacitation of spermatozoa.

PubMed ID: 15883155

DOI: 10.1074/jbc.m504103200

PubMed ID: 17192260

Title: Cumulus oophorus-associated glycodelin-C displaces sperm-bound glycodelin-A and -F and stimulates spermatozoa-zona pellucida binding.

PubMed ID: 17192260

DOI: 10.1074/jbc.m607482200

PubMed ID: 25422905

Title: The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans.

PubMed ID: 25422905

DOI: 10.1042/bj20141003

Sequence Information:

  • Length: 180
  • Mass: 20624
  • Checksum: 0813A74A4231149E
  • Sequence:
  • MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM ATLKAPLRVH 
    ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF KINYTVANEA TLLDTDYDNF 
    LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF

Genular Protein ID: 3981388372

Symbol: B2R4F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 162
  • Mass: 18884
  • Checksum: E6B0D3AA9F5E7D1E
  • Sequence:
  • MDIPQTKQDL ELPKLAGTWH SMAMATNNIS LMVTLKAPLR VHITSLLPTP EDNLEIVLHR 
    WENNSCVEKK VLGEKTENPK KFKINYTVAN EATLLDTDYD NFLFLCLKDT TTPIQSMMCQ 
    YLARVLVEDD EIMQGFIRAF RPLPRHLWYL LDLKQMEEPC RF

Genular Protein ID: 4188907172

Symbol: A6XNE0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 143
  • Mass: 16361
  • Checksum: FC4400DE39F096A6
  • Sequence:
  • MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKLAGTWHSM AMATNNISLM ATLKAPLRVH 
    ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF KINSRVLVED DEIMQGFIRA 
    FRPLPRHLWY LLDLKQMEEP CRF

Genular Protein ID: 279775243

Symbol: B4E3C0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 158
  • Mass: 18279
  • Checksum: 5EAD600B313F221E
  • Sequence:
  • MLCLLLTLGV ALVCGVPAMD IPQTKQDLEL PKAPLRVHIT SLLPTPEDNL EIVLHRWENN 
    SCVEKKVLGE KTENPKKFKI NYTVANEATL LDTDYDNFLF LCLKDTTTPI QSMMCQYLAR 
    VLVEDDEIMQ GFIRAFRPLP RHLWYLLDLK QMEEPCRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.