Details for: PLA1A

Gene ID: 51365

Symbol: PLA1A

Ensembl ID: ENSG00000144837

Description: phospholipase A1 member A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.2983
    Cell Significance Index: -4.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.8181
    Cell Significance Index: -4.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.6565
    Cell Significance Index: 128.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.3297
    Cell Significance Index: 58.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9793
    Cell Significance Index: 42.8800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.9299
    Cell Significance Index: 32.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8696
    Cell Significance Index: 59.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.5946
    Cell Significance Index: 24.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.4114
    Cell Significance Index: 86.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6435
    Cell Significance Index: 16.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5721
    Cell Significance Index: 25.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5630
    Cell Significance Index: 107.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.5194
    Cell Significance Index: 3.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.4510
    Cell Significance Index: 6.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3650
    Cell Significance Index: 7.7700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.3475
    Cell Significance Index: 1.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3405
    Cell Significance Index: 20.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2932
    Cell Significance Index: 3.0400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2799
    Cell Significance Index: 3.1800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2454
    Cell Significance Index: 3.5300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2442
    Cell Significance Index: 24.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2375
    Cell Significance Index: 25.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2030
    Cell Significance Index: 183.2500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.1821
    Cell Significance Index: 1.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1412
    Cell Significance Index: 22.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1401
    Cell Significance Index: 27.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1189
    Cell Significance Index: 8.2300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0885
    Cell Significance Index: 1.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0770
    Cell Significance Index: 4.0100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.0597
    Cell Significance Index: 0.5100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0589
    Cell Significance Index: 1.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0372
    Cell Significance Index: 0.5400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0359
    Cell Significance Index: 0.9600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.0248
    Cell Significance Index: 0.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0031
    Cell Significance Index: 2.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0032
    Cell Significance Index: -5.8600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0035
    Cell Significance Index: -2.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0053
    Cell Significance Index: -3.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0056
    Cell Significance Index: -0.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0065
    Cell Significance Index: -3.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -4.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0089
    Cell Significance Index: -5.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0109
    Cell Significance Index: -4.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0114
    Cell Significance Index: -4.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0127
    Cell Significance Index: -2.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0137
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0199
    Cell Significance Index: -3.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0221
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0247
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0264
    Cell Significance Index: -3.0300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0323
    Cell Significance Index: -3.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0331
    Cell Significance Index: -4.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0344
    Cell Significance Index: -4.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0388
    Cell Significance Index: -2.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0416
    Cell Significance Index: -2.1000
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0430
    Cell Significance Index: -0.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0434
    Cell Significance Index: -0.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0436
    Cell Significance Index: -5.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0438
    Cell Significance Index: -5.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0449
    Cell Significance Index: -4.6800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0467
    Cell Significance Index: -0.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0569
    Cell Significance Index: -2.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0600
    Cell Significance Index: -1.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0602
    Cell Significance Index: -3.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0638
    Cell Significance Index: -0.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0745
    Cell Significance Index: -5.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0762
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0776
    Cell Significance Index: -5.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0801
    Cell Significance Index: -3.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0808
    Cell Significance Index: -2.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0808
    Cell Significance Index: -5.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0834
    Cell Significance Index: -1.2000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0870
    Cell Significance Index: -2.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0872
    Cell Significance Index: -5.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0926
    Cell Significance Index: -1.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0937
    Cell Significance Index: -5.2600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0971
    Cell Significance Index: -1.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1023
    Cell Significance Index: -4.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1028
    Cell Significance Index: -5.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1087
    Cell Significance Index: -4.8100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1202
    Cell Significance Index: -4.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1242
    Cell Significance Index: -4.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1251
    Cell Significance Index: -3.3400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1267
    Cell Significance Index: -1.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1271
    Cell Significance Index: -4.1600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1292
    Cell Significance Index: -1.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1359
    Cell Significance Index: -4.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1378
    Cell Significance Index: -4.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1427
    Cell Significance Index: -2.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The PLA1A gene exhibits a range of characteristics that underscore its importance in phospholipid metabolism. These include: 1. **Specificity for phosphatidylserine**: The PLA1A enzyme is specifically designed to hydrolyze the sn-2 ester bond of phosphatidylserine, a unique feature that sets it apart from other phospholipases. 2. **High expression levels**: The PLA1A gene is highly expressed in various cell types, including mucosal type mast cells, ciliated cells of the bronchus, and small intestine goblet cells. 3. **Regulation of phospholipid metabolism**: The PLA1A enzyme plays a crucial role in the remodeling of phospholipid membranes, particularly phosphatidylserine, which is essential for maintaining membrane structure and function. **Pathways and Functions:** The PLA1A enzyme is involved in several key pathways and functions, including: 1. **Acrosomal membrane remodeling**: The PLA1A enzyme is essential for the remodeling of the acrosomal membrane, a complex structure that plays a critical role in fertilization and sperm function. 2. **Lipid catabolic process**: The PLA1A enzyme is involved in the breakdown of phospholipids, which is an essential step in lipid metabolism. 3. **Glycerophospholipid biosynthesis**: The PLA1A enzyme is also involved in the synthesis of glycerophospholipids, which are essential components of cellular membranes. 4. **Phospholipase A1 activity**: The PLA1A enzyme exhibits phospholipase A1 activity, which is essential for the hydrolysis of phospholipids. **Clinical Significance:** The PLA1A gene's involvement in various immune-related disorders and diseases highlights its clinical significance. Some potential clinical applications of the PLA1A gene include: 1. **Immunological disorders**: The PLA1A gene's expression in mucosal type mast cells and ciliated cells of the bronchus suggests its potential involvement in immunological disorders, such as asthma and allergic reactions. 2. **Inflammatory diseases**: The PLA1A enzyme's role in lipid catabolic processes and phospholipase A1 activity suggests its potential involvement in inflammatory diseases, such as atherosclerosis and rheumatoid arthritis. 3. **Cancer**: The PLA1A gene's expression in various cell types, including Paneth cells of the epithelium of the small intestine, suggests its potential involvement in cancer development and progression. In conclusion, the PLA1A gene is a critical component of phospholipid metabolism, and its involvement in various immune-related disorders and diseases highlights its clinical significance. Further research is needed to fully elucidate the role of the PLA1A gene in human health and disease.

Genular Protein ID: 3494661477

Symbol: PLA1A_HUMAN

Name: Phosphatidylserine-specific phospholipase A1

UniProtKB Accession Codes:

Q53H76 B2R8V2 B4DXA2 O95991 Q86WX6 Q9UPD2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 30 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 ESTHER 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 4 Rhea 12 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9074642

Title: nmd, a novel gene differentially expressed in human melanoma cell lines, encodes a new atypical member of the enzyme family of lipases.

PubMed ID: 9074642

DOI: 10.1016/s0014-5793(97)00098-7

PubMed ID: 10196188

Title: An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans.

PubMed ID: 10196188

DOI: 10.1074/jbc.274.16.11053

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12436198

Title: Polymorphisms in the gene encoding phosphatidylserine-specific phospholipase A1 (PSPLA1).

PubMed ID: 12436198

DOI: 10.1007/s100380200093

Sequence Information:

  • Length: 456
  • Mass: 49715
  • Checksum: CF09D725FD75820B
  • Sequence:
    • MPPGPWESCF WVGGLILWLS VGSSGDAPPT PQPKCADFQS ANLFEGTDLK VQFLLFVPSN 
PSCGQLVEGS SDLQNSGFNA TLGTKLIIHG FRVLGTKPSW IDTFIRTLLR ATNANVIAVD 
WIYGSTGVYF SAVKNVIKLS LEISLFLNKL LVLGVSESSI HIIGVSLGAH VGGMVGQLFG 
GQLGQITGLD PAGPEYTRAS VEERLDAGDA LFVEAIHTDT DNLGIRIPVG HVDYFVNGGQ 
DQPGCPTFFY AGYSYLICDH MRAVHLYISA LENSCPLMAF PCASYKAFLA GRCLDCFNPF 
LLSCPRIGLV EQGGVKIEPL PKEVKVYLLT TSSAPYCMHH SLVEFHLKEL RNKDTNIEVT 
FLSSNITSSS KITIPKQQRY GKGIIAHATP QCQINQVKFK FQSSNRVWKK DRTTIIGKFC 
TALLPVNDRE KMVCLPEPVN LQASVTVSCD LKIACV

Genular Protein ID: 3024088885

Symbol: G5E9W0_HUMAN

Name: N/A

UniProtKB Accession Codes:

G5E9W0

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 ESTHER 1 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 10 RuleBase 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 440
  • Mass: 48085
  • Checksum: 52546C105DB0EDB8
  • Sequence:
    • MHKSSSIWGD APPTPQPKCA DFQSANLFEG TDLKVQFLLF VPSNPSCGQL VEGSSDLQNS 
GFNATLGTKL IIHGFRVLGT KPSWIDTFIR TLLRATNANV IAVDWIYGST GVYFSAVKNV 
IKLSLEISLF LNKLLVLGVS ESSIHIIGVS LGAHVGGMVG QLFGGQLGQI TGLDPAGPEY 
TRASVEERLD AGDALFVEAI HTDTDNLGIR IPVGHVDYFV NGGQDQPGCP TFFYAGYSYL 
ICDHMRAVHL YISALENSCP LMAFPCASYK AFLAGRCLDC FNPFLLSCPR IGLVEQGGVK 
IEPLPKEVKV YLLTTSSAPY CMHHSLVEFH LKELRNKDTN IEVTFLSSNI TSSSKITIPK 
QQRYGKGIIA HATPQCQINQ VKFKFQSSNR VWKKDRTTII GKFCTALLPV NDREKMVCLP 
EPVNLQASVT VSCDLKIACV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.